A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli by Ping Zeng, Xuemei Yang, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan, Sharon Shui Yee Leung, Lanhua Yi

“…Thereafter, morphological changes of E. coli O157:H7 cells were monitored by electron microscopy technologies. Finally, the potential application of zp39 in controlling EHEC in food was tested with spinach juice and the Galleria mellonella larvae model was employed to assess the in vivo efficacy. …”
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Spatial-temporal pattern and driving mechanism of urban land use eco-efficiency in mountainous counties based on multi-source data: a case study of Zhejiang province, China by Li Fan, Lindong Ma, Lindong Ma, Zhongwei Huang

“…Based on this, the spatial-temporal evolution and spatial agglomeration characteristics were analyzed by using spatial analysis techniques, kernel density analysis, and spatial autocorrelation model. Finally, the driving mechanisms were revealed by using the geographical detector model and GWR model. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Additionally, we employed molecular docking techniques to evaluate the potential of inhibin subunit beta B (INHBB) as therapeutic targets and to assess the binding affinity of candidate drugs. Finally, we used gene knockout techniques to silence the key gene INHBB and explored its biological functions in vitro.ResultsIn our study, by analyzing the expression differences of ARGs, we successfully classified patients with COAD. …”
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The Long Echo of Conflict: The Memory of 1990s Black Decade in the Modern Political Culture of Algeria by A. I. Vasilenko

“…During the second stage of post-conflict reconstruction (the second half of the 2000s), the government had tried to consolidate the society while the third stage, which coincided with the Arab Awakening, was marked by governmental efforts to prevent a possible revolutionary outburst and new destabilization of political system. Finally, mass protests in Algeria in 2019 marked the beginning of the fourth stage of the process during which the national elites have made every effort to guarantee the maintenance of the constitutional order even in case of a rapid change of political regime. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

“…However, we also find increased astrocytic TSPO expression in chronic-appearing lesions with astrogliosis. Finally, we find expression of TSPO in a subset of neurons, most frequently GLS2 + glutamatergic neurons. …”
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Pandemia e dinâmicas de comércio internacional: uma análise da relação Bahia-Mercosul sob à ótica das exportações e importações* by Gesner Brehmer de Araújo Silva

“…Después de la Segunda Guerra Mundial y con los procesos de globalización de finales del siglo pasado, las relaciones comerciales internacionales han ido adquiriendo una mayor importancia, lo que ha provocado tanto un aumento de la producción mundial como la aparición de bloques econômicos que pretendían reforzar e impulsar estas relaciones. …”
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Modern contraceptive utilization and associated factors among street working reproductive age women in Ethiopia: A systematic review and meta-analysis. by Bekalu Getnet Kassa, Basazinew Chekol Demilew, Fentahun Yenealem Beyene, Habtamu Gebrehana Belay

“…PubMed, Google Scholar, HINAR, Scopus, Web of Sciences, and grey literature were used to search primary studies. …”
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Prevalence and risk factors for Sick Building Syndrome among Italian correctional officers: A pilot study by Francesco Chirico, Giuseppe Ferrari, Giuseppe Taino, Enrico Oddone, Ines Giorgi, Marcello Imbriani

“…COs reported that their health had been affected by the passive smoking (β = 2.34, P < .05) and unpleasant odour (β = 2.51, P < .05) as environmental risk factors; work-family conflict (β = 2.14, P < .05), psychological and physical isolation (β = 2.07, P < .05), and negative public image (β = 2.06, P < .05) as psychosocial risk factors. Finally, atopy (β = 2.02, P < .05) and to be current smoker (β = 2.02, P < .05) were statistically significant behavioral predictors of SBS among correctional officers. …”
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Conventional Mercury Penetration and Constant Velocity Mercury Penetration Experiments Are Used to Quantitatively Characterize the Difference in Micropore Structure in Low Permeabi... by Kaitao Yuan, Yan Li, Tiaotiao Shi, Husheng Huang, Yanfei Li, Minglei He

“…Taking C 6 and C 7 reservoirs in Ordos Basin as an example, a total of 13 representative pairs of samples were selected to analyze the difference in capillary pressure curve shape and pore throat distribution characteristics between the two experiments and to clarify the reasons for the difference in microscopic pore characteristic parameters measured by the two experiments. Finally, the correlation between the microscopic pore characteristic parameters and the movable fluid saturation parameters is analyzed. …”
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UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy by Lin Li, Rong Fu, Yan Chen, Jin Yao, Xiaobing Jiang, Tao Liang, Jun jun Li, Qian zhi Chen, Liang Liang Shi, Ming Xing Xie, Xin Wei Qiao, Qi Hong Cheng, Min Jie Wang

“…Mechanistically, UBE2T directly interacts with CDC42, promoting its K48-linked polyubiquitination and proteasomal degradation, thereby inhibiting CDC42 from degrading CD276 via the autophagy-lysosomal pathway, indirectly upregulating CD276 and thereby impairing the CD8+ T cells function, ultimately mediating tumor immune escape and BrM. Finally, animal experimental results also showed that inhibition of UBE2T elevated the TNBC sensitivity to immune checkpoint CD276 blockade and inhibited BrM of TNBC.Conclusions In conclusion, our results indicate a new mechanism whereby UBE2T-mediated ubiquitination positively controls the UBE2T/CDC42/CD276 axis to upregulate tumor cell expression of CD276 and thereby impair CD8+ T cells function, ultimately leading to tumor cell immune escape and BrM.…”
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Integrated Approach for Biomarker Discovery and Mechanistic Insights into the Co-Pathogenesis of Type 2 Diabetes Mellitus and Non-Hodgkin Lymphoma by Zhu Y, Liu J, Wang B

“…Topological analysis and machine learning algorithms were applied to refine hub gene selection. Finally, quantitative real-time polymerase chain reaction was performed to validate hub genes in clinical samples.Results: Intersection analysis of DEGs from the T2DM and NHL datasets identified 81 shared genes. …”
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Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) by Parisa Riahi, Amir Hossein Saeidian, Albert Tenesa, Carolyn T. Hogan, Michael March, Kamran Guity, Mahmoud Amiri Roudbar, Asieh Zahedi, Maryam Zarkesh, Farideh Neshati, Mehdi Hedayati, Fereidoun Azizi, Hakon Hakonarson, Maryam S. Daneshpour, Mahdi Akbarzadeh

“…Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. Finally, as one of the evolutionary consequences of AM, long-term spousal resemblance provided an increasing trend for correlation between spouses in terms of their lipid serum level and obesity-related traits.…”
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Identifying households with children who have complex needs: a segmentation model for integrated care systems by Roberta Piroddi, Andrea Astbury, Wesam Baker, Kostantinos Daras, Joe Rafferty, Iain Buchan, Benjamin Barr

“…We then used individual and household linked data across multiple health and social care services to identify these households, providing an algorithm to be used in a case finding interface. Finally, to understand the needs of this segment, and to identify unmet need, to tailor support, we used descriptive statistics and Poisson regression to profile the segment and compare them with the rest of the population. …”
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Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…Subsequently, the obtained data were subjected to further network pharmacological analysis to explore the potential key active compounds, core target genes, and biological processes (BPs) associated with the effect of ZJP against GERD. Finally, the prediction results of NP were validated by MD, and MDS of the optimal core protein-ligand for each component obtained by MD were performed using Gromacs 2020 software. …”
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Avirulence depletion assay: Combining R gene-mediated selection with bulk sequencing for rapid avirulence gene identification in wheat powdery mildew. by Lukas Kunz, Jigisha Jigisha, Fabrizio Menardo, Alexandros G Sotiropoulos, Helen Zbinden, Shenghao Zou, Dingzhong Tang, Ralph Hückelhoven, Beat Keller, Marion C Müller

“…We furthermore provide evidence that Pm60 outperforms Pm60a and Pm60b through more efficient recognition of AvrPm60 effectors, suggesting it should be prioritized for wheat breeding. Finally, we show that virulence towards Pm60 is caused by simultaneous deletion of all AvrPm60 gene paralogs and that isolates lacking AvrPm60 are especially prevalent in the US thereby limiting the potential of Pm60 in this region. …”
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Bireylerin Konut Finansman Tercihlerini Belirlemeye Yönelik Ölçek Geliştirilmesi by Hüdaverdi Bircan, Yılmaz Günel

“…Günümüzde tüketicilerin almak istedikleri konutun fiyatı ile birikimleri arasında oluşan fark bireyleri finans arayışlarına sevk etmektedir. Süreç içerisinde tüketicilerin karar vermelerinde etkili olan faktörler önemli bir yer tutmaktadır. …”
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Blockchain-assisted improved interval type-2 fuzzy deep learning-based attack detection on internet of things driven consumer electronics by Rana Alabdan, Bayan Alabduallah, Nuha Alruwais, Munya A. Arasi, Somia A. Asklany, Omar Alghushairy, Fouad Shoie Alallah, Abdulrhman Alshareef

“…This is followed by the ICOA-IT2FDL technique, which applies the interval type-2 fuzzy deep belief network (IT2-FDBN) model to identify intrusions. Finally, the bald eagle search (BES) model strategy improves the intrusion recognition rate. …”
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Inflamación crónica y enfermedades degenerativas by Alvaro Paul Moina-Veloz, Patricio Gabriel Cargua-Inca, Darwin Bladimir Tinillo-Tapia, Bryan Alexander Cueva-Jara

“…Las consecuencias clínicas de un daño por inflamacion puede llegar a ser grave e incluir un mayor riesgo de síndrome metabólico, diabetes tipo 2; hepatopatías, hipertensión, enfermedades cardiovasculares, enfermedad renal crónica o varios tipos de cáncer. Consideraciones finales: Las inflamaciones crónicas se establecen dependiendo de la población coma el estilo de vida y características genéticas, se establece que la inflamación crónica sistémica deteriora la función inmunológica normal e incrementa la susceptibilidad de otro tipo de infecciones o de tumores. …”
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Prevalence of Intestinal Parasites and Gastrointestinal Carriage of Pathogenic Gram Negative Enteric Bacteria among Apparently Healthy Food Handlers of Public Hospitals, Addis Abab... by Tegegn Belhu, Kinfe Fissehatsion, Abraham Tesfaye, Dr Yohannes Woldekidan, Kassu Desta

“…For bacterial identification culture, biochemical tests and antimicrobial sensitivity (Kirby-Baure disk diffusion method) have been performed. Finally, validated data were analyzed using statistical package for social science version 20 (SPSS). …”
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Nurses' use of social media during the COVID-19 pandemic-A scoping review. by Stinne Glasdam, Helena Sandberg, Sigrid Stjernswärd, Frode F Jacobsen, Anette H Grønning, Lisbeth Hybholt

“…Further, social media functioned as profession-promoting channels partly sharing heroic self-representations and acknowledgment of frontline persons in the pandemic, partly by displaying critical working conditions. Finally, nurses used social media to educate people to perform the 'right 'COVID-19' behaviours in society.…”
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