Efficacy and safety of immune checkpoint inhibitors in patients with advanced intrahepatic cholangiocarcinoma by Ziting Peng, Jianhui Dong, Shuyao Tang, Jiaxu Shi, Tongdong Shi

“…The Kaplan-Meier method was employed to plot survival curves, and differences between groups were assessed using log-rank tests.Results96 patients diagnosed with ICC were included, comprising 60 males (62.50%) and 36 females (37.50%). 85 patients exhibited disease progression, 22 patients succumbed, and 38 patients were lost to follow-up finally. Those who initiated immunotherapy promptly following first-line antitumor treatment exhibited a notably prolonged PFS compared to those experiencing tumor progression (5.63 months (95%CI: 3.12~8.14) vs 2.50 months (95%CI: 1.83~3.17), P=0.002). …”
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Transcriptomic Response of Arabidopsis thaliana to Pseudomonas syringae Infection: An In Silico Approach by Amir Ghaffar Shahriari, Mohamad Hamed Ghodoum Parizipour, Yaser Biniaz, Aminallah Tahmasebi, Fatemeh Gholizadeh

“…Regarding molecular function, 412 genes associated with kinase, catalase, and oxidoreductase activities were up-regulated in the bacteria-infected plants, while down-regulation of hydrolase and transferase activity genes was observed. …”
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Cluster Coordination between High-speed Rail Transportation Hub Construction and Regional Economy Based on Big Data by Liang Zhao, Yuanhua Jia

“…The experimental results prove that each sample is tested in pairs, the standard error level of the mean is 0.002, which is less than 0.05, and high-speed railway construction can finally achieve economic integration. By improving the development of high-speed railways, continuously shortening the distance between time and space, breaking regional trade barriers, and reducing the cost of commodity circulation, industrial interaction and coordinated development between different regions can be effectively promoted.…”
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Optimizing Kernel Extreme Learning Machine based on a Enhanced Adaptive Whale Optimization Algorithm for classification task. by ZeSheng Lin

“…Furthermore, inspired by the grey wolf optimization algorithm, use 3 excellent particle surround strategies instead of the original random selecting particles. Finally, a novel Levy flight was implemented to promote the diversity of whale distribution. …”
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Risk Assessment of Distracted Driving Behavior Based on Visual Stability Coefficient by Haixiao Wang, Xu Ding, Chutong Wang

“…Then, based on the improved CRITIC method, the visual stability coefficient (VSC) was constructed as a new indicator to comprehensively assess the risk level of the driving state, and the assessment criteria were divided. Finally, the grey correlation analysis method was introduced to verify the assessment effect of VSC. …”
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Las políticas sociales para la infancia vulnerable. Algunas reflexiones desde la Psicología by Valeria Llobet

“…La particularidad de las políticas para la infancia, es que en todos los casos se despliegan articulando significaciones y representaciones que configuran a los niños y niñas, con quienes tratan como casos (sociales, psicológicos, en riesgo), y consideran la desigualdad y la asimetría como naturales y objetivas. …”
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Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Satomi Watanabe, Kimio Yonesaka, Junko Tanizaki, Yoshikane Nonagase, Naoki Takegawa, Koji Haratani, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Junji Tsurutani, Kazuhiko Nakagawa

“…In contrast, trastuzumab/pertuzumab/patritumab triple treatment demonstrated potent anticancer efficacy, concomitant with strong repression of Akt. Finally, in heregulin‐expressing BT474‐HRG and JIMT‐1 xenograft models, the addition of pertuzumab and patritumab to trastuzumab also enhanced antitumor efficacy leading to tumor regression. …”
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Toward Robust Lung Cancer Diagnosis: Integrating Multiple CT Datasets, Curriculum Learning, and Explainable AI by Amira Bouamrane, Makhlouf Derdour, Akram Bennour, Taiseer Abdalla Elfadil Eisa, Abdel-Hamid M. Emara, Mohammed Al-Sarem, Neesrin Ali Kurdi

“…The proposed approach achieved optimal results of 100% in all metrics, with 00% false positive and false negative rates. Finally, explainable artificial intelligence (XAI) using Gradient-weighted Class Activation Mapping (Grad-CAM) was employed to better understand the model. …”
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Patient Preferences for Chronic Myeloid Leukemia Medication Regimen Attributes and their Potential Impact on Adherence: Results from a Multi-national Conjoint Study by Ishan Hirji, Jessica Grinspan, Emuella Flood, Diana Chirovsky, Jennifer Devlen, Samuel Wagner, Catherine Davis

“…**Background:** Tyrosine kinase inhibitors (TKIs) have significantly improved survival for patients with chronic myeloid leukemia (CML) but require long-term administration and non-adherence due to regimen requirements has been reported. …”
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FBI-Net: Frequency-Based Image Forgery Localization via Multitask Learning With Self-Attention by A-Rom Gu, Ju-Hyeon Nam, Sang-Chul Lee

“…Subsequently, Dilated Frequency Self-Attention Module, DFSAM in the bridge layer, is incorporated into the network to recalibrate the fused features and enhance the representation. Finally, in the decoder stage, region and edge information of the label are learned through multi-task learning to provide more extensive supervision for forged region localization; the edge stream will give a deeper understanding of features between forged and authentic images and help learn how to predict exquisite representations in images. …”
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The Evolution of the Meaning of “Dūsh” in the Thoughts of Khayyam, Sanai, and Hafez by Ali Mohammad Moazzeni, Ameneh Rajabi

“…Firstly, the well-regarded status of “night” from the perspectives of Zoroastrianism and Islam, and secondly, the connection between “night” or “dawn” with the time of drinking wine and the morning wine (“sabūhi”). Both before and after Khayyam and Sanai, “night” and “dawn” have had an inseparable link with celestial hidden messages. …”
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Application of a New Type of Protective Sputum Suction Device in Clinic against Cross-Infection between Medical Staff and Patients by Kang Lu, Weizhou Wu, Gaomei Jin, Haixia Yang, Xiaowei Cai, Lin Li, Zanchao Chen, Lin Ren, Baoshuan Guo, Qing-feng Xue

“…In addition, the satisfaction of the two suction methods was compared through the questionnaire of suction staff. Finally, with the assistance of this device, an attempt was made to complete the bronchoscopy without weaning of ventilator. …”
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Physical-aware model accuracy estimation for protein complex using deep learning method by Haodong Wang, Meng Sun, Lei Xie, Dong Liu, Guijun Zhang

“…Then, the relationship between local residues and the overall complex topology as well as the inter-residue evolutionary information are characterized by geometry-based features, protein language model embedding representation, and knowledge-based statistical potential features. Finally, these features are fed into a fused network architecture employing equivalent graph neural network and ResNet network to estimate residue-wise model accuracy. …”
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The Value of Immune-Related Genes Signature in Osteosarcoma Based on Weighted Gene Co-expression Network Analysis by Xin Wang, Li Gan, Ju Ye, Mengjie Tang, Wei Liu

“…Cox regression analysis and least absolute shrinkage and selection operator (LASSO) analysis were used to explore IRGs associated with OS prognosis and construct and validate a hazard score model. Finally, we verified the expression and function of EVI2B in OS. …”
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La enseñanza Normal en Yucatán durante el Porfiriato y las fuentes para la escritura de su historia by Alicia Muñoz Vega

“…Para ello estructuro este trabajo de la siguiente manera: el primer apartado está dedicado a una breve introducción acerca del surgimiento de la historiografía mexicana y la historia de la educación, seguido de los trabajos que se han hecho del normalismo en México; posteriormente me refiero a las indagaciones de historia de la educación a nivel regional –el caso de Yucatán–; en una tercera parte menciono las fuentes primarias y secundarias accesibles de esta temática, y por último mis reflexiones finales. …”
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Prognostic model and immune-infiltrating cell landscape based on differentially expressed autophagy-related genes in TP53-mutated multiple myeloma by Yan-Hua Zheng, Hong-Yuan Shen, Xiang Chen, Juan Feng, Guang-Xun Gao

“…Results Three differentially expressed ARGs (CASP8, MAPK8, RB1CC1) were finally incorporated to construct the risk model. …”
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Silencing FOXA1 suppresses inflammation caused by LPS and promotes osteogenic differentiation of periodontal ligament stem cells through the TLR4/MyD88/NF-κB pathway by Miao He, Yangdong Lin

“…Alkaline phosphatase (ALP) staining, alizarin red S staining, and Western blot were employed to evaluate the impact of FOXA1 silencing on the osteogenic differentiation of hPDLSCs. Finally, the protein levels in the Toll-like receptor 4 (TLR4)/Myeloid differentiation factor-88 (MyD88)/NF-κB pathway were analyzed using Western blot. …”
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Exploration of the Mountainous Urban Rail Transit Resilience Under Extreme Rainfalls: A Case Study in Chongqing, China by Chenhui Liu, Xue Su, Zhichun Wu, Yingjun Zhang, Cuizhu Zhou, Xiangguo Wu, Yong Huang

“…Additionally, risk levels for landslide and flood-prone areas are classified using the K-means algorithm, based on rainfall, elevation, and slope data, identifying high-risk stations. Finally, the node recovery sequence and strategies for high-risk nodes affected by landslides and floods are examined. …”
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Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study by Niloufar Rasaei, Atefeh Tavakoli, Saba Mohammadpour, Mehdi Karimi, Alireza Khadem, Azam Mohamadi, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Khadijeh Mirzaei

“…We have employed standard methods to measure biochemical factors, anthropometrics, and physical activity levels. Finally, the GRS was created by combining three SNPs [CAV-1 (rs3807992), Cry-1 (rs2287161), and MC4R (rs17782313)]. …”
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Flexural Behavior of Graphite Tailings RC Beams in Chloride Environment by Bo-Ya Feng, Xun-Guo Zhu, Hong-Chun Xia, Lin Yang, Te Xie

“…The results show that the concentration of graphite tailings has an important influence on the mechanical properties of concrete. Finally, the bending characteristics of the beam and the modified bearing capacity calculation formula are obtained, which provides a theoretical basis and the reference value for the construction of green building materials. …”
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