Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics by Han Yang, Xuanyu Wu, Xiang Xiao, Jiajing Chen, Xiaomin Yu, Wen Zhao, Fei Wang

“…Subsequently, SNP-nearest genes combined with the transcriptomics data of IPF were subjected to multiple bioinformatics analyses such as TIMER, WGCNA, functional enrichment analysis, protein-protein interaction analysis, and ROC to identify IPF biomarkers. Finally, the single-cell RNA sequencing (scRNA-seq) data was used to validate our findings by single-cell analysis.ResultsThe MR study identified 27 immune cell phenotypes causally associated with IPF, of which 20 were associated with a decreased risk of developing IPF and 7 were associated with an increased risk. …”
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Study on a cable jumper method for offshore floating photovoltaic systems with multiple floating bodies by Xiangyu KONG, Yangping SHAO, Qiang FU, Lujie YU, Hongbin LIU

“…In the second stage, the maximum fatigue life in the feasible solution region is determined as the optimal solution. Finally, a cable jumper model was built using Orcaflex software to verify the proposed scheme, and the effectiveness of the proposed method was demonstrated through an example analysis. …”
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Bacillus subtilis HGCC-1 improves growth performance and liver health via regulating gut microbiota in golden pompano by Ming Li, Hui Liang, Jian Zhang, Jie Chen, Shichang Xu, Wenhao Zhou, Qianwen Ding, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran, Zhigang Zhou

“…Furthermore, Bacillus subtilis HGCC-1 enhanced intestinal lipid absorption, promoted hepatic utilization of dietary fat by improving hepatic lipid uptake/transport and fatty acid β-oxidation to provide energy, and reduced hepatic TG level (P < 0.05), which may be the potential mechanism of Bacillus subtilis HGCC-1-mediated growth promotion. Finally, Bacillus subtilis HGCC-1 significantly altered the structure and function of gut microbiota (P < 0.05), leading to enrichment of beneficial taxa such as Bacillus (P < 0.0001) and increased of the ratio of “Functional Group 2/Functional Group 1” (P = 0.00092). …”
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Creatine monohydrate administration delayed muscle glycolysis of antemortem-stressed broilers by enhancing muscle energy status, increasing antioxidant capacity and regulating musc... by Ning Liu, Qingzhen Zhong, Zewei Sun, Bolin Zhang

“…Preslaughter stress induced a negative energy balance of broilers, resulted in an accelerated glycolysis and finally led to an inferior meat quality. The present study aimed to investigate the effects of creatine monohydrate (CMH) supplementation on muscle energy storage, antioxidant capacity, the glycolysis of postmortem muscle and the metabolite profiles in muscle of broilers subjected to preslaughter transport. …”
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The effect of ethanol extract of Aloysia triphylla on anesthesia and improve the physiological parameters of rainbow trout (Oncorhynchus mykiss) after transfer by Ali Hajibeglou, Masoumeh Machanlou, Mohammad Mazandarani, Mohammad Sudagar

“…Conclusions: In general, these results indicated that A. triphylla may have sedative and anesthetic effects on rainbow trout. Finally, it can be used to reduce the negative effects of stress caused by fish manipulation and transportation. …”
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Political Interference and Social Service Delivery in Kanaba Sub-County Kisoro District. by Tumushime, Bosco

“…The study concluded that political interference in social service delivery could be solved by the intervening strategies in place to reduce the rate of interference with social service delivery by political leaders like Leader's commitment, Good governance, Intuitional arrangement, Distribution of costs and benefits, and Secularism in a multi-religious society. The study finally recommended that; Politicians with experience should better understand how to work with the people while delivering social services and affect the change they desire, politicians' delegation decisions should be the key margin by which politicians improve the productivity of the social service delivery, Citizens should influence the people who votes to delegate to the most productive public organizations by tying politicians' electoral incentives to the effective delivery of social services and there should be monitoring and evaluation unit aim at measuring efficiency and effectiveness of the delivery of social services by the political leaders.…”
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Investigating the Suitability of Partial Replacement of Basalt with Scoria as a Base Course Material for a Flexible Pavement. by Wambei, Allan

“…The optimum percentage blend was obtained as 10% scoria-90% basalt. Finally, based on this study it was recommended to use scoria gravel as an alternative base course construction material.…”
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Design and Fabrication of a Motorized Honey Extractor. by Hasahya, Caxton Joel

“…The process is repeated for other unextracted frames. Chapter four finalizes the project design and Chapter Five avails the discussion of the results and analysis of the results of the designed honey-extracting machine taking main consideration the machine components' sized. …”
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Research on entity recognition and alignment of APT attack based on Bert and BiLSTM-CRF by Xiuzhang YANG, Guojun PENG, Zichuan LI, Yangqi LYU, Side LIU, Chenguang LI

“…The proposed method combines the corpus titles and keywords to carry out entity fusion of APT organization names. Finally, the infobox of common APT organizations in this dataset is constructed, and the structured knowledge of each APT organization is formed. …”
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The Impacts of Breakthrough Drug Classes on Total Healthcare Expenditures by Zeynal Karaca, Steven N. Wiggins

“…Third, we separately estimated the effects of each of these groups of drugs on drug and non-drug expenditures. Finally, we measured the cost impact of drug use in a more general way than in the existing literature. …”
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Atmospheric Black Carbon Evaluation in Two Sites of San Luis Potosí City During the Years 2018–2020 by Valter Barrera, Cristian Guerrero, Guadalupe Galindo, Dara Salcedo, Andrés Ruiz, Carlos Contreras

“…At the North, BC mass annual average concentration was (1.11 µg m⁻³), divided into seasonal stations, the cold season was the highest with (1.44 µg m⁻³), followed by the dry season (1.23 µg m⁻³), rainy season (0.94 µg m⁻³) and finally warm dry season (0.83 µg m⁻³). …”
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Comprehensive Analysis of PDLIM3 Expression Profile, Prognostic Value, and Correlations with Immune Infiltrates in Gastric Cancer by Xinpeng Hu, Minfeng Chen, Qiang Ruan, Changzheng Shi, Jinghua Pan, Liangping Luo

“…PDLIM3 expression had significant positive correlations with a variety of immune marker subsets. Finally, correlations were found between PDLIM3 and crucial markers of signaling pathways involving PI3K/Akt and p38 MAPK. …”
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A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum by Alonso Cruz-Cruz, Megan E. Schreeg, John S. Gunn

“…All cecum phenotypes were significantly diminished in mice fed a normal diet (Nd). Finally, we examined the capability of S. Typhi to colonize the cecum and showed S. …”
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Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease by Chengji Jin, Jia Li, Qiaoyu Li, Lipeng Zhang, Shaomao Zheng, Qiong Feng, Yongjie Li, Yu Zheng, Qiuli Nie, Jin Liang, Jing Wang, Jing Wang

“…CTSG showed a primarily positive association with follicular helper T, and SPP1 was most strongly associated with macrophages. Finally, our single-cell sequencing data revealed that in patients with IPF, CXCL12 was highly expressed in the endothelial cell subset (ECs), while SPP1 exhibited high expression in multiple cellular populations. …”
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ON THE SPECIFICS OF TEACHING, SCHOOLS AND INTELLECTUAL CENTERS OF PALESTINE OF LATE ANTIQUITY by Zhanna M. Sukhova, Irina Yu. Vashcheva

“…In the sharp intellectual disputes about Christianity, «soft power» of persuasion could be applied, which involved using terms and authority figures familiar to the opponent. Finally, the ability to engage in intellectual debates required the presence of libraries: one of the most famous and largest libraries in Palestine – the Caesarean library, which appeared at a historically important and complex moment, i.e. during the era of persecutions.…”
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Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma by Jiahui Lin, Jiahui Lin, Aiting Jiang, Juntao Zheng, Jingjing Wu, Hao Li, Hao Li, Shirong Cai, Yulong He, Xiao Chen, Guoping Zhong, Ke-Jing Tang, Ke-Jing Tang, Xinhua Zhang, Yanzhe Xia

“…BackgroundRipretinib, a broad-spectrum tyrosine kinase inhibitor, has been approved for the treatment of advanced gastrointestinal stromal tumors in adult patients. …”
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cigFacies: a massive-scale benchmark dataset of seismic facies and its application by H. Gao, X. Wu, X. Sun, M. Hou, M. Hou, H. Gao, G. Wang, H. Sheng

“…Guided by the graph, we then implement the three strategies of field seismic data curation, knowledge-guided synthesization, and generative adversarial network (GAN)-based generation to construct a benchmark dataset of 8000 diverse samples for five common seismic facies. Finally, we use the benchmark dataset to train a network and then apply it to two 3-D seismic data for automatic seismic facies classification. …”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…The effects of immune cell markers on prognosis were analyzed via univariate Cox regression, least absolute shrinkage and selection operator (LASSO) and gene set variation analysis (GSVA) of bulk sequencing data from The Cancer Genome Atlas (TCGA)-HGSOC cohort. Finally, the effects of key markers on HGSOC cells were evaluated via Cell Counting Kit-8 (CCK-8), Transwell, colony formation, wound healing, immunofluorescence and in vivo tumor growth assays. …”
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Effects of dribbling restrictions in small-sided games on aerobic and anaerobic fitness in youth basketball players by Mingbang Li, Liang Tan, Hong Wu, Jianwei Wu

“…Aerobic capacity was assessed using the Yo-Yo Intermittent Recovery Test Level 1 (YYIRT), while the 30-second Wingate Test measured peak power output (PPO) and average power output (APO) at baseline and post-intervention. …”
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Effects of Fermented Pomegranate Peel Polyphenols on the Growth Performance, Immune Response, Hepatopancreatic Health, and Disease Resistance in White Shrimp (Litopenaeus vannamei) by Zhoulin Yu, Guangye Liu, Sijie Li, Yucong Hong, Shuyan Zhao, Meng Zhou, Xiaohong Tan

“…Additionally, increasing the addition level of FPPP resulted in a more compact hepatosomal arrangement of the shrimp’s hepatopancreas, a more visible star-shaped lumen structure, and a significantly higher number of B cells. Finally, the cumulative SR of shrimp in FPPP groups was significantly higher than that in FP0 group after 7 days of infection with Vibrio alginolyticus (p<0.05). …”
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