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  1. 701

    The Effects of Anlotinib Combined with Chemotherapy following Progression on Cyclin-Dependent Kinase 4/6 Inhibitor in Hormone Receptor-Positive Metastatic Breast Cancer by Ting Xu, Weili Xiong, Lili Zhang, Yuan Yuan

    Published 2024-01-01
    “…Endocrine therapy combined with cyclin-dependent kinase (CDK) 4/6 inhibitors (CDK4/6i) is the preferred treatment for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2–) metastatic breast cancer (MBC). …”
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  2. 702

    Effects of Simulation-Guided Microwave Presintering Process on the Preparation and Final Properties of Pure Ceramic Rings: Lower Sintering Temperature and Higher Mechanical Properties by Xiao Lu, Tong-Tong Zhou, Feng-He Zhao, Xiao-Xiong Wang, Li-Xiang Chen, Yun-Ze Long

    Published 2020-01-01
    “…In order to improve the performance and endurance of steel rings used for twisting and winding yarns in the textile industry, a more wear-resistant ceramic version is studied and examined by conducting multiple simulations combined with microwave sintering experiments of the ring preparation process, aiming to reduce manufacturing costs and improve efficiency. …”
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  3. 703
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    Treatment Interruption and Regimen Change in Firstgeneration versus Second-generation Tyrosine Kinase Inhibitors used as First-line Therapy for Chronic Myeloid Leukemia by Melea A. Ward, Gang Fang, Kristy L. Richards, Christine M. Walko, Stephanie R. Earnshaw, Laura E. Happe, Susan J. Blalock

    Published 2015-04-01
    “…**Objectives:** This study assessed the comparative rates of treatment interruption and regimen change between patients initiating first-line therapy with a first-generation tyrosine kinase inhibitor (1GTKI) imatinib versus second-generation TKI (2GTKI), dasatinib or nilotinib, for the treatment of CML in clinical practice. …”
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    Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity by Yaqin Yuan, Wenqing Ning, Junjie Chen, Jiquan Li, Tianqi Xue, Cuihong An, Lingling Mao, Guangzhi Zhang, Shizhong Zhou, Jiabo Ding, Xiaowen Yang, Jianqiang Ye

    Published 2025-01-01
    “…Here, this study identified the deletion of serine/threonine protein kinase (STPK) gene in B. melitensis as an efficient trigger for rifampicin resistance using bioinformatics predictions, a transposon mutant library, and gene mutation strains. …”
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    Hereditary Xerocytosis due to Mutations in PIEZO1 Gene Associated with Heterozygous Pyruvate Kinase Deficiency and Beta-Thalassemia Trait in Two Unrelated Families by Elisa Fermo, Cristina Vercellati, Anna Paola Marcello, Anna Zaninoni, Richard van Wijk, Nadia Mirra, Cristina Curcio, Agostino Cortelezzi, Alberto Zanella, Wilma Barcellini, Paola Bianchi

    Published 2017-01-01
    “…The concomitant defects did not aggravate the clinical phenotype; however, in one patient, the initial diagnosis of pyruvate kinase deficiency delayed the correct diagnosis of HX for many years and resulted in splenectomy followed by thrombotic complications. …”
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  10. 710
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    MINAT DAN HASIL BELAJAR FISIKA SISWA MELALU MODEL PEMBELAJARAN PROBLEM BASED LEARNING DENGAN PETA KONSEP PADA KONSEP SUHU by Niya Agustina, Connie Connie, Irwan Koto

    Published 2019-08-01
    “…Penelitian ini bertujuan untuk mengetahui apakah model pembelajaran problem based learning dengan peta konsep dapat meningkatkan minat belajar dan hasil belajar siswa pada konsep suhu. …”
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    Analisis Faktor Yang Mempengaruhi Minat Berkunjung Ulang Pasien ke Poliklinik Spesialis di RSI Ibnu Sina Padang (BPJS Kesehatan) by Laiza Faaghna, Ratni Prima Lita, Rima Semiarty

    Published 2019-05-01
    “…Tujuan penelitian ini adalah menentukan faktor yang mempengaruhi minat berkunjung ulang pasien ke poliklinik spesialis RSI Ibnu Sina Padang. …”
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  20. 720

    Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors by Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai

    Published 2025-01-01
    “…In a molecular docking study, these chemicals were docked with the crystal structure of the cyclin-dependent kinase 2 protein (PDB code 2R3J) to assess their binding affinity. …”
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