In silico identification of switching nodes in metabolic networks by Mairet, Francis

“…In P. tricornutum, we show that Erythrose 4-phosphate is an important switch metabolite for mixotrophy suggesting the importance of this metabolite in the non-oxidative pentose phosphate pathway to orchestrate the flux variations between glycolysis, the Calvin cycle and the oxidative pentose phosphate pathway when the trophic mode changes. Finally, a comparison between ISIS and reporter metabolites identified with transcriptomic data confirms the key role of metabolites such as L-glutamate or L-aspartate in the yeast response to nitrogen input variation. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Mechanistically, neuronal CCL21 was shown to regulate microglial cell migration, proliferation, and activation in a CCR7-dependent manner through both canonical (PI3K/AKT) and non-canonical (ERK1/2/JNK) signaling pathways. Finally, we demonstrated that navarixin, a clinically relevant chemokine inhibitor with high affinity for the CCR7 receptor, could block CCL21 effects on microglia and prevent neurodegeneration and behavioral deficits in two mouse models of PD induced with either α-synuclein oligomers (αSynO) or 3,4-dihydroxyphenylacetaldehyde (DOPAL). …”
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Discharge and Optical Emission Spectrum Characteristics of a Coaxial Dielectric Barrier Discharge Plasma-Assisted Combustion Actuator by Pengfei Liu, Liming He, Bingbing Zhao

“…The intensity of the spectral lines (297.54 nm, 315.76 nm, 336.96 nm, and 357.56 nm) first increased, then maintained, and then increased rapidly with the increased radius; however, the intensity of the spectral lines (380.34 nm, 405.80 nm, and 434.30 nm) basically remained unchanged, then increased, and finally decreased with the increased radius. The vibrational temperature first decreased quickly and then increased and reached the minimum at r = 18 mm with the increased radius. …”
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TÜRKİYEDE KATILIM BANKACILIĞI ve BANKACILIK SEKTÖRÜNDEKİ ÖNEMİ by Pınar Pehlivan

“…“İslami bankacılık”, “İslami finans” ya da “faizsiz bankacılık” olarak adlandırılan katılım bankacılığı, son otuz yılda finansal sektörün ve bankacılık sisteminin hızla büyüyen ve gelişen bir parçası haline gelmiştir. …”
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A novel high-resolution eco-functional vegetation mapping of coastal dunes by Michele Innangi, Mirko Di Febbraro, Marco Balsi, Ginevra Colonna, Michele Finizio, Federica Pontieri, Maria Laura Carranza

“…The first class, situated near the drift-line, included Thinopyrum junceum, a species adapted to wind and sand movement. The second class bridged dynamic foredune and more stable areas, featuring ruderal species like Scabiosa atropurpurea. …”
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Elevation gradient effects on grassland species diversity and phylogenetic in the two-river source forest region of the Altai Mountains, Xinjiang, China by Jing Che, Jing Che, Mao Ye, Mao Ye, Qingzhi He, Qingzhi He, Guoyan Zeng, Guoyan Zeng, Miaomiao Li, Miaomiao Li, Weilong Chen, Weilong Chen, Xiaoting Pan, Xiaoting Pan, Jiaorong Qian, Jiaorong Qian, Yexin Lv, Yexin Lv

“…The species diversity along the elevation gradient exhibits a bimodal trend, with an initial increase, followed by a decrease, another increase, and finally a decline as the elevation rises. In contrast, phylogenetic diversity shows a unimodal pattern, characterized by an initial increase followed by a decline with increasing elevation. …”
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Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1<i>H</i>-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1<i>H</i>,5<i>H</i>)... by Thanaa Abdul Ameer Hilal, Ibtihal Kadhim Kareem

“…This indicates that the [Au(L1)Cl]Cl2 complex has a strong affinity for the protein kinase (1HK7). Significant antiproliferative activity was seen in it against human breast cancer (MCF-7) and normal cell lines (MCF-10), as evidenced by the IC50 and selective indices (SI) values. …”
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Case report: The case of T-cell acute lymphoblastic leukemia treated with chemotherapy followed by anti-CD7 CAR-T cells using retroviral vector by Huanhuan Zhou, Wenxiang Zhu, Qihong Ma, Ning Liu, Mengdi Jin, Yaru Feng, Lijun Zhao, Rui Sun, Rongyou Li, Huaxiu Li, Yuanyuan Shi, Jianxun Wang, Liqiong Liu, Zhi Guo, Zhi Guo, Zhi Guo

“…In this study, we reported a case of a 34-year-old male patient with T-ALL who finally developed multi-line drug resistance and refractoriness after multiple lines of high-intensity chemotherapy. …”
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RDAU-Net: A U-Shaped Semantic Segmentation Network for Buildings near Rivers and Lakes Based on a Fusion Approach by Yipeng Wang, Dongmei Wang, Teng Xu, Yifan Shi, Wenguang Liang, Yihong Wang, George P. Petropoulos, Yansong Bao

“…First, we designed a residual dynamic short-cut down-sampling (RDSC) module to minimize the interference of complex building shapes and building scale differences on the segmentation results; second, we reduced the semantic and resolution gaps between multi-scale features using a multi-channel cross fusion transformer module (MCCT); finally, a double-feature channel-wise fusion attention (DCF) was designed to improve the model’s ability to depict building edge details and to reduce the influence of similar features on the model. …”
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Anti-Abortion Mobilization in Latin America: Signs of a Field in Transformation by Marta Rodriguez de Assis Machado, María Angélica Peñas-Defago, Camila Gianella Malca

“…The anti-abortion mobilization shows important signs of adaptation and mutation on different fronts – networks, alliances, strategies, and frameworks. Finally, this process of renovation has led to the expansion of this dispute towards a broader anti-gender alliance, and the increasing importance of legal strategies and tools by anti-abortion actors is remarkable. …”
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Potassium-pillared Na4FeV(PO4)3@C cathode for high-performance sodium-ion batteries by Jiafeng Zhou, Wei Zhang, Jin Bai, Qingqing Wang, Bo Ding, Hao Gong

“…The kinetic analyses and ex-situ characterizations confirm that a small volume change, the pseudocapacitive- dominated sodium storage behavior and highly reversible redox reaction (Fe2+/3+ and V3+/4+) occur during the electrochemical reaction process. Finally, the optimized K-doped NFVP cathode also demonstrates great potential in practical utilization through the evaluation of electrochemical performance for full cells.…”
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CME Magnetic Structure and IMF Preconditioning Affecting SEP Transport by Erika Palmerio, Emilia K. J. Kilpua, Olivier Witasse, David Barnes, Beatriz Sánchez‐Cano, Andreas J. Weiss, Teresa Nieves‐Chinchilla, Christian Möstl, Lan K. Jian, Marilena Mierla, Andrei N. Zhukov, Jingnan Guo, Luciano Rodriguez, Patrick J. Lowrance, Alexey Isavnin, Lucile Turc, Yoshifumi Futaana, Mats Holmström

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Analyzing Rail Traffic Diversion Based on Machine Learning Technique considering Transportation Security by Jing Luo, Dai Zhou, Wenjun Ma, Guohua Zhao

“…Results show that the travel time most notably affects the passenger flow transfer, followed by the vehicle comfort. Finally, Guangzhou Rail Transit Line 3 is considered an example, and the diversion route planning and design are performed according to the constructed diversion transfer probability model to verify the effectiveness and practicability of the model. …”
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The Stress and Adversity Inventory for Adults (Adult STRAIN) in Korean: Initial Validation and Associations with Psychiatric Disorders by Eun Soo Kim, Yun Tae Kim, Kang-Seob Oh, Young Chul Shin, Sang-Won Jeon, Dong-Won Shin, Sung Joon Cho, George M. Slavich, Junhyung Kim

“…Each domain of Korean-style stress, based on the timing, type, life domain, and sociopsychological characteristics of stress exposure, showed a different distribution of lifetime psychiatric diagnosis probabilities (odds ratios = 1.20–4.85). Finally, the test–retest reliability for total lifetime stressor count and severity over four weeks was high. …”
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The strategic synergy of educational psychology and managerial practices for the efficient development of educational institutions by Khaoula Khennou, Bouzekri Touri

“…Among other things, a significant effect size of 45.8% was noted between the educational psychology variable and the school climate aspect. Finally, the relationship between the dependent educational psychology variable and the independent continuing education variable showed a significant effect size of 25.1%. …”
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Statistical Method Based on Bayes-Type Empirical Score Test for Assessing Genetic Association with Multilocus Genotype Data by Yi Tian, Li Ma, Xiaohong Cai, Jiayan Zhu

“…Second, we propose a robust test method based on the new global test and the ordinary PCR test built on a prospective score statistic for testing marginal associations with each single marker when the genotype for each marker is coded as the number of minor alleles by taking the minimum p value of these two tests. Finally, through extensive simulation studies and analysis of the association between pancreatic cancer and some genes of interest, we show that the proposed robust test method has desirable power and can often identify association signals that may be missed by existing methods.…”
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Examining Internal and External Consent in Consensual and Non-Consensual Contexts in Women by Nieves Moyano, Antonio Rafael Hidalgo-Muñoz, María del Mar Sánchez-Fuentes, Kristen Jozkowski, Reina Granados

“…Further, those who experienced nonconsensual sex in an unknown setting (vs. known) reported feeling less safety and readiness in term of internal consent. Finally, women who experienced sexual coercion (vs. sexual assault) indicated greater use of borderline pressure. …”
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Exemplarily view on selected fluorescence textile products by Boris Mahltig, Vanessa Ernst, Lisa Schöder

“…Beside the absorption of UV light by the present fluorescence dyes, also the presence of titanium dioxide supports an UV protective property of the textile samples. Finally, it can be concluded that fluorescent fiber materials are well established products for advanced and functional textiles. …”
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Multi-Spectral Point Cloud Constructed with Advanced UAV Technique for Anisotropic Reflectance Analysis of Maize Leaves by Kaiyi Bi, Yifang Niu, Hao Yang, Zheng Niu, Yishuo Hao, Li Wang

“…The Rahman–Pinty–Verstraete (RPV) model was finally applied to establish maize leaf-level anisotropic reflectance models. …”
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Combining a Standardized Growth Class Assessment, UAV Sensor Data, GIS Processing, and Machine Learning Classification to Derive a Correlation with the Vigour and Canopy Volume of... by Ronald P. Dillner, Maria A. Wimmer, Matthias Porten, Thomas Udelhoven, Rebecca Retzlaff

“…Model overall performance metrics were optimized with grid search-based hyperparameter tuning and repeated-k-fold-cross-validation. Finally, ML-based growth class prediction results were extensively discussed and evaluated for overall (accuracy, f1-weighted) and growth class specific- classification metrics (accuracy, user- and producer accuracy).…”
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