Gene prediction of immune cells association between gut microbiota and colorectal cancer: a Mendelian randomization study by Yan Zhong, Guanglei Chen, Menglu Chen, Junsong Cui, Qianren Tan, Zhenghua Xiao

“…MR-PRESSO was used to detect and correct outliers by excluding anomalous instrumental variables. Finally, we supplemented our analysis with methods such as Bayesian Weighted Mendelian Randomization (BWMR), Maximum-Likelihood, Lasso, Debiased Inverse Variance Weighted, and Contamination Mixture to establish a robust and compelling causal relationship.ResultsAfter accounting for reverse causality, horizontal pleiotropy, and various methodological corrections, Bifidobacterium kashiwanohense, GCA-900066755 sp900066755, Geminocystis, and Saccharofermentanaceae exhibited strong and robust causal effects on CRC. …”
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Eine Systematik diatonischer Skalen by Marc Neufeld

“…The limits of the system’s possibilities are discussed. Finally, the article considers the concept of “new modality” which refers to a connection between scalar and spectral thinking.…”
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Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption by Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer

“…A vaccination assay on a humanized mouse model (HLA-A2/DR1) was used to validate the immunogenicity and the presentation of these peptides. Finally, we used Bulk RNA-Seq sequencing along with MCPcounter, a cellular deconvolution method, to investigate the immune contexture of ESR1-mutated BC. …”
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The effects of mobile phone addiction on learning engagement of Chinese college students - the mediating role of physical activity and academic self-efficacy by Shuqiao Meng, Kai Qi, Panyi Shen, Meng Zhang, Yu Zhang, Nzubechi Onyebuchi, Ge Zhan, Fanqi Wei, Wenxia Tong, Yahui Han, Xiaoyu Ge

“…The survey was conducted using the Chinese online questionnaire platform “Questionnaire Star,”and 4,562 valid questionnaires were finally obtained. SPSS 29.0 and AMOS 29.0 were used for data analysis and structural equation model testing. …”
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Online patients questions regarding reverse total shoulder arthroplasty pertain to timeline of recovery, specific activities, and limitations by Kyle K. Obana, MD, Dane R.G. Lind, BA, Andrew J. Luzzi, MD, Michaela J. O’Connor, MD, Matthew R. LeVasseur, MD, William N. Levine, MD

“…Although all patients will benefit from education on ways to perform activities of daily living while abiding by postoperative restrictions, physicians should set preoperative expectations regarding return-to-activity following rTSA in younger, more active patients. Finally, surgeons should provide patients with physical booklets and online information available on their websites to avoid reliance on low-quality online sources.…”
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Neuropati Auditori by Sukri Rahman, Rossy Rosalinda

“…Conclusion: An accurate clinical and audiological evaluation are needed in auditory neuropathy, and finally, a correct diagnosis allow better treatment and rehabilitative strategies. …”
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Photo-Fenton Degradation of RB5 Dye in Aqueous Solution Using Fe Supported on Mexican Natural Zeolite by José Domenzain-Gonzalez, José J. Castro-Arellano, Luis A. Galicia-Luna, Luis Lartundo-Rojas

“…The optimal RB5 dye degradation was achieved at RB50=100 mg/L in the presence of MNZ/Fe=0.2 g/L, H2O2=3 g/L and pH=2.5 where the highest discoloration and chemical oxygen demand removal were 93 and 70.5 at 180 min. Finally, the kinetic reaction was evaluated as a pseudo-first-order kinetics with an apparent rate constant (kapp) of 0.0225 min-1 at latest conditions.…”
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Heterogeneity in Fluorescence-Stained Sperm Membrane Patterns and Their Dynamic Changes Towards Fertilization in Mice by Momoka Hirai, Satoshi Kishigami

“…After in vitro fertilization (IVF) using pre-stained sperm, zona pellucida-attached sperm were mostly negative for staining. Finally, all sperm detected in the perivitelline space were only negative. …”
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Experimental Investigation of the Effect of Two-Stage Peltier Application on the Temperature of a Microprocessor by Fatih Uysal, Sinan Çobaner

“…In these experiments, four different powers were applied to the micro-heater, and at the maximum power of 9.9 W, the lowest cold surface temperature observed was 126.4 °C. Finally, the two stage Peltier module system was directly applied to a computer processor to observe its cooling performance under real-use conditions. …”
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Crotonylation-Related Prognostic Model of Esophageal Squamous Cell Carcinoma Based on Transcriptome Analysis and Single-Cell Sequencing Analysis by Lin RY, Chen RP, Lin FQ

“…Ruo-Yang Lin,1 Ren-Pin Chen,1 Fu-Qiang Lin2 1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Thoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of ChinaCorrespondence: Fu-Qiang Lin, Email linfq66@qq.comBackground: Crotonylation is an emerging lysine acylation modification implicated in various diseases, yet its role in esophageal squamous cell cancer (ESCC) is unexplored. …”
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Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study by Geke Zhu, Han Zhou, Wanying Wang, Yongbo Ma, Xiangtao Nie, Wenjing Qi, Lei Hao, Xiuming Guo

“…During the 8-week follow-up, in GMG patients, whether positive for acetylcholine receptor (AChR) or muscle-specific tyrosine kinase (MuSK) antibodies, the overall efficacy was significant. …”
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Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress by Mihai Spiridon-Bodi, Cristina Ros-Carrero, J. Carlos Igual, Mercè Gomar-Alba

“…Second, under cell wall stress, Whi7 was specifically recruited to SBF-target promoters, independent of the increase in its protein levels or cell cycle stage. Finally, we found that Whi7 protein instability further increased during cell wall stress and that Whi7 degradation triggered advanced cell cycle re-entry. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Co-culture experiments of synovial fibroblasts with B cells were performed to investigate the influence of synovial cells on B cell activation and differentiation. Finally, transcriptome analysis was utilized to identify potential key molecules and pathways.Results: In OA patients, the infiltration, activation, and differentiation of B cells in synovium and peripheral blood exhibited distinct characteristics. …”
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Extracellular vesicles (EVs) in seminal plasma of buffalo bulls possess spermatozoa specific fertility associated proteins and enzymes by Rakesh Kumar, Mir Ahmad, Bala Subramaniam, Ankit Pal, Aditya Patel, Shiva Shiva, Vitika Chauhan, Seema Karanwal, Mukesh Bhakat, Tirtha K. Datta

“…We observed that protein cargo was successfully assimilated with sperm. Finally, LC-MS/MS-based high throughput proteome was performed to identify the differential abundance of protein cargo in seminal EVs of contrasting fertility bulls. …”
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Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

“…Molecular and cellular experiments were conducted to analyse and validate the role of NSD2 in the development of IBD. Finally, rescue experiments were performed to confirm the molecular mechanism of NSD2 in the development of IBD. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Downregulation of miR-26a activated the LIMS1/integrin-linked kinase (ILK) signaling pathway in the heart and kidney, which represents a common molecular mechanism underlying inflammation and fibrosis in heart and kidney tissues during CKD. …”
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Shared genetic risk and causal associations between Post-traumatic stress disorder and migraine with antithrombotic agents and other medications by Charlotte K. Bainomugisa, Dagmar Bruenig, Heidi G. Sutherland, Lyn R. Griffiths, Dale R. Nyholt, Divya Mehta

“…The genes in the genomic regions shared between PTSD and medication use traits were enriched in neural-related pathways such as neuron development, neurogenesis and protein kinase activity. These results provide further insight into the genetically controlled biological and environmental factors underlying the shared etiology between PTSD and migraine. …”
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Effects of Carbonate Alkalinity on Antioxidants, Immunity and Intestinal Flora of <i>Penaeus vannamei</i> by Chuang Gao, Zhonghong Li, Bo Ma, Rantao Zuo, Xudong Shen, Mingkang Chen, Chuanqi Ren, Wenjun Zheng, Zhonglu Cai, Jiaxing Li, Shuang Li

“…The functional abundance of signal transduction histidine kinase was lower than that of the control group. The results of this study not only indicated that <i>Penaeus vannamei</i> cell structure would change and mortality would increase under high carbonate alkalinity culture environment, but they also analyzed the changes of the intestinal microbial structure under carbonate alkalinity stress. …”
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Magnitude and Factors Associated with Precervical Cancer among Screened Women in Southern Ethiopia by Terefu Teka, Mesfin Kote, Gemechu Kejela, Tagel Getachew

“…After cleaning the data, descriptive analysis was done and multivariable logistic regression model was employed to identify predictors of precervical cancer. Finally, statistical significance was declared at P < 0.05. …”
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Association between exposure to tobacco information through mass media, smoking households and secondhand smoke exposure in adolescents: Survey data from South Korea by Wenbin Du, Gaoran Chen, Minmin Gu, Huixin Deng, Won G. Choi

“…In addition, regression models revealed that exposure to cigarette advertising in magazines (β=0.131; 95% CI: 0.097–0.166), networks (β=0.151; 95% CI: 0.127– 0.175), convenience stores (β=0.061; 95% CI: 0.035–0.087), and supermarkets (β=0.133; 95% CI: 0.108–0.158) is associated with SHS exposure in adolescents. Finally, our study showed stronger ties between SHS exposure, family smoking, and tobacco ads in girls. …”
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