PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression by Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

“…Furthermore, we consistently showed a strong association between meR316-ALKBH5 and poor outcomes in patients with CRC. Finally, we demonstrated that combining an anti-PD1 antibody with the PRMT5 inhibitor GSK3326595 markedly halts the progression of CRC. …”
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Study on seismic performance of high-strength steel earthquake-resilient beam-column joint with double damage elements by Hongchao Guo, Dongdong Zheng, Jing Lu, Xudong Zhou, Wenqi Wang, Yunhe Liu

“…It is recommended to ensure that the stability coefficient of the flange cover plate is not less than 0.967; Considering all factors, it is recommended that hs be taken as 0.2 times the width of the flange cover plate, lc be taken as 1.3 times the height of the beam, and αa taken as 50°. Finally, a calculation method for the joint trilinear skeleton curve model was proposed through theoretical derivation and data fitting. …”

Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts by Sara Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone, M V Iorio

“…Consistently with the biological effects observed, gene expression profiles of NFs upon transient transfection with miR-9 show the modulation of genes mainly involved in cell motility and extracellular matrix remodeling pathways. Finally, we were able to confirm the capability of NFs transiently transfected with miR-9 to promote in vivo tumor growth. …”
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Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…Next, hub gene validation was performed using the least absolute shrinkage and selection operator (LASSO) and receiver operating characteristic (ROC) curves. Finally, we used RT-qPCR, immunofluorescence, Western blotting and Elisa to validate hub gene expression in MASLD and T2DM mouse models.ResultsThis analysis identified 20 genes shared by MASLD and T2DM that were enriched in the bile secretion, phototransduction, cancer, carbohydrate digestion and absorption, cholesterol/glycerol metabolism, and retinol metabolism. …”
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Fuzzy modeling using the similarity-based approximate reasoning system by Jalal Chachi, Mehdi Jalalvand

“…Next,  we validate the effectiveness of the   proposed similarity measure in a bidirectional approximate reasoning system in order to provide a  nonlinear mapping of fuzzy  input data into fuzzy output data. Finally,  using existing experimental data from Uniaxial Compressive Strength (UCS) testing,  the fuzzy inference system constitutive model is produced to describe the influence of joint geometry (joint location, trace length and orientation) on the UCS of rock. …”
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Ultrasonic Time-Frequency Response Characteristics for Damage Evolution of Back-Filling Concrete under Staged Loading Conditions by Xicai Gao, Xichen Zhang, Cheng Zhao, Huan Xia, Shuai Liu, Tengfei Ma, Jianhui Yin, Kai Fan

“…Results show that under staged loading conditions, the concrete specimens underwent a differential change process from nonuniform to uniform deformation, to localized deformation, and finally to failure. The velocity of the ultrasonic wave of the loaded concrete specimens first increased, then decreased with increasing stress, and the macroscopic deformation characteristics were consistent with damage development and evolution, showing clear stage-specific characteristics. …”
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Assessing the Air Humidity Characteristics of Local Climate Zones in Guangzhou, China by Xiao Tan, Qi Zhang, Yiqi Chen, Junsong Wang, Lihua Zhao, Guang Chen

“…The strongest UMI occurred during winter nights in LCZ 8, with a peak intensity of 0.8 hPa, while the UDI was more frequent during summer days in LCZ 1, with a maximum value of −1.2 hPa; meanwhile, compact areas had a slightly higher frequency of UDI than open areas. Finally, the effects of the urban heat island (UHI) and wind speed (<i>V</i>) on UMI were analyzed. …”
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T cell receptor signaling pathway subgroups and construction of a novel prognostic model in osteosarcoma by Huan Xu, Huimin Tao

“…Immune landscape analysis including immune infiltration analysis, ESTIMATE algorithm and immune checkpoints expression levels of molecular subtypes and different risk groups were analyzed. Finally, chemotherapy sensitivity and potential therapeutic agents between different risk groups was identified. …”
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Evaluating approaches for integrating species distributions in spatial conservation planning by Jason M. Winiarski, Amy A. Shipley, Drew N. Fowler, Matthew D. Palumbo, Jacob N. Straub

“…There was also minimal agreement among top‐ranked ecological landscapes (40%) and watersheds (28%) between the two versions of the DST. Finally, we compare tradeoffs and suggest a model‐driven approach for the WWHCS DST. …”
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Metagenomics Analysis of Microbial Species and Antibiotic Resistance Genes (ARGs) in Untreated Wastewater from Different Types of Hospitals in Hangzhou by Song Chen, Yi Zhou, Lu Song, Yanli Yang, Fuming He, Qianming Chen, Xi Cheng

“…The ARGs in the samples were also analyzed using the Antibiotic Resistance Genes Database (ARDB) and Comprehensive Antibiotic Resistance Database (CARD). Finally, the link between abundant species and ARGs in the samples was examined. …”
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The multiple uses of artificial intelligence in exercise programs: a narrative review by Alberto Canzone, Alberto Canzone, Giacomo Belmonte, Antonino Patti, Domenico Savio Salvatore Vicari, Domenico Savio Salvatore Vicari, Fabio Rapisarda, Valerio Giustino, Patrik Drid, Antonino Bianco

“…A total of 24 studies were identified, and finally, after a full-text review, 15 studies were identified as meeting all eligibility criteria for inclusion. …”
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Numerical simulation and theoretical study on the impact of wind-sand flow of high-speed trains in long tunnel space by Shiqun Li, Sihui Dong, Yonghua Li, Liping Zhou

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Spatiotemporal Traffic Density Estimation Based on ADAS Probe Data by Donghyun Lim, Younghoon Seo, Eunjeong Ko, Jaehyun(Jason) So, Hyungjoo Kim

“…Such vehicle trajectory data are used firstly to estimate the distance headway between the vehicles on a specific road section, and the postprocessed distance headway data are finally used to estimate the spatiotemporal traffic density. …”
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Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurpo... by Arnob Sarker, Burhan Uddin, Reaz Ahmmed, Sabkat Mahmud, Alvira Ajadee, Md. Al Amin Pappu, Md. Abdul Aziz, Md. Nurul Haque Mollah

“…Then molecular mechanisms of GBM development were investigated by these three overexpressed driver genes through gene ontology (GO), KEGG-pathways, Gene regulatory network (GRN) and mutation analysis. Finally, overexpressed oncodriver genes guided top-ranked six drug agents (Irinotecan, Imatinib, etoposide, pazopanib, trametinib and cabozanitinib) were recommended against GBM through molecular docking study. …”
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Exploring Anti-Breast Cancer Effects of Live Pediococcus acidilactici and Its Cell-Free Supernatant Isolated from Human Breast Milk by Naa N. Adumuah, Jude T. Quarshie, Harry Danwonno, Anastasia R. Aikins, Elmer N. Ametefe

“…Additionally, the levels of the SLUG gene remained unchanged while the TWIST1 gene was upregulated following exposure of the cancer cells to bacteria, indicating that P. acidilactici may promote epithelial-mesenchymal transition in breast cancer. Finally, the CFS significantly inhibited cancer cell mobility. …”
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The Self-Perception and Political Biases of ChatGPT by Jérôme Rutinowski, Sven Franke, Jan Endendyk, Ina Dormuth, Moritz Roidl, Markus Pauly

“…In addition, ChatGPT’s Big Five personality traits were tested using the OCEAN test, and its personality type was queried using the Myers-Briggs Type Indicator (MBTI) test. Finally, the maliciousness of ChatGPT was evaluated using the Dark Factor test. …”
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Impact in Clinical Practice of the European Medicines Agency Health Alert About the Restriction of the Use of JAK Inhibitors by Elisabet Castañeda-Estévez, Cristina Vergara-Dangond, Martina Steiner, Maria Beatriz Paredes-Romero, Ana Esteban-Vázquez, Tatiana Cobo-Ibañez, Laura Trives-Folguera, Maria Liz Romero-Bogado, Isabel De La Cámara-Fernández, Patricia Richi-Alberti, Ana Acosta-Alfaro, Iría De la Osa-Subtil, Santiago Muñoz-Fernández

“…<b>Background/Objectives:</b> Janus kinase inhibitors (JAKi) have revolutionized the treatment of various inflammatory and immune disorders. …”
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The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Jiang Liu, Chengtong Zhai, Degan Liu, Jianhua Liu

“…What is more, cell migration was also inhibited in vitro in Matrigel Transwell Assay by LOXL1-AS1 knockdown, which might be partly attributed to the reduction of MMP-2 and MMP-9 protein expressions. Finally, cell cycle analysis revealed that knockdown of LOXL1-AS1 induced significantly a G0/G1 phase cell cycle arrest, which might be partly attributed to the downregulation of Cdc2, Cdc25A, and cyclin B1 protein expression. …”
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Amine modified sodium alginate: Synthesis, characterization and in vivo evaluation in rainbow trout (Oncorhynchus mykiss) by Samira Salarvand, Seyed Amir Hossein Jalali, Nasrollah Mahboobi Soofiani, Alireza Allafchian

“…Its cytotoxicity was evaluated using an MTT assay. Finally, its effects were assessed orally in rainbow trout (3 ± 0.3 g) for 6 weeks at 2 levels (2.5 and 5 g kg-1). …”
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A small object detection model in aerial images based on CPDD-YOLOv8 by Jingyang Wang, Jiayao Gao, Bo Zhang

“…Thirdly, a new DSC2f structure is proposed, which uses Dynamic Snake Convolution (DSConv) to take the place of the first standard Conv of Bottleneck in the C2f structure, so that the model can adapt to different inputs more effectively. Finally, the Dynamic Head (DyHead), which integrates multiple attention mechanisms, is used in the head to assign different weights to different feature layers. …”
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