"Preparation and curing kinetics of “bottlebrush-like structure” green bio-based ultra-low-temperature polyfarnesene nanocomposites" by WU Ming-li, LI Yong-xu, CAO Lan?鄢

“…With the increase in iGO fill amount, the glass transition temperature of the nanocomposites decreased gradually and reached as low as -82 ℃, which indica-ted that the nanocomposites had excellent low-temperature resistance. 　Finally, the rheological properties and isothermal curing reaction kinetics of the nanocomposites were studied by rheological test. …”
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Identification of EGR1 as a Key Diagnostic Biomarker in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Through Machine Learning and Immune Analysis by Wu X, Pan T, Fang Z, Hui T, Yu X, Liu C, Guo Z, Liu C

“…A TF-miRNA-mRNA network was constructed, and single-cell RNA sequencing was used to determine the distribution of key genes within key cell clusters. Finally, the expression of the key genes was further validated using the palmitic acid-induced AML-12 cell line and the MCD mouse model.Results: In this study, through differential gene expression (DEGs) analysis and machine learning techniques, we successfully identified 10 hub genes. …”
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Les siphons en terre cuite du monde romain : l’exemple de l’aqueduc d’Almuñécar (Andalousie, Espagne) by Elena H. Sánchez López

“…The analysis result shows that there is not a major difference in the dimensions of the pipes used with either function, which seems to indicate that the clay pipes used in the siphons were not made with any special characteristics.The text finally discusses the possible reasons behind the choice of terracotta over other materials in manufacturing siphon pipes.The analysis of Roman siphons, and more generally Roman aqueducts, produces different explanations. …”
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USP22 inhibits microglial M1 polarization by regulating the PU.1/NLRP3 inflammasome pathway by Ming-chen Yu, Xiao-lin Li, Ming-liang Ning, Zhen-zhong Yan, Wan-tao Yu

“…Additionally, measurement was performed on the inflammasome NLRP3, and its activation-related proteins [NIMA-related kinase7 (NEK7), cleaved-caspase 1, apoptosis-associated speck-like protein containing a CARD (ASC)]. …”
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Pink1/Parkin signaling mediates pineal mitochondrial autophagy dysfunction and its biological role in a comorbid rat model of depression and insomnia by Zirong Li, Yi Shu, Deguo Liu, Sheng Xie, Liangbo Xian, Jiaqi Luo, Xiuwen Huang, Haixing Jiang

“…The abnormal mitochondrial autophagy signaling caused by the putative kinase 1/Parkin E3 ubiquitin protein ligase (Pink1/Parkin) signaling pathway directly affects the normal secretion of melatonin by the pineal gland, which may explain the pathogenesis of depression combined with insomnia. …”
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Association of insulin resistance surrogates with live birth outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization by Shenghao Wu, Yanhong Wu, Lizi Fang, Xiaosheng Lu

“…Results A total of 543 PCOS patients were finally included in the study. In all three regression models for the fresh embryo transfer (ET) cycles, all three IR surrogates showed stable negative correlations with live birth rate (in Model III: TyG-BMI OR = 0.99, 95% CI: 0.98 ~ 0.99; TyG OR = 0.47, 95% CI: 0.27 ~ 0.82; HOMA-IR OR = 0.84, 95% CI: 0.72 ~ 0.97; all P < 0.05), and this association was stable across all subgroups of the population (all P-interaction > 0.05). …”
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Autoimmune glial fibrillary acidic protein astrocytopathy misdiagnosed as intracranial infectious diseases: case reports and literature review by Runhua Bai, Runhua Bai, Li An, Wei Du, Zhiwei Wang, Xiaokun Qi, Jianguo Liu, Ming Ren, Yingxin Yu

“…Anti-tuberculosis treatment was ineffective. Finally, with positive GFAP IgG in CSF, she was diagnosed with A-GFAP-A. …”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…These SNPs were annotated to 425 candidate genes. Finally, A total of 39 candidate genes are closely related to biological processes such as skeletal muscle development, skeletal formation, carcass quality, and embryonic development, where ADIPOQ, CCDD39, PTPRT, ZNF215, VRTN, ABCD4, DLST, ADAMTS2, ROBO1, AKAP13, AQPI, SOX2, and AHSG were identified as an important component of the genetic framework that may control somatic conformational traits in Zhongwei goats. which warrants further investigation and review. …”
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Rehabilitation Effects of Traditional Chinese Medicine Hot Pressing on Female Patients with Stress Urinary Incontinence by HUANG Huirong, LIU Qinyu, YU Zhenling, WU Cuijuan, XUE Jialu, QIU Zhiqin, YU Mengxia

“…ObjectiveTo investigate the rehabilitation effects of traditional Chinese medicine hot pressing on female patients with stress urinary incontinence (SUI).MethodsA total of 80 patients with female SUI were selected and divided into experimental group and control group according to computer random grouping method, with 40 cases in each group. Finally, 77 patients completed the study with 2 cases dropped out in the experimental group and 1 case dropped out in the control group. …”
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Incidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia: a retrospective cohort study by Habtamu Tadesse Gudeta, Shalama Lekasa Nagari, Dessalegn Emana Jabana, Mustefa Aflegn Legese, Demekisa wondimu Biyena, Fantahun Cheklie Kassie

“…Bivariate and multivariable logistic regression analyses were executed to identify predictor variables of adverse birth outcomes. Finally, a multivariable logistic regression model at P-value < 0.05 and adjusted relative risk (ARR) with 95% CI were used to declare predictor variables that were statistically significant with adverse birth outcomes. …”
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Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis by Li-Hui Fang, Jia-Qi Zhang, Jin-Ke Huang, Xu-Dong Tang

“…Four independent summary statistics of pancreatitis from the the European Bioinformatics Institute (EMBL-EBI, 10,630 AP cases and 844,679 controls, 1,424 CP cases and 476,104 controls) and FinnGen Consortium (8,446 AP cases, 4,820 CP cases and 437,418 controls) were used for bidirectional MR analyses and sensitivity analysis. Finally, further meta-analysis was conducted on the MR results. …”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…We evaluated the interplay of ICI response and RECQL4 expression in melanoma cohorts of 95 responders and 85 non‐responders prior to and after ICI‐targeted therapy and tested the prognostic power of RECQL4. Finally, we generated genetically engineered RECQL4 variants and conducted comprehensive multi‐omic profiling, employing techniques such as liquid chromatography with tandem mass spectrometry, to elucidate mechanistic insights. …”
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Characterization of Listeria monocytogenes strains isolated from soil under organic carrot farming by Maciej Nowak, Zbigniew Paluszak, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Anna Budzyńska, Joanna Skonieczna-Kurpiel, Ewa Wałecka-Zacharska, Monika Huse-Kutowska, Krzysztof Skowron

“…The use of natural fertilizers during organic farming can be a source of pathogens, including L. monocytogenes in the soil and finally in vegetables and fruits. The aim of this study was to assess the prevalence of L. monocytogenes in soil samples from organic carrot crops (Poland) and to characterize the tested strains. …”
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Epidemiology, Tear Film, and Meibomian Gland Dysfunction in Facial Palsy: A Comparative Analysis by Guerrero-de Ferran C, Bastán-Fabián D, del Castillo-Morales A, Rivera-Alvarado IJ, Valdez García JE

“…Cohen’s Kappa coefficient was calculated to compare agreement between manual and ImageJ meibography scoring.Results: Tear breakup time was reduced in the affected side (p = 0.21), tear meniscus height was much greater in the non-affected side (p = 0.02). Finally, Meibomian gland alterations were more evident in the affected side, with upper Meibomian glands having a loss of 29.55 ± 13.31% (p = 0.03) and lower glands presenting a loss of 44.44 ± 16.9% (p =< 0.001). …”
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Design and Dynamic Analysis of Ideological and Political Education Platform Based on Network Multimedia Technology by Xiaowen Chen

“…Because of the thought-political education platform design and ideological dynamic analysis of network multimedia technology, this study analyzes the construction and teaching circumstances of the platform, and then uses principal component analysis to analyze students’ political theory, political attitude, civilized etiquette, observance of thought, collective thought, public welfare thought, analysis of learning ideas, get the eigenvalues and variance %, of which the proportion of variance of the first four principal components exceeds 90%; public welfare activities and the idea of abiding by laws and regulations have a better influence on the first main component; collective thinking has a comparison on the impact of the second principal component, the correlation between the indicators of thought-political education and the concept of students’ quality is greater than 0.75; it shows that each index has a large degree of correlation with the concept of students’ quality, among which Political attitudes have the greatest impact on students’ quality outlook, with a correlation coefficient of 0.911; secondly, using a nonhomogeneous hidden Markov model to analyze ideological dynamics, we can get the learning situation in different ideological states; finally, the hot spots during the epidemic are related to ideological dynamics Sexual analysis showed that the p values were all less than 0.05, and the correlation analysis between hotspots and ideological dynamics during the epidemic was significant, namely “national sentiments”, “social responsibility”, “angels in white”, “Chinese power”, and “the benevolence of doctors”. …”
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GPX3 as a Novel and Potential Therapeutic Target in the Shared Molecular Mechanisms of Traumatic Brain Injury and Parkinson&rsquo;s Disease by Wang Y, Fang J, Yuan Q, Yu J, Hu J

“…Subsequently, the expression of hub genes was validated using additional TBI- and PD-related GEO datasets and the Comparative Toxicogenomics Database (CTD). Finally, the expression of hub genes was further validated in a mouse model of TBI induced by controlled cortical impact (CCI).Results: Shared transcriptional signatures between TBI and PD were uncovered, highlighting overlapping molecular networks and pathways. …”
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Pengembangan Media Pembelajaran Video Animasi 2 Dimensi dengan Model ADDIE pada Mata Pelajaran Teknik Pengolahan Audio dan Video Kelas XII Multimedia SMKN 12 Malang by Pratama Aprilianto, Satrio Hadi Wijoyo, Faizatul Amalia

“…The development of learning media is carried out using the ADDIE model with the following stages: (1) Conducting student character analysis, media analysis and learning analysis; (2) Designing character designs, media scenarios and designing instrument sheets; (3) Performing the animation video development stage, audio recording and video finalization; (4) Implementing face-to-face and online learning activities; and (5) Conducting learning evaluation activities and testing the validity of media and materials to 3 media experts and 2 material experts. …”
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Effects of Walking Pattern-Based Intelligent Electrical Stimulation on Outpatients with Stoke： A Randomized Controlled Study by HE Xuguang, SUN Wei, ZHOU Lu, HE Meiyan, WEI Ni

“…ObjectiveTo explore the effects of walking pattern based intelligent electrical stimulation on lower limb function in out-patients with stroke.MethodsA total of 60 outpatients with stroke who met the inclusion criteria were randomly divided into real stimulation group, sham stimulation group and control group. Finally, 52 patients completed the evaluation, including 20 patients in the control group, 15 patients in the sham stimulation group and 17 patients in the real stimulation group. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Systemic knockout of Fhl1 in SD rats via the phosphoinositide 3‐kinase pathway exacerbated graft inflammation, heightened cell proliferation, and accelerated NIH. …”
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A Phenologically Simplified Two-Stage Clumping Index Product Derived from the 8-Day Global MODIS-CI Product Suite by Ge Gao, Ziti Jiao, Zhilong Li, Chenxia Wang, Jing Guo, Xiaoning Zhang, Anxin Ding, Zheyou Tan, Sizhe Chen, Fangwen Yang, Xin Dong

“…., the leaf-on season (LOS, from greenup to dormancy) and the leaf-off season (LFS, after dormancy and before greenup of the next vegetation cycle), and developed the phenologically simplified two-stage CI product for the years 2001–2020 using the MODIS 8-day CI product suite. Finally, we assessed the accuracy of this CI product (RMSE = 0.06, bias = 0.01) via 95 datasets from 14 field-measured sites globally. …”
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