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28501
Video corporativo. Elemento de comunicación e imagen empresarial del siglo XXI
Published 2022-08-01“…Como consecuencia del uso de audiovisuales, la imagen identidad y la cultura corporativa encuentran nuevos escaparates en los que tanto el talento humano como los y las consumidoras finales logran comprender la filosofía corporativa. …”
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28502
Large Scale Experiments Representing a Containment Natural Circulation Loop during an Accident Scenario
Published 2018-01-01“…After the relaxation phase 2, helium (representing hydrogen) was injected in the same vessel (phase 3). Finally in phase 4 no active interventions were done until the end of the test. …”
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28503
Computational analysis of spliced leader trans-splicing in the regenerative flatworm <i>Macrostomum lignano</i> reveals its prevalence in conserved and stem cell related genes
Published 2021-03-01“…We annotated and characterized the sequence of SL RNA and characterized conserved cis- and SL transsplicing motifs. Finally, we found that a majority of SL trans-spliced genes are evolutionarily conserved and signif icantly over-represented in neoblast-specific genes. …”
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28504
Accidental findings of maxillary sinuses in dental patients on CBCT images. A retrospective study
Published 2023-12-01“…The findings of the present study recommend a thorough interpretation of the whole volume CBCT scans, by an oral radiologist, to ensure a proper diagnosis as it might have an impact on the patient’s medical status and advice the referred practitioner about the findings which may affect the treatment plan accord[1]ingly. Finally, referral of the patient to a spe[1]cialist if necessary. …”
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28505
Optimization of land use structure integrating ecosystem service function and economic development—A case study in Dongting Lake Ecological and Economic Zone, China
Published 2025-06-01“…The modeling results show that the economic benefits of the optimized Dongting Lake Eco-Economic Zone range between [15622.72 × 108,19150.50 × 108] CNY, and the optimized areas of farmland, woodland, grassland, water area, construction land, and unutilized land are[25686.99,25932.61]km2, [22093.37,22295.23]km2,[837.11108,841.41]km2,[7536.86,7767.01]km2,[2660.92,2987.49]km2,[1090.72,1116.36]km2.and the ecosystem service function, pollutant emission level and ecosystem service value of the optimized Dongting Lake Eco-Economic Zone in the optimization scenario, which guarantees higher economic benefits than the status quo scenario, show a better performance than the status quo scenario as a whole. Finally, by spatially allocating the optimization results, the coupled model provides a new perspective and tool for decision-makers to develop sustainable regional land use planning.…”
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28506
Addressing evidence needs during health crises in the province of Quebec (Canada): a proposed action plan for rapid evidence synthesis
Published 2025-01-01“…Actions advocating the use of a variety of rapid evidence synthesis methodologies known to be effective in supporting decision-making are presented in axis 3. Finally, axis 4 is about actions on the use of effective knowledge translation strategies to promote the use of rapid evidence synthesis products to support decision-making. …”
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28507
Valuation method for sub-indicators of rock burst risk based on mining depth and tectonic stress
Published 2024-12-01“…A quantitative expression for the critical crustal stress ratio and a criterion for high geostress manifestations were established. Finally, a new sub-indicator of rock burst risk index based on mining depth and geostress was proposed. …”
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28508
AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease
Published 2025-02-01“…QGJZF upregulated the expressions of phosphorylated -Adenosine 5‘-monophosphate (AMP) - activated protein kinase (p-AMPK), Sirtuin deacetylase 1 (SIRT1) and Transcription factor EB (TFEB), accompanied by the changes in autophagy-related proteins. …”
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28509
Serum cardiac and inflammatory biomarker levels following chemotherapy among female patients with breast cancer attending at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiop...
Published 2025-01-01“…An Elecsys 2010 Troponin-T immunoassay analyzer was used to measure serum levels of cardiac troponin T (cTnT), creatinine kinase-myocardial band (CK-MB), C-reactive protein (CRP), and R and D systemic luminex performance assays were used to measure serum Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF- α). …”
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28510
Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis
Published 2025-01-01“…Two researchers screened the retrieved literature based on exclusion and inclusion criteria. Finally, data extraction and quality evaluation were carried out for the included literature, and meta-analysis was executed applying the R package (4.4.1). …”
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28511
Etiopathogenic theories of nervous system diseases in Vilnius in the early 19th century: “insanity and epilepsy exacerbate when the moonlight shines”
Published 2023-10-01“…In addition, the astrological causes of NS diseases were also believed to be of great importance (“somnambulism, insanity, and epilepsy exacerbate when the moonlight shines”). Finally, cutting off the Polish plait (plica polonica) was considered to be an essential etiological factor of various NS diseases in Vilnius in the early 19th century. …”
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28512
Refining prognostic assessment of diffuse large B-cell lymphoma: insights from multi-omics and single-cell analysis unveil SRM as a key target for regulating immunotherapy
Published 2025-01-01“…Bulk and scRNA-seq analyses indicated that upregulation of SRM might mediate cold TME in DLBCL, potentially through suppressing immune activation pathways, promoting dendritic cells (DCs) transformation into tolerogenic DCs, and facilitating M2 polarization of macrophages. Finally, for eventual clinical translation, we integrated the model with other clinical features to develop a comprehensive database for DLBCL. …”
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28513
Evaluation and comparison of methods for neuronal parameter optimization using the Neuroptimus software framework.
Published 2024-12-01“…We also demonstrate the versatility of Neuroptimus by applying it to an additional use case that involves tuning the parameters of a subcellular model of biochemical pathways. Finally, we created an online database that allows uploading, querying and analyzing the results of optimization runs performed by Neuroptimus, which enables all researchers to update and extend the current benchmarking study. …”
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28514
Les sexualités des mineurs sous le contrôle du juge pénal aux XIXe et XXe siècles
Published 2020-03-01“…The legal reasoning never concerns the consequences of the offence on the child. Finally, this analysis of article 334 of the Criminal Code perfectly supports the realistic theory of interpretation developed by the professor of public law and legal philosopher Michel Troper. …”
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28515
N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility
Published 2024-12-01“…In addition, the single-cell dataset GSE214411 was analyzed to explore the role of m6A regulators in various cell types. Finally, clinical samples were collected, and immunohistochemistry analysis was performed. …”
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28516
Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion
Published 2025-01-01“…Some criteria for a high index of suspicion of brain tumors in boys with precocious puberty have been identified. Finally, a progressive increase in the occurrence of idiopathic CPP in boys has been observed over the past two decades with a peak of new diagnoses during the pandemic lockdown, as previously reported in girls.…”
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28517
Mimosapudica L. aqueous extract protects mice against pilocarpine–picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic path...
Published 2025-02-01“…On day 7, open-field, rotarod, and catalepsy tests were performed. Finally, the mice were sacrificed, and the hippocampi were isolated to quantify some biochemical markers of oxidative/nitrosative stress, GABAergic/cholinergic signalling, and BDNF levels in the hippocampus. …”
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28518
Mendelian randomization analysis reveals causal relationship between depression, antidepressants and benign paroxysmal vertigo
Published 2025-01-01“…The main statistical analyses were weighted median, weighted mode, MR-Egger and weighted inverse variance weighting (IVW) for random effects. Finally, we identified associations between BPV, antidepressants and depression. …”
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28519
Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma
Published 2025-01-01“…Similar to tissue findings, no changes were observed in the whole T regulatory (Treg) population, although PD1+ Tregs, which were downregulated in responder patients (vs T0), showed a rebound enrichment in non-responders after three cycles of cemiplimab. Finally, IL8 mirrored the tissue results, unlike IL1β, with early (T1) and then sustained (T3) downregulation of its levels in responder patients, while increased in non-responders.Conclusions Taken together, these findings shed light on the significance of early transcriptomic and immune cell modulation in predicting responses to cemiplimab therapy. …”
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28520
Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury
Published 2025-01-01“…Additionally, relying on the immune infiltration landscape associated with cuproptosis, we carried out immune cell correlation analysis on hub genes. Finally, to corroborate our earlier findings, we utilized single-cell RNA-seq analysis and in vitro experimental validation. …”
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