Characterization of YdgH: a mediator of beta-lactam susceptibility in Enterobacterales by Jacob E. Lazarus, Matthew K. Waldor, David C. Hooper

“…We found that deletion of ydgH neither affects ompC or ompF transcript levels, nor does it alter the processing of lipopolysaccharide, nor does it activate the sigma E regulon alone or in combination with mutations in other periplasmic proteins. Finally, we delineate the results of a genetic screen for spontaneous mutants that complement the detergent susceptibility phenotype, the results of which may fuel the further studies that are necessary to determine the precise role YdgH plays in bacterial physiology.IMPORTANCEBeta-lactams such as penicillins and cephalosporins are the most commonly prescribed antibiotics for serious bacterial infections. …”
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Psychometric properties of the Chinese version of the body image life disengagement questionnaire in a sample of adolescents by Kun Zhang, Huixing Huang, Qiaosong Wang, Lin Ye, Rongjin Lin

“…The reliability of the instrument was verified using Cronbach’s alpha and the intraclass correlation coefficient (ICC). Finally, the convergent validity of the instrument was verified by correlating the BILD-Q scores with the EAT and BAS-2 scores. …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…Next, the evaluation was performed using the Receiver Operating Characteristic (ROC) curve, calibration curve, and decision curve analysis. Finally, the external validation was completed using the data of 496 patients with intracerebral hemorrhage from the Jinjiang Hospital of Traditional Chinese Medicine.ResultsIn the training and test sets of intracerebral hemorrhage, the incidence of poor prognosis was 60.53 and 61.46%, respectively. …”
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Toward Privacy Preservation Using Clustering Based Anonymization: Recent Advances and Future Research Outlook by Abdul Majeed, Safiullah Khan, Seong Oun Hwang

“…., key assertion(s), strengths, weaknesses, clustering methods used in the anonymization process, and %age improvements in quantitative results) about each technique that provides a clear view of how much this topic has been investigated thus far, and what are the research gaps that seek pertinent solutions in the near future. Finally, we discuss the technical challenges of applying CAMs, and we suggest promising opportunities for future research. …”
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Identification of the Role of Mume fructus in Treating Nocturnal Asthma Based on Network Pharmacology and In vitro Investigation by Ling-Ling Tang, Yan-Qiu Xu, Ying Yang, Xian-Hong Sun, Bo-Han Wang, Xiao-Lu Shi, Li Liu

“…Results: Network pharmacology analyses were mainly enriched in nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK) pathway, and interleukin (IL)-6. Mume fructus and LPS had no effect on viability, proliferation, and apoptosis in 16HBE and RAW264.7 cells under certain concentration conditions. …”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

“…Thepredictive factors studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing factor in mobilization, the central venous catheter insertion site, cytapheresis count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low molecular weight heparin .The statistical analysis focused on a univariate study, followed by a multivariate analysis using binary logistic regression. …”
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Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism by Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu

“…To evaluate changes in serum TMAO levels, targeted metabolomics was performed. Finally, the study looked at the intrinsic relationships among modifications in the intestinal flora, metabolite profile changes, and the targets of SMI compounds to clarify how they might be used to treat H-HF. …”
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Intrinsically Noncombustible Thermosets from Sulfur-Containing Epoxy Resin and Benzoxazines: Evaluation of Thermal and Mechanical Properties by Ya Lyu, Haibo Fan, Liliang Qiu

“…The TBP-fa/EPS copolymer also exhibited excellent flame retardancy in cone calorimeter measurement. Finally, the glass transition temperature of the TBP-fa/EPS copolymer at a ratio of 5 : 5 (w/w) reached as high as 289°C. …”
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Understanding North Korea: Rimjin-gang Citizen Journalists Out to Cure the “Sick Man of Asia”? by Suzy Kim

“…But this it hardly covered in the Western media, and it seems the news has finally reached across the Pacific with the publication of the magazine's first English edition in October 2010. …”
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Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

“…ApoE−/−MAPK6flox/floxTEKCre mice finally confirmed that conditional MAPK6 knockout resulted in endothelial inflammation and significant increases in plaque areas. …”
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Two new strains of Streptomyces with metabolic potential for biological control of pear black spot disease by Yi-Huang Chen, Jia-Xing Zhang, Yan Min, Yang Liu, Jian-Ming Wang, Lin-Quan Bai, Xiao-Xia Luo

“…The biocontrol potential of the strain was further substantiated through a combination of plate experiments, gene cluster biopathway resolution and mass spectrometry validation of metabolites. Finally, the biocontrol efficacy of the strain was confirmed through fruit control experiments. …”
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Multi-Timescale Battery-Charging Optimization for Electric Heavy-Duty Truck Battery-Swapping Stations, Considering Source–Load–Storage Uncertainty by Peijun Shi, Guojian Ni, Rifeng Jin, Haibo Wang, Jinsong Wang, Zhongwei Sun, Guizhi Qiu

“…With the widespread adoption of renewable energy sources like wind power and photovoltaic (PV) power, uncertainties in the renewable energy output and the battery-swapping demand for electric heavy-duty trucks make it challenging for battery-swapping stations to optimize battery-charging management centrally. …”
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Modelling the Transition from Shear-Driven Turbulence to Convective Turbulence in a Vertical Heated Pipe by Shijun Chu, Elena Marensi, Ashley P. Willis

“…This is particularly important when shear turbulence starts to be suppressed at intermediate buoyancy numbers. Finally, at such intermediate buoyancy numbers, we confirm that the decay of localised shear turbulence in the heated pipe flow follows a memoryless process, similar to that in isothermal flow. …”
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Should we consider microbiota-based interventions as a novel therapeutic strategy for schizophrenia? A systematic review and meta-analysis by Lucas Hassib, Alexandre Kanashiro, João Francisco Cordeiro Pedrazzi, Bárbara Ferreira Vercesi, Sayuri Higa, Íris Arruda, Yago Soares, Adriana de Jesus de Souza, Alceu Afonso Jordão, Francisco Silveira Guimarães, Frederico Rogério Ferreira

“…This review also discusses clinical and preclinical studies to elucidate the neural, immune, and metabolic pathways by which microbiota manipulation, particularly with Lactobacillus and Bifidobacterium genera, may exert beneficial effects on schizophrenia symptoms via the gut-brain axis. Finally, we address the main confounding factors identified in our systematic review, highlight key limitations, and offer recommendations to guide future high-quality trials with larger participant cohorts to explore microbiome-based therapies as a primary or adjunctive treatment for schizophrenia.…”
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The Pareto effect in tipping social networks: from minority to majority by J. P. Everall, F. Tschofenig, F. Tschofenig, J. F. Donges, J. F. Donges, I. M. Otto

“…These results indicate the potential, but not the inevitability, of rapid social change in certain susceptible populations and contexts. Finally, we provide practical guidance for facilitating difficult norm changes by (1) leveraging trusted community structures and building critical mass in clustered networks (particularly in the 10 %–43 % threshold range), (2) adapting strategies based on norm type and context, and (3) targeting groups with moderate preferences and network positions – avoiding reliance on highly central or well-connected individuals – to enable endogenous spread.…”
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The Genoese consuls of Tana (Azak) according to the tax registers from the State Archives of Genoa: the chronology of consulates (1449–1475) by Karpov S.P.

“…Research results and scientific novelty: the clarification of the dates of the rules of the Genoese consuls of Tana makes it possible to reconstruct the events and circumstances of the political history of the region in the middle of the 15th century, after the capture of Constantinople by the Turks in 1453, to obtain more accurate dates of events, and finally to prove the existence of the Genoese Tana, albeit declining in size until the Ottoman conquest in 1475.…”
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BuDDI: Bulk Deconvolution with Domain Invariance to predict cell-type-specific perturbations from bulk. by Natalie R Davidson, Fan Zhang, Casey S Greene

“…Then we validated that BuDDI could accurately predict cell-type-specific perturbation response when no single-cell perturbed profiles were used during training; instead, only bulk samples had both perturbed and non-perturbed observations. Finally, we validated BuDDI on predicting sex-specific differences, an experimental design where it is not possible to have matched samples. …”
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Instability Mode and Control Technology of Surrounding Rock in Composite Roof Coal Roadway under Multiple Dynamic Pressure Disturbances by Peng Wang, Nong Zhang, Jiaguang Kan, Xingliang Xu, Guangzhen Cui

“…The support scheme was finally applied to the on-site industrial test, and the mine pressure monitoring results showed that the deformation of the roadway surrounding rock was effectively controlled under the new support scheme.…”
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Experimental and Numerical Evaluation of Shear Strength of Directly and Indirectly Loaded Flanged Recycled Self-Compacted Reinforced Concrete Deep Beams by Thamer Hussein Amer Alhussein, Jamal Abdul Samad Khudhair

“…The ultimate strength calculated using ACI318-14 and AASHTO LRFD 2012 was on average 38% and 52% lower than the experimental data, respectively, which reflects the conservative nature of this approach. Finally, 3D finite element models were created to investigate the responses of the beams. …”
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Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…The expressions of phosphate (p)-p38, c-Jun N-terminal kinase (JNK), activator protein 1 (AP-1), B-cell lymphoma-2 (Bcl-2) protein in colon cancer tissues and cells were significantly higher than in precancerous tissues or CCD-18Co cells (P-values < 0.05). …”
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