Efficacy And Safety Of Low Dose Tofacitinib As Induction Therapy In Moderate To Severe Ulcerative Colitis: A Pilot Study by Sadia Ahmed, Muhammad Umar, Muhammad Kamran, Misbah Noureen, Iqra Ashraf, Javeria Khan

“…Tofacitinib, an orally administered micromolecule, blocks the Janus kinase (JAK) signal transducer pathway, thereby reducing mucosal inflammation. …”
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Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. by Taiga Miyazaki, Hironobu Nakayama, Yohsuke Nagayoshi, Hiroshi Kakeya, Shigeru Kohno

“…When misfolded proteins accumulate in the ER lumen, the transmembrane kinase/endoribonuclease Ire1 initiates splicing of HAC1 mRNA to generate the bZIP transcription factor Hac1, which subsequently activates its target genes to increase the protein-folding capacity of the ER. …”
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Circulating Regulatory T-Cells in Monoclonal Gammopathies of Uncertain Significance and Multiple Myeloma: In Search of a Role by Giovanni D’Arena, Giovanni Rossi, Luca Laurenti, Teodora Statuto, Fiorella D’Auria, Luciana Valvano, Vittorio Simeon, Aldo Giudice, Idanna Innocenti, Vincenzo De Feo, Rosanna Filosa, Pellegrino Musto

“…With respect to MM patients and after a median follow-up of 33 months, Tregs did not show any significant correlation with main clinical and laboratory characteristics. Finally, from a functional point of view, Tregs displayed an effective suppressor function, irrespective of disease status. …”
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From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy by E. Pinto, L. Lione, M. Compagnone, M. Paccagnella, E. Salvatori, M. Greco, V. Frezza, E. Marra, L. Aurisicchio, G. Roscilli, A. Conforti

“…It involves multiple steps, including the collection of T cells from patients or healthy donors, in vitro engineering and expansion, and finally reinfusion into patients. Therefore, despite the impressive clinical outcomes, ex vivo manufacturing process makes CAR-T cells out of reach for many cancer patients. …”
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Research Progress on High-Intermediate Frequency Extension Methods of SEA by Jintao Su, Ling Zheng, Zhaoxiang Deng, Yuhan Jiang

“…Neutron structure assembly and modeling, interval and mixed interval analysis, interval variable and mixed interval variable response are also described, so as to justify the development of a hybrid, large-scale interval algorithm. Finally, the engineering application of the above method is introduced, the limitations and shortcomings of SEA and intermediate frequency extension methods are reviewed, and unsolved problems are further discussed.…”
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Enhancers and genome conformation provide complex transcriptional control of a herpesviral gene by David W Morgens, Leah Gulyas, Xiaowen Mao, Alejandro Rivera-Madera, Annabelle S Souza, Britt A Glaunsinger

“…RNA expression profiling demonstrated that three more of these regions act by either repressing or enhancing other distal viral genes involved in ORF68 transcriptional regulation. Finally, we tracked how the 3D structure of the viral genome changes during its lifecycle, revealing that these enhancing regulatory elements are physically closer to their targets when active, and that disrupting some elements caused large-scale changes to the 3D genome. …”
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The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…The immune infiltration levels of most immune cells were upregulated in the high-risk group with elevated expression of PDCD1 and low TMB score. Finally, we found that MLH1 was an independent predictor of STAD prognosis among the four MMR genes. …”
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An Improved YOLOv8 Model for Strip Steel Surface Defect Detection by Jinwen Wang, Ting Chen, Xinke Xu, Longbiao Zhao, Dijian Yuan, Yu Du, Xiaowei Guo, Ning Chen

“…A bidirectional feature pyramid network is introduced at the neck of the model to improve feature transmission efficiency. Finally, the WIoU loss function is employed to accelerate the model’s convergence speed and enhance regression accuracy. …”
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Energy Dissipation and Damage Evolution Characteristics of Shale under Triaxial Cyclic Loading and Unloading by Ziyun Li, Song Xie, Qianghui Song, Peiyong Wang, Dongyan Liu, Baoyun Zhao, Wei Huang

“…Meanwhile, the plastic strain of rock under cyclic loading increases rapidly first, then develops steadily, and finally increases sharply with the increase in axial strain. …”
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Successful Use of Negative Pressure Wound Therapy for Abdominal Wall Necrosis Caused by a Perforated Ascending Colon Using the ABThera System by Kouki Imaoka, Takuya Yano, Yasuhiro Choda, Ko Oshita, Yuma Tani, Tetsushi Kubota, Michihiro Ishida, Daisuke Satoh, Masanori Yoshimitsu, Kanyu Nakano, Masao Harano, Hiroyoshi Matsukawa, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima

“…A reduction was observed in the size of the open wound with visible granulation tissue. The defect was finally covered with a mesh split-thickness skin graft and anterolateral thigh flap. …”
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Exploring sensory processing sensitivity: Relationships with mental and somatic health, interactions with positive and negative environments, and evidence for differential suscepti... by Christienne G. Damatac, Marleen J. ter Avest, Tom F. Wilderjans, Véronique De Gucht, Dion H.A. Woestenburg, Laurens Landeweerd, Tessel E. Galesloot, Linda Geerligs, Judith R. Homberg, Corina U. Greven

“…We then evaluated how environmental factors modify those relationships by testing SPS interactions with lifetime or current measures of positive or negative environments. Finally, we formally tested whether SPS is a factor for differential susceptibility. …”
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Malicious user detection in Momo application based on spatio-temporal behavior and static attribute analysis by YANG Haifeng, DU Shaoyong, WEI Guo, SHI Wenqi, LUO Xiangyang

“…Subsequently, the temporal behavior characteristics of users were characterized by the online probability of users in different time periods, and the spatial behavior characteristics of users were characterized by the degree of clustering of users’ historical location distribution. Finally, the obtained spatio-temporal behavior features and gender attributes were combined to train a user classification model for malicious user detection. …”
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Hypomania, Depression, Euthymia: New Evidence in Parkinson’s Disease by Margherita Canesi, Sara Lavolpe, Viviana Cereda, Alessandra Ranghetti, Roberto Maestri, Gianni Pezzoli, Maria Luisa Rusconi

“…In the MF group, a moderate positive correlation between ISS ACTivation subscale scores and the presence of ICDs and compulsive medication use emerged. Finally, MF patients reported higher BDI-II total scores than DN. …”
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Accurate estimation of Jujube leaf chlorophyll content using optimized spectral indices and machine learning methods integrating geospatial information by Nigela Tuerxun, Sulei Naibi, Jianghua Zheng, Renjun Wang, Lei Wang, Binbin Lu, Danlin Yu

“…Support vector regression (SVR), random forest regression (RFR), and geographically weighted least squares support vector regression (GWLS-SVR) were then used to assess the prediction accuracy. Finally, the optimal variables and regression model were identified. …”
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An Integrated Electricity–Gas–Heat Energy System Based on the Synergy of Long- and Short-Term Energy Storage by Min Zhang, Jinhao Wang, Huiqiang Zhi, Jun Zhao, Xiao Chang, Shifeng Zhang, Xiangyu Guo, Tengxin Wang

“…New energy sources, such as wind and solar energy, have been widely adopted; however, their volatility and instability have become the key issues restricting their utilization. …”
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Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells. by Gergès Rizkallah, Sandrine Alais, Nicolas Futsch, Yuetsu Tanaka, Chloé Journo, Renaud Mahieux, Hélène Dutartre

“…Surprisingly, we then demonstrate that it is not due to the antiviral activity of type-I interferon produced by IFN-α DCs, but that it is likely to be linked to a distinct trafficking route of HTLV-1 in IL-4 DCs vs. IFN-α DCs. Finally, we demonstrate that, in contrast to IL-4 DCs, IFN-α DCs are impaired in their capacity to transfer HTLV-1 to CD4 T-cells, both after viral capture and trans-infection and after their productive infection. …”
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The Potential Dual Role of H2.0-like Homeobox in the Tumorgenesis and Development of Colorectal Cancer and Its Prognostic Value by Shuo Chen, Lin Zhang, Kai Wang, Jizhen Huo, Siqi Zhang, Xipeng Zhang

“…We also found that the six miRNAs target HLX genes, leading to its downregulation, and HLX expression had a negative correlation with its downstream target gene BRI3BP in both CRC and normal samples. Finally, we found that the 12 immune infiltrating cells were observably different between high and low HLX expression groups. …”
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Establishment of a prognostic signature and immune infiltration characteristics for uterine corpus endometrial carcinoma based on a disulfidptosis/ferroptosis-associated signature by Yong Huang, Huibin Li, Zhifu Wei, Wanshan He, Bin Chen, Shuang Cheng, Zhifang Zhao, Lv Deng, Lv Deng, Xiaohua Chen, Yu Lin, Yu Lin, Xiaoshan Hong, Xiaoshan Hong

“…To further explore this new feature, pathway and functional analyses were performed, and the differences in gene mutation frequency and the level of immune cell infiltration between the high- and low-risk groups were studied. Finally, we validated the prognostic gene expression profile in clinical samples.ResultsWe identified five optimal DFRGs that were differentially expressed and associated with the prognosis of uterine corpus endometrial carcinoma (UCEC). …”
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Numerical Investigation of Hydraulic Fracture Propagation Morphology in the Conglomerate Reservoir by Zehao Xu, Xiangjun Liu, Lixi Liang

“…The influence of the mechanical properties of gravel, matrix, matrix-gravel interface, and reservoir stress distribution state, on HF morphology (HF length, stimulated reservoir square, and HF complexity morphology), was investigated. Finally, the main factors affecting fracture propagation were analyzed. …”
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Nurses’ Perspectives of the Supportive Care Needs of Men with Prostate Cancer by Roula Mohammad Abboud, Nassim Samir Saker, Amal Khalaf Kadhim, Mohammad Mahdi Saeed Sahi, Hussein Kadhim Hussein, Alaa Hamza Hermis

“…Results: The majority of studied nurses (82%) aged between 30 and 40 years old, also about half of nurses (46%) were single, two third of nurses (66%) have preparatory degree, the highest ratio of nurses (60%) have from 1 to 5 years of experience, whereas the most of nurses (70%) have from 6 to 10 years of experience in general nursing; finally most of the nurses (78%) did not have any oncology training session. …”
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