A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Our findings reinforce the need for larger, more definitive studies to confirm these associations and to explore the mechanisms by which these drugs may contribute to PV development. Finally, these findings underscore the importance of considering environmental factors in the development and course of PV in genetically susceptible individuals.…”
Get full text

The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis by Xue Gu, Bingfeng Chen, Shengcan Zhang, Xinyu Zhai, Ying Hu, Hui Ye

“…The association of CCL17 level with gene marker of immune cells in THCA was analyzed by GEPIA and TIMER databases. Finally, immunohistochemistry was applied to validate CCL17 expression in 21 tumor and para-carcinoma tissue samples. …”
Get full text

Effect of Multi-Joint Functional Electrical Stimulation Combined with Conventional Rehabilitation Therapy on Lower Limb Motor Function of Patients with Stroke by LIU Jiapeng, WANG Weining, XU Dongyan, WANG Nianhong, WU Yi

“…During the course of the treatment, one case in the control group dropped out due to early discharge, four cases in the experimental group discontinued or dropped out for various reasons, and finally 15 cases were included in each group. The control group received routine rehabilitation treatment and routine walking training. …”
Get full text

Kripto Para Piyasasında Yüksek Frekanslı Verilerde Sürü Davranışı by İbrahim Korkmaz Kahraman

“…Bu, sürü davranışının sıklıkla gözlemlendiği geleneksel finans piyasalarının aksine bir durumdur. İkinci olarak, sonuçlar kripto para yatırımcılarının negatif bilgiye pozitif bilgiden daha duyarlı olduğunu göstermektedir. …”
Get full text

A Mixed Project-and-Stock Portfolio Optimization Model with Mean-SemiVariance-SemiEntropy Approach by Amirhosein Khayyatian, Majid Shakhsi-Niaei

“…For validating this model, a numerical experiment involving three projects and five stocks from the capital market has been tackled, considering the preferences of an investor. Finally, the optimization problem has been solved using three metaheuristic algorithms: Genetic Algorithm (GA), Imperialist Competitive Algorithm (ICA), and Gray Wolfs Optimization (GWO).Findings: The results obtained by solving the model using the above-mentioned metaheuristic algorithms demonstrated that despite the high speed of the GWO algorithm, the solutions provided by the GWO algorithm were not satisfactory compared to the GA and ICA algorithms. …”
Get full text

Analysis of the focal relationship of level five leadership with school organizational excellence by Hosein Majooni, Siroos Ghanbari

“…Therefore, these organizations want to establish a cycle of continuous improvement, achieve excellence, continuously improve the quality of service delivery, increase the capability of internal elements and human resources, and finally compare themselves with other organizations with the same outline of the organizational excellence model. …”
Get full text

Research Progress in and Planning Strategies for Multi-scale Measurement of the Efficiency of Urban Blue-Green Infrastructure in Carbon Sink Enhancement and Emission Reduction by Song LIU, Zhaocheng BAI, Dizi LIU, Peiyu SHEN

“…These strategies include: 1) At the site scale, for carbon sequestration and sink enhancement – carbon sink at the source, land balance, and ecological design; for emission reduction – symbiosis with buildings and integration into daily life. 2) At the community scale, for carbon sequestration – overall balance of revenue and expenditure, precise positioning, and proper interconnection of the carbon chain; for emission reduction – incorporation of cool islands and co-construction. 3) At the urban area scale, for carbon sequestration – enhancement of ecological space management and establishment of a carbon-safe pattern; for emission reduction – demand-based layout and organic dispersion. Finally, the research proposes five major research topics for the planning of UBGI’s carbon sink enhancement and emission reduction: How to construct unified measurement methods for UBGI’s efficiency in carbon sink enhancement and emission reduction across scales? …”
Get full text

Crocin Alleviates Hippocampal Neuron Injury in Rats with Cerebral Ischemia-Reperfusion by Inhibiting JAK2/STAT3 Signaling Pathway by LI Xiaolei, ZHU Haisheng, MA Ruijuan, YAO Li, HU Ke, FENG Lina, WANG Xudong

“…The expression of Janus kinase 2/signal transduction and activator of transcription 3 (JAK2/STAT3) signaling pathway related proteins in hippocampal tissue were detected by Western blot.ResultsCompared with the sham group, the learning and memory ability of the rats in the CI/R group was significantly decreased, and the cerebral infarction rate was significantly increased (<italic>P</italic>&lt;0.05); the neurons in hippocampal CA1 and CA3 showed pathological changes, such as reduced neuron number, enlarged gaps, vacuolar degeneration, blurred nucleolar border, and inflammatory cell infiltration, and the apoptosis rate was significantly increased (<italic>P</italic>&lt;0.05); the levels of IL-1β, IL-8, TNF-α in hippocampal tissue were significantly increased (<italic>P</italic>&lt;0.05); the expression of p-JAK2, p-STAT3, high mobility group protein B1, Bcl-2 associated X protein (Bax), Cleaved Caspase-3 and the ratio of p-JAK2/JAK2, p-STAT3/STAT3, Bax/Bcl-2 were significantly increased, while the expression of Bcl-2 was significantly decreased (<italic>P</italic>&lt;0.05). …”
Get full text

Human Capital, Economic Growth and Environmental Quality with Special Emphasis on Public Education Expenditures: An Application of DSGE Models by Yahya Mohaghegh, hashem zare, Mehrzad Ebrahimi

“…The decrease in inflation led to an increase in the real wages of the workforce and finally the desire of the household to increase the supply of labor. …”
Get full text

Evaluation de la qualité de vie des femmes souffrant d’une fistule obstétricale à Kinshasa [Evaluation of the quality of life of women with obstetric fistula in Kinshasa] by Jonathan Enguta Mwenzi, Ruth Bukabau Babuya, Francine Manyonga Sabowa

“…In terms of marital status, there are 30 married women, 16 divorced women and 10 single women. Finally, there are 7 women who have not had a caesarean section, 40 who have had a caesarean section and 9 who have had two caesareans. …”
Get full text

Borsa İstanbul’da Yatırımcı İlgisi Google Trendleri ve Youtube İzlenmelerinin İlk Halka Arz Performanslarına Etkisinin Rassal Orman Yöntemi ile Analizi by Yunus Emre Akdoğan

“… Geleneksel finans teorisinin varlık fiyatlama modellerinden biri olan “etkin piyasalar hipotezi”, kamuya açık bilginin tam bilgiye sahip olan rasyonel yatırımcılar tarafından fiyatlara yansıtıldığı varsayımına dayanmakta ve dolayısıyla normalüstü getiri elde etmenin mümkün olmadığı görüşünü savunmaktadır. …”
Get full text

The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Subsequently, the seeds were germinated and transferred to plastic pots filled with sterile soil. Finally, the pots were moved to the growth chamber. …”
Get full text

Spare Parts Inventory Optimization for Military Vehicles Using a Mixed Probability Distribution by Mojtaba Salehi, Mojtaba Omidvar, Shohreh Shariati

“…The meta-heuristic method based on the genetic algorithm has been applied to save the total costs. Finally, to prove the effectiveness of the model, the proposed model has been implemented in a case study on the parts of military vehicles in the 177th Brigade of Torbet Heydarieh. …”
Get full text

The pattem of the conquest of the Polabian Slavs and Western Baltic lands from the point of view of Christianization of the Baltic tribes by Marius Ščavinskas

“…The nobility of the Western Baltic tribes (Prussian, Curonian, Semgallian and finally Ugric Livonian tribes in Livonia), contrary to the nobility of the Polabian tribes, were not granted any political rights. …”
Get full text

The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled tria... by Zehua Zhang, Shiyun Tang, Shiyu Liu, Yulin Leng, Xiaoxu Fu, Hongyan Xie, Hong Gao, Hong Gao, Chunguang Xie, Chunguang Xie

“…The publication bias was evaluated with the funnel plot and Egger’s test, and the evidence quality was evaluated by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method.ResultsA total of 41 studies with 3,269 patients were finally enrolled in this study. None of the included studies reported whether renal or cardiovascular disease progression events occurred. …”
Get full text

Identification of positive selection signatures associated with milk and composition traits in Murciano-Granadina and Barki by Hossein Mohammadi, amir hossien khaltabadi farahani, Mohammad Hossein Moradi

“…After quality control of the initial data using Plink software (v1.90; http://pngu.mgh.harvard.edu/purcell/plink), 43,170 SNP markers were finally entered for further analysis. To identify the signatures of selection, the statistical method FST was used under R software packages. …”
Get full text

Security decision method for the edge of multi-layer satellite network based on reinforcement learning by Peiliang ZUO, Shaolong HOU, Chao GUO, Hua JIANG, Wenbo WANG

“…Selection;the strategy acts on the satellite network,which will change the state of the environment,and the environment will evaluate the strategy and feed it back to the edge center node in the form of reward;the edge center node will perform error calculation and update the Q value based on the new environment state and income,in order to optimize the action selection strategy,so as to obtain higher rewards and new environmental states; the above process is continuously iterated to finally obtain the optimal strategy. Results:Keras is used as the simulation platform,and in the simulation experiment,the constellation of low-orbit satellites is assumed to be the common Walker constellation. …”
Get full text

Effect of Body Weight Supported Treadmill Training on Motor Function of Rats with Spinal Cord Injury Based on AMPK-Autophagy Signaling Pathway by CAI Jili, ZHAI Chenyuan, WANG Zun, WU Qi, FANG Lu, WANG Yu, WANG Tong

“…ObjectiveTo explore the effect and mechanism of body weight supported treadmill training on motor function of rats with spinal cord injured (SCI) based on the adenosine monophosphate-activated protein kinase (AMPK)-autophagy signaling pathway.MethodsA total of 30 10-week-old female SD rats were randomly divided into sham operation group, model group, and exercise group, with 10 cases in each group. …”
Get full text

Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

“…The rats in the operation group were treated with the middle cerebral artery occlusion (MCAO) method to prepare the focal cerebral ischemia-reperfusion (I/R) model, and the Zea Longa method was used to score the neurological function 2h after the operation. Finally, 30 rats were included in the operation group. …”
Get full text

Optimization of Identification and Zoning Method for Landscape Characters of Urban Historic Districts by Hong YUN, Zixuan HU, Zehao HU

“…Then the research utilizes K-means clustering algorithm to optimize the zoning method for historic landscape characters. Finally, the research takes the Pun Tong Historic District in Guangzhou as an example to test the effectiveness of the optimized method mentioned above.ResultsThe research shows that the the Pun Tong Historic District consists of four historic layering, namely the traditional rural period (from Tang Dynasty to 1840), the traditional township period (1840 – 1911), the modern township period (1912 – 1948), and the contemporary township period (from 1949 to the present). …”
Get full text