Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

“…Among several ways to enhance the efficacy of ICI, trials are exploring combining ICIs with serine/threonine‐protein kinase mTOR (mTOR) inhibitors in different tumor types. …”
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Phenome-wide association studies between SERINC2 and neuropsychiatric disorders by Ping Liu, Xinqun Luo, Liping Cao, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Xinghua Pan, Ruilan Yang, Zewen Tan, Yunlong Tan, Chiang-shan Li, Xiaoyun Guo, Zhiren Wang, Xingguang Luo, Xingguang Luo

“…The bipolar disorder-risk alleles had these regulatory effects but with different effect patterns. Finally, SERINC2 mRNA was differentially expressed in several brain regions between alcoholism or schizophrenia and controls.ConclusionSERINC2 is primarily linked to substance use disorders, schizophrenia, OCD, autism and bipolar disorder, not only statistically but also biologically.…”
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Indoor ventilation frequency and cognitive function among Chinese old adults: the multiple mediation effect of anxiety and self-rated health by Lu Lin, Pingping He, Sihui Qiu, Xiaohui Qiu, Jiangping Chen

“…Methods Using the 2018 China Longitudinal Health and Longevity Survey (CLHLS) dataset, we finally selected 10,372 Chinese seniors over the age of 65. …”
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CMPK2 promotes NLRP3 inflammasome activation via mtDNA‐STING pathway in house dust mite‐induced allergic rhinitis by YaoMing Zheng, YaDong Xie, JiaYing Li, YuJie Cao, Min Li, Qing Cao, MiaoMiao Han, HongFei Lou, YiLai Shu, Hui Xiao, HuaBin Li

“…Methods We examined the expression of cytidine/uridine monophosphate kinase 2 (CMPK2), STING and the NLRP3 inflammasome in both AR patients and mice. …”
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Clinical Holistic Medicine: Metastatic Cancer by Søren Ventegodt, Elin Solheim, Mads E. Saunte, Mohammed Morad, Isack Kandel, Joav Merrick

“…The holistic therapeutic work includes (1) teaching existential theory, (2) working with life perspective and philosophy of life, (3) helping the patient to acknowledge the state of the disease and the feelings connected to it, and finally (4) getting the patient into the holistic state of healing: (a) feeling old repressed emotions, (b) understanding why she got sick from a holistic point of view, and finally (c) letting go of the negative beliefs and decisions that made her sick according to the holistic theory of nongenetic diseases. …”
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Prognostic Significance of Percutaneous Coronary Intervention for First Acute Myocardial Infarction with Heart Failure: Five-Year Follow-Up Results by Zichao Cheng, Yuchen Shi, Hongyu Peng, Donghui Zhao, Qian Fan, Jinghua Liu

“…Of 671 patients, 62 were lost to follow-up. Finally, 609 patients were recruited in this study. …”
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Design of Network Service Transmission with LDPC Coding in Space Laser Communication by ZHANG Xiaole, TAN Xiaochuan, LI Zhe

“…Each Ethernet frame can be finally recovered by deframing at the receiving end.…”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

“…Its <i>lukF</i> component could be regarded as chimaera comprising parts of <i>lukQ</i> and of <i>lukF-P83</i>. A putative kinase gene of 1095 basepairs was found to be associated with equine strains of <i>S. aureus</i>. …”
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Aracı Kurumların Finansal Performanslarının Vikor Yöntemi İle Değerlendirilmesi by Ali Köse, Kübra Akıllı

“…Niteliksel ve niceliksel kriter veya amaçlara sahip olan kararların varlığı durumunda, karar vericinin çözüme ulaşmasında yardımcı olması amacıyla geliştirilen Çok Kriterli Karar Verme yöntemleri, birden fazla kritere sahip ve aynı anda uygulamaya konulan seçimler karşısında karar vericinin en iyi tercihi yapmasını sağlayan araçlardır. Finans sistemindeki finansal kurumların en önemli faaliyetlerinden biri aracılık faaliyetleridir. …”
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Thematic Curriculum and Pupils’ Academic Performance: A case study of Kitumba Sub-County, Kabale District. by Bibian, Kemigisha

“…The third objective revealed that the quality of instructors using thematic curriculum was influential to pupils’ academic performance (R= 0.621, P-Value=0.005) and finally the fourth objective found out that inadequate teaching resources, lack of proper training for implementers were the major challenges in implementing thematic curriculum. …”
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A Mathematical Modeling and an Optimization Algorithm for Marine Ship Route Planning by Lili Huang

“…To begin, a mathematical model of ship route planning is created, taking into account the impact of nonuniformity in the offshore wind field on ship route planning, with the shortest ship sailing time as the goal. …”
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Pendulum attached to a vibrating point: Semi-analytical solution by optimal and modified homotopy perturbation method by Tapas Roy, Aya Soqi, Dilip K. Maiti, Rania Wannan, Jihad Asad

“…In addition, the analytical expression for the amplitude and the frequency of the oscillations for two cases: simple regular oscillation and the irregular oscillation is computed. Finally, the simplicity of the obtained solutions facilities a clear understanding, and the OM-HPM offer a robust and efficient analytical tool to obtain series based analytical solution for such kind of problems.…”
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Mędrzec – ideał dla wybranych? Tożsamość mędrca w Księdze Syracha by Jolanta Judyta Pudełko

“…He points at hard beginnings, at enjoyment of the fruit of his efforts, and finally at the necessity for sharing his acquired and received wisdom. …”
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Persistent CSF Rhinorrhoea, Pneumocephalus, and Recurrent Meningitis Following Misdiagnosis of Olfactory Neuroblastoma by Neil Barua, David A. Hilton, William Mukonoweshuro, Hisham Khalil, Louis Pobereskin

“…Definitive control of the CSF leak was finally achieved through a transcranial approach with prolonged lumbar drainage. …”
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Research on the big data planning model of mobile wireless network by Yu CHEN, Xiaodong CHEN, Yue LIU

“…With the development of big data technology in recent years,various industries have strengthened their research and application in their professional field.For the wireless network planning specialty of mobile operators,it will effectively improve the accuracy and automation level of network planning by combining the market,network,terminal,base station,planning and other data sources owned by enterprises.For the existing large data planning platforms,there are generally problems that do not fully consider the discrimination of scenario or regional types,which have a certain impact on the planning results.Firstly,the data sources,processing application architecture and implementation method which the large data planning model of mobile wireless network needed were analyzed.Then,the standards,algorithms and parameter settings of the three coverage planning models of surface,line and point were studied after the key steps and model analysis of the big data planning in mobile wireless network.Finally,some ideas and suggestions were put forward for the construction and application of the big data planning model in mobile wireless network.…”
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Development of Floating-Point MAC Engine for 2-D Convolution of Image by Ajay Kumar Sahu, Vishnumurthy Kedlaya K., Subramanya G. Nayak

“…A low power multiplier with reduced dynamic power, specifically when operating on pixels and a faster increment by one circuit based on AND-EXOR gate structures, has been proposed to improve the MAC architecture. Finally, the paper shows the post-synthesis power dissipation, area estimate, and the quality comparison of the image obtained from the RTL Simulation of the proposed architecture.…”
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Network intelligence standards, open source and industry research by Lingli DENG, Ninglun GU, Xiangyang YUAN, Li YU, Junlan FENG, Chao DENG, Zhiqiang YANG, Tongxu ZHANG, Rongyu WU, Xinpeng ZHANG

“…Network intelligence is the deep integration of AI technology and communication network hardware, software, systems, processes, etc.to improve process intelligence, reduce costs, increase efficiency, improve quality, accelerate technology innovation, and enable service agility.The autonomous network proposes to optimize user experience, automate management operations, and maximize resource efficiency by simplifying the network architecture, encapsulating autonomous domains, and providing closed loops for business/network operation control, which clarifies the target architecture and implementation path for network intelligence.Firstly, based on the layered architecture and evaluation framework of the autonomous network, the network intelligent technology system was summerized.Secondly, extensive research on relevant standards organizations, open source communities, industrial collaboration, and R＆amp;D and application status were conducted.Finally, gap analysis, collaborative suggestions and summary prospects for guiding the following-up industry development were provided in terms of the application requirements from operators in related practices.…”
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Discours « tenant lieu » d’un autre discours : un espace générique de la représentation de discours autre by Jacqueline Authier-Revuz

“…It shows how the representation of the other discourse can appear as a primary defining criterion for a variety of discourse genres (summary, press review, pastiche...) thus brought together in a generic space. Finally, he sets out to delimit a specific zone within this space, bringing together genres in which the representing discourse has the property of substituting or "taking the place of" the represented discourse, provided it obeys social and institutional prescriptions, such as the genres of the "minutes" or the "report of meeting".…”
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Current Concepts on Gastric Carcinoid Tumors by George C. Nikou, Theodoros P. Angelopoulos

“…Type II which accounts for 5–10 %, is associated with Zollinger-Ellison syndrome and often occurs in the context of multiple endocrine neoplasia type 1. Type III, finally, represents 15–25% of gastric carcinoids and is characterized by a far more aggressive course. …”
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Network Capability Exposure Scheme in Satellite and Ground Merged Network by Lin LIN, Bin ZHU, Zelin WANG, Guangquan WANG, Jianwei HE, Haipeng YAO

“…Facing the issue of the integration capability opening of terrestrial 5G network and satellite communication network fusion architecture, first the research status of 5G and satellite communication fusion at home and abroad was introduced.Then a layered architecture for consistent capability opening under the fusion architecture of satellite and terrestrial 5G networks was proposed.Finally, the open requirements, feasible architecture and application scheme of consistent capability under the fusion architecture of satellite and terrestrial 5G networks was discussed.Through the proposed capability opening scheme based on the integration of 5G and satellite communication network, on the one hand, the capability invocation path of satellite communication network and terrestrial 5G network was connected, and 5G capability was extended to the application in the fi eld of satellite communication.On the other hand, the platform provided technical reference for satellite management system information for 5G capability decision-making and 5G network capability for satellite link selection.…”
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