Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…BackgroundUpadacitinib, a Janus kinase inhibitor, has been increasingly used over the past few years to treat moderate to severe ulcerative colitis and Crohn’s disease in patients who are insufficiently responsive or intolerant to tumor necrosis factor (TNF) antibodies, demonstrating notable clinical efficacy. …”
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Government and farmer responses to the fall armyworm outbreak in mainland Southeast Asia by Eiichi Kusano, Nipon Poapongsakorn, Urairat Jantarasiri, Kamphol Pantakua, Cuong H. Tran, Khin Akari Tar, Khin Akari Tar, Thong Kong, Viengsavanh V. Phimphachanhvongsod, Youichi Kobori

“…This study provides the following suggestions for the proposal of more acceptable strategies. 1) Studying the actual responses of governments and farmers with special emphasis on cost efficiency; 2) Making alternatives to EMB foliar application more cost-effective inclusive of the cost of labor; and finally, 3) Verifying the effectiveness of the alternative techniques.…”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…Additionally, RNA-seq analysis revealed that the differentially expressed genes among HIIT, MOD, and MCAO groups were highly associated with signaling pathways involved in inflammatory response, more specifically the I-kappaB kinase/NF-kappaB signaling. Following the outcome, we further investigated the infiltrating immune cells abundant in paretic muscles. …”
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PEER TUTORING IN LEARNING A FOREIGN LANGUAGE AS A NON-MAJOR by E. A. Makarova

“…The undertaken experiment lasted for two years, showed that peer tutoring advantages in foreign language training consist in the following: firstly, such way of lessons allows teachers to avoid time-losing monotonous reading and translations of texts discouraging students; secondly, exchanging opinions, students study each other and gain skills of estimation of personal and others' work; thirdly, interacting in pairs or small groups, pupils are more active, than during the independent work or work organized by the teacher, they react to the arising educational situations; finally, such training considerably solves a problem of shortage of class periods on teaching the subject "Foreign language" as students manage to cope with much large scope of a training material as compared they manage to make during the traditional organization of an educational process.Practical significance. …”
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Psychological Characteristics and Health Behavior for Juvenile Delinquency Groups by Fangbin Song, Ruihua Li, Wei Wang, Shenyu Zhang

“…By comparing the odds ratio (OR) of each question in the YPPQ test between the experimental group and the control group, it is found that the psychological characteristics of the experimental group are significantly affected by family, school, and even society. Finally, it proposes a “mixed hierarchical intervention model” for juvenile delinquency to intervene in health behaviors. …”
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High-Performance Computational Early Warning Analysis of Agricultural Economy Relying on Binary Fuzzy Cluster Analysis Algorithm by Fang Tang

“…Its functional structure includes management business, innovation business, service business, production business, and operation business functions, in addition to the design of the collection and storage scheme based on Hadoop data warehouse, to achieve accurate matching of information of science and technology agricultural services in the whole agricultural industry chain. Finally, the implementation and maintenance of the cloud-based science and technology agricultural service information system are deployed, and the operational effects of its information system-related functions are demonstrated using prototype design. …”
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Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

“…This was in line with the common inhibition of ALEKSIN and STATTIC observed on the genome-wide expression of pro-inflammatory IRF/STAT/NF-κB target genes, as well as on the migration of HMECs. Finally, we identified a novel signature of 46 ALEKSIN and STATTIC commonly inhibited pro-atherogenic target genes, which was upregulated in atherosclerotic plaques in the aortas of high-fat diet-fed ApoEKO mice and associated with inflammation, proliferation, adhesion, chemotaxis, and response to lipids. …”
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Dyskryminacja dzieci pozamałżeńskich w ustawodawstwie cywilnym w Drugiej Rzeczypospolitej i próby jej przezwyciężenia w projektach kodyfikacyjnych by Leonard Górnicki

“…The article points out that of the five coexisting systems of family law in independent Poland that originated in the partition era, which were treated as Polish district law (namely: the French-Polish legislation in the central lands, the Russian legislation in the eastern lands, the Austrian legislation in the southern lands, the provisions of the Austrian legislation in force together, as well as some Austrian marriage laws and the Hungarian Personal Marriage Law of 1894 in Spiš and Orava, and finally German legislation in the western lands of the Second Republic of Poland)— all discriminated against extramarital children, then known as “non-marital” and “illegitimate” or “natural” children. …”
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BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data by Cristian Iperi, Álvaro Fernández-Ochoa, Guillermo Barturen, Jacques-Olivier Pers, Nathan Foulquier, Eleonore Bettacchioli, Marta Alarcón-Riquelme, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Divi Cornec, Anne Bordron, Christophe Jamin

“…Methylomics analysis is performed using the ChAMP R package. Finally, Multi-Omics Factor Analysis (MOFA) integration identifies shared sources of variation across omics data. …”
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Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…These results were obtained with a low number of injections (3.7 ± 1.9) with only one case of intraocular drug-related adverse event. Finally, the presence of subretinal hyperreflective material correlates with lower visual recovery.DiscussionOur findings highlight the efficacy of Brolucizumab in managing wet-AMD and suggest its role for long-term efficacy in stabilizing retinal exudation and fluid accumulation, resulting in improved visual prognosis.…”
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Evolucionismo: a face oculta do empreendedorismo by Lucas Frazão Silva, Carolina Lorençato Bassani

“…Procurou-se apresentar e analisar a influência teórica de cada uma dessas correntes de pensamento que poderiam ter influenciado para a formação atual do conceito empreendedor, tecendo comentários finais sobre os possíveis resultados da fusão destas teorias, este artigo debate os possíveis desdobramentos daquilo que o Sebrae (Serviço Brasileiro de Apoio às Micro e Pequenas Empresas) chama de empreendedor. …”
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“Longing is good”: proof-of-concept for a novel psychological intervention to tackle self-blaming emotions by Nahed Lajmi, Suqian Duan, Jorge Moll, Roland Zahn, Roland Zahn

“…Self-blaming thoughts, along with depressive symptoms and other outcomes, were assessed pre- and post-intervention to determine the potential of the intervention, which consisted of creating a 10-min video starting with self-blame evoking materials, transitioning to sadness and finally longing. Participants were then asked to watch their video daily for 7 days.ResultsThe number of participants lost to follow-up was low (n = 3) and engagement with the intervention was very high. …”
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Associations among immunophenotype, plasma metabolites, and benign prostatic hyperplasia: a mediation Mendelian randomization study by FAN Jiuming, ZHAO Yiqiao, JIA Haichang, WANG Tiankun, HAN Yutong, QIN Zihao, CHEN Ping, ZENG Xiantao

“…The causal relationship between plasma metabolites and BPH was evaluated by the same method. Finally, the mediating effect of plasma metabolites between immune cells and BPH was further estimated. …”
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Construction and Optimization of Integrated Yield Prediction Model Based on Phenotypic Characteristics of Rice Grown in Small–Scale Plantations by Jihong Sun, Peng Tian, Zhaowen Li, Xinrui Wang, Haokai Zhang, Jiangquan Chen, Ye Qian

“…Subsequently, the top three models with the best performance in individual model predictions are integrated using voting and stacking ensemble methods to obtain the optimal integrated model. Finally, the impact of different rice phenotypic traits on the performance of the stacked ensemble model is explored. …”
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Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…It also demonstrates the insignificance of seasonal soil temperature fluctuations on storage in unconfined shallow aquifers and it clarifies the thermal energy exchange dynamics directly above the storage volume. Finally, it creates the opportunity to explore different storage conditions in a particular setting, allowing to propose cutoff criteria for the investment in ATES. …”
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Covid-19 Salgınının Türkiye’de Finansal Yatırım Araçları Üzerindeki Etkisi by Sevim Nurbanu Yıldız, Üzeyir Aydın

“…COVID-19’a bağlı gelişen ekonomik belirsizlik, ekonomik birimlerin yatırım kararlarını etkileyerek finans piyasalarında dalgalanmaların ortaya çıkmasını beraberinde getirmiştir. …”
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The status of a woman in the ancient world: features of marital and family relations in Ancient Athens by I. A. Lohvynenko, Ye. S. Lohvynenko

“…Intolerance of the opposite sex, along with the hypertrophied idea of man's purpose and role in society and the state finally formed and became apparent in the classical period of ancient Greece. …”
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Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…Lipidomic analysis revealed changes in the metabolic profile of the developing liver. Finally, we investigated the role of Toll-like receptor 4 (TLR4) signaling in fat storage using knockout mice and cell-specific deletion strategies. …”
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Anterior glenoid rim resorption after arthroscopic Bankart repair by the footprint fixation technique and its correlation with the healing of the repaired capsulolabral complex: a... by Takehito Hirose, MD, PhD, Makoto Tanaka, MD, PhD, Hidekazu Nakai, MD

“…We used 3-dimensional computed tomography scans to calculate the change in glenoid width (Δ%) due to anterior glenoid rim change from baseline to 3 months postoperatively and images from magnetic resonance arthrography, which was performed at around 5 months postoperatively, to evaluate CLC healing according to a 3-point grading scale (good, 3 points; fair, 2 points; poor, 1 point) on 6 oblique axial slices perpendicular to the glenoid long axis. Finally, we calculated the correlation coefficient between Δ% and the healing index, that is, the mean CLC healing grade of the 6 slices. …”
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Study on its application and unstable risk subarea estimation method of mountainous traffic engineering’s spoil ground by Jihong Zhang, Zhongji Dong, Xiaotao Yin, Min Yang

“…So, risk grades and subarea labeled by red, yellow and green colors based on different moving distances are established. Finally, traditional way and the failure risk subarea assessment method are compared in practice, which proves feasibility of the method. …”
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