Stimulation of Alpha7 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Upregulation of MMP, MCP-1, and RANTES through Modulating ERK1/2/AP-1 Signaling Pathway in RAW264... by Liping Liu, Hongxian Wu, Qunan Cao, Zhenzhen Guo, Anmin Ren, Qiuyan Dai

“…Nicotine markedly stimulated the phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2) and c-Jun in RAW264.7 cells. Pretreatment with U0126 significantly suppressed phosphorylation of ERK1/2 and further attenuated nicotine-induced activation of c-Jun and upregulation of MMP-2, MMP-9, monocyte chemotactic protein- (MCP-) 1, and regulated upon activation normal T cell expressed and secreted (RANTES). …”
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Statistical and SWAT Model-Based Performance Evaluation of RCMs in Modeling Streamflow and Sediment Yield at Upper Awash Sub-Basin, Ethiopia by Bekan Chelkeba Tumsa

“…The output of this statistical and SWAT model shows that climate models do not accurately simulate hydro-climatological variables. Finally, this study showed that climate models were better at simulating the rainy season than the dry season. …”
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Development of a Three-Stage Hybrid Model by Utilizing a Two-Stage Signal Decomposition Methodology and Machine Learning Approach to Predict Monthly Runoff at Swat River Basin, Pak... by Muhammad Sibtain, Xianshan Li, Ghulam Nabi, Muhammad Imran Azam, Hassan Bashir

“…Afterward, the SVM algorithm was applied to the decomposed subcomponents for the prediction purpose. Finally, four statistical indices are utilized to measure the performance of the CVS model compared with other hybrid models including CEEMDAN-VMD-MLP (multilayer perceptron), CEEMDAN-SVM, VMD-SVM, CEEMDAN-MLP, VMD-MLP, SVM, and MLP. …”
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Remote-sensing-based forest canopy height mapping: some models are useful, but might they provide us with even more insights when combined? by N. Besic, N. Picard, C. Vega, J.-D. Bontemps, L. Hertzog, J.-P. Renaud, J.-P. Renaud, F. Fogel, M. Schwartz, A. Pellissier-Tanon, G. Destouet, F. Mortier, F. Mortier, M. Planells-Rodriguez, P. Ciais

“…Moreover, we observed that the forest stand vertical structure, the dominant tree species, and the type of forest ownership systematically emerge as statistically significant factors influencing the model divergences. Finally, we observed that the fitted higher-order mixtures, which enabled the presented analyses, do not necessarily reduce bias or prevent the saturation of the predicted heights observed in the individual models.…”
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Development and laboratory evaluation of a novel IoT-based electric-driven metering system for high precision garlic planter. by Abdallah Elshawadfy Elwakeel, Ahmed Elbeltagi, Ahmed Z Dewidar, Ali Salem, Mohamed Anwer Abdeen

“…Additionally, the sensor's monitoring accuracy gradually declined with an increase in the operating speed of the EDMS. Finally, this study introduced a novel EDMS to garlic seed planters that was not used before. …”
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Detection of OqxAB Efflux Pumps, a Multidrug-Resistant Agent in Bacterial Infection in Patients Referring to Teaching Hospitals in Ahvaz, Southwest of Iran by Mojtaba Moosavian, Mahtab Khoshkholgh Sima, Nazanin Ahmad Khosravi, Effat Abbasi Montazeri

“…The antimicrobial susceptibility test was carried out by the Kirby–Bauer disk diffusion method according to CLSI guidelines, and finally, the oqxA and oqxB genes were detected by the PCR method. …”
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Genome‐Wide Diversity in Lowland and Highland Maize Landraces From Southern South America: Population Genetics Insights to Assist Conservation by Pia Guadalupe Dominguez, Angela Veronica Gutierrez, Monica Irina Fass, Carla Valeria Filippi, Pablo Vera, Andrea Puebla, Raquel Alicia Defacio, Norma Beatriz Paniego, Veronica Viviana Lia

“…Outlier detection methods allowed identification of putative adaptive genomic regions, consistent with previously reported flowering‐time loci and chromosomal regions displaying introgression from the teosinte Zea mays ssp. mexicana. Finally, species distribution models were obtained for two future climate scenarios, showing a notable reduction in the potential planting area of HNWA and a shift in the cultivation areas of FNEA. …”
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The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells by Chenyi Ling, Marc D. Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

“…Blocking FcγRIIB receptor significantly attenuated the CRP-induced decrements in eNOS expression only in AA HUVECs. Finally, HiLSS significantly counteracted CRP-induced effects. …”
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ÖN LİSANS DÜZEYİNDE ÖĞRENİM GÖREN ÖĞRENCİLERİN ZORUNLU STAJ UYGULAMASINA İLİŞKİN GÖRÜŞLERİ, SORUNLARI VE ÇÖZÜM ÖNERİLERİ: ISPARTA MESLEK YÜKSEKOKULU ÖRNEĞİ... by Yasemin Duran, Nilgün Dolmacı

“…Isparta Meslek Yüksekokulu bünyesindeeğitim- öğretim faaliyetleri sürdürülen yedi programdan, öğrencilerini2015-2016 Akademik Yılı yaz döneminde zorunlu staj uygulamasına tabi tutan,“Yönetim ve Organizasyon”, “Otel, Lokanta ve İkram Hizmetleri”, “Finans,Bankacılık ve Sigortacılık”, “Halkla İlişkiler ve Tanıtım” ve “Tasarım”programlarında öğrenim gören toplam 350 öğrenci araştırmanın örnekleminioluşturmuştur. …”
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Deixadas para morrer: sobre búfalas, desinformação e especismo estrutural by Fabio Alves Gomes de Oliveira, Érica Quadros do Amaral

“…Nossas considerações finais nos direcionam ao entendimento do especismo estrutural como um problema de ordem informacional por ser produto de estratégias de desinformação e desempenhar o papel de provimento do senso comum, produção de ignorância e manutenção de estruturas de poder que asseguram sua própria existência como um modo de opressão que impacta animais não humanos e humanos…”
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A comprehensive review of energy harvesting and routing strategies for IoT sensors sustainability and communication technology by Hesam Nejati Sharif Aldin, Mostafa Razavi Ghods, Farnoush Nayebipour, Masoud Niazi Torshiz

“…Two scenarios are explored: one where the minimum frequency band and data rate are fixed, revealing that Sigfox consumes more energy than others, while Bluetooth v5.0 is more energy-efficient; and another where the maximum frequency band and data size are fixed, showing that 5G consumes more energy, whereas NB-IoT is more energy-efficient. Finally, the research investigates the energy consumption increments for various network connections (2G, 3G, 4G, 5G, Bluetooth V5.0, Sigfox, WiMAX, LoRaWAN, Zigbee, and NB-IoT) as the frequency band and network data rate increase from minimum to maximum values, revealing increments within the range of 7% to 71%.…”
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Free and Forced Vibrations of an Axially-Loaded Timoshenko Multi-Span Beam Carrying a Number of Various Concentrated Elements by Yusuf Yesilce

“…After the derivation of the coefficient matrices, the numerical assembly technique is used to establish the overall coefficient matrix for the whole vibrating system. Finally, solving the equations associated with the last overall coefficient matrix one determines the exact dynamic response amplitudes of the forced vibrating system corresponding to each specified exciting frequency of the harmonic force. …”
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Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells. by Boning Li, Ashlin M Edick, Madison K Fox, John Doelman, Sergio A Burgos, John P Cant

“…Eight transcription factors were selected as candidate mediators of EAA effects on mammary cell function via the amino acid response (ATF4, ATF6), mitogen-activated protein kinase (JUN, FOS, EGR1), and mechanistic target of rapamycin complex 1 (MYC, HIF1A, SREBF1). …”
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Palmitic Acid Methyl Ester Enhances Adipogenic Differentiation in Rat Adipose Tissue-Derived Mesenchymal Stem Cells through a G Protein-Coupled Receptor-Mediated Pathway by Jian-Hong Lin, Huan-Hsin Chang, Wen-Sen Lee, Pei-Ching Ting, Yu-Po Luo, Kun-Ta Yang

“…Moreover, PAME significantly increased phosphorylation of extracellular signal-regulated kinases (ERK), but not AKT and mTOR. Cotreatment with PAME and a GPR40/120 antagonist together inhibited the PAME-enhanced ERK phosphorylation and adipogenic differentiation. …”
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Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice by Xiaoqian Guo, Xiaoqian Guo, Chi Zhang, Chi Zhang, Yingyu Li, Yingyu Li, Yingyu Li, Wen Wen, Wen Wen, Wen Wen, Yinghui He, Feng Tang, Chunming Chen, Chao Hu, Linqi OuYang, Wenlong Liu, Wenlong Liu, Zhenhua Zhu, Hongyu Liu

“…Subsequently, ARs models with different immune statuses were established, and validated by measuring four serum indicators using enzyme-linked immunosorbent assay (ELISA). Finally, LC-MS metabolomics analysis was performed on mouse serum to evaluate the metabolic pathways.ResultsThe intensity of ARs induced by XSTI in mice was found to increase with the administered dose, with normal mice exhibiting higher AR intensities compared to immunocompromised mice. …”
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The Impacts and Economic Analysis of Jack Mackerel Meal Inclusion in Low Fish Meal Diets on the Growth and Feed Availability of Juvenile Rockfish (<i>Sebastes schlegeli</i>) by Yu Jin Sim, June Kim, Sung Hwoan Cho

“…Conclusively, a 25% FM substitution with CBM, MM, and TBM with the inclusion of 22% JMM in the 55% FM-based diet could be made without reducing the growth and feed consumption of rockfish. Finally, the CBM25J diet produced the highest weight gain and SGRs of rockfish, as well as the highest economic return to farmers.…”
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Large language models for pretreatment education in pediatric radiation oncology: A comparative evaluation study by Dominik Wawrzuta, Aleksandra Napieralska, Katarzyna Ludwikowska, Laimonas Jaruševičius, Anastasija Trofimoviča-Krasnorucka, Gints Rausis, Agata Szulc, Katarzyna Pędziwiatr, Kateřina Poláchová, Justyna Klejdysz, Marzanna Chojnacka

“…Additionally, a radiation oncologist prepared answers to these questions. Finally, a multi-institutional group of nine pediatric radiotherapy experts conducted a blind review of responses, assessing reliability, concision, and comprehensibility. …”
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Balancing globalisation process through Development Agenda: sustainable global justice by S. M. Aamir Ali, A. Ghose

“…This paper examines the influence of globalisation on the policy-making processes of developing nations. Finally, the authors proceed to analyse the concepts of justice, growth, and sustainability.…”
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Research on Public Administration and Resource Allocation Based on Blockchain and Structured Occupational Therapy by Qiyou Zhu

“…On the basis of summarizing and analyzing the previous published literatures, this study expounded the research status and significance of public administration and resource allocations; elaborated the development background, current status and future challenges of blockchain, and structured occupational therapy; introduced the methods and principles of data quality collaboration model and multiparty collaboration standard management; analyzed the case background of public administration and resource allocation in the prevention and control of the COVID-19 epidemic; discussed the public administration mechanism based on blockchain and structured occupational therapy; established a resource allocation method based on blockchain and structured occupational therapy; fathomed the role of the distributed ledger established by blockchain to increase the information symmetry of public administration activities; proposed a blockchain-established special machine trust for resource allocation; and finally, anatomized the data security sharing and access control mechanism based on blockchain and structured occupational therapy. …”
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Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity by Wenlong Liu, Qingxiang Zeng, Yanqiu Chen, Ren Zhong Luo

“…Leptin and OPN mediated migration and activation of eosinophil through phosphatidylinositol-3-OH kinase (PI3K) pathway. Obese AR mice presented with more severe eosinophilia and symptoms compared with nonobese AR mice or control mice. …”
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