Saussurea gossypiphora extracts reduce inflammation by reversing inflammatory cytokine levels in in-vitro and in-vivo by Kalyani Jatoth, Pawan Kumar Anoor, Ramesh Kande, Sandeepta Burgula

“…Effect of MESGD on inflammasome pathway was studied by performing ELISA for IL-1β, TNF-α and confirmed by immunoblotting for NLRP3 and Caspase 1 in THP1 cells. Finally, RAW 264.7 cells treated with LPS were assessed for the synthesis of Nitric Oxide to confirm anti-inflammatory activity of MESGD. …”
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Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects by Juan Iovanna, José Luis Neira

“…The bioavailability of compounds such as antisense oligonucleotides and siRNAs in humans remains a big hurdle, which will require further improvement of gene-delivery strategies. Finally, the long-term goal of the therapy individualization for patients is possible if factors that predict treatment response, such as biological markers, could be determined accurately. …”
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Airborne Levels of Lung Carcinogens at an Ascon Manufacturing Site by Kyeongmin Lee, Sungwon Choi, Miyeon Kim, Dongwoo Song, Ki-Youn Kim

“…The drying process removes moisture from the aggregate and maintains the required temperature for combining the aggregate, asphalt, and additives into ascon during the mixing stage. Finally, the ascon is disgorged from an outlet on the mixing machine and loaded onto dump trucks. …”
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A deep learning-based method for the intelligent identification of the quantity of coals flushed out during borehole hydraulic flushing by Xiaojun LI, Mingyang ZHAO, Miao LI

“…The CIoU loss function was replaced with the SIoU loss function to accelerate the matching between prediction and ground truth boxes. Finally, the improved YOLOv8n algorithm was validated using a self-built dataset. …”
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Identification and validation of glucose metabolism-related gene signature in endometrial cancer by Juan Jiang, Nan Xia, Mei Yang, Ping Qiu, Wei Zhu, Jing Chen, Jiamei Zhu

“…The expression levels of SLC38A3, SLC2A1, and ASRGL1 are higher in tumor samples by RT-qPCR, with IHC confirming increased SLC38A3 expression. Finally, SLC38A3 may function as oncogenes in EC, as revealed by the results of in vitro experiments. …”
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Testing the reliability of global surface temperature reconstructions of the Last Glacial Cycle with pseudo-proxy experiments by J.-P. Baudouin, N. Weitzel, M. May, L. Jonkers, A. M. Dolman, K. Rehfeld, K. Rehfeld

“…We also show that a trade-off exists between the inclusion of many records, which reduces the uncertainty on long timescales, and of only records with low age uncertainty, high accumulation rate, and high resolution, which improves the reconstruction of the short timescales.</p> <p>Finally, the method and the quantitative results presented here can serve as a basis for future evaluations of reconstructions. …”
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Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus... by Dong-Sup Lee, Mi-Ju Park, Namhee Lee, Yun-Hui Jeon, Jiyoon Yoo, Suk-kyung Shin, Songyi Lee, Byung-Jin Jung, Yun-Kyoung Hong, Keunhee Oh

“…The SJ-600 series viruses also expressed human granulocyte-macrophage colony-stimulating factor (GM-CSF) to activate dendritic cells. The viral thymidine kinase (J2R) gene was replaced by genes encoding the CD55 fusion proteins and GM-CSF.Results SJ-600 series viruses expressing human CD55 on the IMV membrane showed resistance to serum virus neutralization. …”
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Thermal properties and non-bonded interactions in human PMP2 variants: A molecular dynamics study by Prabin Aryal, Jhulan Powrel

“…Also, the estimated value of thermal diffusivity indicated that the mutant was slightly more efficient at conducting heat than the wild-type protein; the thermal diffusivity of both proteins was much lower than that of water. Finally, a non-linear (concave nature) change in Cv with temperature was observed in both protein systems. …”
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The influence of intermittent venovenous hemodiafiltration on the course of acute kidney injury in multiple trauma victims by V.M. Dubyna, O.V. Kravets

“…We investigated the levels of total creatine kinase and myoglobin, indicators of kidney function, frequency of vasopressor support, indicators of general blood analysis, liver complex, coagulogram, acid-base and gas composition of blood. …”
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Photosynthetic Pigments with Potential for a Photosynthetic Antenna: A DFT Analysis by Jesús Francisco Monzón-Bensojo, Manuel A. Flores-Hidalgo, Diana Barraza-Jiménez

“…From frequency calculations, IR spectra were obtained for combinations. Finally, excited-state computations were carried out to acquire UV-Vis spectra of the combinations. …”
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Value Cocreation and Codestruction in Digital Health Services: Protocol for a Systematic Review by Elina Laukka, Tuure Tuunanen, Miia Jansson, Minna Vanhanen, Nina Hirvonen, Jenni Palukka, Märt Vesinurm, Paulus Torkki

“…The antecedents, decisions, and outcomes of value cocreation and codestruction in the context of digital health services will be described in a finalized systematic review. In the outcomes, our main interest is the effect on patient outcomes and experiences and professional experiences. …”
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An Experimental Study on Mechanical Properties and Fracture Characteristics of Saturated Concrete under Coupling Effect of Low Temperature and Dynamic Load by Mengxiang Wang, Qi Zong, Haibo Wang

“…The water-saturated low-temperature state of the concrete void is filled with ice crystal particles; for low-temperature water-saturated concrete in the impact of the dynamic load, the microstructure is affected by the ice crystal structure which is not easy to change; the specimen along the axial force direction microdefect development produces a crack, the crack along the parallel to the pressure direction of cracking, through the two ends of the specimen, and finally produces axial splitting tensile damage. The research results have important theoretical significance for the safety design of low temperature saturated concrete structures.…”
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Quality of Life Philosophy IV. The Brain and Consciousness by Søren Ventegodt, Niels Jørgen Andersen, Joav Merrick

“…At organ level, the function can be understood as an extremely complex pattern machine. Finally, the brain’s function can be understood at the cognitive level as what provides consciousness through its ability to keep order in our complicated reality. …”
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Les aqueducs romains de Lyon et d’ailleurs : nouveaux repères by Aldo Borlenghi, Catherine Coquidé

“…Numerous clues can be used in chasing down a chronology, but uncertainty is often the rule and multiple pieces of evidence have to intersect in order to arrive at plausible conclusions.Finally, bringing water into the city centre is the ultimate purpose. …”
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Distribution and Variation of Mining-Induced Stress in the Reverse Fault-Affected Coal Body by Rui Zhou, Yujin Qin, Zhizhen Zhang

“…In other words, the magnitude of coal body stress concentration can be affected by the hanging wall and footwall mining, as well as parameters of the reverse fault. Finally, intrinsically safe GZY25 borehole stress sensors were used to monitor the coal body stresses in the reverse fault area under the influence of mining in Xinchun Coal Mine and ZuoQiuka Coal Mine. …”
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Effects of dam fear and stress on metrics of puppy welfare in commercial breeding kennels by Aynsley C. Romaniuk, Shanis Barnard, Traci Shreyer, Candace Croney

“…Further, dams’ hair cortisol concentrations (HCC) were analyzed at the previously mentioned time points and at 1 week prepartum. Finally, birth and weekly weights were collected from puppies, and litter health metrics were recorded. …”
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Examining the Leverage Effect, Dynamic Conditional Correlation, and Volatility Spillover Among Selected Indices of the Tehran Stock Exchange: Evidence from the ARMA-DCC-GJR-GARCH M... by Gholamhosein Golarzi, Seyed Ramin Abolfazli

“…Then, the GJR-GARCH model was used to check the leverage effects. Finally, the DCC-GARCH (1,1) framework was employed, which helped to deeply analyze the dynamic linkages in volatility among selected indices of the Tehran Stock Exchange. …”
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Characterising COVID-19 empirical research production in Latin America and the Caribbean: A scoping review. by Cristián Mansilla, Cristian A Herrera, Laura Boeira, Andrea Yearwood, Analia S Lopez, Luis E Colunga-Lozano, Eva Brocard, Tatiana Villacres, Marcela Vélez, Gabriel Di Paolantonio, Ludovic Reveiz

“…After removing duplicates, 5,458 titles and abstracts were screened, of which 2,323 full texts were revised to finally include 1,626 empirical studies. The largest portion of research came from people/population of Brazil (54.6%), Mexico (19.1%), Colombia (11.2%), Argentina (10.4%), Peru (10.3%) and Chile (10%), while Caribbean countries concentrated 15.3%. …”
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Collaboration-Based BIM Model Development Management System for General Contractors in Infrastructure Projects by Yu-Cheng Lin, Nan-Hai Lo, Hsin-Tzu Hu, Ya-Ting Hsu

“…Furthermore, to understand its effectiveness, the proposed CBMDM system is applied to a case study of an MRT project in Taiwan. Finally, the major practical advantages, disadvantages, and limitations of the system are identified for infrastructure projects.…”
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The development and application of a risk prediction model for cardiac arrest in ICU patients with mechanical ventilation (ICU机械通气患者心脏骤停风险预测模型的构建及应用研究)... by SHAO Qianqian (邵茜茜), GUO Linlin (郭林林), JIANG Tingting (蒋婷婷)

“…Logistic regression was used to establish a risk prediction model, and the model power and its accuracy were evaluated by receiver operating characteristic. Results The study finally included arrhythmia, hypoxemia, acid-base imbalance, septic shock, history of cardiac arrest, multiple organ dysfunction syndrome to construct the risk prediction model. …”
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