Predicting kidney graft function and failure among kidney transplant recipients by Yi Yao, Brad C. Astor, Wei Yang, Tom Greene, Liang Li

“…Additionally, the model should be dynamic in the sense that it adapts to accumulating longitudinal information, including time-varying at-risk population, predictor-outcome association, and clinical history. Finally, the model should also properly account for the competing risk by death with a functioning graft. …”
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Identification of Cytosolic DNA Sensor cGAS-STING as Immune-Related Risk Factor in Renal Carcinoma following Pan-Cancer Analysis by Zheng Wu, Ying Lin, Li-Min Liu, Yan-Li Hou, Wei-Ting Qin, Lei Zhang, Shu-Heng Jiang, Qin Yang, Yong-Rui Bai

“…Significant positive correlations were noticed between cGAS-STING score and TIICs, including activated CD8+ T cells, activated CD4+ T cells, monocytes, and mast cells. Finally, the cGAS-STING score was revealed to be an independent prognostic factor for KIRC patients and possessed a strong predictive power for the prognostic evaluation of KIRC and KIRP patients. …”
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Investigation of Shock Initiation in Covered Charges under Shock Wave and Fragment Impacts by Xingwang Chen, Jinxiang Wang, Kui Tang, Hongfei Wang, Yuanbo Li

“…Finite element program, for instance, was applied for the simulation of shock initiation processes in pressed charges (when TNT was covered with a steel plate containing a penetrated notch), and then, numerical simulations were validated by experimental findings. Finally, the results obtained from the numerical simulations and theoretical model were applied to evaluate the impacts of shock wave intensity, the thickness of covered metal plate, and the geometrical features of penetrated notch on pressed charge shock initiation. …”
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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage by Shan Tian, Ruixue Li, Jiao Li, Jinhui Zou

“…Exposure to PS-NPs activated the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway both in the AOM/DSS mouse model and cellular model. …”
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Significance of Combining Bronchoalveolar Lavage Fluid With Targeted Next‐Generation Sequencing in the Pathogen Detection‐Based Diagnosis of Pulmonary Infections by Jiangbo Liu, Bo Yang, Yu Wu, Guihong Yang, Xiaojiu Zha, Wei Jiang

“…Results The data of a total of 169 patients (78 in the tNGS group and 91 in the mNGS group) were collected, and 145 patients (67 in the tNGS group and 78 in the mNGS group) were finally diagnosed with lung infections. The comprehensive positive pathogen detection‐based diagnosis rate for tNGS was 86.6%, with a single‐pathogen lung infection diagnosis rate of 85.7% and a mixed‐pathogen pulmonary infection diagnosis rate of 88.0%. …”
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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…Molecular docking demonstrated the binding interactions between core components and targets. Finally, in vitro experiments were conducted to validate the results of the network pharmacology analysis. 14 active components and 29 potential targets of SBH in treating TC were identified from the TCMSP database. …”
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Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation by Lei Sun, Jinhao Zhang, Zhikai Xiahou, Zhenzhen Zhao, Yanchen Liang

“…PySCENIC was used to identify active transcription factors in osteoclasts. Finally, we further demonstrated the results by RT-qPCR analysis, CCK-8 assay, wound healing assay, Transwell assay, etc.ResultsThrough the analysis of single-cell sequencing data in OS, we identified a highly specific subgroup, C2MKI67+ Osteoclast. …”
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Multistage identification method for real-time abnormal events of streaming data by Hao Luo, Kexin Sun, Junlu Wang, Chengfeng Liu, Linlin Ding, Baoyan Song

“…Therefore, this article proposes a strategy based on a variable sliding window to align two waveforms, locating the start point of perceptual disaster wave and template wave by gradually sliding the perceptual window, which can guarantee the accuracy of the matching. Finally, this article proposes a multistage identification mechanism based on the sliding window matching strategy and the characteristics of the waveforms of coal mine disasters, adjusting the early warning level according to the identification extent of the disaster signal, which increases the early warning level gradually with the successful result of the matching of 1/ N size of the template, and the piecewise aggregate approximation method is used to optimize the calculation process. …”
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Linking the life stages of fish into a habitat-ecological flow assessment scheme under climate change and human activities by Yiming Zhang, Wensheng Wang, Siyi Yu

“…Habitat patch area (HPA), weighted usable area (WUA), and habitat connectivity index (HCI) were employed to assess fish habitats during spawning and feeding stages. Finally, a hydrology-hydrodynamic-habitat framework was established to quantify optimal ecological flow (OEF) and threshold ecological flow (TEF). …”
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Enhancing Arabic text-to-speech synthesis for emotional expression in visually impaired individuals using the artificial hummingbird and hybrid deep learning model by Mahmoud M. Selim, Mohammed S. Assiri

“…To improve the performance of the hybrid LSTM+BiGRU methodology, the AMCDD-AHODL technique comprises an AHO-based hyperparameter tuning process. Finally, the WaveNet model enhances the naturalness and clarity of text-to-speech synthesis, delivering high-quality, human-like audio output. …”
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Therapeutic potential of short-chain fatty acids for acute lung injury: a systematic review and meta-analysis of preclinical animal studies by Liying Xie, Linyan Wang, Yongxin Liao, Miaoen Yao, Miaoen Yao, Miaoen Yao, Tong Mai, Rongrong Fan, Rongrong Fan, Rongrong Fan, Yun Han, Yun Han, Yun Han, Gengbiao Zhou, Gengbiao Zhou, Gengbiao Zhou

“…The data were extracted in accordance with the established selection criteria, and the risk of bias was evaluated for each study.ResultsA total of 16 articles were finally included in the meta-analysis. The results indicated that the SCFAs significantly reduced lung wet-to-dry weight (SMD = −2.75, 95% CI = −3.46 to −2.03, p < 0.00001), lung injury scores (SMD = −5.07, 95% CI = −6.25 to −3.89, p < 0.00001), myeloperoxidase (SMD = −3.37, 95% CI = −4.05 to −2.70, p < 0.00001), tumor necrosis factor-alpha (SMD = −3.31, 95% CI = −4.45 to −2.16, p < 0.00001) and malondialdehyde (SMD = −3.91, 95% CI = −5.37 to −2.44, p < 0.00001) levels in animal models of ALI. …”
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Research on Operation Characteristics and Safety Risk Forecast of Bus Driven by Multisource Forewarning Data by Shejun Deng, Hongru Yu, Caoye Lu

“…To prevent and control public transport safety accidents in advance and guide the safety management and decision-making optimization of public transport vehicles, based on the forewarning and other multisource data of public transport vehicles in Zhenjiang, holographic portraits of public transport safety operation characteristics are constructed from the perspectives of time, space, and driver factors, and a prediction model of fatigue driving and driving risk of bus drivers based on BP neural network is constructed. Finally, model checking and virtual simulation experiments are carried out. …”
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Attendance of Patients with ophthalmological problems about Eye Protection from UV/blue Light Radiation from Sun light and Electronic Devices in Sulaimani City by Salah Qadir Mahmood, Muhammad Babakir-Mina, Salar Ibrahim Ali, Abdulrahman M. Ibrahem, Bakhtyar Kamal Talabany

“…Furthermore, only the patients with sun light sensitivity and cataract had a significant knowledge about harmful effects of radiation from electronic devices on human eyes. Finally, most of the patients with dry eyes, eye/lid infection and glaucoma and cataract had significantly more practices for taking visual breaks when using electronic devices. …”
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Bioinformatics screening and clinical validation of CircRNA and related miRNA in male osteoporosis by Jiayi Li, Sijia Guo, Qingyun Sun, Ning An, Jisheng Lin, Qi Fei

“…PPI networks of shared mRNAs were constructed and the hub genes in the PPI networks were identified with CytoHubba, a plugin in Cytoscape software (3.10.1). Finally, a ceRNA network of four circRNAs derived from three hub genes was constructed. …”
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Agent based modelling of blood borne viruses: a scoping review by Seun Ale, Elizabeth Hunter, John D. Kelleher

“…To analyse this corpus of 88 papers, we developed a five-level taxonomy that categorised each paper based first on disease type, then transmission mechanism, then modelled population, then geographic location and finally, model outcome. Results The result of this analysis show significant gaps in the ABM of BBV literature, particularly in the modeling of social and individual factors influencing BBV transmission. …”
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Shoulder Pain in Competitive Swimmers: A Multi-Site Survey Study by Brian D. Stirling, Jonathan C. Sum, Lisa Baek, Lori A. Michener, Adam J. Barrack, Angela R. Tate

“…A secondary purpose was to determine influence of age, competitive swimming experience, and previous history of shoulder pain or injury on shoulder pain, disability, and dissatisfaction, and finally to determine if sex, geographic area, and participation in a second sport relate to shoulder pain, disability, and dissatisfaction…”
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Association between obstructive sleep apnea hypopnea syndrome and arteriosclerosis in patients with type 2 diabetes mellitus: mediating effect of blood pressure by Xinshui Wang, Xiaolin Huang, Yuexian Xing, Xiaohong Jiang, Fei Hua

“…A segmented regression model was used to explain nonlinearity, and subgroup analysis was conducted to assess interactions. Finally, a mediation effect model evaluated AHI’s direct and indirect effects on arteriosclerosis.ResultsThe AHI of the arteriosclerosis group was significantly higher than that of the non-arteriosclerosis group (P < 0.001). …”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

“…Compared with HFD control mice, PCM supplementation increased phosphorylation of AMP-activated protein kinase (AMPK). Peroxisome proliferator-activated receptor (PPAR) α was significantly increased by PCM administration. …”
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Role of the Notch signaling pathway in porcine oocyte maturation by Pil-Soo Jeong, Hyo-Gu Kang, Dabin Cha, Se-Been Jeon, Min Ju Kim, Bong-Seok Song, Bo-Woong Sim, Sanghoon Lee

“…Furthermore, RO significantly impaired the cellular distribution and functions of the mitochondria and endoplasmic reticula, which are important organelles for the cytoplasmic maturation of oocytes. Finally, the involvement of canonical Notch signaling in oocyte maturation was confirmed by the decreased expression of HES and HEY family transcripts and proteins in the RO-treated COCs. …”
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Sub-toxic cisplatin concentrations induce extensive chromosomal, nuclear and nucleolar abnormalities associated with high malignancy before acquired resistance develops: Implicatio... by John G Delinassios, Robert M Hoffman, George Koumakis, Dimitrios Palitskaris, Kyriaki-Nefelli Poulatsidou, George J Delinasios

“…These abnormalities were intensified in cells pre-sensitized to 0.02 or 0.08 μg/ml cisplatin for seven days, then exposed to 0.03 or 0.1 μg/ml cisplatin for 24 hours, and finally cultured in cisplatin-free medium for 24 hours before chromosome analysis.…”
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