Reinvestigation into the role of lipopolysaccharide Glycosyltransferases in Helicobacter pylori protein glycosylation by Hong Li, Xiaoqiong Tang, Tiandi Yang, Tingting Liao, Aleksandra W. Debowski, Tiankuo Yang, Yalin Shen, Hans-Olof Nilsson, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Wolfgang Fischer, Rainer Haas, Hong Tang, Barry J. Marshall, Mohammed Benghezal

“…Moreover, using LPS-protein reconstitution experiments, we demonstrate that the presence of O-antigen containing full-length LPS interferes with the electrophoretic mobility of H. pylori RecA and many other proteins including AlpA/B on SDS-PAGE. Finally, we demonstrate that full-length LPS extracted from E. coli affects electrophoretic migration of H. pylori proteins, while full-length LPS extracted from H. pylori similarly influences the electrophoretic migration of E. coli proteins. …”
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Development and Validation of a Nomogram Model for Predicting the Risk of Readmission in Patients with Heart Failure with Reduced Ejection Fraction within 1 Year by Yue Hu, Xiaotong Wang, Shengjue Xiao, Chunyan Huan, Huimin Wu, Tao Xu, Minjia Guo, Hong Zhu, Defeng Pan

“…A nomogram was established according to the results of univariate and multivariate logistic regression analysis. Finally, the area under the receiver operating characteristic curve (AUC-ROC), calibration plot, and decision curve analysis (DCA) were used to validate the nomogram. …”
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Capturing spatiotemporal variation in salt marsh belowground biomass, a key resilience metric, through geoinformatics by Kyle D. Runion, Deepak R. Mishra, Merryl Alber, Mark A. Lever, Jessica L. O'Connell

“…This reflects both an improvement in predictive performance and an expansion in conditions for potential model application. Finally, we used regression commonality analysis to show that model estimates reflected the spatiotemporal structure of BGB variation observed in field measurements. …”
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Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for EGFR-Mutated NSCLC After Complete Resection by Song Dong, PhD, Bingfa Yan, PhD, Si-Yang Liu, PhD, Xuan Gao, PhD, Hui-Zhao Hong, MD, Hong-Ji Li, MD, Wei Gao, PhD, Hong-Hong Yan, PhD, Si-Yang Maggie Liu, PhD, Hai-Yan Tu, PhD, Yi Pan, PhD, Qing Zhou, PhD, Xue-Ning Yang, PhD, Xue-Feng Xia, PhD, Xin Yi, PhD, Wen-Zhao Zhong, PhD, Yi-Long Wu, MD, Jia-Tao Zhang, PhD

“…Introduction: EGFR tyrosine kinase inhibitor (TKI) is the standard adjuvant treatment for patients with stages IB to IIIA EGFR-mutated NSCLC. …”
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Development and validation of a pragmatic measure of cocreation in research engagement: a study protocol by Bethany M Kwan, Carter Sevick, Cathleen Willging, Bryan J Weiner, Janice Tufte, Brooke Dorsey Holliman, Monica Perez Jolles, Danielle Ostendorf

“…We will then conduct cognitive interviews with a new group of 40 participants to assess survey item comprehension and interpretation, applying an iterative coding process to analyse the data. Finally, we will assess the measure’s psychometric and pragmatic characteristics with a convenience sample of 300 participants and use the Psychometric and Pragmatic Evidence Rating Scale. …”
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Forskolin Stimulates Estrogen Receptor (ER) α Transcriptional Activity and Protects ER from Degradation by Distinct Mechanisms by Houng-Wei Tsai, Vicky Y. Lin, Margaret A. Shupnik

“…In ER-positive GH3 cells (a rat pituitary prolactinoma cell line), forskolin, acting via protein kinase A (PKA), stimulates ERα transcriptional activity without causing degradation, and proteasome inhibition does not block forskolin-stimulated transcription. …”
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Bladder-sparing therapy in a case report of huge muscle-invasive bladder IMT treated with 1470 nm diode laser en bloc resection followed by laparoscopic partial cystectomy by Junhao Chu, Huisheng Yuan, Zhihui Zhang, Jiajun Kan, Shishuai Duan, Zilong Wang, Zilong Wang, Zilong Wang, Muwen Wang

“…Pathological examination following 1470 nm laser resection confirmed the diagnosis of an IMT with malignant potential, showing anaplastic lymphoma kinase (ALK) positivity, a Ki-67 index of 20% in hotspot regions, and ALK gene rearrangement detected by fluorescence in situ hybridization (FISH). …”
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Using the Sleeping Beauty Transposon System for Doxycycline-inducible Gene Expression in RAW264.7 Macrophage Cells to Study Phagocytosis by Parsa Kamali, Gregory Fairn

“…This makes phagocytosis experiments easier since more cells can be analyzed per experiment, allowing for population-based measurements where a ~10% transient transfection rate is insufficient. Finally, using the doxycycline-promoter allows for low near endogenous expression of proteins or robust overexpression.…”
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Spatial suitability evaluation and layout optimization of emergency shelter: A case study in Tianhe District of Guangzhou City by Bo Tang, Zongyuan Li, Yinzhong Chen

“…This paper utilized from GIS-based methods including Grey Correlation Method (GCM) and Entropy Weight Method (EWM), the research process of “suitability evaluation —evacuation gap analysis—site selection—site optimization”is established, and the suitability evaluation results are calculated from the combination of effectiveness, accessibility and safety; based on the principles of fairness, accessibility, safety and feasibility, combined with the analysis of the current situation of land use and evacuation demand, the layout of urban emergency evacuation sites is adjusted. Finally, the spatial layout optimization plan for emergency shelters in Tianhe District was obtained. …”
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The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders by Sean D. Fraser, Sean D. Fraser, Robert J. Harvey, Robert J. Harvey

“…In this review, we highlight the critical role of the GlyR α2 subunit revealed by knockout mice and our current understanding of GlyR α2 pathomechanisms in human NDDs. Finally, we will consider the current gaps in our knowledge, which include: (i) Limited functional validation for GlyR α2 missense variants associated with human NDDs; (ii) The lack of gain-of-function GlyR α2 mouse models; (iii) Our limited knowledge of GlyR α2 interacting proteins. …”
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Flexible Threshold Quantum Homomorphic Encryption on Quantum Networks by Yongli Tang, Menghao Guo, Binyong Li, Kaixin Geng, Jinxia Yu, Baodong Qin

“…We give a specific (3, 5)-threshold example, illustrating the scheme’s correctness and feasibility, and simulate it on IBM quantum computing cloud platform. Finally, it is shown that the scheme is secure by analyzing encryption/decryption private keys, ciphertext quantum state sequences during transmission, plaintext quantum state sequence, and the result after computations on the plaintext quantum state sequence.…”
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SSMM-DS: A semantic segmentation model for mangroves based on Deeplabv3+ with swin transformer by Zhenhua Wang, Jinlong Yang, Chuansheng Dong, Xi Zhang, Congqin Yi, Jiuhu Sun

“…We then employed Swin Transformer as the backbone network, enhancing the capability of global information learning and detail feature extraction. Finally, we optimized the loss function by combining cross-entropy loss and dice loss, addressing the issue of sampling imbalance caused by the small areas of mangroves. …”
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La claredat com a criteri del llenguatge administratiu i jurídic a Andorra by Marta Pujol Palau, Anna Gabernet Piqué

“…La comunicació clara ha estat sempre un criteri implícit en la tasca d’assessorament i correcció desenvolupada pel Servei de Política Lingüística del Govern d’Andorra. Des de finals del segle XX fins a l’actualitat, també s’observa una cura especial d’altres serveis, departaments i institucions per posar el llenguatge administratiu i jurídic a l’abast de tothom a partir de fer-lo clar i accessible. …”
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Integrated Bioinformatics Identifies FREM1 as a Diagnostic Gene Signature for Heart Failure by Chenyang Jiang, Weidong Jiang

“…Then, external independent RNA-seq datasets evaluate the diagnostic value of gene signals. Finally, the convolution tool CIBERSORT estimated the composition pattern of immune cell subtypes in heart failure and carried out a correlation analysis combined with gene signals. …”
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Soil Quality Assessment Strategies for Evaluating Soil Degradation in Northern Ethiopia by Gebreyesus Brhane Tesfahunegn

“…Mean SQI values for LS1 and LS8 using expert opinion dataset selection method were 0.874 and 0.406, respectively. Finally, a sensitivity analysis (S) used to compare PCA and expert opinion dataset selection procedures for various scoring functions ranged from 1.70 for unscreened-SQI to 2.63 for PCA-SQI. …”
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Iron:The missing link of depression prevention and treatment by reza pakzad, Mohammadamin Jandaghian Bidgoli, fatemeh abdi, negin shaterian

“…Results: of 2154 studies,14 studies were included in systematic review and 6 studies were excluded from analysis due to lack of data for calculating PSMD and finally, 8 studies were included in meta-analysis. …”
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Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study by Seda Kahraman, Mutlu Hizal, Burcin Cakan Demirel, Deniz Can Guven, Ozge Gumusay, Basak Oyan Uluc, Ertugrul Bayram, Burcu Gulbagci, Alper Yasar, Sena Ece Davarci, Eda Eylemer Mocan, Omer Acar, Deniz Isik, Esra Aydin, Yusuf Karakas, Melike Ozcelik, Murat Keser, Sadi Kerem Okutur, Onder Eren, Serkan Menekse, Dincer Aydin, Funda Yilmaz, Ozlem Dogan, Gulhan Ozkanli, Hakan Yucel, Veli Sunar, Musa Baris Aykan, Ozlem Ozdemir, Berna Bozkurt Duman, Merve Keskinkilic, Teoman Sakalar, Ali Inal, Muge Karaoglanoglu, Asude Aksoy, Muhammed Muhiddin Er, Nazim Serdar Turhal, Nurhan Onal Kalkan, Mehmet Ali Nahit Sendur

“…Abstract Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. …”
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Numerical simulation and experimental investigation of pressure riveting connection using the smoothed particle Galerkin method by Jianhui Zhang, Tongxiang Huang, Xuan Qin, Changcheng Yin, Xianchao Yan

“…Subsequently, three-dimensional finite element models for press-in push-out and press-in twist-out are established to simulate the riveting process and meet the requirements for quality testing of riveted joints. Finally, we compare the force–displacement curves obtained from the simulations and experiments: The maximum riveting force measured in the experiments was 18.5 kN, while the simulated value was 17.8 kN, which is 3.78% lower than the experimental value. …”
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Aménagement d’ossuaires dans le baptistère paléochrétien de Brioude (Haute-Loire) :  sélection, tri des ossements et relation À l’Âge au décès by Aline Thomas, Fabrice Gauthier, Esther Gatto, Pascal Murail

“…Furthermore, we noted that paired immature skeletal elements were divided between two ossuaries. Finally, the age assessment of these young individuals classified them into the 5-9 age category, a group that was absent from the rest of the burial area. …”
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Dynamic Nonrecurrent Congestion Event Detection and Tracking Method With DBSCAN on Speed Watersheds by Jing Jin, Yizhou Wang, Anjiang Chen, Branislav Dimitrijevic, Joyoung Lee

“…A new event-profile–based 3D speed volume comparison method is proposed to detect NRC events that do not significantly overlap with recurrent congestions in the historical profile. Finally, a bilevel congestion confirmation process is introduced for NRC persistency checking and filtering. …”
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