Analysis of tumor-infiltrating exhausted T cells highlights IL-6 and PD1 blockade as a combined immunotherapy strategy for non-small cell lung cancer by Lulu Zhang, Lulu Zhang, Xiyuan Guo, Xiyuan Guo, Xiaoke Sun, Jue Liao, Qin Liu, Yingchun Ye, Zhihui Yang, Ratchada Cressey, Qing He, Qing Yuan, Qing Yuan

“…We then evaluated the effect of interleukin 6 (IL-6) stimulation on CD8+T cells. Finally, we assessed the effects of combined blockade of PD1 and IL-6 on macrophage recruitment in a zebrafish macrophage model and CD8+ T cell function and tumor growth in PBMC humanized mouse model.ResultsThe expression of exhaustion markers on CD8+ T cells was found to be notably higher in both tumor and paraneoplastic tissues compared to peripheral blood. …”
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Performance optimization of sorption-enhanced DME synthesis (SEDMES) from captured CO2 and renewable hydrogen by I. Tyraskis, A. Capa, G. Skorikova, S. N. Sluijter, J. Boon

“…A lower feed flow rate was found to positively impact carbon selectivity to DME, which is promising for operation under intermittent conditions. Finally, even a minor increase in tube diameter reduced the Gas Hourly Space Velocity (GHSV), enhancing DME selectivity in a manner comparable to the effect of lower feed flow rates. …”
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Design and Test of Combined Air Suction Cotton Breed Seeder by Yudao Li, Zhanhua Song, Fade Li, Yinfa Yan, Fuyang Tian, Xuezhen Sun

“…This paper concludes that the coefficient of variation is small when the velocity is 1.2–1.5 m/s and finds the optimal range of unit velocity when sowing and finally builds the mathematical models including multiples index and missing index. …”
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Randomized controlled trials in central vascular access devices: A scoping review. by Mari Takashima, Gillian Ray-Barruel, Amanda Ullman, Samantha Keogh, Claire M Rickard

“…Additionally, there were extensive gaps within population sub-groups, particularly in tunneled devices, and in pediatrics and neonates. Finally, outcome definitions need to be unified for results to be meaningful and comparable across studies.…”
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Manganese-based immunotherapy synergized with novel supramolecular hydrogel: Advancing localized immune activation strategies in squamous cell carcinoma by Tianqing Wang, Xiaopei Hu, Xin Tian, Ying Wang, Shiyu Zhang, Silu Sun, Ning Ji, Xiaobo Luo, Qianming Chen, Xin Zeng, Hang Zhao, Jing Li

“…This hydrogel not only exhibited acceptable biocompatibility and biodegradability but also was able to load and sustain the release of Mn2+ and PD-1 antibody in situ. Finally, we adopted a range of mouse tumor models to reveal that G-TA-I supramolecular hydrogel drug delivery system loaded with Mn2+ and PD-1 antibody could efficiently activate local immunity, effectively combating the occurrence and progression of HNSCC. …”
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A case report of exacerbation of extrapyramidal symptoms following the switch from risperidone to paliperidone during valproate therapy by Emi Hata, Masatoshi Miyauchi, Nobuhiko Noguchi, Takeshi Asami

“…Shortly after increasing the paliperidone dose, the patient developed significant EPS, including muscle rigidity and elevated creatine kinase levels, indicative of potential neuroleptic malignant syndrome. …”
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Effects of socioeconomic and human-modified landscape variables on medicinal species richness at a macroscale: the case of the Caatinga, Brazil by Aníbal Silva Cantalice, Thiago Gonçalves-Souza, Ulysses Paulino Albuquerque

“…Moreover, our study highlights that the processes influencing knowledge of medicinal species at broader scales are not simply the aggregation of local-scale observations. Finally, we propose strategies to advance the field of macroethnobiology.…”
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Psychological Aspects of a Police Officer’s Professional Success by M. V. Butenko

“…Moreover, the article shows the importance for police work of such an individual property of a person as the level of internality, which determines the ability of a person to control and manage his/her behaviour, take responsibility for his/her own actions, influence the formation and development of such internal factors as motivation, efficiency of decision-making in stressful situations. Finally, it is concluded that the interrelation of external and internal components is important for determining the level of professional success of a police officer.…”
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ISMIP6-based Antarctic projections to 2100: simulations with the BISICLES ice sheet model by J. F. O'Neill, T. L. Edwards, D. F. Martin, C. Shafer, S. L. Cornford, H. L. Seroussi, S. Nowicki, M. Adhikari, L. J. Gregoire

“…Overall, we simulate a sea level contribution range across our experiments from 2 to 178 mm. Finally, we show that collapse of ice shelves due to surface warming increases sea level contribution by 25 mm relative to the no-collapse experiments, for both moderate and high sensitivity of ice shelf melting to ocean forcing.…”
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Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis by Blessy Kiruba, Akshayata Naidu, Vino Sundararajan, Sajitha Lulu S

“…To understand the regulatory mechanism through which these hub genes function in the diseased state, their associations with transcription factors, and non-coding RNAs in different immune cell types were investigated through correlation analysis and regression models. Finally, by integrating these findings, distinct gene regulatory networks were constructed, which provide a novel perspective on the molecular, cellular, and immunological landscapes of SLE. …”
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Machine Learning-Based predictive model for adolescent metabolic syndrome: Utilizing data from NHANES 2007–2016 by Yu-zhen Zhang, Hai-ying Wu, Run-wei Ma, Bo Feng, Rui Yang, Xiao-gang Chen, Min-xiao Li, Li-ming Cheng

“…We further interpreted the LGB model using SHAP, the SHAP hive plot showed that the predictor variables were, in descending order of importance, BMI age sex-specific percentage, weight, upper arm circumference, thigh length, and race. Finally, we deployed it online for broader accessibility. …”
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La Asociación Obrera Textil (1945-1955): la dinámica sindical en los sindicatos peronistas by Marcos Schiavi

“… La Asociación Obrera Textil fue fundada a finales de 1945, pocos días después del 17 de octubre. …”
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Study on the Stability and Control of Gob-Side Entry Retaining in Paste Backfill Working Face by Changtao Xu, Xiangyu Wang, Dingchao Chen, Guanghui Wang, Zhenpeng Niu, Huixing Lu

“…It was found that as the working face advanced, the backfill material and the overlying strata gradually formed a stable composite structure, with the abutment stress in the mining area stabilizing over time. Finally, to address the issue of insufficient initial strength and limited support capacity of the paste backfill material, a comprehensive control system for surrounding rock stability was proposed. …”
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DPD-YOLO: dense pineapple fruit target detection algorithm in complex environments based on YOLOv8 combined with attention mechanism by Cong Lin, Wencheng Jiang, Weiye Zhao, Lilan Zou, Zhong Xue

“…Additionally, Focaler-IoU has been employed to improve CIoU, allowing the network to focus more on small targets. Finally, high-resolution images of the pineapple fields were captured using drones to create a dataset, and extensive experiments were conducted. …”
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A Point Cloud-Based Feature Recognition and Path Planning Method by Changhong Chen, Shaofeng Wang, Shunzhou Huang

“…Second, the robot vision system collects the point cloud information of the area to be inspected and performs point cloud splicing, the accuracy of the original data, the removal of noise such as invalid points, outliers and internal noise points, on this basis, the boundary curve of the hole to be inspected was extracted, the cylindrical equation was fitted, its geometric center was calculated, and the central coordinates and axis direction of the contour of the hole to be inspected were obtained. Finally, all the detection paths were traversed through the multibranch tree to obtain the optimal detection path of the detection points of multiple targets. …”
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Predictive Value of Soluble Growth Stimulator Gene 2 Protein for Coronary Slow Flow/No-Reflow in ST-Elevation Myocardial Infarction Patients Receiving Percutaneous Coronary Interve... by Shu-min Chang, Yan-tan Yu, Bo Luan, Ai-jie Hou, Yong Wang

“…Statistically significant differences (P<0.05) were observed in age, diabetes mellitus, sST2 level, neutrophil-to-lymphocyte ratio (NLR), fasting blood sugar, preprocedural blood pressure, intraprocedural hypotension, N-terminal pro-B-type natriuretic peptide, MB isoenzyme of creatine kinase (CK-MB), and cardiac troponin I (cTNI). Multivariate analysis showed that the sST2 level, NLR, and intraoperative hypotension were independent risk factors for CSF/NRF. …”
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The effects of the urotensin-II receptor antagonist palosuran treatment on the corpora cavernosa of streptozotocin-induced diabetic rats by Murat Olukman, Cenk Can, Sibel Ülker, Yiğit Uyanikgil, Türker Çavuşoğlu, Neslihan Düzenli, Deniz Coşkunsever, Fatma G. Kozcu

“…Contraction of CC induced by potassium chloride, phenylephrine, and NG-nitro-L-arginine methyl ester and relaxation of CC induced by electrical field stimulation (EFS) and sodium nitroprusside (SNP) (endothelium-dependent and endothelium-independent stimuli, respectively), and Y-27632 (Rho-kinase inhibitor) were examined in organ baths. Direct contraction or relaxation induced by palosuran and urotensin-II (U-II) were also evaluated. …”
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Automatic Classification of Difficulty of Texts From Eye Gaze and Physiological Measures of L2 English Speakers by Javier Melo, Leigh Fernandez, Shoya Ishimaru

“…These findings support refining subjective difficulty detection models and their implementation in adaptive language learning systems. Finally, this work contributes to the field of cognitive science and technology by laying the foundation for innovative approaches to cognitive state detection.…”
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Cumbre de Sistemas Alimentarios de la ONU 2021: Desmantelando la democracia y restableciendo el control corporativo de los sistemas alimentarios by Matthew Canfield, Molly D Anderson, Philip McMichael

“… Este artículo analiza el desarrollo y la organización de la Cumbre de Sistemas Alimentarios de las Naciones Unidas (UNFSS), que está siendo convocada por el Secretario General de la ONU, António Guterres, a finales de 2021. Aunque pocas personas discutirán que los sistemas alimentarios globales necesitan transformación, ha quedado claro que la Cumbre es, en cambio, un esfuerzo de una poderosa alianza de corporaciones multinacionales, organizaciones filantrópicas y países orientados a la exportación para subvertir las instituciones multilaterales de gobernanza alimentaria y capturar la narrativa global de la “transformación de los sistemas alimentarios”. …”
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Large-scale high purity and brightness structural color generation in layered thin film structures via coupled cavity resonance by Wang Danyan, Ji Chengang, Li Moxin, Xing Zhenyu, Gao Hao, Li Xiaochan, Zhou Huixian, Hu Yuhui, Lin Zhelin, Zhang Cheng

“…For instance, we demonstrate the production of angle-robust structural colors by utilizing high-index Ta2O5 as the dielectric layer. Finally, we showcase a series of printed color images based on the proposed structures. …”
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