Ablation of IGFBP5 expression alleviates neurogenic erectile dysfunction by inducing neurovascular regeneration by Jiyeon Ock, Guo Nan Yin, Fang-Yuan Liu, Yan Huang, Fitri Rahma Fridayana, Minh Nhat Vo, Ji-Kan Ryu

“…Third, ablating IGFBP5 expression in CNI-induced ED mice promoted neurovascular regeneration by increasing cell proliferation, reducing apoptosis, and decreasing Reactive oxygen species production. Finally, western blot analysis demonstrated that IGFBP5 ablation attenuated the JNK/c-Jun signaling pathway, activated the PI3K/AKT signaling pathway, and increased vascular endothelial growth factor and neurotrophic factor expression. …”
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Twitter user geolocation method based on single-point toponym matching and local toponym filtering by Jin XUE, Fuxiang YUAN, Yimin LIU, Meng ZHANG, Yaqiong QIAO, Xiangyang LUO

“…The availability of accurate toponyms in user tweets is crucial for geolocating Twitter users.However, existing methods for locating Twitter users often suffer from limited quantity and reliability of acquired toponyms, thus impacting the accuracy of user geolocation.To address this issue, a twitter user geolocation method based on single-point toponym matching and local toponym filtering was proposed.A toponym type discriminating algorithm based on the aggregation degree of locations of the toponym was designed.In the proposed algorithm, a single-point toponym database was generated to provide more reliable toponyms extracted from tweets.Then, according to a proposed local place name filtering algorithm based on the aggregation degree of user location, the aggregation degree of user location centered on the longitude and latitude of toponyms and the average longitude and latitude of users were calculated.This process helped in extracting local toponyms with a high aggregation degree, which enhances the reliability of toponyms used in geolocation.Finally, a user-toponym heterogeneous graph was constructed based on user social relationships and user mentions of toponyms, and users were located by graph representation learning and neural networks.A large number of user geolocation experiments were conducted based on two commonly used public datasets in this field, namely GEOTEXT and TW-US.Comparisons with nine existing typical methods for Twitter user geolocation, including HGNN, ReLP, and GCN, demonstrate that our proposed method achieves significantly higher geolocation accuracy.On the GEOTEXT dataset, the average error is reduced by 7.3～342.8 km, the median error is reduced by 2.4～354.4 km, and the accuracy of large area-level geolocation is improved by 1.3%～26.3%.On the TW-US dataset, the average error is reduced by 8.6～246.6 km, the median error is reduced by 5.7～149.7 km, and the accuracy of large area-level geolocation is improved by 1.5%～20.5%.…”
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ADAMTS1, CRABP1, and NR3C1 Identified as Epigenetically Deregulated Genes in Colorectal Tumorigenesis by Guro E. Lind, Kristine Kleivi, Gunn I. Meling, Manuel R. Teixeira, Espen Thiis-Evensen, Torleiv O. Rognum, Ragnhild A. Lothe

“…These genes were unmethylated in tumors (n=82) from three other organs, prostate, testis, and kidney. Finally, analysis of normal colorectal mucosa demonstrated that the observed promoter hypermethylation was cancer-specific. …”
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Anti-Inflammatory and Healing Activity of the Hydroalcoholic Fruit Extract of Solanum diploconos (Mart.) Bohs by Larissa Benvenutti, Roberta Nunes, Ivonilce Venturi, Silvia Aparecida Ramos, Milena Fronza Broering, Fernanda Capitanio Goldoni, Sarah Eskelsen Pavan, Maria Verônica Dávila Pastor, Angela Malheiros, Nara Lins Meira Quintão, Elizabeth Soares Fernandes, José Roberto Santin

“…It also indicates its potential use as a healing agent. Finally, the absence of acute toxic and genotoxic effects reinforces its possible use as medicinal product.…”
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Percutaneous ultrasound-guided radiofrequency ablation for patients with liver metastases from gastrointestinal stromal tumors by Li Liu, Bing Wang, Zhong-Yi Zhang, Song Wang, Hao Wu, Hong Wang, Wei Wu, Kun Yan, Wei Yang

“…Based on the univariate analysis, the number of metastatic tumors and tyrosine kinase inhibitors(TKI) therapy before RFA were prognostic factors for HPFS. …”
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البیلوبیجیا الأنثروبودیرمیکیة أو تجلید الکتب باستخدام جلود البشر : دراسة تاریخیة

“…In subject direction Medicine came first with 45.5%. Finally,by time line the 19th century came first with 59.1% from total number of bookswhich covered with human skin that included in the bibliography of the study, andcontained just twenty-two books covered with human skin…”
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Particle Flow Analysis of Macroscopic and Mesoscopic Failure Process of Salt Rock under High Temperature and Triaxial Stress by Haoran Li, Ziheng Wang, Dekang Li, Yajun Zhang

“…In order to reveal the mechanism of thermal-induced deformation and fracture development of salt rock under high temperature, the particle flow program PFC2D was used to study the triaxial compression failure process of salt rocks under different temperatures; at the same time, a combination model of Burge and Linearpbond was proposed to simulate plastic deformation and heat conduction of salt rock. Finally, the simulation results were compared with the experimental results to verify the validity of the conclusion. …”
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Effect of High-Fat Diet on Spatial Learning and Memory and Regulatory Role of N-Methyl-D-Aspartate Receptors in the Dentate Gyrus by LIU Huaying, DONG Wei, ZHANG Zihan, LI Yingshun, JIN Qinghua

“…The Morris water maze (MWM) test was used to evaluate the spatial learning and memory capacity of the rats; Western blot was used to detect the expression of phosphorylated Ca2+/calmodulin dependent protein kinase II (p-CaMKII) and cAMP-response element binding protein (p-CREB), pro-inflammatory cytokines, including interleukin-6 (IL-6) and IL-1β in the hippocampal dentate gyrus (DG); the expression of ionized calcium binding adapter molecule 1 (Iba1) in the DG were observed by Western blot and immunohistochemistry. …”
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HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis by Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike

“…Furthermore, expression of the lncRNA Caren, which inhibits Hint1 mRNA translation, decreased with age in heart, and CR suppressed this effect. Finally, decreased HINT1 expression due to Caren overexpression antagonized age-related declines in mitochondrial biogenesis, ameliorating age-related cardiac dysfunction, exercise intolerance, and exercise-induced cardiac damage and subsequent death of mice. …”
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Jackknife versus Lithotomy Position for Hemorrhoidectomy Surgery: A Randomized Controlled Trial by Sina Ghasemi, Behzad Imani, Alireza Jafarkhani, Ashkan Karimi, Ali Yamini

“…The first group underwent surgery using the Jackknife position, while the second group underwent the conventional method using the Lithotomy position. Finally, variables such as the amount of bleeding, duration of surgery, surgeon's field of view, local posture discomfort, and postoperative pain were analyzed and compared between the two groups using SPSS software version 24. …”
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Enhanced Disc Herniation Classification Using Grey Wolf Optimization Based on Hybrid Feature Extraction and Deep Learning Methods by Yasemin Sarı, Nesrin Aydın Atasoy

“…Following feature extraction, the GWO algorithm, inspired by the social hierarchy and hunting behavior of grey wolves, is employed to optimize the feature set by selecting the most relevant features. Finally, the optimized feature set is fed into machine learning classifiers (MLP and SVM) for classification. …”
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Analysis of Feature Extraction and Anti-Interference of Face Image under Deep Reconstruction Network Algorithm by Jin Yang, Yuxuan Zhao, Shihao Yang, Xinxin Kang, Xinyan Cao, Xixin Cao

“…Then, the portrait pyramid segmentation and local feature point segmentation are applied to extract the features of face images, and the matching of face feature points is achieved using Euclidean distance and joint Bayesian method. Finally, Matlab software is used to simulate the algorithm proposed in this paper and compare it with other algorithms. …”
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Dissection of the genetic loci for grain hardness and variation of the key genes in common wheat (Triticum aestivum L.) by Jinna Hou, Pengge Sun, Pei Yan, Shenghui Geng, Wenxu Li, Maomao Qin, Ziju Dai, Baoming Tian, Zhengqing Wu, Zhengfu Zhou, Changwen Li, Zhensheng Lei

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Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH by Gopanandan Parthasarathy, Nanditha Venkatesan, Guneet Singh Sidhu, Myeong Jun Song, Chieh-Yu Liao, Fanta Barrow, Amy Mauer, Tejasav Sehrawat, Yasuhiko Nakao, P. Vineeth Daniel, Debanjali Dasgupta, Kevin Pavelko, Xavier S. Revelo, Harmeet Malhi

“…Gene ontology pathway analysis revealed significant suppression of the peroxisome proliferator–activated receptor gamma and mitogen-activated protein kinase pathways in S1pr1 MKO consistent with attenuated MASH in mice. …”
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FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers by Yongchang Tang, Hong Wang, Jiankun Zhang, Chunhui Yang, Fei Xu, Yan Song, Tianen Li, Qiangbo Zhang

“…Abstract The crosstalk between cancers and the immune microenvironment plays a critical role in malignant progression. FMS-like tyrosine kinase 3 (FLT3) is a frequently mutated gene in acute myeloid leukemia (AML). …”
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A espacialização da violência criminal na cidade de Santa Maria, RS by Eliane Melara

“…Thus, in this study, there was a need to question: the data sources researched, the reason for the differentiated occurrence of crimes in the neighborhoods, possible victims and aggressors, why some crimes had bigger visibility than others, what is the relationship with the social inequalities, what is the analysis about white-collar crimes, etc. Finally, with this article, we aimed at contributing to the study of the types of violence that cover the Brazilian middle cities, through one of the many ways in which it is possible to think about this subject in the urban space.…”
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TPDTNet: Two-Phase Distillation Training for Visible-to-Infrared Unsupervised Domain Adaptive Object Detection by Siyu Wang, Xiaogang Yang, Ruitao Lu, Shuang Su, Bin Tang, Tao Zhang, Zhengjie Zhu

“…This convolutional operation is embedded following standard convolution to mitigate the loss of detailed features. Finally, a distillation training strategy that utilizes pseudodetection labels to calculate target information. …”
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Effects of Ginsenoside Biopolymer Nanoparticles on the Malignant Behavior of Non-Small-Cell Lung Cancer by Weizheng Zhou, Chengliang Cai, Hui Shi, Hai Jin, Xiaowei Wang

“…In addition, PTEN was demonstrated as a target gene of miR-192. Finally, by inhibiting the expression level of miR-192 in H125 cells, the Rg3 monomer and HA-Rg3 nanoparticles upregulated the expression of PTEN and thus exerted its antitumor effect; the effects of HA-Rg3 were comparatively more significant than those of the Rg3 monomer. …”
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RELATO DE EXPERIENCIA PEDAGÓGICAS: " EL USO DE FOTOGRAFIAS AÉREAS VERTICALES EN LA ENSEÑANZA DE CONTENIDOS DE GEOGRAFÍA AGRARIA" by Oscar José María Lossio

“…El relato intenta sistematizar una de las propuestas de enseñanza con apoyo de textos aerofotográficos con los que venimos trabajando desde hace algunos años y corresponde, específicamente, a clases desarrolladas a finales de 2007 en una escuela media de la ciudad de Santa Fe. …”
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تأثیر مجموعات المکتبة المرکزیة بجامعة القاهرة فى البحث العلمى فى تخصص المکتبات والمعلومات : دراسة تحلیلیة... by د.سرفیناز أحمد حافظ

“…Thirdly what are the information sources has a weaknesspoints in the Central Library. Finally, practice of acknowledgment by researchersof the libraries role, databases, digital library, etc.in the methodological introduction to the approved thesis. …”
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