LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure by Yongjuan Wang, Xiaoli Xie, Hongqun Liu, Huimin Liu, Huiqing Jiang

“…Furthermore, we also found that LR12 activated the p38 mitogen-activated protein kinase (MAPK) pathway in hepatocytes through promoting the secretion of CCL20 from macrophages. …”
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Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by A. N. Chikaev, A. P. Rudometov, Yu. A. Merkulyeva, L. I. Karpenko

“…We provide an outline of phage display technology, briefly describe the design of antibody phage libraries and the affinity selection procedure, and discuss the biology of HIV-1-specific broadly neutralizing antibodies. Finally, we summarize the studies aimed at identification of broadly neutralizing antibodies using various types of phage libraries.…”
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Model of Liver Fibrosis Induction by Thioacetamide in Rats for Regenerative Therapy Studies by Nathaly Enciso, José Amiel, Fredy Fabián-Domínguez, Jhon Pando, Nancy Rojas, Carlos Cisneros-Huamaní, Ernesto Nava, Javier Enciso

“…The protocol used in this work established a model of advanced hepatic fibrosis as corroborated by METAVIR tests of the histological lesions; by the high levels of the markers α-SMA, CD68, and collagen type I; by functional alterations due to elevated markers of the hepatic lesions; and by alterations of the leukocytes, lymphocytes, and platelets. Finally, transplanted cells in the fibrous liver were detected. …”
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Birth cohort studies using symptom diaries for assessing respiratory diseases-a scoping review. by Susan Langer, Bianca Klee, Cornelia Gottschick, Rafael Mikolajczyk

“…<h4>Results</h4>We examined 735 records as full text articles and finally included 57 according to predefined inclusion criteria. …”
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Evaluation of the Production-Education Integration Performance of the High-Tech Industry: An Empirical Comparison between Three Urban Agglomerations in China by Quan Zhang, Zhen Zhang, Zhuomei Li, Sifeng Li, Tianzhen Tang

“…The main conclusions are as follows: (1) the GHKM Greater Bay Area is far better in education and industry development than YRD Urban Agglomeration and BTH Urban Agglomeration; (2) the PEI performance of the high-tech industry in GHKM Greater Bay Area was evaluated as high level with industry in lead, that in YRD Urban Agglomeration as moderate level with education in lead, and that in BTH Urban Agglomeration high-tech industry PEI as moderate level with industry in lag. Finally, several countermeasures were proposed for the urban agglomerations to further enhance the PEI performance of the high-tech industry: GHKM Greater Bay Area should improve the weak link of education development; YRD Urban Agglomeration should give full play to its advantages in higher education; BTH Urban Agglomeration should focus on high-quality industry development. …”
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CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma by Long He, Lanruo Li, Liting Zhao, Xiaoya Guan, Yujia Guo, Qi Han, Huina Guo, Hongliang Liu, Chunming Zhang

“…Mechanistically, functioning as a competitive endogenous RNA (ceRNA) or miRNA sponge, circCCT2 binds directly to miR-146a-5p and increases interleukin-1 receptor-associated kinase 1 (IRAK1) levels, which enhances the malignant development of HNSCC by driving epithelial-mesenchymal transition (EMT). …”
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Examining the impact of social stressor stimuli in eliciting physiological reactivity in children and adolescents with autism spectrum disorder: a systematic review and meta-analys... by Samantha Burns, Agnes S K Wong, Earl Woodruff

“…Two volunteers pursuing postgraduate-level studies will independently search and screen potential studies for eligibility. Finally, all references considered by hand searching will be reviewed by two researchers. …”
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Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora by Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang

“…Furtherly, we analyzed the protein interaction network of AoMsn2 based on the Kyoto Encyclopedia of Genes and Genomes pathway map and the online website STRING. Finally, Hog1 and six putative targeted proteins of AoMsn2 were identified by Y2H analysis. …”
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Evaluation of Relationship between Serum Liver Enzymes and Hypertension: A Cross-Sectional Study Based on Data from Rafsanjan Cohort Study by Parvin Khalili, Saeedeh Abdollahpoor, Fatemeh Ayoobi, Alireza Vakilian, Hamid Hakimi, Zohreh Rajabi, Zahra Jamali

“…In subjects with normal levels of ALT, AST, GGT, and ALP, dose-response increases were observed for abnormal blood pressure in both genders. Finally, we found that, among liver enzymes, only elevated ALP was significantly correlated with the odds of stage 1 hypertension and stage 2 hypertension for both genders. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Furthermore, our analysis revealed significant interactions between cells at different stages of PDAC and identified three promising therapeutic agents (XR-11576, Ixabepilone, and AMONAFIDE) based on correlated genes. Finally, molecular docking studies validated their potential by confirming stable binding with key protein targets. …”
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Impact of glioma metabolism-related gene ALPK1 on tumor immune heterogeneity and the regulation of the TGF-β pathway by YaoFeng Hu, Sen Qin, RuCui Deng

“…Single-cell sequencing data were employed for clustering and differential expression analysis of genes associated with glioma. Finally, the immune relevance of the model gene ALPK1 in the context of pan-cancer was explored, including its relationship with immune checkpoints.ResultsThe application of NMF, coupled with differential analysis of metabolic-related genes, led to the identification of two clusters exhibiting significant differences in survival, age, and metabolic gene expression among patients. …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…Furthermore, the upstream microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) of the candidate genes were predicted using the online tools of MirDIP, TarBase, and ENCORI. Finally, the regulatory network was constructed using Cytoscape software.ResultsCC cells are significantly inhibited by GA. …”
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The optimal neoadjuvant treatment strategy for HR+/HER2 + breast cancer: a network meta-analysis by Shiwei Liu, Miao Yu, Exian Mou, Meihua Wang, Shuanghua Liu, Li Xia, Hui Li, Hao Tang, Yajing Feng, Xin Yu, Kun Mi, Hao Wang

“…In pCR analysis, three neoadjuvant regimens sequentially ranked at the top, namely those comprising T-DM1, pertuzumab with trastuzumab, and tyrosine kinase inhibitor with trastuzumab, demonstrating significantly higher pCR rates than monotherapies. …”
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Outcome measures for assessing the effectiveness of physiotherapy interventions on equinus foot deformity in post-stroke patients with triceps surae spasticity: A scoping review. by Isabella Campanini, Maria Chiara Bò, Maria Chiara Bassi, Benedetta Damiano, Sara Scaltriti, Mirco Lusuardi, Andrea Merlo

“…A thorough critical appraisal of the construct validity of the scales and of the statistics employed was provided, particularly focusing on the choice of parametric and non-parametric approaches when using ordinal scales. Finally, the complexity surrounding the concept of "spasticity" and the possibility of assessing the several underlying active and passive causes of EFD, with a consequent bespoke treatment for each of them, was discussed.…”
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Jane Air: The Heroine as Caged Bird in Charlotte Brontë’s Jane Eyre and Alfred Hitchcock’s Rebecca by Paul Marchbanks

“…Tandis que dans Jane Eyre, l’image de l’oiseau apparaît chaque fois que Jane s’échappe d’un lieu qui l’emprisonne, celle de la cage s’avère être l’élément dominant dans le film d’Hitchcock, imposant finalement des limites infranchissables à la liberté de l’héroïne.…”
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Effect of seasonality on the dynamics of an imitation-based vaccination model with public health intervention by Bruno Buonomo, Giuseppe Carbone, Alberto d'Onofrio

“…Numerical simulations support the theoretical predictions. Finally, we briefly investigate the qualitative behavior of the non-autonomous system for SIR-type disease, by showing that the stability of the elimination equilibria are, in such a case, determined by the ATR.…”
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Comparison of efficacy of ultrasound-guided erector spinae plane block versus thoracolumbar interfascial plane block in patients undergoing lumbar spine surgeries: A systematic rev... by Siddhavivek Majage, Rajathadri Hosur Ravikumar, Mrudula Prasanna, M Chandramouli, Priyankar Kumar Datta, Dalim Kumar Baidya

“…Results: Among 1107 articles, six RCTs (492 patients) were finally included. The ESP block demonstrated lower 24-h opioid consumption compared to TLIP [SMD -0.32 (95% CI: -0.50, -0.14); P < 0.001, I2 = 83%]. …”
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Explore the Mechanism of Astragalus mongholicus Bunge against Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Verification by Lili Fu, Zhongming Wu, Yanjun Chu, Wenbin Chen, Ling Gao, Shumin Mu, Jiajun Zhao

“…The component targets were visualized using Cytoscape software. Finally, molecular docking and experiments were used to verify the results of network pharmacological prediction. …”
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Vegetation Change and Its Response to Climate Change in Yunnan Province, China by Huaizhang Sun, Jiyan Wang, Junnan Xiong, Jinhu Bian, Huaan Jin, Weiming Cheng, Ainong Li

“…In this study, we explored the temporal changes of normalized difference vegetation index (NDVI) in different seasons based on MOD13Q1 NDVI by the maximum value composite and then analyzed spatial distribution characteristics of vegetation using Sen’s tendency estimation, Mann–Kendall significance test, and coefficient of variation model (CV) combined with terrain factors. Finally, the concurrent and lagged effects of NDVI on climate factors in different seasons and months were discussed using the Pearson correlation coefficient. …”
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Grouting Design of Rich Water Tunnels and the Calculation of Distance between Annular Blind Pipes by Helin Fu, Pengtao An, Kai Li, Guowen Cheng, Jie Li, Xiaohui Yu

“…At the same time, the design parameters of the grouting circle are optimised, and then the formula of annular blind pipe spacing is derived according to the design value of the antiwater pressure of the secondary lining structure and the allowable seepage discharge of the tunnel. Finally, based on the case study of the Hongtu extra-long tunnel under construction, it is verified by field monitoring data. …”
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