Difference Analysis of Organic Matter Enrichment Mechanisms in Upper Ordovician-Lower Silurian Shale from the Yangtze Region of Southern China and Its Geological Significance in Sh... by Ming Wen, Zhenxue Jiang, Kun Zhang, Yan Song, Shu Jiang, Chengzao Jia, Weiwei Liu, Yizhou Huang, Tianlin Liu, Xuelian Xie, Yue Sun, Shichao Fan, Xiangni Cao, Lin Zhu, Chuanxun Zhou

“…Subsequently, the results of elemental analysis and silicon isotope analysis are used to determine the origin of excess silicon. Finally, we used U/Th to determine the characteristics of the redox environment and the relationship between excess barium and TOC content to judge paleoproductivity and further studied the mechanism underlying sedimentary organic matter enrichment in the study area. …”
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Safety and efficacy of oral edible bird’s nest supplementation: Anti-inflammatory and immunomodulatory benefits for Arabian race stallions during exercise by Khalid Obaid AL-Khaldi, Khalid Hamed Al-Ruzaiqi, Abdul Salam Babji, Seng Joe Lim, Mohammed Babatunde Sadiq, Nurhusien Yimer

“…Kidney and liver function tests revealed significantly reduced creatine kinase, total bilirubin, and aspartate aminotransferase levels in the EBN group. …”
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Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway by Yuhua Zhou, Jing Lv, Shengkai Jin, Chaowei Fu, Bo Liu, Yang Shen, Menglu Li, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…RNA-seq analysis was performed to explore the mechanisms by which TMAO influences the proliferation and migration of prostate cancer cells. qPCR and Western blotting were utilized to validate the expression of related mRNA or proteins. Finally, we performed in vivo experiments to evaluate the effect of a high choline diet on the growth of subcutaneous tumors and lung metastases in mice.ResultsOur study found that TMAO enhances the proliferation and migration of prostate cancer cells by upregulating HMOX1 via activation of the MAPK signaling pathway, specifically p38 MAPK. …”
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Durvalumab, Tremelimumab, and Platinum Chemotherapy in EGFR Mutation–Positive NSCLC: An Open-Label Phase 2 Trial (ILLUMINATE) by Chee Khoon Lee, PhD, Bin-Chi Liao, MD, Shalini Subramaniam, MMed (Clin Epi), Chao-Hua Chiu, MD, Antony J. Mersiades, MMed (Clin Epi), Chao-Chi Ho, MD, PhD, Chris Brown, MBiostats, Chun-Liang Lai, MD, PhD, Brett G.M. Hughes, M.B.B.S. (Hons), Tsung-Ying Yang, MD, PhD, Ken O’Byrne, MD, Yung-Hung Luo, MD, PhD, Sonia Yip, PhD, Ching-Liang Ho, MD, Victoria Bray, PhD, Wu-Chou Su, MD, PhD, Melissa Moore, PhD, Wei-Lien Feng, MS, Ya-Ying Bai, MS, Kate Ford, MHSc, Michelle M. Cummins, PhD, Martin R. Stockler, MSc (Clin Epi), Benjamin J. Solomon, PhD, Thomas John, PhD, James Chih-Hsin Yang, MD, PhD

“…We conducted a phase 2 trial to determine the efficacy of durvalumab, tremelimumab, and platinum-pemetrexed in EGFR-mutant NSCLC after progression with EGFR tyrosine kinase inhibitors (TKIs). Methods: Participants were treated with induction durvalumab, tremelimumab, and platinum-pemetrexed, followed by durvalumab-pemetrexed maintenance. …”
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Using Linear Mixed-Effects Models to Analyze Historical Trends in Performance Strategies . Commentary on Majid Motavasseli’s Article “Interpretation of Cyclic Form in Bach’s ‘Goldb... by Bruno Gingras

“…Using a tempo measurement database comprising seventy-six selected recordings of the “Goldberg” cycle, I built a linear mixed-effects model predicting the main tempo for each recording from the following parameters: performer, variation number, instrument (piano or harpsichord), year of recording, variation type, and finally mode (major/minor) of the variation. Two statistically significant interactions emerged: a two-way interaction between instrument and mode, and a three-way interaction between instrument, year of recording, and variation type. …”
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A Survey of Differential Privacy Techniques for Federated Learning by Wang Xin, Li Jiaqian, Ding Xueshuang, Zhang Haoji, Sun Lianshan

“…This paper comprehensively expounds the research status of differential privacy techniques based on the federated learning framework, first providing detailed introductions to federated learning and differential privacy technologies, and then summarizing the development status of two types of federated learning differential privacy(DPFL) techniques respectively; for CDPFL, the paper divides the discussion into first proposal of CDP and typical application examples, the impact of Gaussian mechanisms on model accuracy, optimization based on asynchronous differential privacy, and insights from other scholars; for LDPFL, the paper divides the discussion into first proposal of LDP and typical application examples, processing multidimensional data and improving model accuracy, existing methods and optimization for reducing communication costs, balancing privacy protection and data usability, LDPFL based on the Shuffle model, and insights from other scholars; following this, the paper addresses and summarizes the unique challenges introduced by incorporating differential privacy into federated learning and proposes solutions; finally, based on a summary of existing optimization techniques, the paper outlines future directions and specifically discusses three research ideas for enhancing the optimization effects of federated differential privacy: advanced optimization strategies combining Bayesian methods and the Alternating Direction Method of Multipliers (ADMM), integrating lattice homomorphic encryption techniques from cryptography to achieve more efficient differential privacy protection in federated learning, and exploring the application of zero-knowledge proof techniques in federated learning for privacy protection.…”
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Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia by Ling C, Cao N, Wang H, Wan Y, Liang X, Guo J, Xiao M, Zhang Q, Zhai Z

“…We then constructed a prognostic model comprising five genes (HBP1, RNF130, RMND5B, TRIM32, and UBE2L3) through univariate Cox and LASSO regression analyses in the TCGA cohort and validated it in the BeatAML2.0 cohort. Finally, the expression of UBE2L3 was verified in cell lines and clinical case specimens.Results: The model accurately predicted AML prognosis and identified the UBE2L3 gene within the model as a high-risk biomarker associated with drug resistance, significantly influencing AML outcomes.Conclusion: The high expression of UBE2L3 is a reliable biomarker for drug resistance and poor prognosis of acute myeloid leukemia.Keywords: E3 ubiquitin ligase, prognostic model, UBE2L3, acute myeloid leukemia, drug resistance…”
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Economic burden of chronic obstructive pulmonary disease and post-tuberculosis sequelae in low- and middle-income countries: a database compiled from a systematic review and meta-a... by Fabrizio Tediosi, Klaus Reither, Olivia Keiser, Alexandra Walker, Yuling Lin, Marguerite Batta, Sierra Ottilie-Kovelman, Anna Duchenko, Curdin Brugger, Robert S Wallis, Marina Antillon

“…The costs were lower in lower middle-income countries compared with upper middle-income countries. Finally, considerable economic burden was attributable to smoking and air pollution.Conclusion The review and the CD-CPTB database give a thorough snapshot of the current evidence of the costs and economic burden of COPD and post-TB diseases. …”
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Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway by Yan Ye, Yan Ye, Xiaopeng Huang, Xiaopeng Huang, Xiaopeng Huang, Xueying Li, Xueying Li, Fei Gao, Wenzhen Zhong, Anqi Tang, Anqi Tang, Liangbin Zhao, Dengpiao Xie, Naijing Ye, Naijing Ye

“…NF-κB-RE-Luc transgenic mice were used to construct a CKD mouse model, and changes in fluorescence intensity in mice and isolated kidney tissues were detected within 1–6 days using a small animal live imager. Finally, 16S rRNA amplicon sequencing was used to monitor changes in intestinal flora in CKD patients before and after SSKE treatment.ResultsWe found that SSKE improves renal function, attenuates renal fibrosis, reduces inflammatory factor levels, and decreases damage to intestinal and renal structures in adenine-induced CKD rats. …”
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18F−Prostate−Specific Membrane Antigen PET/CT imaging for potentially resectable pancreatic cancer (PANSCAN−2): a phase I/II study by Jisce R. Puik, Thomas T. Poels, Gerrit K. J. Hooijer, Matthijs C. F. Cysouw, Joanne Verheij, Johanna W. Wilmink, Elisa Giovannetti, Geert Kazemier, Arantza Farina Sarasqueta, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg

“…TBR was defined as the ratio between SUVmax of the primary tumor divided by SUVmax of the aortic blood pool. Finally, tracer uptake on PET was correlated to tissue expression of PSMA in surgical specimens. …”
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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…KEGG analysis suggested that EERM's mechanism may involve signaling pathways such as PI3K-Akt, lipid and atherosclerosis, EGFR tyrosine kinase inhibitor resistance, and MAPK pathways. Molecular docking and molecular dynamics simulations results demonstrated a strong binding affinity between the main compounds of EERM and key targets. …”
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A Fourfold Bi-Filter and Permuted Bi-Quad-Wrapper Feature Selection Method for Finding Optimal Moments of Multi-Trajectory Transient Records in Transient Analysis by Seyed Alireza Bashiri Mosavi, Omid Khalaf Beigi

“…By applying the multifaced filter-wrapper scenario of F2FP2QW on 28-trajectory transient data, the OTMs are obtained. Finally, the efficacy of OTMs survived by the F2FP2QW model in TA is evaluated via a cross-validation scenario. …”
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Snake-DETR: a lightweight and efficient model for fine-grained snake detection in complex natural environments by Heng Wang, Shuai Zhang, Cong Zhang, Zheng Liu, Qiuxian Huang, Xinyi Ma, Yiming Jiang

“…Subsequently, a lightweight Group-Shuffle Convolution is used to optimize the encoder, which reduces dependency on large-scale training data, thereby making it suitable for deployment on edge devices. Finally, we incorporated the Powerful-IoU loss function to improve regression path accuracy. …”
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HKA angle exceeding 5 degrees is strongly associated with lateral patellar translation beyond 2 mm: surgical recommendations for avoiding adverse effects on the patellofemoral join... by Zheng Jiang, Nan Zhen, Yanjie Mao, Axiang He, Han Guo, Weiming Lin, Diwen Tang, Yang Qu, Tsung-Yuan Tsai, Wanjun Liu

“…Moreover, lateral shifts in the contact patterns of both the medial and lateral patellar facets together with increased T2 values (207.10 ± 21.84 ms, P = 0.04) of the lateral patella cartilage were found after surgery. Finally, the lateral patellar shift increased with decreasing varus 3D-HKA after surgery (R= -0.79, P < 0.001). …”
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Evaluation of Radiological and Anatomical Features of Cervical Vertebrae in Adult Persian Cat by Peghah Derakhshi, Siamak Alizadeh, Mohammadreza Hosseinchi

“…The C3 spinous process was a wide, small tubercle, while the C7 spinous process was extended vertically. Finally, the C6 transverse processes had a large ventrocranial tubercle forming a sagittal plate with cranial and caudal parts separated by a notch. …”
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Molecular Imaging of Gliomas by A. H. Jacobs, C. Dittmar, A. Winkeler, G. Garlip, W. D. Heiss

“…First of all, the exact localization, extent, and metabolic activity of the glioma must be determined to identify the biologically active target tissue for a biological treatment regimen; this is usually performed by imaging the expression of up-regulated endogenous genes coding for glucose or amino acid transporters and cellular hexokinase and thymidine kinase genes, respectively. Second, neuronal function and functional changes within the surrounding brain tissue have to be assessed in order to save this tissue from therapy-induced damage. …”
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The Volatile Composition and Activity Evolution of Main-belt Comet 358P/PANSTARRS by Henry H. Hsieh, John W. Noonan, Michael S. P. Kelley, Dennis Bodewits, Jana Pittichová, Audrey Thirouin, Marco Micheli, Matthew M. Knight, Michele T. Bannister, Colin O. Chandler, Carrie E. Holt, Matthew J. Hopkins, Yaeji Kim, Nicholas A. Moskovitz, William J. Oldroyd, Jack Patterson, Scott S. Sheppard, Nicole Tan, Chadwick A. Trujillo, Quanzhi Ye

“…Dynamical dust modeling shows that the coma’s morphology as imaged by JWST's NIRCam instrument on 2023 November 22 can be reproduced by asymmetric dust emission from a nucleus with a midrange obliquity ( ε ∼ 80°) with a steady-state mass-loss rate of ∼0.8 kg s ^−1 . Finally, we find similar Af ρ -to-gas ratios of ${\mathrm{log}}_{10}({Af}\rho /{Q}_{{{\rm{H}}}_{2}{\rm{O}}})=-24.8\pm 0.2$ for 358P and ${\mathrm{log}}_{10}({Af}\rho /{Q}_{{{\rm{H}}}_{2}{\rm{O}}})=-24.4\pm 0.2$ for 238P, suggesting that Af ρ could serve as an effective proxy for estimating water production rates in other active main-belt comets. …”
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Study on Response Probability of Meteorological and Hydrological Drought Characteristics during Drought Recovery Period in Upper Hanjiang River by ZHU Fang, WANG Haiyu, YANG Shaokang, BO Huijuan

“…Furthermore, the characteristics of meteorological and hydrological drought during the drought recovery period were obtained. Finally, a probability model of meteorological and hydrological drought recovery responses based on the Copula function coupled with Bayesian network was established to explore the relationship between meteorological and hydrological drought characteristics during the drought recovery period. …”
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Effect of ticagrelor combined with metoprolol extended-release tablets on cardiac function and clinical prognosis in elderly patients with acute coronary syndrome after percutaneou... by Lili Wang, Linlin Gao, Qin Chen, Li Chen, Hui Xu, Ling Sun, Youbin Hu

“…Additionally, the OG had significantly higher serum levels of cardiac troponin T (cTnT) and creatine kinase isoenzyme (CK-MB) than the CG (P &lt; 0.05). …”
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Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Based on these clues, 24 novel non-covalent proteasome inhibitors (D01–D24) were finally designed and screened. While the binding models between proteasome [protein data bank (PDB) code: 3MG6] and three representative compounds (15, 20, and D24) were also analyzed by using the molecular docking method. …”
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