A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma by Yonglin Luo, Wenyang Wei, Yaxuan Huang, Jun Li, Weiling Qin, Quanxiang Hao, Jiemei Ye, Zhe Zhang, Yushan Liang, Xue Xiao, Yonglin Cai

“…Moreover, the expression of RBL2, E2F1, and CDC25C were significantly correlated with the expression of caspase family genes. Finally, the lower mRNA and protein expression of RBL2 were validated in NPC cell lines and tissues. …”
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Using remote sensing and machine learning to generate 100-cm soil moisture at 30-m resolution for the black soil region of China: Implication for agricultural water management by Liwen Chen, Boting Hu, Jingxuan Sun, Y. Jun Xu, Guangxin Zhang, Hongbo Ma, Jingquan Ren

“…Secondly, leveraging the Extreme Gradient Boosting (XGBoost) model along with reanalysis and in-situ measurements, we estimate soil moisture information across depths of 0–100 cm depth by 10 cm interval over large geographical extents. Finally, the accuracy of the soil moisture model is assessed using metrics such as Pearson correlation coefficient, root mean square error (RMSE), unbiased RMSE (ubRMSE), and bias. …”
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Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis by Linsa Zhou, Qiang Zhou, Qian Guo, Peng Lai, Chen Rui, Wanqing Li, Xuemei Chen, Yue Zhuo, Xiaoping Zhong, Sen Lin

“…The MR studies were conducted mainly using Inverse Variance Weighting (IVW), MR-Egger, Weighted Median, simple and weighted patterns to predict the correlation between sun-exposed skin and CM. Finally, the role of target genes in CM was revealed by pan-cancer analysis, expression and immune-infiltration evaluations, immuno-checking targeting analysis, immunotherapy response analysis, survival analysis, and protein-protein interactions (PPI) network and enrichment analyses. …”
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Myxedema Psychosis: Neuropsychiatric Manifestations and Rhabdomyolysis Unmasking Hypothyroidism by Sundus Sardar, Mhd-Baraa Habib, Aseel Sukik, Bashar Tanous, Sara Mohamed, Raad Tahtouh, Abdelrahman Hamad, Mouhand F. H. Mohamed

“…Additional investigations revealed a high thyroid-stimulating hormone (TSH) of 56.6 mIU/L, low free T4<0.5 pmol/L, elevated creatine kinase of 3601 U/L, and urine dipstick positive for blood, suggestive of myoglobinuria. …”
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A review on techno-economic analysis of lignocellulosic biorefinery producing biofuels and high-value products by Ronak Patel, T.S. Rajaraman, Paresh H. Rana, Nikita J. Ambegaonkar, Sanjay Patel

“…Key issues and opportunities for LCB-based biorefineries, in general, for CBE have also been addressed. Finally, the role of policy mechanisms, Artificial Intelligence (AI) and other data-driven technologies are also discussed in the biorefinery context.…”
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Effects of Tannic Acid Supplementation of a High-Carbohydrate Diet on the Growth, Serum Biochemical Parameters, Antioxidant Capacity, Digestive Enzyme Activity, and Liver and Intes... by Yi Wang, Jianjun Wu, Luoxin Li, Yuanfeng Yao, Chiqing Chen, Yucong Hong, Yi Chai, Wei Liu

“…However, it was also found that 200–400 mg/kg TA enhanced the antioxidant capacity of largemouth bass in the case of the high-carbohydrate diet, reduced liver glycogen levels, and improved liver and intestinal health. Finally, it should be noted that, when the dietary TA level exceeded 800 mg/kg, TA appeared to play a pro-oxidation role in the liver, which may cause oxidative stress in the liver.…”
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Development and Assessment of a Color-Variable Chlorine Dioxide Slow-Releasing Card for Litchi Preservation by Li Guo, Guang Wu, Qingchun Yin, Lin Luo, Hao Deng

“…Card B was soaked in 1 mol/L oxalic acid, 0.3 mol/L CaCl₂, and natural pigment. Finally, cards A and B were dried and adhered using 60% gelatin. …”
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Evaluation of Rainfall-Induced Accumulation Landslide Susceptibility Based on Remote Sensing Interpretation by Zhen Wu, Runqing Ye, Jue Huang, Xiaolin Fu, Yao Chen

“…Subsequently, the accuracy of the evaluation models was compared and verified using the Receiver Operating Characteristic (ROC) curve, and the evaluation results were analyzed. Finally, the developed Random Forest model was applied to Gongping Town in Fengjie County to verify its applicability in other regions. …”
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Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway by Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo

“…Mechanistic studies focused on the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways, along with the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. …”
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Optimizing VGG16 deep learning model with enhanced hunger games search for logo classification by Mohammed Hussain, Thaer Thaher, Mohamed Basel Almourad, Majdi Mafarja

“…Second, a custom-developed VGG16 model is tested on the Flickr-27 logo classification dataset and compared against state-of-the-art deep learning models such as ResNet50V2, InceptionV3, DenseNet121, EfficientNetB0, and MobileNetV2. Finally, EHGS is integrated into the VGG16 model to optimize its hyperparameters. …”
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Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. by Zeinab Chaharlashkar, Yousof Saeedi Honar, Meghdad Abdollahpour-Alitappeh, Sepideh Parvizpour, Abolfazl Barzegar, Effat Alizadeh

“…After exploration of DEGs of NS and metastatic-melanoma, identification of relevant transcription factors (TFs) and kinases, the Gene Ontology (GO), and pathways analyses of DEGs were performed. …”
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Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…CTSB further induced ferroptosis via spermidine/spermine-N1-acetyltransferase (SAT1)-mediated lipid peroxidation, mitochondrial damage and mitogen-activated protein kinase (MAPK) signalling pathway activation, eventually affecting the function of HSFs. …”
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Validation of the shortest version of the eating attitude test (EAT-7) as a screening tool for disordered eating in patients with first-episode schizophrenia by Feten Fekih-Romdhane, Youssef Boukadida, Majda Cheour, Souheil Hallit

“…No significant differences in EAT-7 scores between males and females were found. Finally, EAT-7 scores positively correlated with scores of depression and anxiety, supporting concurrent validity of the scale. …”
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Association between Serum Uric Acid Levels and Perinatal Outcome in Women with Preeclampsia by Robinson Uchenna Ugwuanyi, Irozuruike Munachiso Chiege, Felix Eke Agwu, George Uchenna Eleje, Nonso Martin Ifediorah

“…One hundred and two participants were finally analysed. Fifty-one participants were recruited in each arm. …”
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FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells by Baoyuan Zhang, Hang Geng, Kai Zhao, Moussa Omorou, Shuang Liu, Zhihui Ye, Fanting Zhang, Haiyan Luan, Xuesong Zhang

“…We then analyzed proliferation, oxidative stress, transdifferentiation, cell migration, and the nuclear factor kappa-B (NF-κB) signaling pathway potentially involved in FSTL1 effects. Finally, we blocked the NF-κB pathway to see its influence on these cellular processes. …”
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Effects of functional diversity on ecosystem services in cocoa agroforestry systems in Costa Rica by Cassio Pinheiro Edelstein, Marney E. Isaac, Marney E. Isaac, Luis Orozco-Aguilar, Felipe Peguero, Felipe Peguero, Diego Delgado-Rodríguez, Rolando H. Cerda

“…Nevertheless, the models indicated that a win-win scenario can be achieved when shade trees are productive, generating additional benefits. …”
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Urine miRNA signature as potential non-invasive diagnostic biomarker for Hirschsprung’s disease by Abhijit Sreepada, Abhijit Sreepada, Rasul Khasanov, Enas Zoheer Elkrewi, Enas Zoheer Elkrewi, Carolina de la Torre, Judith Felcht, Ahmad A. Al Abdulqader, Ahmad A. Al Abdulqader, Richard Martel, Nicolás Andrés Hoyos-Celis, Michael Boettcher, Lucas M. Wessel, Karl-Herbert Schäfer, María Ángeles Tapia-Laliena

“…Further search in miRNAwalk and miRDB databases showed that certainly most of these dysregulated miRNAs identified target HSCR associated genes, such as RET, GDNF, BDNF, EDN3, EDNRB, ERBB, NRG1, SOX10; and other genes implied in neuronal migration and neurogenesis. Finally, we could also validate some of these miRNA changes in HSCR urine by RT-qPCR. …”
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Efficacy and safety of jaktinib hydrochloride tablets in active axial spondyloarthritis: a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial by Xiaomei Li, Xiaoxia Wang, Jian Wu, Xiao Zhang, Chunde Bao, Shengqian Xu, Lingyun Sun, Juan Wang, Guixiu Shi, Xiaofei Wang, Qing Dai, Antao Xu, Huaxiang Wu, YongQing Wang, Yan Ye, Yongfu Wang, Huaxiang Liu, Chenyin Lv, Jun Miao, Weiqi Min, Kuanting Wang, Luan Xue, Shanhui Ye

“…Objective The objective of this study is to evaluate the efficacy and safety of jaktinib hydrochloride tablets (jaktinib), a Janus kinase inhibitor, in patients with active radiographic axial spondyloarthritis (r-axSpA).Methods Adults with active r-axSpA who met modified New York criteria and had an inadequate response to non-steroidal anti-inflammatory drugs were randomised 1:1:1 to receive jaktinib 75 mg two times per day, 100 mg two times per day, or placebo. …”
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A COMPETÊNCIA ARTÍSTICA DE PROFESSORES DE ARTES VISUAIS: ESTUDO DE CASO EM PONTA GROSSA (PARANÁ) by CAMILA BOURGUIGNON DE LIMA, ADRIANE KNOBLAUCH

“…Pretende-se refletir, sobretudo, como a apropriação artística dos professores configura a docência em arte no ensino fundamental anos finais. À maneira de Bourdieu, parte-se do pressuposto que a competência artística de professores resulta da combinação entre trajetória social, formação acadêmica e socialização profissional. …”
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Auditory attention decoding based on neural-network for binaural beamforming applications by Roy Gueta, Elana Zion-Golumbic, Jacob Goldberger, Sharon Gannot

“…With the goal of alleviating the problem of same-trial overfitting, this architecture employs a new data organization structure that presents the neural network (NN) with a single speaker’s speech and the corresponding EEG signal as inputs. Finally, posterior probability post-processing is applied to the outputs of the NN to improve detection accuracy. …”
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