Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing by Anjana Hevaganinge, Eva Lowenstein, Anna Filatova, Mihir Modak, Nandi Thales Mogo, Bryana Rowley, Jenny Yarmowsky, Joshua Ehizibolo, Ravidu Hevaganinge, Amy Musser, Abbey Kim, Anthony Neri, Jessica Conway, Yiding Yuan, Maurizio Cattaneo, Sui Seng Tee, Yang Tao

“…The model achieves reasonable quantification performance for large fructose level (100–1000 mg/dL) quantification (r2 = 0.92, MAE = 25.1 mg/dL) and small fructose level (< 60 mg/dL) concentrations (r2 = 0.85, MAE = 4.97 mg/dL) in complex media like Fetal Bovine Serum (FBS). Finally, the model provides sparse interpretable weight matrices that hint at the underlying solution changes that correlate to each cell parameter prediction.…”
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Human development II: We Need an Integrated Theory for Matter, Life and Consciousness to Understand Life and Healing by Sören Ventegodt, Tyge Dahl Hermansen, Maj Lyck Nielsen, Birgitte Clausen, Joav Merrick

“…We suggest that life utilizes an unseen fine structure of the physical energy of the universe at a subparticular or quantum level to give information-directed self-organization; we give a first sketch of a possible fractal structure of the energy able to both contain and communicate biological information and carry individual and collective consciousness. Finally, thorough our analysis, we put up a model for adult human metamorphosis.…”
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AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice by Zhuan Zou, Songmu Pan, Changzheng Sun, Jiyong Wei, Yi Xu, Kaizhen Xiao, Jinmin Zhao, Ronghe Gu

“…The specific action modes and binding sites of AM1241 with NEMO/IκB kinases (IKKs) in the NF-κB pathway and Keap1 protein in the Nrf2 pathway were predicted via molecular docking and molecular dynamics simulation, and the NF-κB and Nrf2 pathways were detected using western blot and immunofluorescence. …”
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Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells. by Raven M Osborn, Justin Leach, Michelle Zanche, John M Ashton, ChinYi Chu, Juilee Thakar, Stephen Dewhurst, Sonia Rosenberger, Martin Pavelka, Gloria S Pryhuber, Thomas J Mariani, Christopher S Anderson

“…We then tested the dissociation and methanol-acetone inactivation method on primary human lung epithelial cells that had been differentiated on an air-liquid interface. Finally, we performed scRNAseq quality control analysis on the resulting cell populations to evaluate the effects of our virus inactivation and sample preparation protocol on the quality of the cDNA produced. …”
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The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3 by Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai, Xiaodan Jiang

“…The production and secretion of the cytokines IL-6, IL-12, TNF-α, and IL-10 in DCs induced by GSCs were determined by enzyme-linked immunosorbent assay. Finally, the cytotoxic functions of T cells stimulated by GSC-DC fusion cells transfected with a miR-106a/20b mimic in vitro and the antitumour activity in vivo were detected. …”
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Prophylactic norepinephrine infusion to treat hypotension after spinal anaesthesia during caesarean section: a meta-analysis by Chunli Zhang, Jie Qiu, Yuyuan Huang, Renkang Tan

“…The methods recommended by the Cochrane Handbook, Begge’s and Egger’s tests were used for risk of bias evaluation of the included literature.Results Nine studies were finally included in this study. The results showed that prophylactic administration of norepinephrine was superior to the control group in four aspects of treating hypotension after spinal anaesthesia in caesarean delivery: the incidence of hypotension was reduced [RR = 0.34, 95%CI (0.27–0.43), P < 0.01]; the incidence of severe hypotension was reduced [RR = 0.32, 95%CI (0.21–0.51), P < 0.01]; and maternal blood pressure was more stable with MDPE [MD = –5.00, 95%CI (–7.80–−2.21), P = 0.06] and MDAPE [MD = 4.11, 95%CI (1.38–6.85), P < 0.05], the incidence of nausea and vomiting was reduced [RR = 0.52, 95%CI (0.35–0.77), P < 0.01]. …”
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Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome by Jingyi Xu, Shucheng Si, Yijun Han, Lin Zeng, Jinxia Zhao

“…A total of 4 inflammatory cytokines and 7 circulating proteins exhibited potential causal relationships with SS despite no significant result achieved after FDR correction. Finally, results of mediation analysis indicated that CD40L receptor levels had significant mediating effects (β = 0.0314, 95% CI: 0.0004–0.0624, P = 0.0471) at a mediation proportion of 28% (95% CI: 0.364%-55.6%) in causal relationship between CD27 on IgD + CD24 + B cell and SS. …”
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In silico development of a multi-epitope-based vaccine against Burkholderia cepacia complex using reverse vaccinology by Donya Ghorbani, Donya Ghorbani, Masoumeh Beig, Masoumeh Beig, Narjes Noori Goodarzi, Mohammad Sholeh, Mohammad Sholeh, Behzad Shahbazi, Behzad Shahbazi, Yaser Moghaddam, Farzad Badmasti

“…Molecular docking analysis was performed to assess the interaction of the selected proteins. Finally, molecular dynamics (MD) simulations were conducted using GROMACS 2019 to evaluate the feasibility and dynamics of the interactions between the chimeric MEV and Toll-like receptor complexes, TLR2 and TLR4.ResultsOf 16,723 proteins identified in B. multivorans and B. cenocepacia strains, nine proteins (six OMPs and three extracellular) were selected as ideal candidates based on established criteria. …”
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The Antiobesity Effect of GLP-1 Receptor Agonists Alone or in Combination with Metformin in Overweight /Obese Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Ana... by Xiaorui Lyu, Taibiao Lyu, Xue Wang, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong

“…A total of eight eligible RCTs were finally enrolled in our meta-analysis from the 587 retrieved literature. …”
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The Effect of Lithium on Inflammation-Associated Genes in Lipopolysaccharide-Activated Raw 264.7 Macrophages by Raymond T. Makola, Vusi G. Mbazima, Matlou P. Mokgotho, Vincent S. Gallicchio, Thabe M. Matsebatlela

“…Lithium has been shown to lower the production of the chemokine RANTES; furthermore, this inhibitory action of lithium has been suggested to be independent of glycogen synthase kinase-3 β (GSK3β) activity. It is shown here that lithium modulates the expression of several inflammatory genes including IκB-α, TRAF3, Tollip, and NF-κB1/p50 which are regulators of the NF-κB pathway. …”
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Global trends and research frontiers on machine learning in sustainable animal production in times of climate change: Bibliometric analysis aimed at insights and orientations for t... by Robson Mateus Freitas Silveira, Concepta Mcmanus, Iran José Oliveira da Siva

“…The present study provides new insights that were not previously fully captured or assessed in other reviews. Finally, improving livestock production sustainability is particularly important, because a significant part of the projected increases in the global food demand is expected to come from livestock, and artificial intelligence will certainly help producers in decision-making processes, mainly in times of climate change.…”
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Deep learning based approaches for intelligent industrial machinery health management and fault diagnosis in resource-constrained environments by Ali Saeed, Muazzam A. Khan, Usman Akram, Waeal J. Obidallah, Soyiba Jawed, Awais Ahmad

“…Subsequently, the survey covers techniques related to RUL prediction and edge-cloud architectures for resource-constrained environments. Finally, this survey consolidates the outlook on relevant issues in IMHM, explores potential solutions, and offers practical recommendations for further consideration.…”
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Advancements for the Future: A National Survey of Fastpitch Softball Coaches’ Perspectives on Injury Prevention Programming by Jaime Nurrenbern, Courtney Klueppel, Jeff Tilly, Kyle Matsel

“…The secondary purpose was to identify barriers to the implementation of injury prevention programs. Finally, this survey explored the coaches' knowledge of injury risk factors and their views on design and usage of preventative programs…”
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Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes by Mengmeng Sang, Jia Ge, Juan Ge, Juan Ge, Gu Tang, Qiwen Wang, Jiarun Wu, Liming Mao, Liming Mao, Xiaoling Ding, Xiaorong Zhou

“…The increased expression of NT5E and its prognostic significance were confirmed through multiplex immunohistochemistry in pancreatic adenocarcinoma. Finally, dasatinib and tozasertib were identified as drug candidates capable of converting cold pancreatic adenocarcinoma tumors into hot tumors.ConclusionIn this study, we developed a framework for discerning clinically significant immune subtypes across various cancer types, further identifying several potential targets for converting cold tumors into hot tumors to enhance anticancer treatment efficacy.…”
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The prevalence of sexual dysfunction and erectile dysfunction in men with multiple sclerosis: A systematic review and meta-analysis by V. Shaygannejad, O. Mirmosayyeb, S. Vaheb, N. Nehzat, M. Ghajarzadeh

“…Results: We found 3163 studies by primary search, 2246 were included after deletion of duplicates. Finally, 29 studies were included for meta-analysis. …”
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Reading from the Guts: of Text and Disgust by Solveig Dunkel

“…How can a text, which relies on words on a page and not images, provoke such violent reactions? And finally, can a text be “digested”? Can there be any “pleasure of the text,” to use Roland Barthes’ expression, in the description of something “so, so unpleasant”? …”
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Musiktheorie und ›Satzlehre‹ im Kontext der Diskussion um Artistic Research by Robert Christoph Bauer

“…Furthermore, as an example of my own artistic research, I present an analytical recomposition that explores the tonal implications of an ‘atonal’ song by Alban Berg and is intended not only to open up new perspectives on the original work, but also to include my own subjectively justified artistic choices. Finally, I discuss potentials of a ‘new music’ that artistically addresses the exploration of theory and traditional techniques of composition.…”
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Correlation Between Vitamin D3 Levels, Autoantibodies, and Antibody-Related Diseases in Patients with Hashimoto's Thyroiditis by Ali Saad Kadhim, Abdullah Salim Al-Karawi

“…Likewise, a strong direct correlation (r=+0.98) was observed in the increased concentrations of both anti-TSH and anti-VitD3. Finally, IgG4-RD had a significantly positive association with the concentrations of 1,25 VitD3-XP, and TSH in patients with a highly significant difference (p&lt;0.001). …”
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Blockchain Technology Applications in Healthcare Supply Chains&#x2014;A Review by Sarthak Dhingra, Rakesh Raut, Koteswararao Naik, Kamalakanta Muduli

“…In the first stage, articles were identified through literature search and were subjected to keyword selection, database search and screening process. Finally, 124 papers were categorized through bibliographic coupling. …”
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Potential profiling of social alienation in older female patients with stress urinary incontinence by Yakun Li, Hongxia Wang

“…The General Information Questionnaire, the Family Care Index Scale, the Toronto Alexithymia Scale, and the General Alienation Scale were used to conduct the survey.ResultsA total of 365 respondents were included, and three potential categories of social alienation were finally identified, namely, low social alienation (29.0%), medium social alienation-self alienation (49.4%), and high social alienation (21.6%). …”
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