Development and validation of a risk prediction model for PICC-related venous thrombosis in patients with cancer: a prospective cohort study by Zeyin Hu, Mengna Luo, Ruoying He, Zhenming Wu, Yuying Fan, Jia Li

“…Univariate and multivariate regression analyses were used to identify independently associated risk factors of PICC-RVT and develop a risk prediction model. 275 patients were finally included for data analysis, and 18 (6.5%) developed PICC-RVT. …”
Get full text

Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome by Xinlei Sun, Shuang Qu, Fenglian Zhou, Fujie Shi, Yunfei Wu, Lin Gu, Minghui Liu, Zhen Bian, Lei Shi, Zhihong Liu, Yuan Liu, Ke Zen

“…In a mouse model of Stx1/2-positive EDL933 infection-induced HUS, the presence of Stx2-positive monocytes in peripheral blood and infiltrated kidney tissues was observed. Finally, depleting monocytes through the usage of a CD14 neutralizing antibody or blocking monocyte chemotaxis via inhibition of CCL2 notably mitigates kidney injury and dysfunction caused by lipopolysaccharide (LPS)/Stx2 treatment. …”
Get full text

Las raíces del Enoturismo en Brasil by Vander Valduga, Rosa Maria Vieira Medeiros

“…La inmigración italiana en Brasil ha sido uno de los mayores movimientos migratorios mundiales de finales del siglo XIX. Sus consecuencias identitarias, territoriales y económicas fueron y siguen siendo significativas, especialmente para el Estado de Rio Grande do Sul, que recibió el mayor contingente de inmigrantes. …”
Get full text

Assessment of residential exposures to agricultural pesticides: A scoping review. by Raphaëlle Teysseire, Guyguy Manangama, Isabelle Baldi, Camille Carles, Patrick Brochard, Carole Bedos, Fleur Delva

“…These studies assessed exposure by measuring pesticides in biological and environmental matrices, mostly in urines and house dust. Finally, we found only eight publications (5.3%) that quantified the risk to human health due to residential exposure for management purposes, in which exposure was mainly determined using probabilistic models. …”
Get full text

Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation by Zhong-Hui Wang, Wei-Ying Ren, Lei Zhu, Li-Juan Hu

“…To further evaluate the role of PAI-1, the PAI-1 gene was downregulated and overexpressed using the siRNA transfection technology and the pCDH-PAI-1, respectively. Finally, the GFP Positive Expression Rate Method was used to determine the rate of GFP-LC3 positive NR8383 cells. …”
Get full text

Overview of 5G multi-channel redundant transmission technology by MA Shuai, YANG Bohan, YANG Fengbo, WEI Anni, ZHENG Chenglong

“…In terms of technical routes, the development direction of 5G multi-channel redundant transmission technology and various possible implementation paths were comprehensively considered. Finally, the difficulties and challenges of the future development of 5G multi-channel redundant transmission technology were pointed out, and its future development trend was discussed, so as to better understand the key role and prospect of 5G redundant transmission technology in the field of wireless communication.…”
Get full text

Designing a Model of Effective Factors on Creative Cultural Industries in Iran by Abbas Ghaedamini Harouni, Mehrdad Sadeghi Deh Cheshmeh, Sadegh Sadeghi Deh Cheshmeh, Narjes Mohsenifar

“…Both validity questionnaires were confirmed, and Cronbach's alpha coefficient measured its reliability above 0.70.Findings: The Delphi identification test was used to identify the influential factors and was screened in two stages. Finally, the experts identified the criteria gathered in the research background in 6 criteria and 16 sub-criteria affecting the creative cultural industries in 7 main criteria, and 17 sub-criteria were agreed upon. …”
Get full text

Alzheimer’s Disease and Cardiovascular Disease: A Particular Association by Giacomo Tini, Riccardo Scagliola, Fiammetta Monacelli, Giovanni La Malfa, Italo Porto, Claudio Brunelli, Gian Marco Rosa

“…Further studies are needed in order to understand the effect of CVD and its risk factors on AD in order to better comprehend the effects of subclinical and clinical CVD on the brain. Finally, we need to clarify the impact of the underlying hypothesized mechanisms of this association and to investigate gender issues.…”
Get full text

Serine Deficiency Exacerbates Inflammation and Oxidative Stress via Microbiota-Gut-Brain Axis in D-Galactose-Induced Aging Mice by Fengen Wang, Hongbin Zhou, Ligang Deng, Lei Wang, Jingqing Chen, Xihong Zhou

“…Additionally, serine deficiency in combination with D-galactose injection significantly decreased fecal butyric acid content and gene expression of short-chain fatty acid transporters (Slc16a3 and Slc16a7) and receptor (Gpr109a) in the brain. Finally, serine deficiency exacerbated the decrease of expression of phosphorylated AMPK and the increase of expression of phosphorylated NFκB p65, which were caused by D-galactose injection. …”
Get full text

Vertical Profile of Wind Diurnal Cycle in the Surface Boundary Layer over the Coast of Cotonou, Benin, under a Convective Atmosphere by Hagninou E. V. Donnou, Aristide B. Akpo, Clément A. Kouchadé, Basile B. Kounouhewa, Guy H. Hounguè, Gbènoukpo F. Nonfodji, Julien Djossou

“…The average wind speed during this cycle is therefore evaluated to 8.07 m·s−1 for August which is the windiest month and to 4.98 m·s−1 for the least windy month (November) at 60 m of the ground. …”
Get full text

A comparison of Bayesian and frequentist confidence intervals in the presence of a late Universe degeneracy by Eoin Ó. Colgáin, Saeed Pourojaghi, M. M. Sheikh-Jabbari, Darragh Sherwin

“…In addition, we confirm that MCMC degeneracies observed in 2D posteriors are not due to curves of constant $$\chi ^2$$ χ 2 . Finally, on the assumption that the Planck- $$\Lambda $$ Λ CDM cosmological model is correct, using profile likelihoods we confirm a $$>2 \sigma $$ > 2 σ discrepancy with Planck- $$\Lambda $$ Λ CDM in a combination of CC and baryon acoustic oscillations (BAO) data beyond $$z \sim 1.5$$ z ∼ 1.5 . …”
Get full text

Fault localization for automatic train operation based on the adaptive error locating array algorithm by Yanpeng Zhang, Yuxiang Cao

“…These cases are designed to locate the MFS more easily in the given parameter range using the Adaptive Particle Swarm Optimization (APSO) algorithm. Finally, the MFS is determined. The validity and accuracy of the proposed method are verified through the simulation testing platform for Beijing-Shenyang high-speed rail. …”
Get full text

Evaluation of Serum Leucine-Rich Alpha-2 Glycoprotein as a New Inflammatory Biomarker of Inflammatory Bowel Disease by Tetsuhiro Yoshimura, Keiichi Mitsuyama, Ryosuke Sakemi, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Shuhei Fukunaga, Toshihiro Araki, Masaru Morita, Kozo Tsuruta, Hiroshi Yamasaki, Takuji Torimura

“…Disease activity was assessed clinically and endoscopically. Finally, LRG gene expression in the PBMCs from a different cohort (41 patients with UC, 34 patients with CD, and 30 healthy controls) was examined. …”
Get full text

The Prediction of Metro Shield Construction Cost Based on a Backpropagation Neural Network Improved by Quantum Particle Swarm Optimization by Lanjun Liu, Denghui Liu, Han Wu, Xinyu Wang

“…This method combined the strong nonlinear analysis capabilities of the BP and the global search capabilities of the QPSO. Finally, we selected 50 projects in China for a case analysis. …”
Get full text

PFAS residue analysis in fish and fish feed by applying a modified QuEChERS method in combination with LC-HRMS detection by Ourania Koloka, Vasiliki Boti, Dimitra Hela, Triantafyllos Albanis, Ioannis Konstantinou

“…Matrix effect studies demonstrated low, and medium values and the method showed an acceptable expanded uncertainty of <57.66 %. Finally, the modified method was applied to analyze fish and fish feed samples from Greek aquaculture facilities. …”
Get full text

A Multiobjective Model for a Multilevel Blood Supply Chain to Improve the Attractiveness of Blood Centers during the COVID-19 Pandemic by Abolfazl Moghimi Esfandabadi, Davood Shishebori, Mohammad-Bagher Fakhrzad, Hassan Khademi Zare

“…It produces Pareto solutions using the ε-constraint method. Finally, the efficiency of the proposed approach and the sensitivity of the corresponding parameters are analyzed through a practical case study. …”
Get full text

Effect of Black Cumin on the Expression of Genes Related to Lipid Metabolism in Adipose Tissue: A Mouse Model Study by Roya Maleki, Ali Ahadi, Hoda Ayat

“…In addition, adipose tissue and cell size were analyzed using the Oil Red O staining method and quantitation using Image J software. Finally, GraphPad prisim 9.0 was applied to statistically evaluate the cell size difference and gene expression changes. …”
Get full text

RESEARCH ON THE FATIGUE LIFE CALCULATION METHOD OF HYDRO-TURBINE HEAD COVER CONNECTING BOLTS BASED ON PD-STFA by LIU Yu, JIN Jian, WANG YongFei, ZHAO JunJie, YU Bo

“…Long-term alternating loads on the connecting bolts of hydro-turbine head cover,which results in fatigue damage causing many serious accidents.Therefore,it is necessary to carry out in-depth study on the calculation method of fatigue life of head cover bolts in order to improve the accuracy of fatigue life calculation.In order to solve the above problems,a method for calculating the fatigue life of Turbine head cover bolts based on combination of power density and short-time Fourier analysis（PD-STFA） is put forward,with emphasis on the influence of coupling action of loading frequency and amplitude load on the fatigue life of head cover bolts.Firstly,the position and stress of dangerous section of connecting bolt are calculated by finite element method;secondly,the average stress of contact surface of bolt head is measured by strain-based hollow pressure sensor,and then the measured average stress of contact surface of bolt head is transformed into the stress of dangerous section according to generalized Hooke’s law;finally,based on linear damage accumulation theory,the fatigue life of the head cover bolts is calculated by PD-STFA method and the traditional rain flow counting method.The calculation results show that the fatigue life of the head cover bolts is 1.966× 10~5 h based on PD-STFA method and 4.113 ×10~5 h based on traditional rain flow counting method.According to the investigation of power plant users,the calculation results based on PD-STFA method are closer to the actual service life of bolts for about 30 years,and can predict the fatigue life of the turbine head cover connecting bolts more accurately,thus providing theoretical guarantee for the safe and stable operation of the hydro-turbine.…”
Get full text

Excavating trajectory planning of electric shovel based on dynamic excavating volume prediction by Juan Wu, Rui Liu, Baoguo Lin

“…Then, the trajectory model of the dipper tooth tip is established by using the 6th polynomial interpolation method, and the minimum excavation energy consumption per unit volume is taken as the optimization objective, and the whale optimization algorithm is used to plan the excavation trajectories for four kinds of complex stacking surfaces (concave, convex, convex–concave and stepped stacking surfaces). Finally, an electric shovel scaled model test bench is built to experimentally verify the trajectory planning results of the simulation. …”
Get full text

Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…Determination of the pathway followed by various cytokines can be achieved using specific inhibitors which include theophylline (TPH), TMB-8 and W7 that hinder calmodulin binding to Ca2+; sphingosine (SPH), H7 and staurosporine that inhibit protein kinase C (PKC) activation; and mevalonate (MEV) or the anti-p21ras antibody which block G-proteins. …”
Get full text