Technology acceptance and use among nursing staff in Latin American hospitals: A mixed methods study by Juan Manuel Aranda, María Elisa Moreno-Fergusson, William Javier Guerrero, Beatriz Sanchez Herrera, María Alejandra Galiano, Maryory Guevara, Ingrid Xiomara Bustos, Francisca Muñóz

“…Quantitative data were analyzed using descriptive statistics and hypothesis testing for mean differences, while qualitative data underwent content analysis. Finally in the third phase, both qualitative and quantitative data were integrated to establish the acceptability and use of the technology. …”
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The role of vitamin D in slipped capital femoral epiphysis in children and adolescents: a retrospective case-control study by Peng Ning, Shuting Lin, Huiyu Geng, Tianjing Liu

“…The study also explored whether these factors were correlated with SCFE severity, determined by measuring the slip angle and displacement on the anteroposterior pelvic or frog-leg lateral views.ResultsOne hundred and twenty subjects were finally included, with 40 SCFE patients (36 males, 4 females) and 80 controls (72 males, 8 females). …”
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Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients by Shi-Xia Liao, Lan-Ying Zhang, Ling-Mei Shi, Huai-Yu Hu, Yan-Hui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun

“…AddModuleScore analysis quantified RNA methylation and autophagy effects. Finally, a COPD mouse model was used to validate the expression of critical RNA methylation genes (FTO and IGF2BP2) in lung macrophages via RT-qPCR and flow cytometry. …”
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Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…In vitro, EVs as well as perfusates from G3 partially recovered endothelial cell metabolic activity after hypoxia. Finally, RNA‐seq performed on kidney biopsies showed different profiles between G1 and G3 with regulation of potential IR targets of EVs therapy. …”
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Effect of Five Elements Music Concrete Hypnosis Technique on Subthreshold Depression after Stroke by ZHANG Jiale, ZHOU Xia, LIU Jianxian, QIAN Qian, WANG Qin, WANG Zhensong

“…During the treatment,a total of 3, 1 case fell off/stopped in the control group and the observation group respectively. Finally, a total of 36,38 cases were included in the control group and the observation group respectively. …”
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Association between domain-specific physical activity and triglyceride‑glucose (TyG) index among US adults: Evidence from NHANES 2007–2018 by Kai Yao

“…Furthermore, the stratified analysis found that the correlation between LT-MVPA and TyG index was stronger in females, those with higher family incomes, and non-smokers. Finally, mediation analyses indicated a significant joint mediation effect of BMI on the relationships between LT-MVPA (≥ 150 min/week) and the TyG index, accounting for 31.48% of the total effect. …”
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In silico analysis of the effect of HCV genotype-specific polymorphisms in Core, NS3, NS5A, and NS5B proteins on T-cell epitope processing and presentation by Samina Baig, Samina Baig, Assel Berikkara, Ramsha Khalid, Syed A. Subhan, Tanveer Abbas, Syed Hani Abidi

“…PEP-FOLD was used to model selected epitopes, followed by peptide-HLA docking using HPEPDOCK. Finally, molecular dynamics simulations were conducted for 200 ns using Desmond software to analyze differences in HLA-epitope (from different HCV genotypes) interaction kinetics and dynamics.ResultsA total of 3,410, 8,054, 6,532, and 14,015 CTL epitopes were observed in the HCV Core, NS3, NS5A, and NS5B sequences, respectively. …”
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Research on time–frequency characteristics of electromagnetic signals from coal and rock blasting based on DBO-VMD filtering by Litao WANG, Liming QIU, Menghan WEI, Dazhao SONG, Rentao GOU, Lin LIU, Shiqiang ZHONG, Tianyi XIE

“…The DBO-VMD achieves a signal-to-noise ratio about two times that of the EMD. Finally, we conducted a statistical analysis of the entropy, energy, bispectrum, and time–frequency domain characteristics of pure electromagnetic signals associated with coal–rock ruptures. …”
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Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

“…The two-component CovRS system, comprising the sensor kinase CovS and transcription factor CovR, is a central regulator of GAS virulence genes. …”
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Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study by Li-Qiong Chen, Yong-Can Zhou, Fang Ning, Ming-Jin Zhu

“…Networks and pathways that overlapped between Insomnia-associated proteins and JW-SZRT target proteins were then used to predict candidate protein targets of JW-SZRT in insomnia. Finally, 40 rats were selected in animal experimentation and 30 perimenopausal insomnia rat models were created through ovariectomy and a modified multi-platform water environment 72-hour sleep deprivation method. …”
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Influence law and control mechanism of coal seam permeability on coal and gas outburst by Chaolin ZHANG, Mingliang LIU, Enyuan WANG, Peizhong WANG, Qiaozhen JIANG, Wei ZENG

“…At the same time, the seepage force near the exposed surface is low and quickly transfers to the distant location, unable to further damage the exposed coal seam, resulting in the decrease of outburst strength or even no outburst. Finally, from the perspectives of gas pressure gradient and gas seepage force, the evolution characteristics of the entire process of coal and gas outburst are systematically explored. …”
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Analysis of Fatigue Crack Propagation of an Orthotropic Bridge Deck Based on the Extended Finite Element Method by Ying Wang, Zhen Wang, Yuqian Zheng

“…Moreover, based on the extended finite element method (XFEM), the static crack and dynamic crack propagation in this critical position were analyzed. Finally, thermoelastoplastic analysis was carried out on the connection of the U-rib and deck with a length of 500 mm to obtain the residual stress, and then the results of residual stress were introduced into the segmental model to further study its influence on the evolution of fatigue crack propagation. …”
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The Mycoplasma hyopneumoniae protein Mhp274 elicits mucosal and systemic immune responses in mice by Mengqi Xie, Zhongshun Huang, Yun Zhang, Yujie Gan, Huiying Li, Dan Li, Honglei Ding

“…The levels of IFN-γ, IL-4, and IL-17, in the supernatants of splenocytes and in serum were measured, and the mRNA levels of three cytokines in splenocytes were analyzed. Finally, lymphocyte proliferation after stimulation with corresponding proteins or crude extract of M. hyopneumoniae J strain was assessed.ResultsWe successfully constructed recombinant bacteria expressing rMhp170, rMhp274, and rMhp336. …”
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A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…BackgroundCytokine release triggered by a hyperactive immune response is thought to contribute to severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2)–related respiratory failure. Bruton tyrosine kinase (BTK) is involved in innate immunity, and BTK inhibitors block cytokine release. …”
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Dos décadas de transformaciones de la nupcialidad uruguaya. La convergencia hacia la segunda transición demográfica by Wanda Cabella

“…Con un desfasaje temporal de aproximadamente dos décadas, la nupcialidad uruguaya experimentó transformaciones similares a las que se presentaron en los países desarrollados desde finales de los años sesenta. Entre mediados de la década de 1980 y los primeros años de 2000 la tasa de nupcialidad se redujo a la mitad, mientras que las uniones consensuales experimentaron un crecimiento de gran magnitud entre los jóvenes de todos los estratos educativos. …”
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The Impact of Complete Revascularization in Symptomatic Severe Left Ventricular Dysfunction between Coronary Artery Bypass Graft and Percutaneous Coronary Intervention by Hsiu-Yu Fang, Yen-Nan Fang, Yin-Chia Chen, Jiunn-Jye Sheu, Wei-Chieh Lee

“…The patients (N = 236) who were diagnosed with dilated cardiomyopathy or valvular heart disease without coronary artery stenosis, those with prior history of CABG or valvular surgery (N = 59), those who presented ST-segment elevated myocardial infarction (STEMI), those with a CAD and SYNTAX score of  ≦ 22 (N = 175), those who received emergent CABG for coronary perforation (N = 3), and those who had NYHA class ≦ 2 (N = 65) were excluded. Finally, 116 patients with reduced LVEF and those who had a SYNTAX score >22, who received CABG (N = 47) and PCI (N = 69), were recruited for this study.Results. …”
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Analysis of Gait and Foot Pressure in Patients with Different Severity of Knee Osteoarthritis by LING Xingjin, OU Jianlin, XIE Wenhao, CHEN Zhuoming, OUYANG Hui

“…ObjectiveTo analyze the gait characteristics of patients with different severity of knee osteoarthritis and the differences in the peak pressure points in different subdivisions of the foot to provide a basis for the clinical diagnosis, treatment and rehabilateral of knee osteoarthritis.MethodsA total of 64 patients with bilateral knee osteoarthritis admitted to the Department of Bone and Joint Surgery, Department of Rheumatology and Immunology, Department of Rehabilitation Medicine, and Department of Spine and Trauma Surgery of the First Affiliated Hospital of Jinan University from August 2020 to February 2021 were selected, based on the K-L classification (Kellgren-Lawrence classification) criteria of imaging, and the 50 cases of patients who met the criteria were divided into mild and moderate-severe groups, of which 26 cases of patients with grades I and II were included in the mild group, and 24 cases of patients with grades III and IV were in the moderate-severe group.The gait spatiotemporal parameters and peak plantar pressure points of the two groups were detected using the gait and balance function training assessment system and smart rehabilitation shoes respectively. …”
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Bevezetés az analitikus feminizmushoz by Áron Dombrovszki

“…During this investigation, Véber evokes important concepts for feminist thinking, such as the issue of implicit bias and its harmful effects, or the distinction between hostile and benevolent sexism. Finally, we would like to thank our reviewers for their essential help and assistance. …”
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Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Gene set enrichment analysis (GSEA) was used to obtain information on key gene pathways and interactions with UC or AS-related diseases, followed by immune infiltration analysis. Finally, peripheral blood samples of AS and UC were used to verify the mRNA expression of the eight key genes using reverse transcription-polymerase chain reaction (RT-PCR).Results: Our results revealed that GMFG, GNG11, CLEC4D, CMTM2, VAMP5, S100A8, S100A12 and DGKQ are potential diagnostic biomarkers of AS and UC. …”
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The relationship between social support and psychological crisis vulnerability among family impoverished undergraduates: the intermediary role of psychological resilience by Weimin Yuan, Jinhui Ning, Mengke Huo, Yiwei Feng

“…Second, we expanded the independent variables that affect psychological crisis vulnerability among family impoverished undergraduates and conducted multiple linear regression analyses. Finally, we employed a structural equation modeling approach to analyze the underlying mechanisms between social support and psychological crisis vulnerability and to test the conspicuousness of the mediating role of psychological resilience in the process by which social support affects psychological crisis vulnerability.ResultsAnalysis of 1,549 valid questionnaires revealed that the overall level of psychological crisis vulnerability among family impoverished undergraduates was moderate. …”
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