Exploring the Mechanism of Antioxidant Action of Bitter Almond Based on Network Pharmacology and Molecular Docking Techniques by Xuehua Feng, Jingya Niu, Zurong Song, Ali Tao, Rumin Zong, Wenqing Pei, Panpan Gong

“…The active ingredients of bitter almond were obtained through the traditional Chinese medicine systematic pharmacology database and analysis platform (TCMSP), and the main active ingredients were screened by bioavailability (OB) and drug-like properties (DL); the GeneCards database was used to search antioxidant-related disease targets through the traditional Chinese medicine systematic pharmacology database and analysis; building a “drug-disease-target” visual network map with Cytoscape 3.9.0 software; a protein interaction (PPI) network was constructed using STRING website and core targets were screened; GO function and KEGG pathway enrichment analysis were obtained using Metoscape. Finally, SailVina software was used to molecularly dock the major active ingredients and target proteins and visualize them using PyMOL software. …”
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Age-related aspects of glioma: current understanding. Literature review by Serhii P. Luhovskyi, Tetiana Y. Kvitnytska-Ryzhova

“…Moreover, pLGG differs from aLGG in its potential for malignant transformation and spontaneous regression, as well as in mutations affecting the MAPK (mitogen-activated protein kinase) pathway. While pediatric-type and adult-type high-grade gliomas (pHGG and aHGG) share histological features, they differ in location, biological behavior, molecular-genetic profiles, and prognosis. …”
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Study on Fracture and Stress Evolution Characteristics of Ultra-Thick Hard Sandstone Roof in the Fully Mechanized Mining Face with Large Mining Height: A Case Study of Xiaojihan Co... by Feng Ju, Meng Xiao, Zequan He, Pai Ning, Peng Huang

“…Moreover, the fracture structure consistency was verified through physical simulation and a field measurement method. Finally, the stress evolution laws in the ultra-thick hard sandstone roof fracture were studied through numerical simulation. …”
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Experimental Study on Physicomechanical Properties of Deep Sandstone by Coupling of Dry-Wet Cycles and Acidic Environment by Xin Huang, Jianyong Pang, Guangcheng Liu, Yu Chen

“…Uniaxial compressive strength tests and microtests were carried out. Finally, using a combination of scanning electron microscopy (SEM) and backscatter electron images (BSE), the microstructural changes of sandstone under the combined action of an acidic environment and a dry-wet cycle were described. …”
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Analyzing the Perspectives of Instructors of General Medical Modules on the Inclusion of Health Humanities Fundamentals in the Curriculum by SeyedAmir Mohseni, Fattaneh Amuei, Siavash Moradi

“…These codes were categorized into 14 categories, which were finally placed in two more general themes of “necessity” and “how”. …”
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Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney by Hui Zou, Jie Song, Xianzu Luo, Waseem Ali, Sifan Li, Ling Xiong, Yan Chen, Yan Yuan, Yonggang Ma, Xishuai Tong, Zongping Liu

“…In addition, treatment of Cd and PVC-MPs alone caused mitochondrial damage, increase or decrease of mitochondria-associated proteins (Fis1, Drp1, PGC-1α, Nrf1), and Nrf2 signaling pathway plays a key role in detoxification and alleviation of oxidative stress, and we found that PVC-MPs+Cd treatment recovered related proteins (Nrf2, Keap-1, HO-1, NQO1, AC-SOD2, SOD2) compared with the Cd and PVC-MPs alone treatment. Finally, we detected changes in apoptosis-related proteins and genes (Caspase-3, Caspase-9, Bax, Bcl-2, Cytc) and TUNEL staining, and after PVC-MPs+Cd treatment, apoptosis-related proteins/genes recovered and the apoptosis rate decreased compared with the Cd and PVC-MPs alone treatment. …”
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Design dimensions of electrocutaneous warning stimulation patterns in workplace safety devices. by Eva-Maria Dölker, Stephan Lau, Maria Anne Bernhard, Jens Haueisen

“…Participants rated the perceived amplitude on a scale from 1 to 9 after a training phase. Finally, we presented five consecutive stimulation pulses in a pseudo-random order at eight electrode pair positions, asking participants to report the stimulated electrode pair. …”
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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice by Jia-Jin Wu, Xiaoyu Zheng, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen

“…Microbial elimination and fecal microbiota transplantation (FMT) experiments were then conducted to confirm the efficacy of melatonin through regulating gut microbiota. Finally, a lipopolysaccharide (LPS)-challenged experiment was performed to verify the mechanism by which melatonin alleviates HS-induced reproductive impairment. …”
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Accuracy of Teledentistry for Diagnosis and Treatment Planning of Pediatric Patients during COVID-19 Pandemic by Ozra Golsanamloo, Sanaz Iranizadeh, Amir Reza Jamei Khosroshahi, Leila Erfanparast, Ali Vafaei, Yalda Ahmadinia, Solmaz Maleki Dizaj

“…Then, teledentistry can be considered as a supplement to clinical examinations of pediatric dentistry, finally resulting in better patient management. However, more studies are necessary for teledentistry.…”
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Limitations of temporal (forehead) temperature readings as a screening method for covid-19 by Luis Fernando Aragón-Vargas

“…., 2020; Sainati & Biffi, 2020); this type of screening is also commonly observed in TV reports before people are admitted to health care clinics, restaurants, worksites, or public transportation. Finally, screening for fever is part of the World Health Organization recommendations for management of ill travelers at international borders (World Health Organization [WHO], 2020). …”
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Which combination of medical expulsive therapy is more effective for treatment of distal ureteral stone in adults? A systematic review and network meta-analysis by Maryam Taheri, Nasrin Borumandnia, Hamidreza Abdi, Amir H Kashi, Setareh Nourani, Sogand Sheikholeslami, Yasamin Maleki Gilvaei, Pardis Ziaeefar, Abbas Basiri

“…The combination MET of α-blockers with PDE-5 inhibitors (MD: -3.8, CI=-7.0, -0.5) showed significantly lower SET compared to α-blockers alone. Finally, combination MET of α-blockers with PDE-5 inhibitors (MD:1.0, CI = 0.4,1.7) and nifedipine with corticosteroids (MD:1.2, CI = 0.4,1.9) showed a significant decrease in analgesia use. …”
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Continuous Patient-Independent Estimation of Respiratory Rate and Blood Pressure Using Robust Spectro-Temporal Features Derived From Photoplethysmogram Only by Muhammad Ahmad Sultan, Wala Saadeh

“…For fewer computations and accurate measurements of BP, the most significant features are selected using correlation and mutual information measures in the feature engineering part. Finally, RR and BP are estimated using breath counting and a neural network regression model, respectively. …”
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Automated MSCT Analysis for Planning Left Atrial Appendage Occlusion Using Artificial Intelligence by Kilian Michiels, Eva Heffinck, Patricio Astudillo, Ivan Wong, Peter Mortier, Alessandra Maria Bavo

“…The difference between the automatically predicted and manually measured perimeter-based diameter was −0.8 ± 1.3 mm (anatomical ostium), −1.0 ± 1.5 mm (Amulet landing zone), and −0.1 ± 1.3 mm (Watchman FLX landing zone), which is similar to the operator variability on these measurements. Finally, the detected mitral valve annulus and fossa ovalis were close to the manual detection of these landmarks, as shown by the Hausdorff distance (3.9 ± 1.2 mm and 4.8 ± 1.8 mm, respectively). …”
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Evaluation of Rapeseed Leave Segmentation Accuracy Using Binocular Stereo Vision 3D Point Clouds by Lili Zhang, Shuangyue Shi, Muhammad Zain, Binqian Sun, Dongwei Han, Chengming Sun

“…Furthermore, the study results show that combining plane fitting with pass-through filtering effectively removes the ground point cloud noise, while statistical filtering successfully denoises outlier noise points generated during scanning. Finally, using the region-growing algorithm during the seedling stage with a normal angle threshold set at 5.0/180.0* M_PI and a curvature threshold set at 1.5 helps to avoid the under-segmentation and over-segmentation issues, achieving complete segmentation of rapeseed seedling leaves, while the LCCP clustering method fully segments rapeseed leaves at the bolting stage. …”
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Systematic review and bayesian network meta-analysis: comparative efficacy and safety of six commonly used biologic therapies for moderate-to-severe Crohn’s disease by Haohang Su, Haohang Su, Shengwei Xiao, Zhiqing Liang, Zhiqing Liang, Tianrong Xun, Jinfang Zhang, Jinfang Zhang, Xixiao Yang, Xixiao Yang

“…A random-effects model was performed with rankings according to the surface under cumulative ranking curve (SUCRA) probability. Finally, we completed sensitivity and consistency analyses, and evaluated the certainty of evidence through GRADE working group guidance.ResultsWe identified 22 and 20 RCTs for induction and maintenance therapy, respectively. …”
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Gastric precancerous conditions or lesions and Helicobacter pylori by M Areia, M. Dinis-Ribeiro

“…Two studies provided further insights regarding the relation between dynamic tuft cell expansion, gastric precancerous conditions, and dysplasia and between gastric cancer and gastric diffuse large B-cell or mucosa-associated lymphoid tissue lymphomas. Finally, a new review article about gastric cancer in Western countries updates the data supporting primary prevention by H. pylori eradication, but also secondary prevention by endoscopic surveillance of precancerous conditions or endoscopic screening when combined with a colonoscopy performed for colorectal screening.…”
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Variability of Scots pine (<i>Pinus sylvestris</i> L.) plus trees in the Middle and Upper Volga Region with the use of ISSR markers by O. V. Sheikina, E. M. Romanov

“…The genetic variabil ity varied within the following limits: 95.7–96.9 %, polymorphic loci; 1.96–1.97, the number of alleles per locus; 1.31–1.48, the number of effective alleles per locus: finally, 0.291–0.429, Shannon’s index; 0.205–0.298, the expected heterozygosity. …”
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Identification of Potential Abnormal Methylation-Modified Genes in Coronary Artery Ectasia by Xiuchun Yang, Yijun Zong, Zhentian Zhang, Yan Zhao, Xueying Gao, Jie Zhang, Qian Hou, Renyi Li, Bing Xiao

“…Then, the DNA methylation profile of CAE was downloaded from GSE87016 (HumanMethylation450 BeadChip data, involving 11 cases and 12 normal controls) to identify differentially methylated genes (DMGs). Finally, after taking interaction genes between DEGs and DMGs, abnormal methylation-modified genes were identified, followed by protein–protein interaction analysis and expression validation using reverse transcriptase polymerase chain reaction. …”
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Photovoltaic Farm Production Forecasting: Modified Metaheuristic Optimized Long Short-Term Memory-Based Networks Approach by Aleksandar Stojkovic, Bosko Nikolic, Miodrag Zivkovic, Nebojsa Bacanin

“…The best produced models attained mean squared error (MSE) scores of only 0.007297 for Indian Plant 1, 0.007662 for Indian Plant 2, and 0.001812 for Institute Mihailo Pupin dataset, emphasizing considerable potential of the suggested approach for real-world applications. Finally, the applicability of the top-performance models was validated with tiny machine learning (TinyML).…”
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Mechanistic studies on regulation of the activity of GPI-anchored serine protease testisin by WAN Jiahui, ZHOU Aiwu

“…The self-cleavage site of the protease was identified by using Edman degradation and site-directed mutagenesis. Finally, the regulatory mechanism of protease activity was examined by analyzing the proteolytic rate of the protein towards its substrates.Results·The recombinant mTN zymogen was expressed in eukaryotic HEK293S cells, and high-purity, uniform recombinant protein was obtained through a two-step purification process. …”
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