Analysis of Hydrogeochemical Characteristics of Tunnel Groundwater Based on Multivariate Statistical Technology by Chen Peng, Yuanming Liu, Huiyu Chen, Qiaowei Yuan, Qingzhi Chen, Shilong Mei, Zhonghu Wu

“…Cluster 3 is dominated by upper surface river water and characterizes the geochemistry in natural water bodies dominated by the dissolution of carbonate, sulfate, and salt rocks. Finally, groundwater quality is mostly found in Class IV, with NO3- and F- being the main contaminants in the water.…”
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Genetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian random... by Wenting Zhou, Rui He, Ruwei Ou

“…In this study, we used a Mendelian randomization study to analyze the causal relationship between Hypothyroidism and VWD and to investigate whether polyunsaturated fatty acids mediate the effects of Hypothyroidism on VWD.MethodsUsing a large publicly available genome-wide association study of predominantly European ancestry to obtain data on Hypothyroidism, VWD, and PUFA, we conducted a two-sample Mendelian randomization study to assess the causal relationship between Hypothyroidism and VWD and assess the potential role of Polyunsaturated fatty acids in mediating the causal pathway between Hypothyroidism and VWD. Finally, we also inferred reverse causality between VWD and Hypothyroidism. …”
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Towards personalized immersive virtual reality neurorehabilitation: a human-centered design by Salvatore Luca Cucinella, Joost C. F. de Winter, Erik Grauwmeijer, Marc Evers, Laura Marchal-Crespo

“…We conducted (i) observations, (ii) interviews with eleven neurorehabilitation experts, and (iii) an online questionnaire with 24 neurorehabilitation experts to examine how therapists modify current training environments to promote patients’ recovery in conventional sensorimotor neurorehabilitation settings. Finally, (iv) we involved eight neurorehabilitation experts in a participatory design workshop to co-create examples of IVR training environments. …”
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Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages by Yuan Li, Yanping Chen, Yuan Meng, Meng Shen, Fan Yang, Xiubao Ren

“…Objective: The combination of epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and immune checkpoint inhibitors (ICIs) leads to an increased incidence of severe immune-related adverse events (irAEs). …”
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Velocity field and dynamics behavior of a boiling droplet during impact onto a molten phase change material by Mohammadreza Asadi, Mohammad Behshad Shafii, Amirreza Ghahremani

“…Solidified area at this Weber number at T = 90 °C is 9.3 % of that at 65 °C. Finally, the acetone vapor is visualized using Z-type Schlieren imaging. …”
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ReliefF guided variable spiral tuna swarm optimization algorithm with somersault foraging for feature selection by Yu-Cai Wang, Jie-Sheng Wang, Min Zhang, Hao-Ming Song, Jia-Ning Hou, Yu-Liang Qi, Yu-Wei Song

“…In the second set of experiments, RReTSO CY is compared with other binary swarm intelligence optimization algorithms, with results indicating that the proposed method effectively reduces the feature subset size, improves classification accuracy and achieves the lowest average fitness value. Finally, the Wilcoxon rank-sum tests were conducted to statistically validate the effectiveness of the proposed algorithm.…”
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A Fine-Grained Aircraft Target Recognition Algorithm for Remote Sensing Images Based on YOLOV8 by Xiao-Nan Jiang, Xiang-Qian Niu, Fan-Lu Wu, Yao Fu, He Bao, Yan-Chao Fan, Yu Zhang, Jun-Yan Pei

“…Subsequently, a focus modulation mechanism is employed to enhance the network's interactive understanding of local and global features, thereby improving the recognition accuracy for small and challenging targets. Finally, a multitype feature fusion is designed, which optimizes the generation of feature maps by integrating local features, high-level semantic information, and low-level texture information, enhancing the accuracy of fine-grained target recognition. …”
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DIGITAL HUMANISM IN THE AGE OF THE INTERNET AND ARTIFICIAL INTELLIGENCE: CHALLENGES, OPPORTUNITIES, AND PROSPECTS FOR DEVELOPMENT by Mykyta Slyusar, Vitaliia Nikitenko, Valentyna Voronkova

“…The following research objectives are proposed: firstly, to clarify the essence, characteristics, and developmental trajectories of the concept of digital humanism; secondly, to examine the transformation of digital humanism in the context of the internet and artificial intelligence; thirdly, to establish the concept of digital humanism as a framework for harmonising technological advancement with the preservation of human potential; and finally, to explore cultural diversity as an embodiment of digital humanism and human values. …”
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Molecular Characterization of Antibiotic Resistance and Genetic Diversity of Klebsiella pneumoniae Strains by Bahareh Arabzadeh, Zeynab Ahmadi, Reza Ranjbar

“…The occurrence of plasmid-mediated quinolone resistance genes (qnrA, qnrB, and qnrS) was also investigated by PCR. Finally, genotyping of the strains was performed by PFGE in a standard condition. …”
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Dispersion modeling of NOx from stacks of cracking furnaces of OLEFIN unit using AERMOD by Iman Jalali, Somayeh Tourani

“…Additionally, the output concentrations did not exceed the standard limits in all urban and residential areas. Finally, the study results indicate that the pollutant concentrations obtained from the model are lower than the measured values. …”
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Immunological characterization and prognostic of colon cancer evaluated by angiogenesis-related features: a computational analysis and in vitro experiments by Fei Liu, Yi Wang, Leiming Xia, Chen Sun, Yun Li, Yunhong Xia

“…We evaluated the differences in tumor immune microenvironment based on prognostic signature. Finally, cell experiments confirmed the function of genes in colon cancer. …”
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Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…In the developing limbs, LRP1 partially colocalises with Wnt5a and its deficiency alters abundance and distribution of Wnt5a and Vangl2. Finally, using Xenopus as a model system, we show the regulatory role for LRP1 in Wnt/PCP signalling. …”
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Influence of cement particle size, ultra-fine fly ash, and ultra-fine silica fume on the physical and microscopic properties of slurry by Kai Wang, Siyang Guo, Hua Yuan, Jiahui Ren, Pengyu Chen, Qihao Zhang

“…Therefore, replacing cement with UFA and USF can reduce cement consumption and improve performance. Finally, using orthogonal experiments, the optimal slurry ratio with comprehensive performance was selected as follows: UC of K1340, 0.7 W/C, 30 % UFA, 10 % USF, and 1 % water reducer. …”
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Therapeutic development to accelerate malaria control through intentional intervention layering by Lydia Braunack-Mayer, Narimane Nekkab, Josephine Malinga, Sherrie L. Kelly, Evelyn Ansah, Joerg J. Moehrle, Melissa A. Penny

“…Specifically, this means designing products with components that target parts of the parasite life cycle beyond the scope of existing therapeutics, and better addressing populations and settings not well covered by existing tools. Finally, when do the population-level benefits of a multi-tool prevention programme justify the individual-level outcomes from receiving multiple interventions? …”
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Comparison of spectrophotometric, potentiometric and voltammetric methodologies for the determination of nitrite and nitrate in industrial effluents and in watercourses by Cherrine Kelce Pires, Efraim Lázaro Reis, Maria Isabel Cristina Batista Mayrink, Gabriel Henrique Sperandio

“…Because it is more affordable, it is considered an excellent option for use in routine analyses, especially in places where resources are limited; and finally, differential pulse voltammetry, which is a more complex technique, but offers high sensitivity and can be useful in cases where very low concentrations of ions need to be detected. …”
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A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC in Fires—III: EN 60754-2 and the Species in Solution Affecting pH and C... by Iacopo Bassi, Claudia Bandinelli, Francesca Delchiaro, Gianluca Sarti

“…A further outcome regards the experimental demonstration of the limits and incongruencies of EN 60754-2 as an instrument for assessing the additional classification for acidity for cables. Finally, a statistical method to understand through pH and conductivity measurements if the scavenging mechanism acts in the condensed phase is presented.…”
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Real-world outdoor air exposure effects in a model of the human airway epithelium – A comparison of healthy and asthmatic individuals using a mobile laboratory setting by Pavel Rossner, Helena Libalova, Tereza Cervena, Michal Sima, Zuzana Simova, Kristyna Vrbova, Antonin Ambroz, Zuzana Novakova, Fatima Elzeinova, Anezka Vimrova, Lubos Dittrich, Michal Vojtisek, Martin Pechout, Michal Vojtisek-Lom

“…We measured lactate dehydrogenase (LDH) and adenylate kinase (AK) production and transepithelial electrical resistance (TEER), analyzed 15-F2t-isopostane (IsoP) and a panel of 20 cytokines/chemokines/growth factors. …”
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HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-κβ Pathway by Hao Wu, Legao Chen, Kaiping Lu, Yi Liu, Weiqin Lu, Jinsong Jiang, Chao Weng

“…We detected reactive oxygen species generation, Fe2+ level, and ferroptosis-related protein levels in Ang-II-treated VSMCs, which were typical characteristics of ferroptosis. Finally, the mice model of AAA was established to verify the function of HMGB2 in vivo. …”
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Comparison of Resistive Index, Pulsatility Index, and Arterial Waveform at the Comparison of Resistive Index, Pulsatility Index, and Arterial Waveform at the Site of Hepatic Artery... by Hussein Soleimantabar, Saeed Nasiri, Farshad Gharebakhshi, Samaneh Ahmadi

“…The evaluated indicators were analyzed as the average of three consecutive measurements. Finally, the results obtained in the two groups were compared using SPSS statistical software. …”
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review by Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao

“…Secondly, it examined recent advances in the treatment and intervention of NAFLD with drugs and polyphenols and the therapeutic effect of the combination of the two. Finally, we highlight the underlying mechanisms of polyphenol combined drug therapy in NAFLD. …”
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