Parental perception of treatment options for mucopolysaccharidosis: a survey to bridge the gap for personalized medicine by Anna-Maria Wiesinger, Florian B. Lagler

“…Results Most likely parents would choose an approach to repurposed treatments for their child (neuronopathic: 82%, 14/17 and non-neuronopathic: 94%, 16/17), followed by enzyme replacement therapy (ERT, both 88%, 15/17), hematopoietic stem cell therapy (HSCT, 70%, 12/17 and 76%, 13/17), and finally gene therapy (GT, 58%, 10/17 and 53%, 9/17). …”
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Association of oxidative balance scores with cardiovascular and all cause mortality in patients with asthma by Wei Zhao, Yiyuan Sun, Bohui Zhu

“…Rigor was maintained through the implementation of subgroup and sensitivity analyses to authenticate the findings. The study finally included 4,639 individuals with a mean age of 42.55 years and 43.46% males. …”
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Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation by Chang Dong Yeo, Dong Won Park, Seong Hoon Yoon, Eun Young Kim, Jeong Eun Lee, Shin Yup Lee, Chang‐Min Choi, In‐Jae Oh, Do Jin Kim, Jeong Seon Ryu, Jae Cheol Lee, Young‐Chul Kim, Tae Won Jang, Kye Young Lee, Seung Hun Jang, Seung Joon Kim, for the Korean EGFR Registry Investigators

“…Moreover, it will investigate various aspects, including the safety and efficacy of a new third‐generation EGFR tyrosine kinase inhibitor (TKI), lazertinib, approved for both first‐ and second‐line treatments. …”
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Comparison of the Efficiency of Ultraviolet/Zinc Oxide (UV/ZnO) and Ozone/Zinc Oxide (O3/ZnO) Techniques as Advanced Oxidation Processes in the Removal of Trimethoprim from Aqueous... by Moayede Taie, Abdolmajid Fadaei, Mehraban Sadeghi, Sara Hemati, Gashtasb Mardani

“…With regard to the results, the photocatalyst process and catalytic ozonation by ZnO nanoparticles can make acceptable levels for an efficient posttreatment. Finally, this combined system is proven to be a technically effective method for treating antibiotic contaminants.…”
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Differential expression of plasma proteins and pathway enrichments in pediatric diabetic ketoacidosis by Paolo Spagnolo, Enis Cela, Maitray A. Patel, David Tweddell, Mark Daley, Cheril Clarson, Saverio Stranges, Gediminas Cepinskas, Douglas D. Fraser

“…Changes in lipid and fatty acid metabolism were also observed, aligning with the lipolysis and ketosis characteristic of severe DKA. Finally, several signaling pathways were associated with clinical biochemical variables. …”
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Designing and testing novel artificial shelter traps to mass-trap overwintering brown marmorated stink bugs: a proof-of-concept study in Northwestern China by Jin-Ping Zhang, Gonzalo Avila, Gang Ma, Qian-Qian Mi, Adriana Najar-Rodriguez, Ju-Hong Chen, Chun-Sen Ma, Feng Zhang

“…Results Although trapped BMSB numbers were generally low across all traps tested, the black corflute trap was found to attract the highest average number of BMSB males and females, followed by the wooden-made trap, the bee-hive box and finally the wooden-made locked trap, which attracted the lowest numbers of BMSB. …”
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An integrated corporate governance index for Spain: From construction to construct validity by Paolo Saona, Laura Muro, Erika López-Quesada

“…In practical terms, the index can support the implementation of the United Nations 2030 Sustainable Development Agenda, which promotes the adoption of good governance codes. Finally, it is suggested that future research should focus on creating and validating robust indices to assess the quality of corporate governance in other contexts, thereby promoting best practices globally. …”
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Histone Arginine Methylation-Mediated Epigenetic Regulation of Discoidin Domain Receptor 2 Controls the Senescence of Human Bone Marrow Mesenchymal Stem Cells by Zhenyu Xu, Wenming Wu, Fang Shen, Yue Yu, Yue Wang, Charlie Xiang

“…Further, we found through knockdown and overexpression approaches that coactivator-associated arginine methyltransferase 1 (CARM1) regulated the expression level of DDR2 and the senescence of hBM-MSCs. Finally, chromatin immunoprecipitation analysis confirmed direct binding of CARM1 to the DDR2 promoter region with a high level of H3R17 methylation in early-passage hBM-MSCs, and inhibition of CARM1-mediated histone arginine methylation decreased DDR2 expression and led to cellular senescence. …”
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Optimizing in vitro fertilization in four Caribbean coral species by Valérie F. Chamberland, Matthew-James Bennett, Tania Doblado Speck, Kelly R. W. Latijnhouwers, Margaret W. Miller

“…We then provide recommendations for coral breeding practitioners to maximize larval production from gamete collections, and finally, we discuss our findings’ potential implications on fertilization dynamics during natural coral spawning events.…”
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The Role of the Key Differentially Mutated Gene FGFR3 in the Immune Microenvironment of Bladder Cancer by Jun Jiang, Yan Zhan, Jun Li

“…We then identified differentially expressed genes (DEGs) and differentially mutated genes (DMGs) according to the high-stromal score cohort and low-stromal score cohort. Finally, fibroblast growth factor receptor 3 (FGFR3) was the main differentially mutated gene in bladder carcinoma that we discovered after conducting a cross-study on DEGs and DMGs. …”
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Comparative transcriptome analysis reveals potential regulatory mechanisms in response to changes in physiological functions in Oreochromis aureus under salinity stress by Chang Yuan, Kangqi Zhou, Xianhui Pan, Yong Lin, Junqi Qin, Dapeng Wang, Zhong Chen, Xuesong Du, Yin Huang

“…On the basis of GO, KEGG and STEM analyses, the data enabled the development of a mechanistic model that details how O. aureus adapts to salinity stress by regulating physiological changes. Finally, RT-qPCR assays verified the accuracy and reliability of the high-throughput sequencing results. …”
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Camrelizumab-Related Lethal Arrhythmias and Myasthenic Crisis in a Patient with Metastatic Thymoma by Bo Zhang, Laxman Gyawali, Zengzhang Liu, Huaan Du, Yuehui Yin

“…Workups on admission indicated dramatically elevated transaminase, troponin I, creatine kinase, and a new-onset conduction abnormality on electrocardiography. …”
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Association between the triglyceride glucose index and acute kidney injury following traumatic brain injury by Rujun Pan, Shaojie Li, Baofang Wu, Jiayin Wang, Shanglu Lin, Longjie Chen, De Wei, Hongzhi Gao

“…TyG was identified as an independent risk factor for AKI using logistic regression and propensity score matching (PSM). Finally, the association between TyG index and AKI was further assessed using multivariate logistic regression, restricted cubic spline (RCS) regression, and subgroup analysis. …”
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Differential proteome analysis of pea roots at the early stages of symbiosis with nodule bacteria by I. V. Leppyanen, A. N. Kirienko, A. A. Lobov, E. A. Dolgikh

“…Other proteins that might be interesting were annexin D8 and D1, protein kinase interacting with calcinerin B, actin-binding protein profilin, GTP-binding protein Ran1. …”
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Moderating effect of teacher–student relationship and mediating role of self-efficacy on the relationship between peer-assisted learning and mathematics performance by Bright Asare

“…Moreover, self-efficacy somewhat mediates the relationship between peer-assisted learning and mathematics performance. Finally, the association between peer-assisted learning and students’ mathematics performance was positively and considerably moderated by the teacher–student relationship.Originality/valuePrevious research has looked at how peer-assisted learning, teacher–student relationships, and self-efficacy influence mathematics performance. …”
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Improved Dark Channel Defogging Algorithm for Defect Detection in Underwater Structures by Longsheng Bao, Chunyan Zhao, Xingwei Xue, Ling Yu

“…Moreover, for accurate disease area statistics, the binary morphology and optimal threshold segmentation theories are combined to perform disease edge screening and remove interference information. Finally, accurate statistics of the proportion of diseased pixels are achieved, as well as the quantitative detection of surface diseases of underwater structures. …”
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Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells by Alaleh Rezalotfi, Ghasem Solgi, Marzieh Ebrahimi

“…The proliferation was evaluated using CFSE staining; the percentages of CD4+CD25+FoxP3+ Treg and CD4+IL-17+ Th17 cells and IFN-γ+cells and the production of IL-17, TGF-β, and IL-10 were assessed by flow cytometry and ELISA, respectively. Finally, the cytotoxic potential of induced immune cells was measured by examining the secretion of lactate dehydrogenase from target cells. …”
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Sex-biased gene expression across tissues reveals unexpected differentiation in the gills of the threespine stickleback by Sylvestre, Florent, Aubin-Horth, Nadia, Bernatchez, Louis

“…We find that the liver is extremely differentiated between sexes (36% of autosomal genes) and reflects ongoing reproduction, while the brain shows very low levels of differentiation (0.78%) with no functional enrichment. Finally, the gills exhibit high levels of differentiation (5%), suggesting that sex should be considered in physiological and ecotoxicological studies of gill responses in fishes. …”
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Bandorên Stereotîpên Zayenda Civakî Li Ser Pêkanîna Kevneşopiya Dengbêjiyê: Mînaka Eyşe ŞAN by Leyla Kaplan

“…Lê di civaka em tê de dijîn de helwestên zayenda civakî gelek zêde ne û ev helwest jî bi piranî li dijê jinan in. Eyşe Şan yek ji wan dengbêjên jin e ku di serdema xwe de dengê xwe daye bihîstin û bandora wê hêj jî dewam dike. …”
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Disulfidptosis-related gene SLC3A2: a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma by Xinyi Zhang, Yiqi Lin, Liang Shi, Aixia Zhai, Chao Wu, Qian-Ying Zhu

“…Differentially expressed genes (DEGs) between the high and low SLC3A2 expression groups were primarily involved in cytokine-cytokine receptor interaction and immune response. Finally, in vitro experiments demonstrated that SLC3A2 stimulates tumor cell proliferation and migration. …”
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