Biomechanical Modeling and Evaluation of Buttocks Automatic Assisted Repositioning in Bedridden Patients by Liqing Yang, Ganjun Song, Di Luo, Haotian Xu, Jiamei Han, Mingzhao Xiao, Dingqun Bai, Shan Tian, Wensheng Hou, Jisi Tang, Xin Zhang, Lin Chen

“…Inverse modeling was used to reconstruct the 3D shape of the buttocks, nodal equivalence techniques were employed to simplify the mesh and accurately represent internal tissue contacts, and soft tissue parameters were optimized using Response Surface Methodology (RSM). Finally, finite element (FE) analysis was conducted to evaluate the biomechanical responses and optimize the repositioning strategies. …”
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Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…After filtering using methods such as phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking, six potentially druggable genes (BAK1, AMFR, LAMP3, STK17B, ACP5, and CD9) and six drugs (beclomethasone, propyl pyrazole triol, momelotinib, monoisoamyl-2,3-dimercaptosuccinate, pterostilbene, and naftidrofuryl) that may affect ARHL outcomes were finally identified. Conclusions: Our findings identified 14 potential drug targets for ARHL. …”
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El desvanecimiento del umbral como límite entre el exterior y el interior en la obra de Rogelio Salmona by Edgard Mauricio Carvajal Ronderos

“…Esto lo logra eliminando los cerramientos que dan la idea de un gueto, permitiendo a los visitantes su recorrido en todas las direcciones; esta relación no tiene que ver con la escala o el uso del proyecto, aparece en conjuntos de vivienda, equipamientos o viviendas unifamiliares, de modo que se puede decir sin temor a equivocarse que Salmona trabaja para la ciudad, que entiende al peatón como su cliente y no solo a quien financia sus proyectos, aunque la mayoría de las veces tenga con diferencias con ellos o con los usuarios finales. La metodología que se empleó en la investigación consistió en analizar la forma en que Rogelio Salmona resuelve el acceso a sus proyectos, como es el cerramiento de los mismos, el trabajo de las esquinas, la localización de los edificios en el terreno y la composición de fachada; los proyectos se seleccionaron teniendo en cuenta que fueran de diferentes escalas y tuvieran diversos usos, así comprobaríamos que las operaciones corresponden a una tipología buscada y no como solución a un problema específico.  …”
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Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients by Minjie Li, Yu Gao, Lin Han, Ping Wang, Jie Li, Junhua Song, Shasha Du, Yunfei Zhang, Yumin Lyu

“…Dicentric chromosomes were searched automatically using a high-throughput chromosome analysis system and were then confirmed manually. Finally, the relationships of the frequency of dicentric chromosomes (also referred to as the dic frequency) with acute skin and marrow toxicities were assessed. …”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…This enhanced activity was associated with an enrichment of CD8+ effector T cells in the tumor-microenvironment and upregulation of several effector molecules such as GNLY, GZMB, ZNF683, and HMGN2. Finally, we also showed that the CT3.28H.BBζ CAR we developed was more potent than a recently clinically tested GD2-targeted CAR to control NB growth in vivo.Conclusion Given the robust preclinical activity of CT3.28H.BBζ, these results form a promising basis for further clinical testing in children with NB.…”
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GWAS Identifies SNP Markers and Candidate Genes for Off-Flavours and Protein Content in Faba Bean (<i>Vicia faba</i> L.) by Antonio Lippolis, Boudewijn Hollebrands, Valentina Acierno, Catrienus de Jong, Laurice Pouvreau, João Paulo, Salvador A. Gezan, Luisa M. Trindade

“…Key candidate regulators included genes involved in lipid biosynthesis (<i>ATS2</i>, <i>KAS</i>, <i>LPP</i>), amino acid transport (<i>CAT4</i>) for protein storage, <i>zero tannins locus-1</i> (<i>zt-1</i>), and regulators of the phenylpropanoid pathway, such as a <i>shikimate kinase</i> gene and transcription factors <i>bHLH137-like</i> and <i>MYB</i>. …”
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Dynamic relationships between environment-related technologies, agricultural value added, transport infrastructure and environmental emissions in the five most populous countries by Yinuo Wang, Arshad Ali, Zhaojie Chen

“…The moderating effect of environment-related technologies shows that the application of environment-related technologies in both transportation and agriculture can alleviate environmental pollution. Finally, the threshold level of environment-related technologies shows that as environment-related technologies move from lower threshold levels (≤ − 1.05) to higher threshold levels (> -1.05), agricultural value added and transportation infrastructure investment significantly improve the reduction of environmental contamination. …”
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Evolutionary analysis of slope direction deformation in the Gaojiawan landslide based on time-series InSAR and Kalman filtering. by Jingchuan Yao, Runqing Zhan, Jiliang Guo, Wei Wang, Muce Yuan, Guangyu Li, Bo Zhang, Rui Zhang

“…Subsequently, the combination of ascending and descending orbit data converts the landslide's line of sight (LOS) deformation into along-slope deformation. Finally, the Kalman filtering method is utilized for dynamic reconstruction of the landslide deformation, and an analysis of the evolutionary characteristics of the landslide is conducted to explore its impact on transportation infrastructure, thereby significantly improving the temporal resolution and accuracy of landslide monitoring. …”
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Fragmenty písemností z kavalírské cesty hrabat z Clary-Aldringenu z roku 1727 by Jiří Kubeš

“…They also made some trips through the Netherlands and they observed the most important towns and ports (Amsterdam, the Hague, Rotterdam, Utrecht, etc.). Finally, the paper comes to the conclusion that this journey reminds much more the old style of grand tours. …”
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Identification of new genes regulating nodule development in Medicago truncatula: an in-silico approach by Mahboobeh Azarakhsh, Sara Eslami, Maryam Moghadas, Zahra Ataei

“…This results in the formation of structure named infection thread and initiation of cell division in root cortex and finally formation of functional nodules. Due to the importance of biological nitrogen fixation to improve soil fertility, the molecular mechanism of nodule development is studied extensively. …”
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La diversion comme genre : L’écriture et ses labyrinthes à l’époque élisabéthaine by Sophie Chiari-Lasserre

“…More generally, writers re-shaped labyrinthine discourses in order to respect the ideal of copia which had been defended by Erasmus. Finally, this essay explores the multiple meanings of “erring” for the Renaissance artists, given the fact that many of them played on its different facets (going astray or making a wrong choice), in order to produce “amazing”, and sometimes deceiving, literary works.…”
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Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer by Lei Dou, Yan Yan, Enting Lu, Fangmei Li, Dongli Tian, Lei Deng, Xue Zhang, Rongjin Zhang, Yin Li, Yi Zhang, Ye Sun

“…Then, LC-MS/MS analysis of GFC chemical composition. qRT-PCR, scratch tests, transwell, pseudopodium formation, immunofluorescence, and western blotting were used to explore the mechanism by which GFC inhibited A2780/DDP cell migration and invasion. Finally, the anti-tumor efficacy of GFC was verified by in vivo experiments. …”
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Antibacterial and Antioxidant Activities of Triterpenoids and Cyclic 1,7-Diarylheptanoids from the Stem Bark of Myrica salicifolia: A Combined Experimental and Computational Study by Abraham Dilnesa Gashaw, Kibrom Gebreheiwot Bedane, Taye B. Demissie, Japheth O. Ombito, Estifanos Ele Yaya, Mekonnen Abebayehu Desta

“…The lowest binding affinity for compound 7 was found to be −7.26 to −10.35 kcal/mol against PqsA protein of P. aeruginosa, pyruvate kinase (PK) enzyme of S. aureus, LuxS protein of S. pyogenes, and DNA gyrase B of E. coli, which showed better binding affinity compared to the standard drug ampicillin (−7.36 to −8.03 kcal/mol) and ciprofloxacin (−6.19 to −6.83 kcal/mol). …”
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British Policy and Strategy in the Middle East in 1941: Three Wars ‘East of Suez’ by A. M. Fomin

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Association of the Preoperative Controlling Nutritional Status (CONUT) Score with Clinicopathological Characteristics in Patients with Papillary Thyroid Carcinoma by Doohwa Kim, Myungsoo Im, Soree Ryang, Mijin Kim, Yun Kyung Jeon, Sang Soo Kim, Bo Hyun Kim

“…Results Among the 2,997 PTC patients who underwent total thyroidectomy at Pusan National University Hospital between 2012 and 2016, those without preoperative blood test were excluded (n=149). Finally 2,403 patients were analyzed after excluding 439 patients taking lipid-lowering drugs and six patients without available T stage data after surgery. …”
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Sporoderm-Removed Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway by Jingyan Liu Master degree, Tao Zeng Doctor degree

“…In addition, sporoderm-removed Ganoderma lucidum spore powder treatment was found to inhibit esophageal squamous cell carcinoma cell proliferation, to block the cell cycle, to induce cell apoptosis and to inhibit cell migration and invasion. Finally, we found that sporoderm-removed Ganoderma lucidum spore powder decreased the expression of PI3K/AKT/mTOR and Erk signaling pathways. …”
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Gated communities in mar del plata: territorial ordination and social construction of space by Alejandro Maya

“…In this case, the article pursues a double purpose, namely: a) Highlighting urban transformations and the expansion of gated communities in the south periurban area of the city of Mar del Plata, and b) Examining the role of public and private actors and his intervention in urban areas. Finally, the study showed that the proliferation of closed urbanisations and the urban transformation of the southern territory of the municipality find a foundation in the current regulations in the Strategic Plan, which does not consider the area when planning the growth of the city. …”
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Imaging and Spectral Fitting of Bright Gamma-Ray Sources with the COSI Balloon Payload by Jarred M. Roberts, Steven Boggs, Thomas Siegert, John A. Tomsick, Marco Ajello, Peter von Ballmoos, Jacqueline Beechert, Floriane Cangemi, Savitri Gallego, Pierre Jean, Chris Karwin, Carolyn Kierans, Hadar Lazar, Alex Lowell, Israel Martinez Castellanos, Sean Pike, Clio Sleator, Yong Sheng, Hiroki Yoneda, Andreas Zoglauer

“…Cygnus X-1 was also observed during this flight, and we obtain a measured flux of (1.4 ± 0.2) × 10 ^3 ph cm ^−2 s ^−1 in the same energy band and a best-fit result (including data from NuSTAR, Swift-BAT, and INTEGRAL/IBIS) was a cutoff power law with a high-energy cutoff energy of 138.3 ± 1.0 keV and a photon index of Γ = 1.358 ± 0.002. Finally, we present the measured spectrum of Centaurus A and our best model fit to a power law with a photon index of Γ = 1.73 ± 0.01.…”
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Event-related theta synchronization over sensorimotor areas differs between younger and older adults and is related to bimanual motor control by Andreas Wulff-Abramsson, Ana Zvornik, Keenie Ayla Andersen, Yan Yang, Mikael Novén, Jesper Lundbye-Jensen, Leo Tomasevic, Anke Ninija Karabanov

“…Older adults also showed stronger lateralization, displaying higher theta ERS over the dominant motor cortex. Finally, event-related theta synchronization appeared to be behaviorally relevant across groups and correlated with task performance. …”
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Teaching System Design of Art Design Major under the Background of Economic Management Mode Change by Jiaxin Zheng

“…These methods include the use case diagram of the subsystem, the flow chart of the main module, the system architecture, and the design and application of UML. Finally, this paper designs a test case for the teaching resource management system.…”
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