Exploring the mechanism of berberine treatment for atherosclerosis combined with non-alcoholic fatty liver disease based on bioinformatic and experimental study. by Shushu Wang, Kachun Lu, Liwen Lin, Gaijie Li, Yuxin Han, Zhichao Lin, Qingmin Chu, Kunsheng Wu, Peijian Liu, Guiting Zhou, Rui Peng, Chuanjin Luo

“…Single cell validation identified six key genes: dual specificity phosphatase 6 (DUSP6), chemokine ligand 3 (CCL3), complement component 5a receptor 1 (C5AR1), formyl peptide receptor 1 (FPR1), myeloid nuclear differentiation antigen (MNDA), and proviral integration site of murine 2(PIM2). Finally, molecular docking and animal experiments showed that BBR significantly reduced lipid deposits and inflammatory markers in liver and aortic tissues. …”
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Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers‐Based Model by Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Luca Boldrini, Agnese Latorre, Deniz Can Guven, Serena Iacovelli, Tiziana Talienti, Alessandro Rizzo, Francesco Alfredo Zito, Raffaella Massafra

“…Discussion As far as we know, our research is the first proposal using ViTs on DCE‐MRI exams to monitor pCR over time during NAC. Conclusion Finally, the changes in DCE‐MRI at pre‐ and mid‐treatment could affect the accuracy of pCR prediction to NAC.…”
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Effectiveness of the User-Centered “Healthcare CEO” App for Patients With Type 1 Diabetes Transitioning From Adolescence to Early Adulthood: Protocol for a Randomized Controlled Tr... by Yueh-Tao Chiang, Hsing-Yi Yu, Pei-Kwei Tsay, Chi-Wen Chen, Chi-Wen Chang, Chien-Lung Hsu, Fu-Sung Lo, Philip Moons

“…Recruitment resumed in August 2023, with findings expected to be finalized by July 2025. ConclusionsThe Healthcare CEO app is a comprehensive solution tailored specifically for individuals with T1D transitioning from adolescence to early adulthood. …”
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Clinical Features and Risk Factors of Mortality in Patients with Posterior Reversible Encephalopathy Syndrome by Hong-Wei Cui, Ru-Yi Lei, Bo-Ai Zhang

“…All patients were followed up by telephone. Finally, the patients were divided into the survival group and death group for prognosis analysis. …”
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The Role of Organizational Support in Work Engagement Among Nurses Working in Intensive Care Units by Marwa Badwan, Nidal Eshah, Rayan Ahmad

“…Also, results showed no significant differences in perceived organizational support and work engagement based on nurses' socio-demographics or work-related factors. Finally, there was a significant positive weak correlation between perceived organizational support and work engagement (r= 0.23, P=0.002). …”
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Development of a Solar-Powered Edge Processing Perimeter Alert System with AI and LoRa/LoRaWAN Integration for Drone Detection and Enhanced Security by Mateo Mejia-Herrera, Juan Botero-Valencia, José Ortega, Ruber Hernández-García

“…The evaluation results show notable progress in the acoustic detection of helicopters and drones under controlled conditions. Finally, all the original data presented in the study are openly available in an OSF repository.…”
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Multiresidue Pesticides Analysis of Vegetables in Vietnam by Ultrahigh-Performance Liquid Chromatography in Combination with High-Resolution Mass Spectrometry (UPLC-Orbitrap MS) by Nam Vu-Duc, Trung Nguyen-Quang, Thuy Le-Minh, Xuyen Nguyen-Thi, Tri Manh Tran, Hai Anh Vu, Lan-Anh Nguyen, Tien Doan-Duy, Bui Van Hoi, Cam-Tu Vu, Dung Le-Van, Lan-Anh Phung-Thi, Hong-An Vu-Thi, Dinh Binh Chu

“…Experimental results demonstrated that the ionization suppression or enhancement was the main contribution on the overall recoveries of target analytes. Finally, the in-house validated method was applied to pesticides screening in vegetables samples in local villages in Hanoi, Vietnam. …”
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Territorial obstacles causing early school dropout in Morocco: Multivariate spatial analysis by Aomar Ibourk, Soukaina Raoui

“…In particular, in the labor market component, there is a pull effect to school dropout decisions from low-skilled job prospects (TC3) and (TC4). Finally, preschooling has an impact on the foundation of human capital at an early age (TC9) as well as on the supply and type of schools (Satelite), which remains a proximity model for the retention of young children, especially girls (TC10). …”
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Exploring diazotrophic diversity: unveiling Nif core distribution and evolutionary patterns in nitrogen-fixing organisms by Bruno Thiago de Lima Nichio, Roxana Beatriz Ribeiro Chaves, Fábio de Oliveira Pedrosa, Roberto Tadeu Raittz

“…A partial Nif core set was observed in eight species in this study. Finally, we cataloged 662 species with Nif core, of which 52 were novel. …”
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Nickel removal from electroplating industry wastewater: A bamboo activated carbon by D. Sivakumar, J. Nouri, T.M. Modhini, K. Deepalakshmi

“…Isotherm results revealed that Langmuir model was best suited with the equilibrium data than Freundlich model.  Finally, this study concluded that bamboo activated carbon was best suited for removing nickel from electroplating industry wastewater.…”
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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents by Chongshan Dai, Erjie Tian, Hui Li, Subhajit Das Gupta, Zhihui Hao, Zhanhui Wang, Tony Velkov, Jianzhong Shen

“…Several signaling pathways, including gasdermin D, toll like receptor 2 (TLR2), TLR4, Akt, NF-κB, ERK/MAPK, protein kinase C (PKC), and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell death. …”
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“What does ‘often’ even mean?” Revising and validating the Comprehensive Autistic Trait Inventory in partnership with autistic people by Friederike Charlotte Hechler, Outi Tuomainen, Nathan Weber, Frank Fahr, Bodie Karlek, Marie Maroske, Meike Misia, Nathan Caruana

“…Convergent validity was demonstrated by significant correlations between the CATI-R and two contemporary inventories of autistic traits: the AQ (rho = .86, p < .01) and BAPQ (rho = .82, p < .01). Finally, a measurement invariance analysis indicated that total-scale scores can be compared across genders. …”
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Implications of Diminishing Lifespan Marginal Utility for Valuing Equity in Cost-Effectiveness Analysis by R. Scott Braithwaite

“…Third, DMLU may bias the interpretation of relative measures of inequality aversion toward prioritarianism. Finally, not considering DMLU implicitly biases life-year–based metrics against equity. …”
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Scare Behavior Diffusion Model of Health Food Safety Based on Complex Network by Jun Luo, Jiepeng Wang, Yongle Zhao, Tingqiang Chen

“…The health food safety information transparency shows a marginal diminishing decreasing characteristic in relation to the scale of the health food safety scare behavior diffusion, whereas the health food consumers’ ability to process information and the recovery rate of the health food consumers show marginal incremental decreasing characteristics in relation to the scale of the health food safety scare behavior diffusion. Finally, the network structure of health food consumers significantly affects the health food safety scare behavior diffusion. …”
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Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats by Shadan Saberi, Mohammad Amin Rajizadeh, Mohammad Khaksari, Azadeh Saber, Mohammad Akhbari, Soheil Aminizadeh, Forouzan Rafie

“…Aim This study aimed to investigate the effects of different intensities of endurance training on kidney function and inflammation in a rat model of lithium-induced nephropathy, focusing on the expression of aquaporin 2 (AQP2), glycogen synthase kinase 3-beta (GSK-3β), and SIRT1. Methods Thirty-five male Wistar rats were divided into five groups: control, lithium-only, lithium with low-intensity exercise (LIT), lithium with medium-intensity exercise (MIT), and lithium with high-intensity exercise (HIT). …”
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Optimal needle characteristics for classical inferior alveolar nerve block anesthesia: a systematic review by Mennat Allah Ashraf Abd-Elsabour, Ayat Gamal-AbdelNaser

“…The authors ran the search, selected the eligible studies, assessed the risk of bias using RoB 1 and extracted the data of the finally included studies. All the steps were performed in duplicates. …”
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The Effects of Different Nanoadditives on the Physical and Mechanical Properties of Similar Silty Mudstone Materials by Ji-jing Wang, Zhen-ning Shi, Ling Zeng, Shuang-xing Qi

“…The physical and mechanical parameters are more in line with silty rock. Finally, nanometer additives suitable for silty mudstone similar materials are determined by conducting density test, natural water absorption test, uniaxial compression test, splitting test, softening coefficient test, expansibility test, and microscopic test. …”
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A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases by Eva Lukas, Rada R. Veeneman, Dirk J. A. Smit, Tarunveer S. Ahluwalia, Jentien M. Vermeulen, Gita A. Pathak, Renato Polimanti, Karin J. H. Verweij, Jorien L. Treur

“…Next, we assessed biological, behavioural, and psychosocial factors as potential mediators. Finally, we employed multivariable Mendelian randomization to examine causal pathways between PTSD and CVD, incorporating the same potential mediators. …”
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A Method for Quantifying Automobile Brake Creep Groan Intensity Based on Friction-Induced Vibration and Noise by Lijun Zhang, Jianfeng Wu, Dejian Meng

“…Analytically, four vibration indexes and four noise indexes are established to evaluate the intensity of creep groan, the validity of which is verified by linear regression analysis. Finally, by combining all effective indexes, multiple linear regression analysis is performed, based on which the mapping relationship between the subjective evaluation of creep groan and effective indexes is obtained. …”
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Modeling and Analysis of Optical Time-domain Reflectometry in Strongly-coupled Multi-core Fiber by XING Rui, YANG Zhiqun, YAN Hui, LIU Yaping, WANG Xutao, WANG Yanze, ZHANG Wendou, ZHANG Lin

“…Based on the theoretical research, the article also proposes a modeling scheme for Rayleigh scattering effects in coupled-core optical fibers, taking into account the impact of fiber end-face reflection on the transmission process and providing a technical route to verify the Rayleigh scattering effects. Finally, the article processes the transmission data simulated by the model and conducts a comparative analysis based on the set parameters.…”
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