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  1. 28561

    An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells. by Heidi H Cao, Sabrina Molina, Susan Sumner, Blake R Rushing

    Published 2025-01-01
    “…Analysis of A549 cells found a greater emphasis of perturbations on various amino acids along with lipid synthesis-related pathways, and catecholamine biosynthesis. Finally, analysis of treated MDA-MB-231 cells found spermidine and spermine biosynthesis, carnitine synthesis, plasma membrane-related pathways (phosphatidylcholine synthesis and alpha linolenic acid and linoleic acid metabolism), and various amino acid metabolism pathways to be most affected. …”
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  2. 28562

    Exploring the genetic correlation and causal relationships between breast cancer and meningioma using bidirectional Mendelian randomization by Lu Ding, Bo Chen, Zhou Zhou, Zhaojun Mei, Kan Cao, Xinyu Lu, Wei Chen

    Published 2025-02-01
    “…Next, linkage disequilibrium score regression (LDSC) was used to assess the genetic correlation between BC and meningioma. Finally, we applied the Functional Mapping and Annotation (FUMA) platform to conduct an in-depth analysis of the GWAS data. …”
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  3. 28563

    An eCIRP inhibitor attenuates fibrosis and ferroptosis in ischemia and reperfusion induced chronic kidney disease by Fangming Zhang, Zhijian Hu, Asha Jacob, Max Brenner, Ping Wang

    Published 2025-01-01
    “…Treatment with C23 also attenuated BUN and creatinine. Finally, GFR was significantly decreased in RIR mice with left nephrectomy and C23 treatment partially prevented their decrease. …”
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  4. 28564

    Insulin Resistance and Chronic Kidney Disease in Patients with Type 1 Diabetes Mellitus by Mihaela Vladu, Diana Clenciu, Ion Cristian Efrem, Mircea-Cătalin Forțofoiu, Anca Amzolini, Simona Tudorică Micu, Maria Moţa, Maria Forțofoiu

    Published 2017-01-01
    “…The study design was an epidemiological, transversal, noninterventional type. Finally, the study group included 200 subjects with type 1 DM. …”
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  5. 28565

    Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis by Arun Chockalingam, Menelaos Konstantinidis, Brandon Koo, John Timothy Moon, Andrew Tran, Sahar Nourouzpour, Emily Lawson, Kathleen Fox, Peiman Habibollahi, Bruno Odisio, Mohammed Loya, Ali Bassir, Nariman Nezami

    Published 2022-06-01
    “…For each outcome, given enough studies, we will conduct a network meta-analysis. Finally, we will use the Confidence in Network Meta-Analysis tool to assess quality of the evidence for each of the primary outcomes.Ethics and dissemination We aim to share our findings through high-impact peer review. …”
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  6. 28566
  7. 28567

    The Epidemiological Characteristics of Coronavirus Disease (COVID-19) in Halabja Province/Kurdistan –Iraq by Osama Hamid Shareef, Othman Abdulrahman Mohammed, Dashty Aziz Ghafor, Ari Shareef Ali, Hardi Rafat Baqi, Ali Aziz Ali, Aryan Mahmood Faraj, Syamand Ahmed Qadir, Ali Muhi Aldeen Omar Aljabary

    Published 2022-01-01
    “…Besides, the confirmed cases for other age groups for both sexes were (50-59) years old was 397, (60-69) years old was 205, (70-79) was 77. Finally, the data showed that, the common confirmed cases were among groups 20-59 years old and the rare cases were under 9 and over 80 years. …”
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  8. 28568

    A phase II trial of anlotinib plus EGFR-TKIs in advanced non-small cell lung cancer with gradual, oligo, or potential progression after EGFR-TKIs treatment (CTONG-1803/ALTER-L001) by Hua-Jun Chen, Hai-Yan Tu, Yanping Hu, Yun Fan, Guowu Wu, Shundong Cang, Yi Yang, Nong Yang, Rui Ma, Gaowa Jin, Ximing Xu, Anwen Liu, Shubin Tang, Ying Cheng, Yan Yu, Chong-Rui Xu, Qing Zhou, Yi-Long Wu

    Published 2025-01-01
    “…Abstract Background The study is to evaluate the efficacy and safety of combined anlotinib and EGFR-tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC) who had gradual, oligo, or potential progression after previous EGFR-TKIs treatment. …”
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  9. 28569

    Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content by Baohua Luo, Qingling An, Jingyu Lei, Dengxu Tan, Xiaoqiu Liu, Hui Li, Yong Zhao, Jing Qin, Caiqin Zhang, Yongbin Zhang, Changhong Shi

    Published 2025-12-01
    “…Furthermore, metabonomics showed that the combination therapy significantly increased the abundance of the metabolite prostaglandin D2 (PGD2), which was most likely related to the increased abundance of Desulfovibrio fairfieldensis. Finally, we confirmed that PGD2 amplified anti-tumor effect of α-PD-1 by activating prostaglandin D receptor 1 (DP1) to promote CD8 infiltration in double humanized PC mice and subcutaneously transplanted KPC mice. …”
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  10. 28570

    Assessing the Impact of Climate Change on the Landscape Stability in the Mediterranean World Heritage Site Based on Multi-Sourced Remote Sensing Data: A Case Study of the Causses a... by Mingzhuo Zhu, Daoye Zhu, Min Huang, Daohong Gong, Shun Li, Yu Xia, Hui Lin, Orhan Altan

    Published 2025-01-01
    “…The landscape stability model was developed utilizing land cover information and landscape indicators to explore the landscape stability and its distribution features within the study area. Finally, we adopted the Geographical Detector to quantify the extent to which climatic factors influence the landscape stability’s spatial distribution across different periods. …”
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  11. 28571

    Synthesis and Characterization of Green Zinc Oxide Nanoparticles with Antiproliferative Effects through Apoptosis Induction and MicroRNA Modulation in Breast Cancer Cells by Amir Hossein Aalami, Mohammad Mesgari, Amirhossein Sahebkar

    Published 2020-01-01
    “…These NPs had a significant effect in reducing the expression of microRNAs in breast cancer cells. Finally, ZnO-NPs exerted antioxidant and antimicrobial activities.…”
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  12. 28572

    Nanoscale Pore Structure Characterization and Permeability of Mudrocks and Fine-Grained Sandstones in Coal Reservoirs by Scanning Electron Microscopy, Mercury Intrusion Porosimetry... by Na Zhang, Fangfang Zhao, Pingye Guo, Jiabin Li, Weili Gong, Zhibiao Guo, Xiaoming Sun

    Published 2018-01-01
    “…Moreover, the PSD curves of NMR quantitatively converted from the NMR T2 spectra by T2Pc and weighted arithmetic mean (WAM) methods are in good agreement with the PSD curves of MIP. Finally, the applicability of three classic permeability estimation models based on MIP and NMR data to the investigated rock samples was evaluated.…”
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  13. 28573

    Examining Family Influence on the Academic Performance of Pupils in Selected Primary Schools in Hamurwa Sub-County, Rubanda District. by Kiconco, Kate

    Published 2023
    “…Implying that parental support was very vital in improving pupils learning outcomes. Study findings finally recommended that the Ministry of education and Sports should provide both formal and informal education to parents to make them aware of education needs of their children. …”
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  14. 28574

    Adoption of Electronic Records Management System in Managing Patients Records at Kabale Regional Referral Hospital. by Musiimenta, Lucky

    Published 2024
    “…Participants gave the challenges as low service quality due to lack of qualified staff, followed by inadequate knowledge, Lack of security and privacy, technological changes, unstable power supply, additional operating costs, computer viruses, and lastly information hacking and misuse Possible ways of improving electronic records in Kabale Regional Referral Hospital were installation of anti virus soft wares which was ranked highly by the Participants followed by regular change of passwords, using only trained personnel, Restrictions on access to records, have stable power supply, Records be maintained in its Cycle, have a backup system and more workshops be provided to all records keepers at Kabale RRH for proper maintenance of records. then finally the study recommended that there is need for the hospital to increase its training programs or workshops in electronic records keeping to the record managers, recruit trained personnel and the records and information keeping department should keep viruses monitoring soft ware's updated…”
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  15. 28575

    Factors associated with knowledge on the spread of HIV/AIDS among Secondary School Students of Groupe Scolaire De Rugando in Kigali City, Rwanda. by Nwankwo, Chinenye Mercy, Uwizeye, Denyse Sibomana

    Published 2024
    “…This study recommends the need to design interventions that aim to raise awareness of the negative consequences of risky sexual behaviors; increase the availability and accessibility of condoms; fight against the entry of drugs into the country as well as their circulation and accessibility to the youth and finally, guidance and counseling services should be introduced in schools.…”
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    Article
  16. 28576

    Design and Simulation of a Cutting Mechanism for a Millet Harvesting Machine. by Twebazibwe, Edson

    Published 2024
    “…Chapter three talks about the methodology used to come out with a designed machine including customers’ requirements, the operating principle of the machine, and the layout of the machine in solid works. Chapter four finalizes the project design, and chapter five discusses and analyzes the results of the designed millet cutter, taking into account the size of the machine components. …”
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  17. 28577

    Career Guidance and Academic Performance in Secondary Schools in Kisoro District; A case Study of Namirembe and Nyanamo Comprehensive Secondary Schools in Bukimbiri Sub-County. by Robert, Mwesigwa

    Published 2020
    “…To gather primary data for the study during the field, the researcher used, questionnaire, interview observation guides and focused group discussion guide and the documentary review for secondary data respectively. Data was finally analysed using Microsoft Excel later presented in tables, pie-charts, and graphs.The study findings revealed that the majority of respondents (99%) wereaware of the various career guidance programmes initiated in the study area. …”
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    Thesis
  18. 28578

    Factors associated with knowledge on the spread of HIV/AIDS among Secondary School Students of Groupe Scolaire De Rugando in Kigali City, Rwanda by Mercy Nwankwo, Chinenye, Denyse Sibomana, Uwizeye

    Published 2022
    “…This study recommends the need to design interventions that aims to raise awareness on the negative consequences from risky sexual behaviors; increase availability and accessibility of condoms; fight against the entry of drugs in the country as well as their circulation and accessibility to the youth and finally, guidance and counseling services should be introduced in schools.…”
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    Article
  19. 28579

    Influence of Omega-3 and Green Tea Extract on Alcohol-Induced Liver Injury in Rats by Ridha Hassan Hussein, Zana Hassan Ibrahim

    Published 2018-07-01
    “…Biochemical parameters including: lipid profiles: (total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C), serum malondialdehyde (MDA), liver function tests (LFT): (Serum albumin (ALB), serum total protein (TP), total serum bilirubin (TSB), serum alkaline phosphatase (ALP), serum alanine aminotransferase (ALT), and serum aspartate aminotransferase (AST) and finally hepatic histological changes were also investigated. …”
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  20. 28580

    A Hybrid Model for Soybean Yield Prediction Integrating Convolutional Neural Networks, Recurrent Neural Networks, and Graph Convolutional Networks by Vikram S. Ingole, Ujwala A. Kshirsagar, Vikash Singh, Manish Varun Yadav, Bipin Krishna, Roshan Kumar

    Published 2024-12-01
    “…The attention mechanism enables more effective spatial feature encoding by focusing on critical image regions, while the HGNN captures interaction patterns that are complex between diverse data types. Finally, VAEs can generate robust feature representation. …”
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