High-reward, high-risk technologies? An ethical and legal account of AI development in healthcare by Maelenn Corfmat, Joé T. Martineau, Catherine Régis

“…We then proposed a breakdown within such categories that emphasizes the different - yet often interconnecting - ways in which ethics and law are approached for each category of issues. Finally, we identified several key ideas for healthcare professionals and organizations to better integrate ethics and law into their practices. …”
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Evaluation of the Palatal Features in Relation to Graft Harvesting in the Saudi Population by Razan Alaqeely, Sumaiah Ajlan, Faisal Alsanqar, Abdulmahsin Alaqil, Abdulaziz Almansour, Mohammad A. Aldosari

“…The digital casts were evaluated, and measurements of arch width at molars and canines, palatal vault height (PVH), palatal height index (PHI), and extension of the palatal rugae were registered. Finally, the amount available for soft tissue graft harvesting was calculated. …”
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Possibility of Using NO Modulators for Pharmacocorrection of Endothelial Dysfunction After Prenatal Hypoxia by Igor Belenichev, Olena Popazova, Oleh Yadlovskyi, Nina Bukhtiyarova, Victor Ryzhenko, Sergii Pavlov, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Levels of sEPCR, Tie2 tyrosine kinase, VEGF-B, SOD1/Cu-Zn SOD, GPX4, and GPX1 in the heart’s cytosolic homogenate were assessed using ELISA. …”
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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Using single-cell multiomics sequencing, we identify cell-specific gene expression changes associated with DNMT3A mutations, along with significant epigenomic deregulation affecting enhancer accessibility, resulting in overexpression of interleukin-32 (IL-32), a proinflammatory cytokine that can result in inflammasome activation in monocytes and macrophages. Finally, we show with single-cell resolution that the loss of function of DNMT3A is directly associated with increased chromatin accessibility in mutant cells. …”
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Structural Improvement of the ω-Type High-Speed Rail Clip Based on a Study of Its Failure Mechanism by Xiaogang Gao, Anbin Wang, Yu He, Xiaohan Gu

“…The high-frequency fatigue test result further verified that the failure mechanism of the ω-type clip was due to the resonance of the clip with its excitation force from the wheel-rail interaction. Finally, the clip was then structurally improved taking into account the stiffness and mass, which led to its resonant frequencies shifting away from the high-frequency excitation range, hence avoiding resonance failure of the subject clip.…”
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Impact of Blended Learning Use On Agricultural Entrepreneurship Development by B. P Siriwardena, L. M Abeywickrama, A. L Sandika, N. P Vidanapathirana

“…After time management, the ranking from highest to lowest is as follows, risk-taking ability, achievement motivation, resourcefulness, financial elements, non-financial aspects, and finally innovativeness. Conclusion: undergraduate entrepreneurs grow their entrepreneurship through blended learning. …”
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Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors by Philippe Rochigneux, Philippe Rochigneux, Alexandre Bertucci, Elika Loir, Alexia Mattei, Danielle Robert, Michael Dassa, Brice Chanez, Mikael Ebbo, Lea Gaigne, Anne Sophie Chretien, Giovanni Corazza, Giovanni Corazza, Nicolas Schleinitz

“…We also discussed the elimination of differential diagnoses (notably with normal MRI and cerebrospinal fluid analysis) and finally the clinical management of this severe irAE.ResultsA 57 years woman presented multiple sub-diaphragmatic adenopathies related with an advanced melanoma of unknown primary. …”
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Provide a reliable location-allocation model in the humanitarian supply chain network using combined transport and the application of feasibility-robust planning by Alireza Hamidieh, Maryam Besharat Meymandi

“…The reliability policy used in the distribution hub set has improved the confidence capability of the humanitarian distribution network. Finally, the output results of the case study show the application and effectiveness of the extended relief network model.Originality/Value: The present study, as a decision support system, facilitates relief in the regions of the country in the event of a crisis. …”
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Küreselleşmenin Yoksulluk Üzerine Etkisi: Türkiye Örneği by Başak Karşıyakalı, Gökhan Ersoy

“…Bu durum mali piyasalarda sermaye hareketliliğinin artmasına, bankacılık ve finans piyasalarının derinleşmesine ve gelişmesine katkı sağlamış ancak beraberinde getirdiği krizler ve şoklar ile ekonomilerin daha hassas hale gelmesine neden olmuştur. …”
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Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas by Xiaohui Yao, Yazhuo Zhang, Lijuan Wu, Rui Cheng, Chuzhong Li, Chongxiao Qu, Hongming Ji

“…Expressions of nuclear receptor subfamily 2 group C member 2 (NR2C2), B cell translocation gene 2, T-box-19 (TBX19), and cyclin-dependent kinase 2 (CDK2) in surgically resected specimens were assessed by immunohistochemistry. …”
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The Feshbach Resonances Applied to the Calculation of Stark Broadening of Ionized Spectral Lines: An Example of Interdisciplinary Research by Sylvie Sahal-Bréchot, Haykel Elabidi

“…Then, in the middle of the 1970s, this gave rise to the idea of including the Feshbach resonances in the calculation of electron impact broadening (the so-called “Stark” broadening) of isolated spectral lines of ionized atoms. Finally, in the recent example of the Stark broadening of the Mo VI <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>5</mn><mi mathvariant="normal">d</mi><mrow><mo> </mo><mmultiscripts><mrow><mi mathvariant="normal">D</mi></mrow><mrow><mn>5</mn><mo>/</mo><mn>2</mn></mrow><none></none><mprescripts></mprescripts><none></none><mn>2</mn></mmultiscripts><mo>−</mo><mn>5</mn><mi mathvariant="normal">p</mi><mo> </mo><mmultiscripts><mrow><mi>P</mi><mo>°</mo></mrow><mrow><mn>3</mn><mo>/</mo><mn>2</mn></mrow><none></none><mprescripts></mprescripts><none></none><mn>2</mn></mmultiscripts></mrow></mrow></semantics></math></inline-formula> line, the S-matrices will be calculated using the semi-classical perturbation formalism and will be compared to those of the more recent quantum distorted wave formalism.…”
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Evaluación del contenido de materia orgánica y sus efectos, por registros geofísicos en el ejemplo de pozos petroleros del sector Varadero Oeste, Cuba by Olga Castro-Castiñeira, Ronal Barcala-Alvarez

“… Desde finales del pasado siglo, varios investigadores han argumentado sobre la utilidad de los registros geofísicos de pozo para identificar rocas madres y cuantificar su potencial, a partir del efecto de la materia orgánica presente en las rocas sedimentarias sobre la respuesta de los registros. …”
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An Evolutionary Game Model of a Regional Logistics Service Supply Chain Complex Network in a Blockchain Environment by Guangsheng Zhang, Zhaomin Zhang

“…After validating the effectiveness of the model, this research investigates how market environmental factors influence the adoption behaviors of LSPs and LSIs. Finally, through case simulations, the effects of key influencing factors on participatory behaviors within the regional logistics service supply chain are analyzed. …”
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Influences of multi-pass friction stir alloying on characterization of AZ91D alloy-based dual reinforcement bio-ceramic nano-composites by Surendra Kumar Patel, Guoxin Dai, Lu Liu, Zhen Sun, Lei Shi

“…The typically worn surface revealed reduced deep pits, pits and cracks due to better ionization of the hydrogen generated during immersion. Finally, this research was carried out for treatment of bone defects and fractures as well as improving corrosion resistance of the mg-containing biocompatible implants.…”
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Investigating a role for PUB17 and PUB16 in the self‐incompatibility signaling pathway in transgenic Arabidopsis thaliana by Paula K. S. Beronilla, Daphne R. Goring

“…Abstract In Brassicaceae self‐incompatibility (SI), self‐pollen rejection is initiated by the S‐haplotype specific interactions between the pollen S cysteine‐rich/S‐locus protein 11 (SCR/SP11) ligands and the stigma S receptor kinases (SRK). In Brassica SI, a member of the Plant U‐Box (PUB) E3 ubiquitin ligases, ARM‐repeat containing 1 (ARC1), is then activated by SRK in this stigma and cellular events downstream of this cause SI pollen rejection by inhibiting pollen hydration and pollen tube growth. …”
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Clinical Holistic Medicine: The Case Story of Anna. I. Long-Term Effect of Childhood Sexual Abuse and Incest with a Treatment Approach by Søren Ventegodt, Birgitte Clausen, Joav Merrick

“…Using holistic existential therapy in accordance with the life mission theory and the holistic process theory of healing, she finally was able to confront her old traumas and heal her existence. …”
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“Italy System” as a Case of Innovative Economic Diplomacy by R. O. Raynkhardt

“…Another important trend and particular feature of Italy's modern economic diplomacy is the practice of decentralization of financial management within the MFA system through providing the heads of diplomatic representations with specific competences in this area. Finally, a special emphasis is put on the tight link between instruments of "soft power" and economic diplomacy and their institutional usage, which has deep historical roots.…”
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CRISPR/Cas9, a universal tool for genomic engineering by A. V. Smirnov, A. M. Yunusova, V. A. Lukyanchikova, N. R. Battulin

“…In addition, we review Cas9-augmented genetic screens that allow an unbiased search for new genes and pathways involved in a plethora of biological aspects, owing to Cas9 efficiency and versatility. Finally, we argue that gene drivers based on CRISPR/ Cas9 represent a powerful tool to modify ecosystems in the nearest future.…”
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Some complex probabilistic hesitant fuzzy aggregation operators and their applications to multi-attribute decision making by Yanpo Yang, Baoquan Ning, Fengjuan Tian, Guihui Lu

“…Furthermore, we provide an example about purchasing a most suitable car to demonstrate the effectiveness and practicability of the proposed decision process. Finally, we point out the superiorities of MADM in working under the CPHF environment through comparing it with the existing method and also offer some possible prospects for further research. …”
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Inhibition of miR-652-3p Regulates Lipid Metabolism and Inflammatory Cytokine Secretion of Macrophages to Alleviate Atherosclerosis by Improving TP53 Expression by Haiyun Liu, Changpeng Zuo, Lijuan Cao, Naiquan Yang, Tingbo Jiang

“…Based on the TargetScan database, the TP53 3′UTR region had complementary bases with miR-652-3p, which was also verified by dual-luciferase reporter gene assay. Finally, the regulation of miR-652-3p and TP53 was confirmed by rescue assay in atherosclerosis. …”
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