mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular Endothelial Barrier by Shan-Shan Meng, Feng-Mei Guo, Li-Li Huang, Ying-Zi Huang, Jian-Feng Xie, Cong-Shan Yang, Hai-Bo Qiu, Yi Yang

“…Studies have exhibited the mammalian TORC1 (mTORC1) signaling is of potent angiogenesis effects. The mTOR protein kinase has two distinct multiprotein complexes mTORC1 and mTORC2 that regulate different branches of the mTOR network. …”
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Characterization of Somatic Mutations in Malaysian Luminal Breast Cancer by Yock Ping Chow, Ryia Illani Mohd Yunos, Isa Mohd Rose, Norlia Abdullah, Rohaizak Muhammad, Shahrun Niza Abdullah Suhaimi, Saladina Jaszle Jasmin, Norshahidah Mahamad Nadzir, Nurul-Syakima Ab Mutalib, Rahman Jamal

“…PIK3CA is the most frequently mutated gene in our discovery cohort of patients (n=4/9). Kinases and phosphatases were found as the most significantly enriched mutated genes (enrichment score = 3.12), with all nine luminal breast cancer samples harboring at least one non-synonymous mutation in this cluster of genes. …”
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Sociometric network analysis in illicit drugs research: A scoping review. by Naomi Zakimi, Alissa Greer, Martin Bouchard, Arshpreet Dhillon, Alison Ritter

“…The second domain, public health, focused on the social networks and social support of people who use drugs. Finally, the third domain focused on the collaboration networks of policy, law enforcement, and service providers.…”
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Point-of-care lung ultrasonography for early identification of mild COVID-19: a prospective cohort of outpatients in a Swiss screening center by Olivier Hugli, Jean-Yves Meuwly, Noémie Boillat-Blanco, Pierre-Nicolas Carron, Siméon Schaad, Thomas Brahier, Mary-Anne Hartley, Jean-Baptiste Cordonnier, Luca Bosso, Tanguy Espejo, Olivier Pantet

“…Two blinded independent experts reviewed LUS recording and classified abnormal findings according to prespecified criteria to investigate their predictive value to diagnose SARS-CoV-2 infection according to PCR on nasopharyngeal swabs (COVID-19 positive vs COVID-19 negative).Primary and secondary outcome measures We finally combined LUS and clinical findings to derive a multivariate logistic regression diagnostic score.Results Of 134 included patients, 23% (n=30/134) were COVID-19 positive and 77% (n=103/134) were COVID-19 negative; 85%, (n=114/134) cases were previously healthy healthcare workers presenting within 2–5 days of symptom onset (IQR). …”
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Analysis of players and scenarios of the Iranian aluminum industry with a combination of fuzzy DEMATEL and game theory by Maryam Musavi-Nogholi, Mohammad Taghi Rezvan

“…The purpose is to identify and analyze the upcoming scenarios of the aluminum industry and, finally, its market analysis, to draw a correct vision of the future and choose the appropriate strategy in this industry.Methodology: Firstly, the key variables affecting the development of the aluminum industry are identified through interviews with experts and specialists in the industry, and the probability of variables is determined by completing a questionnaire; and then based on the extracted variables, specific scenarios are developed. …”
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Implementation of Distributed Generation with Solar Plants in a 132 kV Grid Station at Layyah Using ETAP by Ghulam Mujtaba, Zeeshan Rashid, Farhana Umer, Shadi Khan Baloch, G. Amjad Hussain, Muhammad Usman Haider

“…Furthermore, the voltage profile improves, the power factor enhances, and the line losses reduce to a great extent. Finally, overloaded transformers and distribution lines also return to normal working conditions.…”
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Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom by Alice Mentana, Virgilio Quaresima, Pavel Kundrát, Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Andrea Previtali, Giorgia Santi Amantini, Luca Lunati, Virginia Boretti, Livio Narici, Luca Di Fino, Luca Bocchini, Claudio Cipriani, Giorgio Baiocco

“…However, our results demonstrate that great care is needed when applying weighting factors as a function of incident neutron energy only, not explicitly considering RBE variation in the target. Finally, to facilitate the use of our results, we propose look-up RBE tables, explicitly considering the depth variable, and an analytical representation of the maximal RBE vs. neutron energy.…”
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Perspectivas de una producción sostenible en acuicultura multitrófica integrada (IMTA): una revisión by D. C. Naspirán-Jojoa, A. G. Fajardo-Rosero, M. Ueno-Fukura, L. F. Collazos-Lasso

“…Aplicada, la producción IMTA puede mejorar la sostenibilidad de la acuicultura al reducir el impacto de los efluentes y generar mayor rentabilidad económica, debido a la producción simultanea de dos o más productos finales y al uso mínimo de fertilizantes. El objetivo de la presente revisión es presentar los fundamentos básicos de los sistemas de IMTA, como una alternativa a los sistemas de producción en piscicultura.…”
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Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma by Kai Zhang, Kai Zhang, Luyao Wang, Huili Chen, Lili Deng, Mengling Hu, Ziqiang Wang, Yiluo Xie, Chaoqun Lian, Xiaojing Wang, Xiaojing Wang, Jing Zhang

“…Based on the prognostic model, LUAD patients were classified into different nucleotide metabolism subtypes, and the differences between patients of different subtypes were explored in terms of genomic mutations, functional enrichment, tumor immune characteristics, and immunotherapy responses. Finally, the key gene SNRPA was screened, and a series of in vitro experiments were performed on LUAD cell lines to explore the role of SNRPA in LUAD.ResultLUAD patients could be accurately categorized into subtypes based on the nucleotide metabolism-related prognostic risk score (NMBRS). …”
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Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro. by Justin Komguep Nono, Katrien Pletinckx, Manfred B Lutz, Klaus Brehm

“…While none of the larvae induced the secretion of pro-inflammatory IL-12p70, the production of immunosuppressive IL-10 was elevated in response to primary cell E/S-products. Finally, upon incubation with DC and naïve T-cells, E/S-products from metacestode vesicles led to a significant expansion of Foxp3+ T cells in vitro.…”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…Additionally, immune simulations showed elevated levels of cell-mediated immunity, while repeated exposure simulations indicated rapid antigen clearance. Finally, in silico cloning was performed using the expression vector pET28a (+) with optimized restriction sites to develop a viable strategy for large-scale production of the chosen vaccine constructs. …”
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Molecular Epidemiology of Human Norovirus Variants from Outbreaks in Zhejiang Province, China, during 2021 by Yi Sun, Yongjuan Yuan, Haiyan Mao, Lingxuan Su, Qiong Ge, Jian Gao, Changping Xu, Liming Gong

“…Furthermore, the whole genomes of positive samples were sequenced, enabling the characterization of both nucleotide and amino acid differences within the virus. Finally, phylogenetic trees were constructed to further analyze and understand the genetic relationships among the detected viruses. …”
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Data-Driven Bearing Fault Diagnosis of Microgrid Network Power Device Based on a Stacked Denoising Autoencoder in Deep Learning and Clustering by Fast Search without Data Labels by Fan Xu, Xin Shu, Xin Li, Xiaodi Zhang

“…The root mean square (RMS), kurtosis, Shannon entropy (SHE), approximate entropy (AE), permutation entropy (PE), and principal component analysis (PCA) are also used to construct the HI. Finally, the results show that the performance of the method (SDAE-CFS) presented is superior to other combination HI models, such as EEMD-SVD-FCM/k-means/k-medoids, stacked autoencoder-CFS (SAE-CFS), RMS, kurtosis, SHE, AE, PE, and PCA.…”
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Prognostic impact of primary versus secondary resistance to sorafenib in patients with HCC by Jin Lei, Hongyuan Dai, Ya Zhang, Guangling Ou, Zhi Peng Liang, Yinying Lu, Haiyang Li

“…Compared with tyrosine kinase inhibitor (TKI) monotherapy, the use of TKI plus PD-1 inhibitor combination therapy as second-line treatment conferred a longer median PFS (6.0 vs 10.0 months, p  < 0.001) and OS (13.0 vs 22.0 months, p  < 0.001). …”
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Advancing Pandemic Preparedness in Healthcare 5.0: A Survey of Federated Learning Applications by Saeed Hamood Alsamhi, Ammar Hawbani, Alexey V. Shvetsov, Santosh Kumar

“…Moreover, we speculate on the potential scenarios where FL could enhance pandemic preparedness and make healthcare more resilient. Finally, we recommend that policymakers, technologists, and educators address potential challenges and maximize the benefits of FL in Healthcare 5.0. …”
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Effective Removal of Malachite Green from Aqueous Solutions Using Magnetic Nanocomposite: Synthesis, Characterization, and Equilibrium Study by Ali Q. Alorabi

“…The desorption of MG dye from Fe3O4@AJPL was performed using a solution of 90% ethanol. Finally, it could be concluded that the designed Fe3O4@AJPL magnetic nanocomposite will be a cost-effective and promising adsorbent for the elimination of MG from aqueous media.…”
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Research priorities for autosomal dominant polycystic kidney disease: a UK priority setting partnership by Tess Harris, Albert Ong, Paul J D Winyard, Richard N Sandford, Maryrose Tarpey, Hannah R Bridges, Wendy D Brown, Natasha L O’Brien, Ann C Daly, Bharat K Jindal, Gillian S Mundy, Albert J Power, John Sayer, Roslyn J Simms, Patricia D Wilson

“…These were refined into indicative questions with Steering Group oversight. Finally, the 10 most important questions were established via a survey and online consensus workshop.Setting UK.Participants 747 survey respondents (76% patients, 13% carers, 11% healthcare professionals); 23 workshop attendees.Results 117 uncertainties in ADPKD care were identified and refined into 35 indicative questions. …”
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Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…Therefore, OI protected mice from Con A-induced liver damage and may be associated with Nrf2 activation and NF-𝜅B inhibition. Finally, our study revealed that OI inhibited TNF-α, or supernatants from Con A-treated RAW264.7 cells induced hepatocyte apoptosis. …”
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Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis by Subhash Chander, Ahmad Bin Aamir, Rabia Latif, Om Parkash, F. N. U. Sorath, Sam Tan, Abhi Chand Lohana, Sheena Shiwlani, Mohammed Yaqub Nadeem

“…Results Our search strategy yielded 5861 studies, of which 1960 duplicate entries were removed in the prescreening stage, 3326 were excluded after title/abstract screening, and 519 after full-text screening for not meeting our inclusion criteria. Finally, 11 studies were included in the analysis, and two more were selected from the bibliography list of previous reviews. …”
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A Step Forward Towards Exploring Nutritional and Biological Potential of Mushrooms: A Case Study of Calocybe gambosa (Fr.) Donk Wild Growing in Serbia by Jovana Dragan Petrovic, Ângela Fernandes, Dejan Stojković, Marina Soković, Lillian Barros, Isabel C.F.R. Ferreira, Aditya Shekhar, Jasmina Glamočlija

“…Nevertheless, at a sub-inhibitory level, the methanolic extract disrupted cell-to-cell communication using Pseudomonas aeruginosa PAO1 as a model system. Finally, enrichment of oatmeal cookies with C. gambosa flakes not only improved their nutritional value, but was praised among the participants in sensory evaluation test, indicating that along with results of chemical composition and biological activity, this mushroom has a potential to be regarded as functional food.…”
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