Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…These proteins were involved in signaling pathways such as Mitogen-Activated Protein Kinase （MAPK） signaling, focal adhesion and phospholipase D signaling pathways, and were involved in biological processes such as cell adhesion, signaling, macromolecular modification, etc. …”
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The Merit-based Incentive Payment System: Pearson’s Chi-Square and Categorical Dependent Variable Models Analyzed for Domains---Effective Clinical Care and Efficiency/Cost Reductio... by Amrita Shenoy

“…This changed minutely with significantly less process measures (93.75% vs 93.81% \[*P*=.000]) in 2019 versus 2018. Finally, measure types changed minutely but significantly with less process measures (93.81% vs 93.75% \[*P*=.000]) in 2020 versus 2019. …”
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An overlap-weighted analysis on the association of constipation symptoms with disease progression and survival in amyotrophic lateral sclerosis: a nested case-control study by Tongyang Niu, Peize Wang, Xiaomeng Zhou, Tingting Liu, Qi Liu, Rui Li, Haitao Yang, Hui Dong, Yaling Liu

“…Survival differences between the two groups were analyzed using Kaplan-Meier’s plots and log-rank tests. Finally, the bioinformatic analysis explored common pathways between ALS and constipation. …”
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Identification of macrophage polarisation and mitochondria-related biomarkers in diabetic retinopathy by Weifeng Liu, Bin Tong, Jian Xiong, Yanfang Zhu, Hongwei Lu, Haonan Xu, Xi Yang, Feifei Wang, Peng Yu, Yunwei Hu

“…Key genes were obtained by Mendelian randomisation (MR) analysis, then biomarkers were obtained by machine learning combined with receiver operating characteristic (ROC) and expression validation between DR and control cohorts in GSE221521 and GSE160306 to obtain biomarkers. Finally, biomarkers were subjected to immune infiltration analysis, gene set enrichment analysis (GSEA), and gene–gene interaction (GGI) analysis. …”
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Individual and organizational factors associated with public health workforce competencies to advance health equity. by Paula M Kett, Shahida Shahrir, Betty Bekemeier, Kay Schaffer, Danielle J Zemmel, Davis G Patterson

“…Black (AOR = 0.68) and Hispanic/Latino (AOR = 0.83) staff had lower odds, however, of reporting engagement in activities to address racism. Finally, competencies positively associated with nearly all outcomes included cross-sector collaboration, ability to incorporate health equity into programming, and policy advocacy. …”
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The Optimum Dietary Phenylalanine Requirement of Hybrid Grouper (Epinephelusfuscoguttatus ♀ × Epinepheluslanceolatus ♂) Juveniles: Effects on Growth Performance, Gut Micromorpholog... by Pinxian Yang, Haijiao Wang, Lei Ma, Haoran Yin, Zhanying Zhu, Cong Liu, Wei Huang, Zhiyu Zhou, Xiaoyi Wu, Sehrish Taj

“…The Phe 13.3 group had lower expression of S6 kinase 1 (S6K1) and target of rapamycin (TOR) than other groups. …”
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Quantitative Analysis of the Multicomponent and Spectrum–Effect Correlation of the Antispasmodic Activity of Shaoyao-Gancao Decoction by Yanli Xu, Chenxi Li, Ting Chen, Xiaochun Li, Xiaoyu Wu, Qili Zhang, Lei Zhao

“…Grey relational analysis combined with partial least square regression was used to study the spectrum–effect correlation of SGD. Finally, the potential antispasmolytic components were validated using an isolated tissue experiment. …”
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Larvicidal Effectiveness of Azolla pinnata against Aedes aegypti (Diptera: Culicidae) with Its Effects on Larval Morphology and Visualization of Behavioural Response by Nor Shaida Husna Zulkrnin, Nurul Nadiah Rozhan, Nur Amanina Zulkfili, Nik Raihan Nik Yusoff, Mohd Sukhairi Mat Rasat, Nor Hakimin Abdullah, Muhammad Iqbal Ahmad, Rajiv Ravi, Intan H. Ishak, Mohamad Faiz Mohd Amin

“…The highest mortality was at 1853 ppm for powdered A. pinnata compared with fresh A. pinnata at 2,521,535 ppm, while the LC50 for both powdered and fresh A. pinnata recorded at 1262 ppm and 1853 ppm, respectively. Finally, the analysis of variance (ANOVA) showed significant difference on Ae. aegypti larval mortality (F=30.439, df=1, p≤0.001) and concentration (F=20.002, df=1, p≤0.001) compared to powdered and fresh A. pinnata at 24-hour bioassay test. …”
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Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of <i>Centella asiatica</i> by Steven R. Chamberlin, Jonathan A. Zweig, Cody J. Neff, Luke Marney, Jaewoo Choi, Liping Yang, Claudia S. Maier, Amala Soumyanath, Shannon McWeeney, Nora E. Gray

“…Interestingly, in metabolomics analysis, the TTCQA treatment saw the highest number of changes in individual metabolites (20), followed by CQA (15), then TT (8), and finally CAW (3). WGCNA analysis found two metabolomics modules with significant eigenmetabolite differences for TT and CQA and possible compound interactions at this level. …”
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Factors accounting for limited sexual reproduction in a long-lived unisexual plant species by Irene Bisang, Flavien Collart, Flavien Collart, Alain Vanderpoorten, Lars Hedenäs

“…Topography and climatic conditions at 1-km resolution were employed to measure niche overlap between (i) sex-expressing and non-expressing and (ii) male and female specimens. We finally modelled sex expression and sporophyte production depending on these topo-climatic predictors.ResultsAmong the 63% of reproductive samples across the entire latitudinal gradient, females outnumbered males by a factor 5.6, and 8% of the female samples bore sporophytes. …”
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Diversity and Conservation Status of Large Mammals in Ghamot National Park, Azad Jammu and Kashmir, Pakistan by Muhammad Jahangeer, Siddique Muhammad, Muhammad Shakeel, Mir Muhammad Saleem, Ali Usman, Hussain Abid

“…The forest and riparian zone had the greatest similarity in species composition, both between and among seasons. Finally, our findings show that GNP has an essential influence in Pakistan mammal conservation. …”
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Agricultural GDP exposure to drought and its machine learning-based prediction in the Jialing River Basin, China by Xinzhi Wang, Qingxia Lin, Zhiyong Wu, Yuliang Zhang, Changwen Li, Ji Liu, Shinan Zhang, Songyu Li

“…Additionally, cropland exposure to drought was evaluated using gridded agricultural GDP data derived from pixel interpolation. Finally, four machine learning methods (Bayesian, BiGRU, CLA, and MLP) were employed to predict hydrometeorological variables from 2021 to 2030, and the agricultural economic exposures to drought under five shared socioeconomic pathways (SSPs) were also predicted. …”
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Analysis of the VERNALIZATION-A1 exon-4 polymorphism in polyploid wheat by A. F. Muterko, E. A. Salina

“…Haplotype segregation was attained among accessions carrying only intact exon-4 of VRN-A1 and among dominant alleles of this gene. Finally, based on the associations revealed between the VRN-A1 alleles and haplotypes, the new putative dominant VRN-A1 allele (designated Vrn-A1k) carrying a 42-bp insertion within the promoter region was identified in tetraploid wheat of Triticum dicoccum.…”
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Fondo regional en América Latina y el Caribe para el desarrollo económico local y los gobiernos locales: Estrategia para la reducción de la pobreza y de la desigualdad social by Erik Vittrup Christensen, Oscar Fernando Marmolejo Roldan

“…El tercer año será de consolidación y sostenibilidad de los proyectos y evaluación de los mismos. A finales del tercer año se dará inicio al segundo ciclo de proyectos representado en la selección de otros nuevos países…”
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Identification of Potential Biomarkers for Coronary Artery Disease Based on Cuproptosis by Bohong Zhang, Mingliang He

“…To further reveal the regulation mechanisms, a lncRNA-miRNA-mRNA ceRNA network based on the marker genes was established. Finally, 13 potential therapeutic drugs targeting 2 marker genes (S100A12 and F5) were identified using the Drug Gene Interaction Database (DGIdb). …”
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Depression Detection and Diagnosis Based on Electroencephalogram (EEG) Analysis: A Systematic Review by Kholoud Elnaggar, Mostafa M. El-Gayar, Mohammed Elmogy

“…Additionally, integrating Internet of Things (IoT) devices with EEG for continuous mental health monitoring and distinguishing between different types of depression are identified as critical research areas. Finally, the review emphasizes improving the reliability and predictability of computational intelligence-based models to advance depression diagnosis. …”
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La géographie des élections en Algérie, de 2007 à 2017 by Gilles Van Hamme

“…Secondly, the parties of the ruling bloc (FLN and RND) and those of the opposition show a very variable geography, making it impossible to identify electoral bastions, with the notable exception of support for some opposition parties in Kabylie. Finally, the power bloc was able to maintain itself in 2017 in 80% of the municipalities where it was in power, indicating its ability to maintain its influence from the local to the national level.In urban areas, support for power appears to be very limited, and opposition is characterised by very low voter turnout and the importance of spoiled or blank ballots. …”
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Strategies for genetic manipulation of the halotolerant black yeast Hortaea werneckii: ectopic DNA integration and marker-free CRISPR/Cas9 transformation by Yainitza Hernandez-Rodriguez, A. Makenzie Bullard, Rebecca J. Busch, Aidan Marshall, José M. Vargas-Muñiz

“…The same construct was used to express cytosolic green fluorescent protein. Finally, we developed a marker-free CRISPR/Cas9 protocol for targeted gene deletion using the melanin synthesis pathway as a visual reporter of successful transformation. …”
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Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Sestrin2 leads to AMP-activated protein kinase- (AMPK-) and GTPase-activating protein activity toward Rags (GATOR) 1-mediated inhibition of mammalian target of rapamycin complex 1 (mTORC1), thereby enhancing autophagy. …”
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Exploring the shared gene signatures and mechanism among three autoimmune diseases by bulk RNA sequencing integrated with single-cell RNA sequencing analysis by Xiaofang Liu, Bin Li, Yuxi Lin, Xueying Ma, Yingying Liu, Lili Ma, Xiaomeng Ma, Xia Wang, Nanjing Li, Xiaoyun Liu, Xiaohong Chen

“…The Cibersort algorithm was and scRNA-seq analysis was performed to identify key gene expression patterns and assess the infiltration of immune cells in MS patients. Finally, the biomarkers’ expression was validated in human and mice experiments.ResultsSeveral shared genes among MS, SLE, and RA were identified, which play crucial roles in immune responses and inflammation regulation. …”
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