Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…Furthermore, this study also aims to highlight the efforts made in exploiting the structural information in conjunction with molecular modeling techniques to discern the mechanism of action of the fusion inhibitors and to assist the design and interpretation of structure-activity relationships of novel lead compounds will be highlighted. The final section will be dedicated to elucidating novel and promising antiviral strategies proceeding from the transformation of known small molecule antivirals in proteolysis targeting chimera (PROTAC)-based targeted protein degradation. …”
Get full text

Dietary inclusion of Moringa oleifera leaf extracts as alternatives to antibiotic growth promoter on live performance, carcass traits, physical meat quality, and health status of b... by Al Ibne Rifat, Chondhon Chandro Bormon, Md Golam Akib, Mohammad Shamsul Ataher, Md Kamruzzaman, Amitush Dutta, Amio Kante Das, Kanan Talukder, Mahmoud Azzam, Mohammed Hamdy Farouk, Razib Das, Shad Mahfuz

“…The MLE group had the highest average daily gain, final body weight, and lower feed conversion ratio than both control and antibiotic groups. …”
Get full text

Conocimientos, prácticas y seroprevalencia humana de brucelosis en la zona lechera central de Cochabamba, Bolivia by Rosse Mary Yanez, Rocío Quitón, Ernesto Rojas, Tania Vargas, Daniel Eid, Jean-Jacques Letesson, Patricia Rodríguez

“…La validación de las pruebas se realizó inicialmente en un grupo de 76 personas, la población de estudio final fue de 330 personas, que además participaron en una encuesta socioepidemiológica. …”
Get full text

Sensory outcome of exotropia surgery in Thailand: a retrospective multicenter study by Narisa Rattanalert, Supaporn Tengtrisorn, Supawan Surukrattanaskul, Phanthipha Wongwai, Nutsuchar Wangtiraumnuay, Wadakarn Wuthisiri, Suntaree Thitiwichienlert, Warassabhorn Ployprasith, Rattiya Pornchaisuree, Piangporn Saksiriwutto, Penny Singha, Warakorn Thiamthat, Parnchat Pukrushpan, Sirinya Suwannaraj, Yutthaphong Imsuwan, Arpha Pornseth, Atchareeya Wiwatwongwana, Oracha Teerakapong, Juthathip Hiriotappa, Apatsa Lekskul, Variya Nganthavee, Poonyawee Nunthanid, Worawalun Honglertnapakul, Worapot Srimanan, Prangkhwan Jiaranaisilawong, Prapatsorn Patikulsila, Phantaraporn Tangtammaruk, Dussadee Tatritorn, Thunyaluck Jiwanarom, Jipada Pruksacholavit, Puncharut Preechaharn, La-ongsri Atchaneeyasakul, Phawasutthi Keokajee, Thammanoon Surachatkumtonekul, Pittaya Phamonvaechavan, Sorot Wutthiphan, Orapan Aryasit, Parichat Damthongsuk, Alan Frederick Geater

“…The factors related to achieve binocular function includes type of XT as X(T), without amblyopia, angle of deviation at final visit less than 10 PD, isometropia type of refraction and underwent only one surgical correction.…”
Get full text

Identifying the factors affecting the growth of the employees of the country's property and documents registration organization by Najmeh Ahmadi, Kolsoum Nami, Nader Ghourchian, Parivash Jafari

“…Factors, indicators and the final research model were designed based on the results of the qualitative interview. …”
Get full text

Presenting a merit-oriented service compensation system model for veterans in sports by Hoseain Aeinehchi, Mohammad reza Esmaeilzadeh Ghandehari, Hoseain peymanizad, Hasan Fahim Davin

“…In order to confirm the final research model, confirmatory factor analysis was performed. …”
Get full text

Providing a customer satisfaction model of non-attendance services in the social security organization by Hossein Barzgar, Vahid Sanavi Garoosiyan, ali hossein zadeh

“…Confirmatory factor analysis was performed to confirm the final research model. The findings of the research showed that the research model has a suitable fit with the collected data. …”
Get full text

Development, validation, and clinical application of a machine learning model for risk stratification and management of cervical cancer screening based on full-genotyping hrHPV tes... by Binhua Dong, Zhen Lu, Tianjie Yang, Junfeng Wang, Yan Zhang, Xunyuan Tuo, Juntao Wang, Shaomei Lin, Hongning Cai, Huan Cheng, Xiaoli Cao, Xinxin Huang, Zheng Zheng, Chong Miao, Yue Wang, Huifeng Xue, Shuxia Xu, Xianhua Liu, Huachun Zou, Pengming Sun

“…The final optimal XGBoost model for predicting CIN2+ showed good discrimination (AUROC, maximum 0.989 [0.987–0.992]; minimum 0.781 [0.74–0.819]), and calibration (brier score, maximum 0.118 [0.099–0.137]) in the five external validation sets. …”
Get full text

Effect of Planting Systems on the Physicochemical Properties and Bioactivities of Strawberry Polysaccharides by Qiuqiu Zhang, Renshuai Huang, Guangjing Chen, Fen Guo, Yan Hu

“…Biological activity assays revealed that GP-SP generally exerted stronger non-enzymatic glycation inhibition at both early and final stages (IC₅₀: 7.47 mg/mL vs. 7.82 mg/mL and 11.18 mg/mL vs. 11.87 mg/mL, respectively), whereas EP-SP was more effective against intermediate α-dicarbonyl compounds (maximum inhibition of 75.32%). …”
Get full text

Optimizing the Construction Supply Chain Network Considering the Flow of Materials, Equipment, Manpower, Drawings and Technical Documents by Seyed Saeid Helli, Hadi Mokhtari, Saeed Dehnavi

“…In the classic supply chain, the flow of materials and output at the end of the chain includes the manufactured product, while in the construction supply chain, the final output includes a building or a structure. …”
Get full text

Decoding links between magmatic processes and eruption dynamics: whole-rock time series petrology of the 2021 Tajogaite eruption, La Palma by Jane H. Scarrow, Matthew J. Pankhurst, Olivia A. Barbee, Katy J. Chamberlain, Daniel J. Morgan, Marc-Antoine Longpré, Samantha Tramontano, James Hickey, David A. Neave, Gavin K. Rollinson, Alexander G. Stewart, Penny E. Wieser, Beverley C. Coldwell, William Hernández, Luca D’Auria, Nemesio M. Pérez

“…Transition to more primitive, uniform compositions recorded progressively deeper tapping of pre-existing magmatic zonation (Stage 2 - evacuation). The final stage (Stage 3 - waning) was characterised by more evolved magma compositions on the same fractionation trend as Stage 2, with tephra glass compositions suggesting a proportionately larger role of mush interstitial melts. …”
Get full text

Factors influencing evidence-based cardiovascular disease prevention programming in rural African American communities: a community-engaged concept mapping study by Amelia DeFosset, Breanna Deutsch-Williams, Mysha Wynn, Katrina Blunt, Scott Rosas, Mary Wolfe McKinley, Brian Ellerby, Shirley McFarlin, Veena Reddy, Giselle Corbie, Gaurav Dave

“…Absolute pattern matches comparing ratings of the relative importance and feasibility of each factor were generated and depicted via ladder graphs. Results The final concept map included five factors: Accessibility, Community and Social Factors, Education and Training, Financial/Resource Development, and Organization Capacity and Staffing. …”
Get full text

Complete pathway elucidation of echinacoside in Cistanche tubulosa and de novo biosynthesis of phenylethanoid glycosides by Wenqian Huang, Yaru Yan, Weisheng Tian, Xiaoxue Cui, Yingxia Wang, Yuelin Song, Ting Mo, Xiping Xu, Saijing Zhao, Yuyu Liu, Xiaohui Wang, Juan Wang, Yong Jiang, Jun Li, She-po Shi, Xiao Liu, Pengfei Tu

“…In addition, a distinct downstream assembly process from tyrosol to ECH is revealed that includes sequential glucosylation, acylation, hydroxylation, and rhamnosylation to form acteoside, and ends with a final glucosylation converting acteoside to ECH. …”
Get full text

Pattern of Disinfection of Root Canal Dentin by Alternated Acid-Base Irrigating Regimen by Janir Alves Soares, Maria Auxiliadora Roque de Carvalho, Suelleng Maria Cunha Santos Soares, Rodrigo Dantas Pereira, Manoel Brito-Júnior, Paula Prazeres Magalhães, Isabel Alessandra Miranda Nunes, Rudys Rodolpho de Jesus Tavarez, Claudia de Castro Rizzi, Rafaela Nogueira Moreira, Luiz de Macêdo Farias, Etevaldo Matos Maia Filho

“…After initial sampling (S1), the CMP was aided by irrigants: saline solution (control; n=12), a conventional regimen (CR) (group 1; n=12) using 5.25% NaOCl and a final rinse with 17% EDTA, and an alternating regimen (AR) of intercalated use of NaOCl and EDTA (group 2, n=12), followed by a second sampling (S2). …”
Get full text

Military-Applied Means of Physical Education in Pre-University Educational Institutions of the Russian Ministry of Defence by D. V. Vinograd, A. V. Zykov

“…The following methods were applied: interview, pedagogical observation, questionnaire survey, technique of entrance and final testing of selection of the research participants, formative experi ment, monitoring, comparative analysis and systematisation of indicators (resultant scores) of sports achievements of examinees. …”
Get full text

Le port antique de Chelles (Seine-et-Marne) : une course après la rivière by Yann Le Jeune, Corinne Charamond, Christian Charamond

“…-Phase 4, around 70 AD: a much smaller structure, formed of two parallel stone walls associated with wooden posts, was established at the western border of the port area and more than 7 m from the original ancient riverbank. This is the final development in connection with the river in the space investigated; the activity on the shore was then reduced and only a potter’s oven can be associated with it. …”
Get full text

Tipificación morfológica de cursos principales. Cuenca del arroyo El Negro, Sistema de Ventania, Argentina by Alicia M. Campo, Verónica Gil, Guadalupe Ybarra Alcaráz, Antonela Volonté

“…Previo a la tipificación final se sectorizó el río en tramos siguiendo criterios de Ollero Ojeda y otros (2003). …”
Get full text

Mortality risk prediction model in AIDS patients with pneumocystis pneumonia in China by Xi Wang, Letian Liu, Wen Wang, Yang Zhang, Hui Chen, Zhangli Wang, Jianwei Li, Yue Gao, Yanqun Huang, Lijun Sun, Tong Zhang, Aixin Li

“…The Shapley Additive exPlanation (SHAP) method was applied to explain the final model and the weights of features.ResultsThe overall mortality rate among hospitalized patients was 17.8%. …”
Get full text