Secretarios, música y diplomacia cultural: el inventario post mortem de Juan de Castro Laurel (Roma, 1709) by José María  Domínguez

“…Los secretarios de los ministros de la Italia española a finales del siglo XVII fueron importantes agentes de diplomacia cultural. …”
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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

“…Single-cell functional analysis elucidated the involvement of MAP3K genes in shaping the tumor microenvironment. miRNA-mRNA network analysis revealed intricate regulatory mechanisms, with hsa-mir-200b-3p emerging as a key regulator. Finally, the MAP3K1 knockdown has shown significant impacts on the cellular behavior of the BGC823 cells. …”
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Effect of Dalmavital and Ovulik Plus on conception rate in Ovsynch synchronized Nili-Ravi buf- faloes by Muhammad Tayyab Khan, Muhammad Muzammal Niaz, Ghulam Shabbir Khan

“…For the Ovsynch protocol, buffaloes were administered with 2ml (IM) injection of GnRH (Lecirelin acetate 25μg/ml) at day 0, followed by 2ml (IM) injection of PGF2α (D-cloprostenol 75μg/ml) at day 7. Finally, 2ml GnRH was injected (IM) at day 9. Dalmavital was injected (IM) at the rate of 1ml/40kg body weight at day 5 in G1, and Ovulik Plus was offered by drenching gun just after 1st AI as a single dose of 1000 g/ buffalo. …”
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Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…IR did also not affect mRNA markers for inflammation or epithelial-mesenchymal transition (EMT), but did increase mRNA levels of the cell cycle inhibitor P21/CDKN1A and resulted in downregulation of the proliferation markers MKI67 and E2F1. Finally, IR of ALI-PBEC had a marked effect on organoid formation capacity, which was markedly impaired following IR in a dose-dependent manner. …”
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Development and Validation of a Risk Prediction Model for Ventricular Arrhythmia in Elderly Patients with Coronary Heart Disease by Ying Dong, Yajun Shi, Jinli Wang, Qing Dan, Ling Gao, Chenghui Zhao, Yang Mu, Miao Liu, Chengliang Yin, Rilige Wu, Yuqi Liu, Yang Li, Xueping Wang

“…In the retrospective study, a total of 2231 consecutive elderly patients (≥60 years old) with CHD hospitalized were investigated, and finally 1983 patients were enrolled as the model group. …”
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A complex case of right heart masses in a leukemia patient: a case report by Xiaoning Wang, Mahsa Fatahichegeni, Mohammad Amin Ansarian, Seifollah Ranjbarha, Juan Ren

“…Which complicated the differential diagnosis. Finally, considering the need for leukemia treatment, allo-HSCT was performed after extensive workup, including echocardiography, MRI, and PET/CT, which ruled out leukemic infiltration, typical infectious vegetation, and primary or metastatic cardiac tumors. …”
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Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients by Tzu-Chun Cheng, Mien-Chie Hung, Lu-Hai Wang, Shih-Hsin Tu, Chih-Hsiung Wu, Yun Yen, Chi-Long Chen, Jacqueline Whang-Peng, Wen-Jui Lee, You-Cheng Liao, Yu-Ching Lee, Min-Hsiung Pan, Hui-Kuan Lin, Huey-En Tzeng, Peixuan Guo, Cheng-Ying Chu, Li-Ching Chen, Yuan-Soon Ho

“…We also observed the nuclear translocation of HNMT/HER2-ICD cells using fluorescent double staining and DeltaVision microscopy. Finally, ChIP sequencing was employed to identify target genes affected by the HNMT/HER2-ICD complex. …”
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Analysis of gene expression difference and biological process in chorionic villi of unexplained recurrent spontaneous abortion by Linling Shi, Lun Wei, Meiqiu Lu, Hongmei Ding, Le Bo

“…Differentially expressed genes were analyzed by the “Limma” package in R Studio, and Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were carried out with “Cluster Profiler” and “org.hs.eg.db” packages. Finally, hub genes were identified through constructing the protein-protein interaction (PPI) network from the differentially expressed gene dataset in the STRING database. …”
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SOME ASPECTS OF TEETH ERUPTION. A LITERATURE REVIEW by L.V. Smaglyuk, Н.V. Voronkova, A.Y. Karasiunok

“…The passive eruption usually occurs after teething and continues in adolescents and finally stops after facial growth. Altered passive eruption (APE) (also known as delayed passive eruption) occurs when the edge of the gums is incorrectly (occlusively) located on the anatomical crown in adulthood and does not approach the CEJ. …”
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Effects of Land Use Types on Selected Soil Properties in Central Highlands of Ethiopia by Daniel Jaleta Negasa

“…The study recommends further studies on the effects of Eucalyptus on soil properties by comparing among different ages and species of Eucalyptus. Finally, planting of Eucalyptus on central highlands of Ethiopia should be supported by land use management decision.…”
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Cytotoxic and cytostatic activity of five new imidazotetrazine derivatives on breast cancer cell cultures MDAMB231, BT474, and MCF-7 by Ahmed Hamid Al-Humairi, Svetlana E. Sitnikova, Valery V Novochadov

“…Imidazotetrazine 1 and iminothiotriazine 5 showed cytotoxic activity higher than that of the comparison drug and we classified these compounds as the ones with a moderate CTA. Finally, we found imidazotetrazine 4 with IC50 of 0.85 mM/L and CTA of 7.34 as a compound with a potentially strong anticancer effect for further investigation. …”
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Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis... by Wenji Pu, Wenji Pu, Wenji Pu, Wenqi Chen, Haiman Jing, Jishi Li, Yong Jiang, Shasha Li, Weijie Wen, Zhiyuan Xu, Jing Jin

“…BackgroundWe conducted the meta-analysis to compare the therapeutic effects of total neoadjuvant therapy (TNT) based on short-course radiotherapy followed by consolidation chemotherapy (SCRT/CCT) and long-course chemoradiotherapy (LCCRT) for locally advanced rectal cancer (LARC) according to certain significant randomized controlled trials (RCTs).MethodsThe researchers retrieved several databases, including PubMed, Embase, Web of Science, and the Cochrane Library, to collect all the relevant literature published since the establishment of the databases until July 30, 2024, and then screened to determine the qualified literature and extracted the relevant information. Finally, RevMan 5.4 software was utilized to conduct the meta-analysis for determining the 95% confidence interval (CI) and pooled risk ratio (RR). …”
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TÜRKİYE'DE 1980 SONRASI İZLENEN PARA POLİTİKASI by Öğr. Gör. Kamil Cura

“…Bu ortamda uluslararası para kuruluşları Tür-kiye'nin kredi notunun düşürüldüğünü medyayla duyurdu. Finans piyasalarında…”
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Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma by Weiwei Chen, Chutian Wu, Yuting Li, Tonghua Wang, Miaoling Huang, Min Wang, Linjing Long, Yanfang Chen, Shufen Feng, Xuyou Liu, Shaohui Tang

“…Then, the mechanism by which active IGF2/H19 enhancer mediated by miR-483-5p activate IGF2/H19 promoters was studied in HCC cells. Finally, the effect of MED1 on the expression of IGF2/H19 as well as the malignant phenotype of HCC cells in vitro and in vivo mediated by miR-483-5p was evaluated. …”
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Resilience throughout COVID-19: Unmasking the realities of COVID-19 and vaccination facilitators, barriers, and attitudes among Black Canadians. by Obidimma Ezezika, Toluwalope Adedugbe, Isaac Jonas, Meron Mengistu, Tatyana Graham, Bethelehem Girmay, Yanaminah Thullah, Chris Thompson

“…As many as 97 participants expressed feelings of isolation, while 63 reported restricted mobility. Finally, participants discussed determinants that influenced their vaccination decisions, in which 46 barriers and four facilitators were identified and mapped onto nine overarching themes. …”
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3D-QSAR, design, molecular docking and dynamics simulation studies of novel 6-hydroxybenzothiazole-2-carboxamides as potentially potent and selective monoamine oxidase B inhibitors by Dong Xie, Dong Xie, Yongzheng Tian, Li Cao, Penghang Guo, Penghang Guo, Zhibiao Cai, Jie Zhou

“…The ten most promising compounds were screened based on the IC50 values and tested for molecular docking. Finally, the binding stability and dynamic behavior of these compounds with MAO-B receptors were analyzed by molecular dynamics simulation (MD).ResultsThe 3D-QSAR model showed good predictive ability, with a q2 value of 0.569, r2 value of 0.915, SEE of 0.109 and F value of 52.714 for the COMSIA model. …”
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Advanced analysis via statistical physics model to study the efficiency of catechol removal from wastewater using Brazil nut shell activated carbon by Salah Knani, Ismahene Ben Khemis, Wassim Zahrouni, Besma Graba, Ridha Selmi, Safwat A. Mahmoud, Abdulaziz Alenazi, Abdulmajeed Alshammari, Guilherme Luiz Dotto

“…Moreover, the calculated molar adsorption energies, which varied between 19.04 and 22.37 kJ/mol, showed exothermic (ΔE > 0) and physical (ΔE < 40 kJ/mol) adsorption process involving hydrogen bonds, π-π interactions, electron donor-acceptor interactions, and dispersion forces. Finally, the tested adsorbent exhibited unimodal pore size and site energy distributions with peaks centered at pore radius ranging from 2.26 to 2.68 nm, and at adsorption energy ranging from 20.01 to 23.78 kJ/mol, respectively. …”
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Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells by Sukannika Tubtimsri, Tiraniti Chuenbarn, Suwisit Manmuan

“…Conclusion Quercetin is greatly cytotoxic in oral cancer cells, triggering cells undergoing apoptosis and ROS-mediated cell death, possessing S and G2/M cell cycle arrest properties, and exhibiting anti-metastatic activities. Finally, this discovery opens up a wide range of possibilities for developing an anti-oral cancer drug and further investigating its effectiveness in vivo and in clinical trials as an alternative cancer treatment.…”
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Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer by Zhang JN, Li LW, Cao MQ, Liu X, Yi ZL, Liu SS, Liu H

“…Furthermore, CDC45 expression was closely linked to immune infiltration levels, immune checkpoint inhibitors, and the therapeutic response to small molecule drugs. Finally, both in vitro and in vivo experiments confirmed the cancer-promoting effect of CDC45 in BC.Conclusion: The expression level of CDC45 is linked to the prognosis, immune infiltration, and drug sensitivity of BC. …”
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Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits by Jie Wu, Jiamin Zhai, Haofan Jia, Ifeanyi Solomon Ahamba, Xianggui Dong, Zhanjun Ren

“…Skin samples collected at 4, 5 and 5.5 months, representing the morphological features of the anagen, catagen and telogen stage separately, were finally selected for whole-transcriptome analysis. 25,736 mRNA, 8280 lncRNA, 24,885 circRNA and 1138 miRNA transcripts were identified. 6027 differently expressed mRNAs (DEGs), 2381 differently expressed lncRNAs (DELs), 438 differently expressed circRNAs (DECs) and 167 differently expressed miRNAs (DEMs) were detected in the anagen vs. catagen (AvC) comparison. 4092 DEGs, 1540 DELs, 356 DECs and 141 DEMs were detected in the anagen vs. telogen (AvT) comparison. 2290 DEGs, 779 DELs, 249 DECs and 92 DEMs were detected in the catagen vs. telogen (CvT) comparison. …”
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