A comprehensive analysis to reveal the underlying molecular mechanisms of natural killer cell in thyroid carcinoma based on single-cell RNA sequencing data by Xiaoqiong Li, Kejiang Wang, Jiaxin Liu, Yan Li

“…In addition, FN1 and RUNX1 were also found to have the highest correlation in TF network. Finally, NK cell-related drugs belinostat and vorinostat were identified based on ASGARD. …”
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Explaining the perception of students and professors regarding the clinical education challenges and strategies of the operation room by Somayeh Akbari Farmad, Marzieh Khosravi, Sadegh Abaei Hasani, Sarvin Bosak

“…CONCLUSION: This study can increase the awareness of clinical professors and educational managers of operating room majors about clinical education challenges in this field and strategies for solving them. Finally, such actions can help to create a more effective clinical environment.…”
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A High-Salt Diet Disturbs the Development and Function of Natural Killer Cells in Mice by Xiaokang Zeng, Yan Li, Weibiao Lv, Xinhuai Dong, Chong Zeng, Liming Zeng, Zibo Wei, Xu Lin, Yanning Ma, Qiang Xiao

“…Moreover, it was also found that the ability of NK cells to secrete CD107a and IFN-γ in HSD-fed mice was decreased following stimulation with RMA-S and YAC-1 tumor cells. Finally, the underlying molecular mechanism was evaluated, and it was found that HSD increased the production of reactive oxygen species (ROS) by NK cells, while the expression of CD122 was decreased, suggesting that HSD downregulates CD122 expression in NK cells via ROS signaling, thereby reducing the responsiveness to IL-15 and ultimately inhibiting NK cell function. …”
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Understanding the regulatory-procurement interface for medicines in Africa via publicly available information on standards, implementation, and enforcement in five countries by Jillian C. Kohler, Mariangela Castro-Arteaga, Saher Panjwani, David Mukanga, Murray M. Lumpkin, Bonface Fundafunda, Anthony B. Kapeta, Chimwemwe Chamdimba, Anna S. Y. Wong, Kristin N. Harper, Charles Preston

“…In addition, we documented a lack of publicly available information related to the role that quality plays in selecting medical products. Finally, none of the five countries have publicly published the results of their selection decisions with key product details, making it difficult to assess whether basic quality standards are being met.Conclusion Based on these findings, one of the most important next steps for improving the effectiveness and transparency of national procurement is for procurement agencies to publish detailed quality selection criteria and an up-to-date list of the medical products they have purchased, with key product information. …”
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scATAC-seq generates more accurate and complete regulatory maps than bulk ATAC-seq by E. Ravza Gur, Jim R. Hughes

“…Furthermore, we found that scATAC-seq identified differences in what was previously assumed to be a homogenous population of cells. Finally, we determined the number of cells required to generate aggregated open chromatin profiles from single cells and to identify biologically meaningful clusters after pseudo-bulking of data. …”
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Deep Feature Learning for Intrinsic Signature Based Camera Discrimination by Chaity Banerjee, Tharun Kumar Doppalapudi, Eduardo Pasiliao, Tathagata Mukherjee

“…Our system is end-to-end, requires no complicated pre-processing steps and the trained model is computationally efficient during testing, paving a way to have near instantaneous decisions for the problem of digital camera identification in production environments. Finally we present comparisons against the current state-of-the-art in digital camera identification which clearly establishes the superiority of the end-to-end solution.…”
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Maritime Small Object Detection Algorithm in Drone Aerial Images Based on Improved YOLOv8 by Peng Ling, Yihong Zhang, Shuai Ma

“…Then, we propose an improved network fusion model based on weighted bi-directional feature pyramid network (BiFPN) to reconstruct the neck, which can enhance the features of small targets through weighted fusion of feature information of different scales and bidirectional cross-scale connection. Finally, we add a new detection layer in the neck to capture more object location information in images. …”
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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. by Danelle S Eto, Tiffani A Jones, Jamie L Sundsbak, Matthew A Mulvey

“…Furthermore, focal adhesion and Src family kinases, which propagate integrin-linked signaling and downstream cytoskeletal rearrangements, are shown to be required for FimH-dependent bacterial invasion of target host cells. …”
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User-Centric Radio Access Technology Selection: A Survey of Game Theory Models and Multi-Agent Learning Algorithms by Giuseppe Caso, Ozgu Alay, Guido Carlo Ferrante, Luca De Nardis, Maria-Gabriella Di Benedetto, Anna Brunstrom

“…Models and algorithms are analyzed by comparatively reviewing relevant literature. Finally, open challenges are discussed, in light of ongoing research and standardization activities.…”
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Foreign Policy Orientation and Electoral Behavior: Analyzing Opinion Polls in Belarus, Georgia, and Kazakhstan by I. Yu. Okunev, M. N. Shestakova

“…., Such a demarcation was singled out by many researchers, singled out concerning Russia; however, we found the same demarcations in Belarus (“Minsk and the rest of the country”) partly in Georgia and Kazakhstan. Finally, the authors admit to it the possibility of delimitation along the north-south lines: in Georgia and, to some extent, in Kazakhstan, as a result of territorial differentiation in the residence of Russians in the northern regions of the republic, where sympathy for Russia is more clearly manifested than in the southern regions remote from it; and this demarcation is less pronounced in Belarus, where it refers to the regions bordering Russia and Ukraine.…”
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Workplace violence and associated factors against nurses working in public hospitals in Ethiopia: a systematic review and meta-analysis by Yeshiwas Ayale Ferede, Agerie Mengistie Zeleke, Jember Ayelgne Beyene, Getanew Kegne Nigate, Worku Chekol Tassew

“…Methods A systematic and methodical literature search was conducted using electronic databases such as Google Scholar, EMBASE I, Scopus, PubMed, HINAR, the Web of Science, and the African Journal Online (AJOL). …”
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Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. …”
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Cell Differentiation Trajectory Predicts Prognosis and Immunotherapeutic Response in Clear Cell Renal Cell Carcinoma by Jin Xu, Xi Chen, Yinyu Chen, Qiushuang Wang, Yingliang Jin, Huashuo Zhao

“…In the study of immune checkpoints, we found that patients in the high-risk group had a disposition to get worse prognosis and better effects of immune checkpoint blocking therapies. Finally, we found the expression level of model DRGs was associated with a tumor-immune microenvironment (TIME) pattern and the response of 83 compounds or inhibitors was significantly different in the two risk groups. …”
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Business or Security? Goals and Decision-Making Inside the French Oil Policy of the 1920s by I. E. Magadeev

“…First, to diversify the supplies; second, to acquire control or direct access to the oil sources; and, finally, to consolidate the French business interests with the mediation of the state authorities. …”
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Biological functions of extracellular vesicle double C2-like domain beta in cervical cancer by Sangavi Eswaran, Samatha Bhat, Dinesh Upadhya, Roshan Mascarenhas, Shama Prasada Kabekkodu

“…Re-expression of DOC2B significantly altered the global metabolite profile of EVs.  Finally, we demonstrated that intracellular calcium chelation significantly reduces DOC2B localization to EVs and impacts its tumor-suppressive properties. …”
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Model Construction of InSAR-based Rainfall Thresholds for Landslide Hazards in Yanhe Basin, Chinese Loess Plateau by WANG Zhenliang, CHEN Manyu, ZHAO Jianlin, YUAN Ke, YANG Jie, ZHANG Chen

“…Then the correlations between rainfall factors and landslide shape variables were calculated to determine the rainfall days and effective rainfall attenuation coefficient in the early period. Finally, the effective rainfall (E), rainfall intensity (I) and rainfall duration (D) were calculated, and the E-D, I-D and E-I rainfall threshold models were established by combining the power function. …”
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Psychological Motivation of Athletes’ Physical Training Based on Deep Learning Model by Yining Yang

“…Based on the change of the same training volume, the change law and relationship between RPE and POMS, and the change law and relationship between RPE, POMS, heart rate, and blood pressure were analyzed. Finally, it was concluded that the athletes are feeling more and more about the amount of training, and the minimum value P<0.01 showed a very significant difference, reflecting that the increase of training volume has a significant impact on the t-test value. …”
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Küreselleşme Olgusu Bağlamında Yeni Güvenlik Algısı by İbrahim Erdoğan

“…Ulusal veya küresel ekonomiye ya da finans piyasalarına saldırılar, refaha, çevreye, sağlığa yönelen tecavüzler ile göçler ve mülteci hareketleri de ulusal çıkarları zedeleyen tehditler olarak öne çıkmıştır. …”
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Urinary Proteome and Exosome Analysis Protocol for the Discovery of Respiratory Diseases Biomarkers by Laura Martelo-Vidal, Sara Vázquez-Mera, Pablo Miguéns-Suárez, Susana Belén Bravo-López, Heidi Makrinioti, Vicente Domínguez-Arca, Javier de-Miguel-Díez, Alberto Gómez-Carballa, Antonio Salas, Francisco Javier González-Barcala, Francisco Javier Salgado, Juan José Nieto-Fontarigo

“…., miR-16-5p, miR-21-5p, miR-146a-5p, and miR-215-5p) in urine exosomes by RTqPCR. Finally, we detected 333 miRNAs using Nanostring, 15 of them up-regulated in T2^high asthma (N = 4) compared to T2^low asthma (N = 4) and healthy subjects (N = 4). …”
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Political and Institutional Approaches to Advancing International Religious Freedom in the U.S. Foreign Policy in 1998–2020 by V. A. Shchipkov

“…The study concludes that over the past twenty years, religion has finally developed as an independent track of the US foreign policy, although it has been developing inconsistently and has undergone repeated corrections. …”
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