Depletion and Reversal of Hepatocellular Carcinoma Inducing CTL through ER Stress-Dependent PERK-CHOP Signaling Pathway by Mengnan Guo, Wei Wang, Wen Bai, Zekun Bai, Weixi Chen, Yali Su, Jinghua Wu

“…After sh-CHOP or GSK2656157 (PERK inhibitor) stimulation, the activation of the PERK-CHOP pathway was detected in CTLL-2 cells. Finally, changes in PD-1, TIM-3, PRF1, and GzmB levels were detected to verify the reversal of CTL depletion by TP. …”
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Potential and costs required for methane removal to compete with BECCS as a mitigation option by Yann Gaucher, Katsumasa Tanaka, Daniel J A Johansson, Olivier Boucher, Philippe Ciais

“…We show that to totally replace bioenergy based CDR with MR, the MR potential should reach at least 180–290 MtCH _4 per year, i.e. between 50% and 90% of current anthropogenic methane emissions, with maximum unit cost between 11 000 and 69 000 $/tCH _4 , depending on the climate target. Finally, we found that replacing CDR by MR reshapes the intergenerational distribution of climate mitigation efforts by delaying further the mitigation burden.…”
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Deformation Failure and Support Test of Surrounding Rock in Deep Arched Roadway with Straight Wall by Shuqi Pan, Shuaitao Liu, Liming Cao, Jianqiang Guo, Chao Yuan

“…First, load the test body to the set initial stress state, and then carry out the full-face excavation and unloading of the roadway; finally, load it in the vertical direction until the roadway wall is damaged. …”
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Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens by Relu Cocoș, Bogdan Ovidiu Popescu

“…This review highlights the critical importance of adopting a systems genetics approach to unravel the complex genetic architecture of neurodegenerative diseases. Finally, this emerging holistic understanding of multi-omics data and the exploration of the intricate genetic landscape aim to provide a foundation for establishing more refined genetic architectures of these diseases, enhancing diagnostic precision, predicting disease progression, elucidating pathogenic mechanisms, and refining therapeutic strategies for neurodegenerative conditions.…”
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PhyIndBC: Development of a machine learning tool for screening of potential breast cancer inhibitors from phytochemicalsGitHub by Agneesh Pratim Das, Subhash M. Agarwal

“…NPs predicted as actives were further screened via ensemble virtual screening (eVS) technique against erb-b2 receptor tyrosine kinase 2 (HER2), to identify high-affinity molecules against this breast cancer drug target. …”
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Intrinsic and Extrinsic Neuronal Mechanisms in Temporal Coding: A Further Look at Neuronal Oscillations by Rémy Lestienne

“…Moreover, adjustable frequency oscillators are suitable for use in “phase locked loops” (PLL) networks, a device that can convert time coding to frequency coding; such PLL units have been found in the somatosensory cortex of guinea pigs. Finally, are oscillations stricto sensu necessary to induce synchronization in the discharges of downstream neurones? …”
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The Economics of Immortality: The Demi-Immortal Oriental, Enlightenment Vitalism, and Political Economy in Dracula by J. Jeffrey Franklin

“…Two monstrous alternatives—demi-immortality and an archaic economy of gold and land—are wedded in/as Dracula. Finally, I will delineate a counter-argument, both to my own preceding argument and to that most common among criticisms of the novel, that Dracula, far from being the anti-capitalist anti-Christ, is at once both more spiritual and truer to laissez-faire economics than the vampire slayers who purportedly defend those very values.…”
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Time dependence effect of metal toxicology and application in WQC derivation of main water basins in China by Tianxin Li, Yao Wang, Ning Qin, Wenjing Zhao, He Huang

“…The ecological indicators, including the hazardous concentration for 5% of species (HC5) values and water quality criteria (WQC), were derived for different exposure times. Finally, the dynamic ecological risks of heavy metals in major Chinese water basins were evaluated. …”
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Self-Sacrifice of a Scientist in Soviet-Russian Cinema by S. M. Medvedeva

“…Each period has its unique tradition of presentation of self-sacrifice of a scientist. Finally we ague, that in the late soviet time appeared a trend to show the sacrifice in the name of science as a senseless and useless action. …”
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A Compact Multi-Identity Fully Homomorphic Encryption Scheme Without Fresh Ciphertexts by Ziwei Wang, Ruwei Huang, Xiyi Wei

“…This adaptation also utilizes approximation errors to reduce overall noise. Finally, we expand the modified IBE scheme’s ciphertext using the decomposition method to construct the WZ-MIBFHE scheme. …”
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Consommation des produits écologiques et inégalités sociales. Le cas tunisien by Ridha Abdmouleh

“…Les produits écologiques demeurent-ils perçus comme une sorte de luxe et un privilège réservés aux classes sociales aisées ? Finalement, en dépit de sa bonne cause, la problématique environnementaliste n’échappe pas au découpage de classes et à la reproduction des inégalités sociales, d’où la nécessité de reconsidérer les conceptions et les relations traditionnelles entre les sphères économiques et sociales et la sphère environnementale. …”
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Multiscale Method for Seismic Response of Near-Source Sites by Shutao Li, Jingbo Liu, Zhou Yang, Xin Bao, Fei Wang, Xiaofeng Wang, Mohsen Saleh Asheghabadi

“…Then, using the method of seismic wave input based on artificial boundary substructures, the free-field motion of the wave is transformed into the equivalent seismic load, which is the seismic wave input data for the small-scale region of interest. Finally, with the help of local elements with special shapes to realize the grid transition of different scales, a small-scale model with reasonable soil-underground structure interaction is established, and the seismic response of the overall model can be effectively solved. …”
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Articulatory-to-Acoustic Conversion Using BiLSTM-CNN Word-Attention-Based Method by Guofeng Ren, Guicheng Shao, Jianmei Fu

“…In this paper, we used the electromagnetic articulography (EMA) database designed by Taiyuan University of Technology, which contains ten speakers’ 299 disyllables and sentences of Mandarin, and extracted 8-dimensional articulatory features and 1-dimensional semantic feature relying on the word-attention layer; we then trained 200 samples and tested 99 samples for the articulatory-to-acoustic conversion. Finally, Root Mean Square Error (RMSE), Mean Mel-Cepstral Distortion (MMCD), and correlation coefficient have been used to evaluate the conversion effect and for comparison with Gaussian Mixture Model (GMM) and BiLSTM of recurrent neural network (BiLSTM-RNN). …”
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DVCW-YOLO for Printed Circuit Board Surface Defect Detection by Pei Shi, Yuyang Zhang, Yunqin Cao, Jiadong Sun, Deji Chen, Liang Kuang

“…By enhancing prominent features and suppressing less important ones, this modification allows the model to better focus on key regions, thereby improving feature representation capabilities. Finally, the WIoU loss function is implemented to replace the traditional CIoU function in YOLOv8n. …”
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RB-TRNet: a regularity-guided and boundary-aware architecture for toponym recognition from Chinese text by Haigang Sui, Jindi Wang, Xining Zhang, Huihan Ning, Wentao Wang, Lieyun Hu

“…Additionally, an orthogonal space is established after the BiLSTM network to facilitate the learning of different rule features by the two modules. Finally, after joint optimization training of the three modules, the toponym regularity perception module is used to predict the Chinese place name entities. …”
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Short‐Term Memory and Regional Climate Drive City‐Scale Water Demand in the Contiguous US by Wenjin Hao, Andrea Cominola, Andrea Castelletti

“…Our model achieves an average R2 higher than 0.8 for one‐month‐ahead prediction of water demand across various cities, leveraging the Granger causal relationships in different spatial contexts. Finally, the exploration of temporal dynamics among determinants and water demand amplifies the interpretability of the model results. …”
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Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain by Saeideh Aran, Mohammad Ghasem Golmohammadi, Mohsen Sagha, Kamran Ghaedi

“…Thus, the embryonic and adult-derived NSPCs for cardinal characteristics were analyzed, and then, the expression of candidate genes related to neural patterning using real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) was evaluated at various stages of embryonic (E14 and E18), neonatal, and adult brains. Finally, it was assessed the effect of cell attachment and passage on the initial neural patterning of NSPCs.ResultsThe analysis of gene expression revealed that although temporal patterning is maintained in vitro, it shows a decrease over time. …”
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Ewing sarcoma – pathomechanisms, standard treatment and new therapeutic perspectives by Wojciech Zezuliński, Filip Woliński, Julia Zyśk, Mateusz Korga, Jakub Klas, Jacek Baj, Eliasz Dzierżyński

“…The paper discusses, among other things, treatment attempts based on the role of the EWS-FLI1 protein, epigenetics, tyrosine kinase inhibitors, immunotherapies and the use of nanomedicine and viruses, as well as the difficulties associated with their application. …”
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Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres by David Young, Sohail Rahmany, Deborah Taylor, Emma Davis, Michael Colwill, Sonia Kalyanji Mehta, Roisin Campbell, Karl Hazel, Karishma Sethi-Arora, Susan Ritchie, Ashley I Heinson, Helen Moyses, Keith Bodger, Emma Johnston, Lucy Hicks, Anjan Dhar, Jimmy Limdi, Rachel Cooney, John Paul Seenan, Kamal Patel, Alissa Walsh, Fraser Cummings

“…Background: Filgotinib, an oral Janus kinase 1 preferential inhibitor, has been shown to be an effective treatment for ulcerative colitis (UC) in pre-registration studies. …”
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Design and Development of Monolithic Microwave Integrated Amplifiers and Coupling Circuits for Telecommunication Systems Applications by R. Makri, M. Gargalakos, N. K. Uzunoglu

“…A meander-kind design as well as shunt capacitors were implemented for a 90° quadrature coupler and a Wilkinson one in order to reduce size. Finally, a two stages low noise amplifier was designed with the use of H40 GaAs process in order the differences between the relevant designs to be explored. …”
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