Bio-active composition, antibacterial activity and molecular docking studies of Salicia nitida (Benth.) root extracts by Wisdom U. Ike, Okereke C. Stanley, Nosiri Ijeoma, Okamgba C. Okezie, Nwokocha W. Osita, Aguwanba Chinedu, Aaron C. Friday

“…A computational analysis was conducted to analyze the potential antibacterial bioactive component, Butylated hydroxytolene (Compound Identification number CID: 31404) and 5-Eicosene (Compound Identification number (CID): 5364600), identified from Gas Chromatography-Mass Spectrophotometry (GC-MS) analysis, against class A beta-lactamase enzyme (Protein Data Bank (PDB): 3BLM) to identify its inhibition potentials. Finally, we also investigated the antibacterial potentials of S. nitida. …”
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Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

“…Additionally, we performed immunoblotting to quantify the expression of DHCR24, total calmodulin-dependent protein kinase 2 (CAMK-2), p-CAMK2 (T286), caveolin-1, total synapsin-1, phosphorylated synapsin-1 (p-synapsin-1; S605), and synaptophysin in each experimental group. …”
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Evaluation of In Vitro Production Capabilities of Indole Derivatives by Lactic Acid Bacteria by Bingyang Ma, Yan Zhao, Liping Liu, Jianguo Xu, Qingping Hu, Saisai Feng, Liangliang Zhang

“…IPA and IAA were not detected in any strains. Finally, these indole derivative-producing capabilities were not related to their geographical origins or isolation sources. …”
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Vers un Laocoon plus neuf by Clement Greenberg

“…(II) Le romantisme, courant d’inspiration bourgeoise cherchant la communication immédiate du sentiment, va venir oblitérer le médium, avant de retomber finalement dans le sentimentalisme poétique. (III) En réaction à l’ordre bourgeois, les avant-gardes, soucieuses de l’autonomie de leur art, vont venir s'opposer aux idées abstraites comme à la littérature. …”
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From Trinidad to Cyberspace: Reconsidering Ernst Toch’s “Geographical Fugue” by Carmel Raz

“…The latter are also examined through a linguistic analysis of the vowel and syllabic distribution within the “Geographical Fugue” itself. Finally, the afterlife of these features is explored in various contemporary remixes of Toch’s work on YouTube, and the ways in which contemporary possibilities of musical creation enable the work to return to a state that evokes its original context of technological experimentation. …”
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Identitas Komunikasi Penggemar K-Pop di Media Sosial X by Alsa Aisiyah Sutardi, Yoka Pradana, Rah Utami Nugrahani

“…In the relational layer, their identity is shaped by close social circles such as family and friends. Finally, in the communal layer, fans face negative stigma as being fanatical, although some are still regarded as normal fans…”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…In addition, further confirmed the mechanisms by how TLR4 and MGL synergistic pathway endow the nanovaccines towards dendritic cells (DCs). Finally, the safety and tumor immunosuppressive microenvironment were evaluated in the CRC tumor-bearing mouse model.Results: We successfully developed a nanovaccine that facilitates the endocytosis and maturation of DCs via a synergistic pathway involving TLR4 and MGL, which endow the nanovaccines towards dendritic cells (DCs) and promote the differentiation, thereby enhancing the cytotoxicity of CD8+T cells. …”
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A Live Video Resiliency Dyadic Intervention for Persons With Dementia and Their Care-Partners Early After Diagnosis: Protocol for Open Pilot of Resilient Together for Dementia by Sydney McCage, Kristin Walker, Talea Cornelius, Robert A Parker, Kristen Dams-O'Connor, Brad Dickerson, Christine Ritchie, Ana-Maria Vranceanu, Sarah Bannon

“…Eligible dyads will include couples (up to N=10) referred from Mount Sinai Hospital (MSH) clinics within 3 months of an ADRD diagnosis. …”
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BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes by Honggang Xu, Bin Xu

“…BMSCs or chondrocytes were transfected with miR-326 mimics or inhibitors to investigate the effect of miR-326 in BMSC-Exos on pyroptosis of chondrocytes and the potential mechanism. Finally, a rat OA model was established to verify the effect and mechanism of miR-326 in BMSC-Exos on cartilage of pyroptosis. …”
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Introduction à « Convergences franco-chinoises: la valeur de la créativité transculturelle » by Rosalind Silvester, Guillaume Thouroude

“…While the first revolves around the question of the plurality of the artists’ positions, which goes beyond the binary relationship between France and China, the second section reflects on cultural production as a transformative act putting the inner world of the migrant into a meaningful relationship with the outside world, whether human or non-human. Finally, the third section observes and evaluates the increasingly important role of the visual arts within franco-Chinese artistic production. …”
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Predictors of the Short‐Term Outcomes of Guillain–Barré Syndrome: Exploring Electrodiagnostic and Clinical Features by Yi‐Hsiang Chen, Chia‐Lun Wu, Wei‐Chieh Weng, Yi‐Chia Wei

“…The patients were stratified into two groups by their scores on the GBS Disability Scale: good (score ≤ 2) and poor (score > 2) outcome groups. Results The study finally included 24 GBS patients (mean age: 53.0 ± 20.9 years; female‐to‐male ratio: 2.3; good outcome group: 13; poor outcome group: 11). …”
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Phylogenomic analysis reveals exceptions to the co-evolution of ZAR1 and ZRK immune gene families in plants by Li Yang, Shengyi Liu, M. Eric Schranz, Klaas Bouwmeester

“…To initiate defense, ZAR1 associates with different HOPZ-ETI-DEFICIENT 1 (ZED1)-Related Kinases (ZRKs) to form resistosomes to indirectly perceive effector-induced perturbations. …”
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Geospatial distribution and predictors of postnatal care utilization during the critical time in Ethiopia using EDHS 2019: A spatial and geographical weighted regression analysis. by Muluken Chanie Agimas, Tigabu Kidie Tesfie, Nebiyu Mekonnen Derseh, Meron Asmamaw, Habtamu Wagnew Abuhay, Getaneh Awoke Yismaw

“…The ordinary least squares method was used to select factors explaining the geographical variation of postnatal care during the critical time. Finally, the geographical weighted regression was used to show the spatial variation of the association between predictors and outcomes. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…Besides, the associations between hub genes, immune cells, and key pathways were explored. Finally, the expression levels of key genes were determined in a dextran sulfate sodium (DSS)-induced UC mouse model by qRT-PCR.Results: UC samples were classified into two subtypes (1 and 2), which displayed significant differences in the immune landscape and JAK/STAT signaling pathways. …”
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Seven Immune-Related Genes’ Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma by Rui Mu, Yuehong Shen, Chuanbin Guo, Xinyun Zhang, Hongyu Yang, Huijun Yang

“…The protein-protein interaction (PPI) network and functional enrichment pathway investigations were utilized to explore possible potential molecular mechanisms. Finally, the hub gene’s differential mRNA expression levels were evaluated by means of the Gene Expression Profiling Interactive Analysis (GEPIA), and the Human Protein Atlas (HPA) was utilized for the validation of their translational levels. …”
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From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment by Basingab FS, Alshahrani OA, Alansari IH, Almarghalani NA, Alshelali NH, Alsaiary AH, Alharbi N, Zaher KA

“…The technical challenges include efficient and targeted delivery to tumor sites without affecting healthy tissue; biological, such as potential toxicity, immune system activation, or resistance mechanisms; economic, involving high production and scaling costs; and regulatory, requiring rigorous testing for safety, efficacy, and long-term effects to meet stringent approval standards. Finally, we have explored emerging trends, the potential for personalized medicine, and the ethical and social implications of this transformative technology. …”
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The physiological responses to volume-matched high-intensity functional training protocols with varied time domains by Jessica S. Smith, Jessica S. Smith, Gabriella F. Bellissimo, Gabriella F. Bellissimo, Fabiano T. Amorim

“…Measurements of heart rate (HR), oxygen consumption (VO2), rating of perceived exertion (RPE) (1–10 scale), blood lactate (BLA), creatine kinase (CK), excess post-exercise oxygen consumption (EPOC), and muscle oxygen saturation (SmO2) were performed.ResultsTime domains were significantly different for the EMOM and RFT workouts (20 vs. 12 min ± 3 min, p < 0.00). …”
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Management of Irritable Bowel Syndrome: Novel Approaches to the Pharmacology of Gut Motility by Carmelo Scarpignato, Iva Pelosini

“…Besides decreasing colonic sensitivity to distension, these drugs prolong intestinal transit and may be particularly useful in diarrhea-predominant IBS. Finally, when administered in small pulsed doses, octreotide, besides reducing the perception of rectal distension, accelerates intestinal transit, although other evidence disputes such an effect.…”
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Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats by Jin R, Pei H, Yue F, Zhang X, Zhang Z, Xu Y, Li J

“…Pharmaceutical factory, Beijing, 100079, People’s Republic of China, Tel +86-10-87632655, Email xy706@sina.com; yarily@126.comPurpose: This study aims to explore the mechanism of Yangxuerongjin pill (YXRJP) in the treatment of diabetic peripheral neuropathy (DPN) by network pharmacology and metabolomics technology combined with animal experiments, and to provide scientific basis for the treatment of DPN.Methods: In this study, network pharmacology analysis was applied to identify the active compounds, core targets and signal pathways, which might be responsible for the effect of DPN. …”
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À la recherche de l’immortalité : intelligence artificielle, vie artificielle et post-humanisme dans La Cité des permutants de Greg Egan. by Ross Farnell

“…Leur calvaire confirme finalement que seul ce qui a une fin est supportable. …”
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