Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…These results were obtained with a low number of injections (3.7 ± 1.9) with only one case of intraocular drug-related adverse event. Finally, the presence of subretinal hyperreflective material correlates with lower visual recovery.DiscussionOur findings highlight the efficacy of Brolucizumab in managing wet-AMD and suggest its role for long-term efficacy in stabilizing retinal exudation and fluid accumulation, resulting in improved visual prognosis.…”
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Evolucionismo: a face oculta do empreendedorismo by Lucas Frazão Silva, Carolina Lorençato Bassani

“…Procurou-se apresentar e analisar a influência teórica de cada uma dessas correntes de pensamento que poderiam ter influenciado para a formação atual do conceito empreendedor, tecendo comentários finais sobre os possíveis resultados da fusão destas teorias, este artigo debate os possíveis desdobramentos daquilo que o Sebrae (Serviço Brasileiro de Apoio às Micro e Pequenas Empresas) chama de empreendedor. …”
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“Longing is good”: proof-of-concept for a novel psychological intervention to tackle self-blaming emotions by Nahed Lajmi, Suqian Duan, Jorge Moll, Roland Zahn, Roland Zahn

“…Self-blaming thoughts, along with depressive symptoms and other outcomes, were assessed pre- and post-intervention to determine the potential of the intervention, which consisted of creating a 10-min video starting with self-blame evoking materials, transitioning to sadness and finally longing. Participants were then asked to watch their video daily for 7 days.ResultsThe number of participants lost to follow-up was low (n = 3) and engagement with the intervention was very high. …”
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Associations among immunophenotype, plasma metabolites, and benign prostatic hyperplasia: a mediation Mendelian randomization study by FAN Jiuming, ZHAO Yiqiao, JIA Haichang, WANG Tiankun, HAN Yutong, QIN Zihao, CHEN Ping, ZENG Xiantao

“…The causal relationship between plasma metabolites and BPH was evaluated by the same method. Finally, the mediating effect of plasma metabolites between immune cells and BPH was further estimated. …”
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Construction and Optimization of Integrated Yield Prediction Model Based on Phenotypic Characteristics of Rice Grown in Small–Scale Plantations by Jihong Sun, Peng Tian, Zhaowen Li, Xinrui Wang, Haokai Zhang, Jiangquan Chen, Ye Qian

“…Subsequently, the top three models with the best performance in individual model predictions are integrated using voting and stacking ensemble methods to obtain the optimal integrated model. Finally, the impact of different rice phenotypic traits on the performance of the stacked ensemble model is explored. …”
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Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…It also demonstrates the insignificance of seasonal soil temperature fluctuations on storage in unconfined shallow aquifers and it clarifies the thermal energy exchange dynamics directly above the storage volume. Finally, it creates the opportunity to explore different storage conditions in a particular setting, allowing to propose cutoff criteria for the investment in ATES. …”
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Covid-19 Salgınının Türkiye’de Finansal Yatırım Araçları Üzerindeki Etkisi by Sevim Nurbanu Yıldız, Üzeyir Aydın

“…COVID-19’a bağlı gelişen ekonomik belirsizlik, ekonomik birimlerin yatırım kararlarını etkileyerek finans piyasalarında dalgalanmaların ortaya çıkmasını beraberinde getirmiştir. …”
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The status of a woman in the ancient world: features of marital and family relations in Ancient Athens by I. A. Lohvynenko, Ye. S. Lohvynenko

“…Intolerance of the opposite sex, along with the hypertrophied idea of man's purpose and role in society and the state finally formed and became apparent in the classical period of ancient Greece. …”
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Physiological accumulation of lipid droplets in the newborn liver during breastfeeding is driven by TLR4 ligands by Wanderson Ferreira da Silva Júnior, Karen Marques de Oliveira Costa, Hortência Maciel Castro Oliveira, Maísa Mota Antunes, Kassiana Mafra, Brenda Naemi Nakagaki, Pedro Sérgio Corradi da Silva, Júlia Duarte Megale, Sarah Campos de Sales, Douglas Carvalho Caixeta, Mário Machado Martins, Robinson Sabino-Silva, Cristina Maria Pinto de Paula, Luiz Ricardo Goulart, Rafael Machado Rezende, Gustavo Batista Menezes

“…Lipidomic analysis revealed changes in the metabolic profile of the developing liver. Finally, we investigated the role of Toll-like receptor 4 (TLR4) signaling in fat storage using knockout mice and cell-specific deletion strategies. …”
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Difference Analysis of Organic Matter Enrichment Mechanisms in Upper Ordovician-Lower Silurian Shale from the Yangtze Region of Southern China and Its Geological Significance in Sh... by Ming Wen, Zhenxue Jiang, Kun Zhang, Yan Song, Shu Jiang, Chengzao Jia, Weiwei Liu, Yizhou Huang, Tianlin Liu, Xuelian Xie, Yue Sun, Shichao Fan, Xiangni Cao, Lin Zhu, Chuanxun Zhou

“…Subsequently, the results of elemental analysis and silicon isotope analysis are used to determine the origin of excess silicon. Finally, we used U/Th to determine the characteristics of the redox environment and the relationship between excess barium and TOC content to judge paleoproductivity and further studied the mechanism underlying sedimentary organic matter enrichment in the study area. …”
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Safety and efficacy of oral edible bird’s nest supplementation: Anti-inflammatory and immunomodulatory benefits for Arabian race stallions during exercise by Khalid Obaid AL-Khaldi, Khalid Hamed Al-Ruzaiqi, Abdul Salam Babji, Seng Joe Lim, Mohammed Babatunde Sadiq, Nurhusien Yimer

“…Kidney and liver function tests revealed significantly reduced creatine kinase, total bilirubin, and aspartate aminotransferase levels in the EBN group. …”
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Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway by Yuhua Zhou, Jing Lv, Shengkai Jin, Chaowei Fu, Bo Liu, Yang Shen, Menglu Li, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…RNA-seq analysis was performed to explore the mechanisms by which TMAO influences the proliferation and migration of prostate cancer cells. qPCR and Western blotting were utilized to validate the expression of related mRNA or proteins. Finally, we performed in vivo experiments to evaluate the effect of a high choline diet on the growth of subcutaneous tumors and lung metastases in mice.ResultsOur study found that TMAO enhances the proliferation and migration of prostate cancer cells by upregulating HMOX1 via activation of the MAPK signaling pathway, specifically p38 MAPK. …”
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Durvalumab, Tremelimumab, and Platinum Chemotherapy in EGFR Mutation–Positive NSCLC: An Open-Label Phase 2 Trial (ILLUMINATE) by Chee Khoon Lee, PhD, Bin-Chi Liao, MD, Shalini Subramaniam, MMed (Clin Epi), Chao-Hua Chiu, MD, Antony J. Mersiades, MMed (Clin Epi), Chao-Chi Ho, MD, PhD, Chris Brown, MBiostats, Chun-Liang Lai, MD, PhD, Brett G.M. Hughes, M.B.B.S. (Hons), Tsung-Ying Yang, MD, PhD, Ken O’Byrne, MD, Yung-Hung Luo, MD, PhD, Sonia Yip, PhD, Ching-Liang Ho, MD, Victoria Bray, PhD, Wu-Chou Su, MD, PhD, Melissa Moore, PhD, Wei-Lien Feng, MS, Ya-Ying Bai, MS, Kate Ford, MHSc, Michelle M. Cummins, PhD, Martin R. Stockler, MSc (Clin Epi), Benjamin J. Solomon, PhD, Thomas John, PhD, James Chih-Hsin Yang, MD, PhD

“…We conducted a phase 2 trial to determine the efficacy of durvalumab, tremelimumab, and platinum-pemetrexed in EGFR-mutant NSCLC after progression with EGFR tyrosine kinase inhibitors (TKIs). Methods: Participants were treated with induction durvalumab, tremelimumab, and platinum-pemetrexed, followed by durvalumab-pemetrexed maintenance. …”
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Using Linear Mixed-Effects Models to Analyze Historical Trends in Performance Strategies . Commentary on Majid Motavasseli’s Article “Interpretation of Cyclic Form in Bach’s ‘Goldb... by Bruno Gingras

“…Using a tempo measurement database comprising seventy-six selected recordings of the “Goldberg” cycle, I built a linear mixed-effects model predicting the main tempo for each recording from the following parameters: performer, variation number, instrument (piano or harpsichord), year of recording, variation type, and finally mode (major/minor) of the variation. Two statistically significant interactions emerged: a two-way interaction between instrument and mode, and a three-way interaction between instrument, year of recording, and variation type. …”
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A Survey of Differential Privacy Techniques for Federated Learning by Wang Xin, Li Jiaqian, Ding Xueshuang, Zhang Haoji, Sun Lianshan

“…This paper comprehensively expounds the research status of differential privacy techniques based on the federated learning framework, first providing detailed introductions to federated learning and differential privacy technologies, and then summarizing the development status of two types of federated learning differential privacy(DPFL) techniques respectively; for CDPFL, the paper divides the discussion into first proposal of CDP and typical application examples, the impact of Gaussian mechanisms on model accuracy, optimization based on asynchronous differential privacy, and insights from other scholars; for LDPFL, the paper divides the discussion into first proposal of LDP and typical application examples, processing multidimensional data and improving model accuracy, existing methods and optimization for reducing communication costs, balancing privacy protection and data usability, LDPFL based on the Shuffle model, and insights from other scholars; following this, the paper addresses and summarizes the unique challenges introduced by incorporating differential privacy into federated learning and proposes solutions; finally, based on a summary of existing optimization techniques, the paper outlines future directions and specifically discusses three research ideas for enhancing the optimization effects of federated differential privacy: advanced optimization strategies combining Bayesian methods and the Alternating Direction Method of Multipliers (ADMM), integrating lattice homomorphic encryption techniques from cryptography to achieve more efficient differential privacy protection in federated learning, and exploring the application of zero-knowledge proof techniques in federated learning for privacy protection.…”
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Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia by Ling C, Cao N, Wang H, Wan Y, Liang X, Guo J, Xiao M, Zhang Q, Zhai Z

“…We then constructed a prognostic model comprising five genes (HBP1, RNF130, RMND5B, TRIM32, and UBE2L3) through univariate Cox and LASSO regression analyses in the TCGA cohort and validated it in the BeatAML2.0 cohort. Finally, the expression of UBE2L3 was verified in cell lines and clinical case specimens.Results: The model accurately predicted AML prognosis and identified the UBE2L3 gene within the model as a high-risk biomarker associated with drug resistance, significantly influencing AML outcomes.Conclusion: The high expression of UBE2L3 is a reliable biomarker for drug resistance and poor prognosis of acute myeloid leukemia.Keywords: E3 ubiquitin ligase, prognostic model, UBE2L3, acute myeloid leukemia, drug resistance…”
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Economic burden of chronic obstructive pulmonary disease and post-tuberculosis sequelae in low- and middle-income countries: a database compiled from a systematic review and meta-a... by Fabrizio Tediosi, Klaus Reither, Olivia Keiser, Alexandra Walker, Yuling Lin, Marguerite Batta, Sierra Ottilie-Kovelman, Anna Duchenko, Curdin Brugger, Robert S Wallis, Marina Antillon

“…The costs were lower in lower middle-income countries compared with upper middle-income countries. Finally, considerable economic burden was attributable to smoking and air pollution.Conclusion The review and the CD-CPTB database give a thorough snapshot of the current evidence of the costs and economic burden of COPD and post-TB diseases. …”
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Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway by Yan Ye, Yan Ye, Xiaopeng Huang, Xiaopeng Huang, Xiaopeng Huang, Xueying Li, Xueying Li, Fei Gao, Wenzhen Zhong, Anqi Tang, Anqi Tang, Liangbin Zhao, Dengpiao Xie, Naijing Ye, Naijing Ye

“…NF-κB-RE-Luc transgenic mice were used to construct a CKD mouse model, and changes in fluorescence intensity in mice and isolated kidney tissues were detected within 1–6 days using a small animal live imager. Finally, 16S rRNA amplicon sequencing was used to monitor changes in intestinal flora in CKD patients before and after SSKE treatment.ResultsWe found that SSKE improves renal function, attenuates renal fibrosis, reduces inflammatory factor levels, and decreases damage to intestinal and renal structures in adenine-induced CKD rats. …”
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18F−Prostate−Specific Membrane Antigen PET/CT imaging for potentially resectable pancreatic cancer (PANSCAN−2): a phase I/II study by Jisce R. Puik, Thomas T. Poels, Gerrit K. J. Hooijer, Matthijs C. F. Cysouw, Joanne Verheij, Johanna W. Wilmink, Elisa Giovannetti, Geert Kazemier, Arantza Farina Sarasqueta, Daniela E. Oprea-Lager, Rutger-Jan Swijnenburg

“…TBR was defined as the ratio between SUVmax of the primary tumor divided by SUVmax of the aortic blood pool. Finally, tracer uptake on PET was correlated to tissue expression of PSMA in surgical specimens. …”
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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…KEGG analysis suggested that EERM's mechanism may involve signaling pathways such as PI3K-Akt, lipid and atherosclerosis, EGFR tyrosine kinase inhibitor resistance, and MAPK pathways. Molecular docking and molecular dynamics simulations results demonstrated a strong binding affinity between the main compounds of EERM and key targets. …”
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