Picometre-level surface control of a closed-loop, adaptive X-ray mirror with integrated real-time interferometric feedback by Ioana-Theodora Nistea, Simon G. Alcock, Andrew Foster, Vivek Badami, Riccardo Signorato, Matteo Fusco

“…Aside from demonstrating the extreme sensitivity of the interferometer sensors, this study also highlights the voltage repeatability and stability of the programmable high-voltage power supply, the accuracy of the correction-calculation algorithms and the almost instantaneous response of the bimorph mirror to command voltage pulses. Finally, we demonstrate the robustness of the system by showing that the bimorph mirror's optical surface was not damaged by more than 1 million voltage cycles, including no occurrence of the `junction effect' or weakening of piezoelectric actuator strength. …”
Get full text

Development of a Conceptual Model to Understand Disease Burden in Patients With Systemic Lupus Erythematosus and Organ Damage by Lynne Broderick, Wen-Hung Chen, Roger A. Levy, April Mitchell Foster, Cindy Umanzor Figueroa, Kerry Gairy, Deven Chauhan

“…Findings from the KOL and patient interviews were used to finalize the conceptual model. **Results:** KOLs highlighted that SLE-associated OD carried a higher rate of mortality than SLE alone. …”
Get full text

Three-dimensional structure of entire hydrated murine hearts at histological resolution by Jasper Frohn, Frederik Böddeker, Marius Reichardt, Hendrik Bruns, Titus Czajka, Amara Khan, Ludovic Broche, Michael Krisch, Alberto Bravin, Frauke Alves, Jana Zschüntzsch, Tim Salditt

“…All datasets have been analyzed using semi-automated image segmentation of the ventricles, rotation into a common coordinate system, classification into different anatomical compartments, and finally the structure tensor approach. A 3d streamline representation of the cardiomyocyte orientation vector field is provided. …”
Get full text

Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy by Dingchao Li, Jingang Jian, Manhong Shi, Zihao Chen, Anguo Zhao, Xuedong Wei, Yuhua Huang, Yalan Chen, Jianquan Hou, Yuxin Lin

“…Then a knowledge-guided network strategy was applied to prioritize key targets of miR-221-3p in PCa progression based both on topological and functional characterization of genes in multi-omics miRNA-mRNA and protein-protein interaction networks. Finally, a key gene was computationally identified and experimentally validated using cell line and clinical samples through EdU assay, scratch assay, transwell assay, dual-luciferase reporter assay and the epithelial-to-mesenchymal transition (EMT)-related analysis. …”
Get full text

Impact of EML4‐ALK Variants and TP53 Status on the Efficacy of ALK Inhibitors in Patients With Non‐small Cell Lung Cancer by Zihua Zou, Lige Wu, Xuezhi Hao, Yan Li, Li Liang, Yangchun Gu, Jianming Ying, Junling Li, Puyuan Xing

“…Statistical analysis was employed to investigate the impact of different EML4‐ALK variants and TP53 status on the efficacy of first‐line ALK‐TKIs. Results Finally, 49 patients were enrolled in cohort 1 and 53 patients in cohort 2. …”
Get full text

PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD) by Stefania Angelicola, Francesca Giunchi, Francesca Ruzzi, Mariateresa Frascino, Mary Pitzalis, Laura Scalambra, Maria Sofia Semprini, Olga Maria Pittino, Chiara Cappello, Irene Siracusa, Ilaria Candida Chillico, Martina Di Noia, Cristian Turato, Silvia De Siervi, Francesco Lescai, Teresa Ciavattini, Giulia Lopatriello, Luca Bertoli, Hugo De Jonge, Luisa Iamele, Annalisa Altimari, Elisa Gruppioni, Andrea Ardizzoni, Marzia Rossato, Francesco Gelsomino, Pier-Luigi Lollini, Arianna Palladini

“…Further, the cytokine induced a partial activation of both type I and type II IFN-pathway mediators, together with a striking increase in NSCLC-B growth in 3D cell culture systems. Finally, low IFN-γ doses and PD-L1 modulation both promoted plastic changes in NSCLC-B, increasing CD44 expression and its ability to produce spheres. …”
Get full text

Hepatitis B virus hijacks MRE11-RAD50-NBS1 complex to form its minichromosome. by Kaitao Zhao, Jingjing Wang, Zichen Wang, Mengfei Wang, Chen Li, Zaichao Xu, Qiong Zhan, Fangteng Guo, Xiaoming Cheng, Yuchen Xia

“…Interestingly, Mirin, a MRN complex inhibitor which can inhibit the exonuclease activity of MRE11 and MRN-dependent activation of ATM, but not ATM kinase inhibitor KU55933, could decrease cccDNA level. …”
Get full text

Mathematical Modelling and Analysis of Transmission Dynamics of Lassa Fever by E. A. Bakare, E. B. Are, O. E. Abolarin, S. A. Osanyinlusi, Benitho Ngwu, Obiaderi N. Ubaka

“…It was established that, to eliminate Lassa fever disease, treatments with ribavirin must be provided early to reduce mortality and other preventive measures like an educational campaign, community hygiene, isolation of infected humans, and culling/destruction of rodents must be applied to also reduce the morbidity of the disease. Finally, the obtained results gave a primary framework for planning and designing cost-effective strategies for good interventions in eliminating Lassa fever.…”
Get full text

A Semianalytical Model for Analyzing the Infill Well-Caused Fracture Interference from Shale Gas Reservoirs by Sidong Fang, Yonghui Wu, Cheng Dai, Liqiang Ma, Hua Liu

“…The results also show that late time well interference will result in a more significant increase in production rate on the log-log plots for the severe depletion around the parent well. Finally, the proposed model is used to analyze the production data of a field case from Fuling shale in Southwestern China. …”
Get full text

Understanding how, for whom and under what circumstances telecare can support independence in community-dwelling older adults: a realist review by Lauren Fothergill, Niall Hayes, Yvonne Latham, Jenny Hamilton, Saiqa Ahmed, Carol Holland

“…Telecare that enables connections to existing or new social networks may reduce loneliness and social isolation for those who lack social resources. Finally (4), telecare must integrate into everyday life by fitting people’s existing context, skills, resources, and identity. …”
Get full text

Assessing the Adherence of ChatGPT Chatbots to Public Health Guidelines for Smoking Cessation: Content Analysis by Lorien C Abroms, Artin Yousefi, Christina N Wysota, Tien-Chin Wu, David A Broniatowski

“…The least common was information about considering the use of non–nicotine replacement therapy prescription drugs (14.1%). Finally, some types of misinformation were present in 22% of responses. …”
Get full text

Ice-proximal sea ice reconstruction in the Powell Basin, Antarctica, since the Last Interglacial by W. W. Khoo, J. Müller, J. Müller, J. Müller, O. Esper, W. Xiao, C. Stepanek, P. Gierz, G. Lohmann, G. Lohmann, G. Lohmann, W. Geibert, J. Hefter, G. Mollenhauer, G. Mollenhauer, G. Mollenhauer

“…A short-term sea ice readvance also occurred towards the end of each deglaciation. Finally, despite similar findings between the proxy and model data, notable differences persist between both interglacials – emphasizing the necessity for different Antarctic ice sheet configurations to be employed and more robust paleoclimate data to enhance climate model performance close to the Antarctic continental margin.…”
Get full text

Mesenchymal Stem Cell-Derived Neuron-Like Cell Transplantation Combined with Electroacupuncture Improves Synaptic Plasticity in Rats with Intracerebral Hemorrhage via mTOR/p70S6K S... by Guoqiang Yang, Jiayi Zhu, Guwen Zhan, Guangbi Fan, Li Deng, Huajun Tang, Xiaoqian Jiang, Bo Chen, Chaoxian Yang

“…We also measured the levels of the phosphorylated mammalian target of rapamycin (mTOR) and 70 kDa ribosomal protein S6 kinase (p70S6K) proteins, as well as the expression of synapse-related proteins. …”
Get full text

Nomogram for prognosis prediction in metastatic pancreatic cancer patients undergoing intra-arterial infusion chemotherapy: incorporating immune-inflammation scores and coagulation... by Yifan Yang, Shaoqi Zong, Yongqiang Hua

“…Additionally, the predictive performance of the nomogram was assessed by the concordance index (C-index), the area under the ROC curve (AUC), and calibration curves. Finally, patients were stratified into risk groups based on the total score of the nomogram. …”
Get full text

Causal Inference for Hypertension Prediction With Wearable E lectrocardiogram and P hotoplethysmogram Signa... by Ke Gon g, Yifan Chen, Xinyue Song, Zhizhong Fu, Xiaorong Ding

“…We further fused the 6 causal graphs into 1 causal graph and identified features that were causally related to hypertension from the causal graph . Finally, we used these features to detect hypertension via machine learning algorithms. …”
Get full text

The prognostic value of systemic immune-inflammation index in patients with unresectable hepatocellular carcinoma treated with immune-based therapy by Tian He, Bin Xu, Lu-Na Wang, Zi-Yi Wang, Huan-Chen Shi, Cheng-Jie Zhong, Xiao-Dong Zhu, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Bo Hu, Cheng Huang

“…A training cohort of 93 patients received atezolizumab plus bevacizumab (T + A), while a validation cohort of 175 patients underwent treatment with tyrosine kinase inhibitors (TKIs) combined with anti-PD-(L)1 therapy. …”
Get full text

FREQÜÊNCIA CARDÍACA E PERCEPÇÃO DE ESFORÇO NA CAMINHADA AQUÁTICA E NA ESTEIRA EM MULHERES SEDENTÁRIAS E COM DIFERENTES PERCENTUAIS DE GORDURA by Jaqueline Maria Andriolo Lazzari, Flávia Meyer

“…A TPE (Escala de Borg) foi registrada nos 10 segundos finais de cada minuto. A média e o dp da velocidade da CA foi de 2,68 ± 0,23 km xh-1. …”
Get full text

A recurrence model for non-puerperal mastitis patients based on machine learning. by Gaosha Li, Qian Yu, Feng Dong, Zhaoxia Wu, Xijing Fan, Lingling Zhang, Ying Yu

“…A combination of four machine learning algorithms (XGBoost、Logistic Regression、Random Forest、AdaBoost) was employed to predict NPM recurrence, and the model with the highest Area Under the Curve (AUC) in the test set was selected as the best model. The finally selected model was interpreted and evaluated using Receiver Operating Characteristic (ROC) curves, calibration curves, Decision curve analysis (DCA), and Shapley Additive Explanations (SHAP) plots.…”
Get full text

Experimental Study on Improving the Compressive Strength of UHPC Turntable by Jiawei Wang, Quansheng Sun

“…The compressive strength and mechanical characteristics of the UHPC structure meet the requirements of the turntable, and more importantly, the manufacturing process (on-site pouring) of the aforementioned UHPC turntable structures is relatively simple. Finally, the manufacturing cost of the turntables is expected to be reduced by more than 50% compared to those of traditional turntables.…”
Get full text

The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathw... by Ning Chai, Tanja Stachon, Sabrina Häcker, Tim Berger, Zhen Li, Maryam Amini, Shweta Suiwal, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry

“…Additionally, the involvement of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways which are downstream of the Toll-like receptor 4 (TLR4) pathway were examined.…”
Get full text