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Cumulative incidence and risk of infection in patients with rheumatoid arthritis treated with janus kinase inhibitors: A systematic review and meta-analysis.
Published 2024-01-01“…The goal of our study was to calculate the pooled cumulative incidence and risk of infection in patients with RA treated with Janus kinase inhibitors (JAKi). The PubMed and EMBASE databases were queried for randomized controlled trials comparing patients with RA treated with JAKi (upadacitinib, baricitinib, tofacitinib, peficitinib, or filgotinib), defined as the treatment group, compared with control subjects, defined as participants receiving placebo or treatment regimen that was similar to that of participants in the treatment group, with the exception of JAKi. …”
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Janus kinase inhibitors in rheumatoid arthritis-associated interstitial lung disease: where do we stand and what may be the future?
Published 2025-01-01“…Over the past few years, Janus kinase inhibitors (JAKis) have been reported to have promising efficacy in the treatment of active RA, but recent concerns have been raised about their safety profile, namely malignancy and cardiovascular disease, limiting their use to certain patient categories. …”
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545
Involvement of different protein kinases and phospholipases A2 in phorbol ester (TPA)-induced arachidonic acid liberation in bovine platelets
Published 2000-01-01“…The effect of various phospholipase A2 and protein kinase inhibitors on the arachidonic acid liberation in bovine platelets induced by the protein kinase activator 12-O-tetradecanoylphorbol–13-acetate (TPA) was studied. …”
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546
Os oficiais da Justiça central régia nos finais da Idade Média portuguesa (ca. 1279-ca. 1521)
Published 2023-12-01“…Uma panorâmica do desenvolvimento da Justiça régia e dos seus juízes no Portugal de finais da Idade Média.…”
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547
Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder
Published 2020-01-01“…Cyclin-dependent kinase-like 5 (CDKL5, also known as STK9) is a serine/threonine protein kinase originally identified in 1998 during a transcriptional mapping project of the human X chromosome. …”
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Aporte de Trabajos Finales de Graduación a la Orientación vocacional, Universidad de Costa Rica (2012-2023)
Published 2025-01-01“… Este estudio es una investigación documental realizada en el 2024 y basada en los Trabajos Finales de Graduación (TFG) de la Licenciatura en Ciencias de la Educación con énfasis en Orientación de la Universidad de Costa Rica entre el 2012 y el 2023. …”
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People of the Past and Present. Magazine Stolitsa i usaďba, the Russian Nobility and Its Self-Presentation in the Final Years of the Tsarist Regime
Published 2016-03-01“…The article is focused on the public role of the Russian nobility in the final years of the tsarist regime. The author analyzes several ways of the nobility self-presentation towards the public and tries to answer the question how far the “portrait of the nobility” was real or imagined. …”
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550
Blood pressure variation and hypertension rates in a pre-modernized Bedouin population: data from tribes of the Sinai Peninsula (Egypt)
Published 2001-11-01“…The Towara tribes of the Sinai Peninsula represent traditional Bedouin subsistence and culture.The Towara sample includes 318 men and 91 women, age 17 up to 85 years. …”
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Influence of Ceramic Roof Tile Waste Powder as a Partial Cementitious Material on the Initial and Final Setting Times of Cement Paste
Published 2025-01-01“…The study encompasses both the initial and final setting times. The research results showed that the addition of ceramic tile waste powder as a cement substitute increased the initial setting time and final setting time.…”
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Research on failure mechanism of final drive gears of a passenger car based on multi-condition varying-speed accelerated test
Published 2025-02-01“…Regarding the fracture failure of the driving and driven gears of the final drive, a heat treatment quality inspection is conducted on the fractured gears. …”
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Activating Mutation (V617F) in the Tyrosine Kinase JAK2 is Absent in Locally-Confined or Castration-Resistant Prostate Cancer
Published 2010-01-01“…The receptor-associated tyrosine kinase Jak2 is a known key activator of Stat5a/b in prostate cancer cells in response to ligand stimulation. …”
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TIEMPO, CONCEPTO E HISTORIA: DOS MONUMENTOS, EN PUERTO RICO Y CUBA, A FINALES DEL SIGLO XX
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Students Perceptions, Satisfactions and Challenges on Problem-Based Learning (PBL): A Survey Study Among Final Year Pharmacy Students
Published 2025-01-01“…Method: A cross-sectional study using a validated closed and open-ended questionnaire consisting of 22 statements was distributed among 84 final-year pharmacy students. Results: Eighty-four final-year pharmacy students participated in this study. …”
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Clinical and diagnostic study of ovine chronic progressive pneumonia (Maedi-Visna) in sheep of Basrah, Iraq
Published 2025-01-01Subjects: Get full text
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Explaining geopolitical components affecting the strategic linkages of countries Case Study: Iran and Iraq
Published 2018-03-01Subjects: Get full text
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558
A study examining the effects of changed rules of wrestling competitions on the muscular damage levels of the elite wrestlers
Published 2014-06-01Subjects: Get full text
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HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders
Published 2025-02-01Subjects: “…hematopoietic progenitor kinase 1…”
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