Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer by Anne Meunier, Javier Alejandro Hernández-Castro, Nicholas Chahley, Laudine Communal, Sara Kheireddine, Newsha Koushki, Nadia Davoudvandi, Sara Al Habyan, Benjamin Péant, Anthoula Lazaris, Andy Ng, Teodor Veres, Luke McCaffrey, Diane Provencher, Peter Metrakos, Anne-Marie Mes-Masson, David Juncker

“…We perform GµF of blood from orthotopic ovarian cancer mouse models and characterize the morphological features of scCTCs and cCTCs, and the expression of molecular markers for aggressiveness. Finally, we analyze blood from 17 epithelial ovarian cancer patients with either localized or metastatic disease, and from 13 colorectal cancer liver metastasis patients. …”
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Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro by Ting Li, Ting Fang, Linxin Xu, Xiangyang Liu, Xiaoyu Li, Mei Xue, Xiaochen Yu, Bei Sun, Liming Chen

“…The autophagy inhibitor (3-methyladenine, 3-MA) and AMP-activated protein kinase (AMPK) activator (AICAR)/inhibitor (Compound C) were used to determine the involvement of AMPK and autophagy in the regulation of lipid accumulation by empagliflozin. …”
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PLUNC downregulates the expression of PD-L1 by inhibiting the interaction of DDX17/β-catenin in nasopharyngeal carcinoma by Ranran Feng, Yilin Guo, Meilin Chen, Ziying Tian, Yijun Liu, Su Jiang, Jieyu Zhou, Qingluan Liu, Xiayu Li, Wei Xiong, Lei Shi, Songqing Fan, Guiyuan Li, Wenling Zhang

“…Later, we further verified that PLUNC regulates PD-L1 through β-catenin. Finally, the effect of PLUNC on β-catenin was verified by co-immunoprecipitation (Co-IP). …”
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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development. by Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger

“…Positive and negative regulation of developmental signaling by its different catalytic domains could allow Rabex-5 to precisely coordinate developmental signaling to fine-tune patterning. Finally, we report that Rabex-5 also inhibits the overgrowth due to loss of PTEN or activation of PI3K but not activation of AKT. …”
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Comparison of Ultrasound-Guided Fine-Needle Cytology Quality in Thyroid Nodules with 22-, 23-, and 25-Gauge Needles by YiJie Dong, LiLi Gao, Yang Sui, MinJing Mao, WeiWei Zhan, JianQiao Zhou

“…Each nodule was sampled using 22 G, 23 G, and 25 G needle according to designed orders, and 1240 smears were finally obtained. Cytology quality was scored by a cytologist blinded to needle selection. …”
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A EFICÁCIA DE PLANTAS MEDICINAIS NO TRATAMENTO DE DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS by Luis Roberto Gomes Mohana, Rodolfo Francisco, Hálmisson D’Árley Santos Siqueira, Caroline Jordana Azevedo dos Santos, Josemeire da Costa Ximenes, Nair Portela Silva Coutinho, Jéssica Maria Silva Ribeiro, Jacqueline Martins Cantanhede, Renata Pinheiro Pedra Fernandes, Rodolfo Ritchelle Lima dos Santos

“…Resultados: Ao todo foram incluídos 12 estudos considerados elegíveis para compor a síntese de evidências, na qual destacou-se que existe um grande acervo de plantas medicinais, ainda pouco explorado, mas que vem sendo desbravadas ao longo dos anos, sendo incluídas como terapias alternativas e complementares podendo ser usadas no tratamento de múltiplas doenças crônicas, com diferentes formas e usos, apresentam também um baixo teor de toxicidade sendo consideradas com potencial eficácia e segurança. Considerações Finais: ressalta-se que o uso de plantas medicinais deve ser feito sobre orientação profissional da saúde e que ainda são necessários mais estudos que enfatizem sobre dosagem, segurança e reais efeitos das plantas medicinais no tratamento de doenças crônicas não transmissíveis.  …”
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(Re)defining Resilience: How Engineering Educators Understand and Teach Resilience by Natalie Wint, Inês Direito

“…Secondly, engineering degrees prepare students for a profession, and likely place emphasis on graduate attributes such as resilience. Finally, the rate of technological advancement and societal change places additional demands on graduates to adapt to career changes. …”
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Assessing the impact of land use and cover change on above-ground carbon storage in subtropical forests: a case study of Zhejiang Province, China by Zihao Huang, Huaqiang Du, Fangjie Mao, Xuejian Li, Guomo Zhou, Jiaqian Sun, Yanxin Xu, Jie Xuan, Yagang Lu, Lei Huang, Meixuan Song

“…We first mapped the land cover patterns using the random forest and spatiotemporal filtering algorithm and then applied these patterns to drive an optimized BIOME-BGC model to simulate the spatiotemporal distribution of AGC density. Finally, the LUCC trajectories were classified into three categories: afforestation, deforestation, and forest type transformations. …”
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Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations by Ashley E. Tessnow, Rodney N. Nagoshi, Robert L. Meagher, Todd M. Gilligan, Ben M. Sadd, Yves Carrière, Holly N. Davis, Shelby J. Fleischer, Kelly Richers, John C. Palumbo, Patrick Porter, Jose Carlos Verle Rodrigues, Gregory A. Sword

“…We provide the first evidence for nuclear genomic differentiation between the two major overwintering populations of fall armyworm in the US. Finally, our data reveal population-specific patterns of selection on genomic regions containing putative insecticide resistance alleles, which could relate to their biogeography. …”
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Regulatory networks of mRNAs and miRNAs involved in the immune response of diamondback moth, Plutella xylostella to fungal infection by Mei-Qiong Xie, Long-Jiang Wang, Hua-Mei Xiao, Shu-Jun Wei

“…Gene functional enrichment analysis indicated that these miRNAs could target genes associated with various pathways, such as the immune system, infectious diseases, digestive system, endocrine system, nervous system, and signal transduction. Finally, the regulatory relationships of six miRNA-mRNA pairs were validated using quantitative reverse transcription PCR. …”
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Characteristics of ChatGPT users from Germany: Implications for the digital divide from web tracking data. by Celina Kacperski, Roberto Ulloa, Denis Bonnay, Juhi Kulshrestha, Peter Selb, Andreas Spitz

“…In terms of political variables, political knowledge and political self-efficacy as well as some political behaviors such as voting, debating political issues online and offline and political action online were all associated with ChatGPT activity, with online political debating and political self-efficacy negatively so. Finally, need for cognition and communication skills such as writing, attending meetings, or giving presentations, were also associated with ChatGPT engagement, though chairing/organizing meetings was negatively associated. …”
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Bytecode-based approach for Ethereum smart contract classification by Dan LIN, Kaixin LIN, Jiajing WU, Zibin ZHENG

“…In recent years, blockchain technology has been widely used and concerned in many fields, including finance, medical care and government affairs.However, due to the immutability of smart contracts and the particularity of the operating environment, various security issues occur frequently.On the one hand, the code security problems of contract developers when writing contracts, on the other hand, there are many high-risk smart contracts in Ethereum, and ordinary users are easily attracted by the high returns provided by high-risk contracts, but they have no way to know the risks of the contracts.However, the research on smart contract security mainly focuses on code security, and there is relatively little research on the identification of contract functions.If the smart contract function can be accurately classified, it will help people better understand the behavior of smart contracts, while ensuring the ecological security of smart contracts and reducing or recovering user losses.Existing smart contract classification methods often rely on the analysis of the source code of smart contracts, but contracts released on Ethereum only mandate the deployment of bytecode, and only a very small number of contracts publish their source code.Therefore, an Ethereum smart contract classification method based on bytecode was proposed.Collect the Ethereum smart contract bytecode and the corresponding category label, and then extract the opcode frequency characteristics and control flow graph characteristics.The characteristic importance is analyzed experimentally to obtain the appropriate graph vector dimension and optimal classification model, and finally the multi-classification task of smart contract in five categories of exchange, finance, gambling, game and high risk is experimentally verified, and the F1 score of the XGBoost classifier reaches 0.913 8.Experimental results show that the algorithm can better complete the classification task of Ethereum smart contracts, and can be applied to the prediction of smart contract categories in reality.…”
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Semantic and Syntactic Aspects of “Bāyestan” in Tārīkh-i Bayhaqī by Mona Valipour

“…In this regard, it was found that unlike Davari's analysis (1394), modality in non-finite clauses may also be agent-oriented, and at least based on Tārīkh-i Bayhaqī data, it is not possible to consider moving from action-oriented modality to agent-oriented modality as a grammaticalization process. Finally, the semantic examination of the verb bāyestan supported the previous analyses in this field and revealed that all uses of the verb in the Tārīkh-i Bayhaqī are non-epistemic modality.…”
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International legal framework for the regulation of judicial immunity by S. O. Demchenko

“…Moreover, there are some peculiarities of the ‘cooling effect’ concept in the field of judicial indemnity. Finally, the author concludes that the key elements of the European Court of Human Rights case law relating to the essence of judicial indemnity and its limits should be adapted and integrated into the Ukrainian judicial system, given their importance for the development of the relevant doctrine.…”
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Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro by Renlei Feng, Hongli Liu, Yunqing Chen

“…Interestingly, in TGF-β1-stimulated cardiac fibroblasts, baricitinib decreased the expressions of Col1, Col3, α-SMA, Fn, MMP9, and TIMP1 in a dose-dependent manner (From 10 to 2000 nM), also exhibited a dose-dependent impact on the expressions of p-STAT3 and TGF-βRII. Finally, JAK2 knockdown by siRNA downregulated the expressions of Col1, Col3, α-SMA, and Fn in TGF-β1-stimulated cardiac fibroblasts. …”
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Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…The mechanisms through which TI-076 acts seem to involve the modulation of several genes associated with inflammation (Il1b, Nlrp3, Pparα and Pparγ), white adipose and liver metabolism (Cartpt, Mgll, Ramp3, Faah, Cck, Clps, Pparα and Pparγ), liver damage and fibrosis (Creb1, Col1a1 and Col3a1). Finally, TI-076 did not interact with CYP3A4 in vivo and proved to be safe. …”
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Bioinformatics Analysis of miRNAs Targeting TRAF5 in DLBCL Involving in NF-κB Signaling Pathway and Affecting the Apoptosis and Signal Transduction by Chunyao Li, Lanshan Huang, Yongqin Wen, Muhua Yi, Min Gao

“…The KOBAS database was used to assist in the screening of miRNAs of interest and construct the regulatory network of miRNA-mRNA. Finally, the expression level and diagnostic performance of miRNAs were analyzed with GEO datasets, and DEGs were identified from the GEPIA database. …”
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A Lightweight Network for Ship Detection in SAR Images Based on Edge Feature Aware and Fusion by Yuming Li, Jin Liu, Xingye Li, Xiliang Zhang, Zhongdai Wu, Bing Han

“…Furthermore, a lightweight feature fusion network, Filter-Pruned Bi-directional Feature Pyramid Network (FP-BiFPN), is carefully designed, which can not only suppresses background information, but also accentuates ship targets. Finally, we propose a selective quantization algorithm based on a bit-width selection mechanism to reduce model memory usage without compromising performance. …”
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Automatic detection and counting of wheat spike based on DMseg-Count by Hecang Zang, Yilong Peng, Meng Zhou, Guoqiang Li, Guoqing Zheng, Hualei Shen

“…Secondly, an element-by-element point multiplication mechanism was designed to fuse global and local contextual supervision information of wheat spike. Finally, the total loss function was constructed to optimize the model. …”
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Türkiye’de İnternet Gazeteciliği: Meslek Profesyonellerinin Gözünden Gazetecilik Ortamı by Konur Alp Koz, Umur Işık

“…Gazeteciler bu ortamda bir çeşit “teknolojik abluka” altında faaliyetlerini sürdürmekte ve bu durum ana ürün haberi negatif yönde etkilemektedir. Haber siteleri; finans yönünden “arama motorlarına”, haber yönünden ise eski medyaya bağımlı “ikinci el habercilik” faaliyeti içerisindedirler. …”
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