DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…Our modelling offers the following benefits: i) better prediction of intrinsic liver clearance of drugs compared to the conventional model and ii)explainability of behaviour based on physiological parameters. Finally, we illustrate the clinical significance of this approach by applying the findings to humans, utilising propranolol as a proof-of-concept example. …”
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Manière de dire et manière d’exercer la parenté en Kabylie. Pour une approche renouvelée du croisement genre et fait matrimonial by Mohand Anaris

“…Thus, women commonly employ a gynocentric and matrifocal discourse that gives the impression that everything is done by and for women, almost to the exclusion of men.Finally, the study establishes the central and decisive role played by women in matrimonial processes. …”
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Microcephaly protein ANKLE2 promotes Zika virus replication by Adam T. Fishburn, Cole J. Florio, Thomas N. Klaessens, Brian Prince, Neil A. B. Adia, Nicholas J. Lopez, Nitin Sai Beesabathuni, Sydney S. Becker, Liubov Cherkashchenko, Sophia T. Haggard Arcé, Vivian Hoang, Traci N. Shiu, R. Blake Richardson, Matthew J. Evans, Claudia Rückert, Priya S. Shah

“…Knockdown of the ANKLE2 ortholog in Aedes aegypti cells also decreases virus replication, suggesting ANKLE2 is a beneficial replication factor across hosts. Finally, we show that NS4A from four other orthoflaviviruses physically interacts with ANKLE2 and is also beneficial to their replication. …”
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Hydrogen and hydrogen sulphide in volcanic gases: abundance, processes, and atmospheric fluxes by Aiuppa, Alessandro, Moussallam, Yves

“…These heterogeneous reactions, when occurring, can also control the temperature dependence of the volcanic gas H$_{2}$/H$_{2}$O ratios. Finally, by using our volcanic gas dataset in tandem with recently published global volcanic SO$_{2}$ and CO$_{2}$ budgets, we provide refined estimates for total H$_{2}$S (median, 1.4 Tg/yr; range, 0.9–8.8 Tg/yr) and H$_{2}$ (median, 0.23 Tg/yr; range, 0.06–1 Tg/yr) fluxes from global subaerial volcanism.…”
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Public Benefit and Public Interest – Two Sides of the Same Coin? by Tina Sever

“…Additionally, synthesis is used to identify commonalities and divergences between different perspectives on these concepts. Finally, conclusions about the relationship between public benefit and public interest are drawn based on the analysed data. …”
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Investigation of the Performance of a Sb2S3-Based Solar Cell with a Hybrid Electron Transport Layer (h-ETL): A Simulation Approach Using SCAPS-1D Software by Pierre Gérard Darel Kond Ngue, Ariel Teyou Ngoupo, Aimé Magloire Ntouga Abena, François Xavier Abomo Abega, Jean-Marie Bienvenu Ndjaka

“…In particular, the parameters of the Sb2S3 absorber layer (thickness, defect density, and doping), ETL and HTL layer thicknesses, h-ETL/Sb2S3 interface defect density, and series and shunt resistances have been optimized. Finally, by combining high performance and thermal stability, the results show that the thermal stability of the solar cell depends on the back contact type; thus, nickel (Ni) was found to combine high performance and better thermal stability among the back contacts investigated. …”
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PLANIFICACIÓN FRAGMENTARIA Y MANEJO DE RECURSOS NATURALES AL ESTE RIONEGRINO. CRÍTICA REGIONAL by Marcos Damián Mare

“…El problema específico refiere al inadecuado manejo del agua en la cuenca del arroyo Salado, al Este de la Provincia de Río Negro, a partir de la concreción del emprendimiento minero de Sierra Grande, en el contexto de proyectos desarrollistas de finales de la década de 1960 y de políticas del gobierno de facto en el segundo lustro de los 70s. …”
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Mechanism of <italic>Coptis chinensis</italic> in Treatment of Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking by LIU Huiling, TAN Dingying, HUANG Min, CHEN Pingping, ZHANG Wang

“…It can act on mitogen-activated proteinase 1 (MAPK1), serine/threonine protein kinase (AKT1), tumor protein p53 (TP53), transcription factor AP-1 (JUN), tumor necrosis factor (TNF), interleukin-6 (IL-6), which can regulate MAPK, AGEs-RAGE, PI3K-Akt, Toll-like receptors, HIF-1, TNF signaling pathways, etc. ④ The molecular docking results showed that, the molecular docking affinity between the active ingredients of <italic>Coptis chinensis</italic> and the above core targets was less than -7.0 kcal/mol (1 kca/mol=4.186 kJ/mol), and the binding activity was better.Conclusion<italic>Coptis chinensis</italic> may play an important role in the treatment of type 2 diabetes mellitus and its complications by regulating glucose and lipid metabolism, inflammatory response, cell proliferation and apoptosis and promoting oxidative stress, etc.…”
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The use of bacterial culture for Leptospirosis di- agnosis in female water buffaloes by Rosaura Pérez-Gil, Oriana Gavidia, Juan Torres

“…Additionally, these preliminary findings confirm Leptospira is an agent involved in abortions, as we obtained Leptospira spp. growth from aborted fetus samples. Finally, it is likely that this bacterium growing in the bacteriological cultures belongs to a serovar different from those in the panel of strains used in MAT, so the cultures were preserved for subsequent studies that contemplate molecular identification. …”
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Aetiology and Outcomes of Thrombocytopenia in Pregnancy: A Cross-Sectional Study in a University Hospital, India by Sudha V. Hooli, Neelima Shah, Prashant Shah, Shrradha Suresh, Bali Sukeshani Sunil

“…Twenty-eight percent of gestational TCP cases; 47.6% of PIH cases, both cases of haemolysis, elevated liver enzymes, and low platelets syndrome; 50.0% of dengue cases; and one COVID-19 positive case (33.0%) had moderate TCP. Finally, 6.25% of patients who underwent lower segment caesarean section had severe TCP, 6.00% of patients who underwent vaginal delivery had severe TCP, and out of two patients who had a spontaneous abortion, one (50.00%) had severe TCP at the time of admission. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…Hong Liu,1,&ast; Manxue Mei,1,&ast; Hua Zhong,2 Shuyin Lin,1 Jiahui Luo,1 Sirong Huang,1 Jiuyao Zhou1 1Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jiuyao Zhou, Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China, Email yaoli@gzucm.edu.cn, zhoujiuyao@vip.tom.comBackground: Chronic kidney disease (CKD) is a progressive condition that arises from diverse etiological factors, resulting in structural alterations and functional impairment of the kidneys. …”
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EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles by Noha Elsherbini, Dong Hyun Kim, Richard J. Payne, Thomas Hudson, Véronique-Isabelle Forest, Michael P. Hier, Alexandra E. Payne, Marc P. Pusztaszeri

“…While 55% of thyroid nodules were benign at the time of surgery, the possible malignant transformation of these nodules, had they not been resected, is unknown. Finally, 13% of the nodules with EIF1AX mutations were aggressive with a significant PDTC component. …”
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Comparing the Technological and Intraoperative Performances of Da Vinci xi and DaVinci 5 Robotic Platforms in Patients Undergoing Robotic-Assisted Radical Prostatectomy by Ahmed Gamal, Marcio Covas Moschovas, Shady Saikali, Sumeet Reddy, Yu Ozawa, Rohan Sharma, Avaneesh Kunta, Travis Rogers, Vipul Patel

“…In sequence, we control the prostate arterial pedicles with hem-o-lok clips and then we perform the apical dissection until dividing the urethra. Finally, we perform the hemostasis, posterior reconstruction (Rocco's technique) and anastomosis with barbed suture. …”
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Influence of Interactive Scalp Acupuncture Combined with Upper Limb Exoskeleton Robot on Upper Limb Function in Stroke Patients by WANG Zihao, HU Chuan, ZHANG Haiquan, WANG Xin

“…In addition, within the ICF activity domain, the Wolf motor function test (WMFT) was utilized to assess patients' abilities to perform functional tasks with their upper limbs. Finally, within the ICF participation domain, the modified Barthel index (MBI) was used to evaluate the independence of patients in activities of daily living.Results(1) Body function and structure domain: Compared with those before treatment, the FMA-UE score of both groups significantly increased after 4 weeks of treatment (<italic>P</italic>&lt;0.05), and the observation group showed a more significant improvement in the FMA-UE score than the control group (<italic>P</italic>&lt;0.05). (2) Activity domain: Compared with those before treatment, the WMFT score of both groups significantly increased after 4 weeks of treatment (<italic>P</italic>&lt;0.05), and the observation group showed a more significant improvement in the WMFT score than the control group (<italic>P</italic>&lt;0.05). (3) Participation domain: The MBI score of both groups significantly increased after 4 weeks of treatment (<italic>P</italic>&lt;0.05), and the observation group showed a more significant improvement in the MBI score than the control group (<italic>P</italic>&lt;0.05).ConclusionInteractive scalp acupuncture combined with upper limb exoskeleton robot can significantly improve upper limb motor function, upper limb functional task performance, and activities of daily living in stroke patients.…”
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Identification of the Granule-Bound Starch Synthase (GBSS) Genes Involved in Amylose Biosynthesis in Tartary Buckwheat (<i>Fagopyrum tataricum</i> (L.) Gaertn.) by Juan Huang, Fei Liu, Jieqiong Zhang, Bin Tang, Jiao Deng, Taoxiong Shi, Liwei Zhu, Hongyou Li, Qingfu Chen

“…A protein–protein interaction network was constructed and co-expression was analyzed based on the gene expression patterns of the <i>FtGBSSs</i>, and the identified TFs, belonging to bZIP, ERF, bHLH, and MADS-box TF families, were identified within this network, and their expression patterns were significantly correlated to the expression patterns of two seed-specific <i>FtGBSS</i> genes (<i>FtGBSS-3</i> and <i>FtGBSS-5</i>). Finally, <i>FtGBSS1-5</i> was successfully transformed into rice through transgenic manipulation, and the <i>FtGBSS1-5</i> overexpression lines showed an increase in amylose content accompanied by a reduction in amylopectin and total starch contents compared with WT. …”
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Effect of Forbrain Cognitive Training Intervention Prescriptions Based on Risk Factors on Patients with Cognitive Impairment After Traumatic Brain Injury by ZHANG Xueru, WANG Hongbin, CUI Huiying, HAO Xijun, CHEN Changxiang

“…During the intervention, 3, 1, 1 cases dropped out respectively in the control group, observation group 1 and observation group 2, and 37, 39 and 39 cases were finally included in the three groups respectively. …”
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Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome by Lingmei Li, Ce Cao, Hao Guo, Li Lin, Lei Li, Yehao Zhang, Gaojie Xin, Zixin Liu, Shujuan Xu, Xiao Han, Qiong Zhang, Jianhua Fu

“…Myocardial enzymes such as aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) were measured by chemiluminescence (CL) method. …”
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Comparing Deep Learning models for mapping rice cultivation area in Bhutan using high-resolution satellite imagery by Biplov Bhandari, Timothy Mayer

“…Further this study successfully demonstrated the usage of regional land cover products such as SERVIR’s Regional Land Cover Monitoring System (RLCMS) as a weak label approach to capture different strata addressing the class imbalance problem and improving the sampling design for Deep Learning application. Finally, through preliminary model testing and comparisons outlined it was demonstrated that using additional features such as NDVI, EVI, and NDWI did not drastically improve model performance.…”
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Identifying Touchpoints for Foreign Tourists in the Customer Journey through 5 A's Approach by Mostafa Esmaeili Mahyari, Mohammad Ghaffari, Hamid Reza Irani, Elham Ebrahimi

“…Moving on to the Act stage involves the desire for immediate and individual experience, living an Iranian life, and discovering cultural and historical beauties. Finally, in the Advocacy stage, aspects like recommendation, defending against negative comments, willingness to revisit, bringing others in next travels, content creation on social media, and caring about Iran news play a role. …”
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Constructing TheKeep.Ca With Thrivers of Cancer in Manitoba, Canada, in Support of Enhancing Patient Engagement: Protocol for a Pragmatic Multimethods Study by Maclean Thiessen, Kellie Jewitt, Raina Stromberg, Janelle Marie Lamontagne, Genevieve Richardson Tanguay, Annette Albo, Chantale Thurston, Diana E McMillan

“…Findings from objective 1 are expected to be finalized within the first six months after the website launch. …”
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