Multifunctional Proteins Bridge Mitosis with Motility and Cancer with Inflammation and Arthritis by Jihong Jiang, Rosaely Casalegno-Garduno, Helen Chen, Anita Schmitt, Michael Schmitt, Christopher A. Maxwell

“…For these and other genes/proteins, we will highlight points of structural and functional intersection during cellular division and differentiation, as well as states associated with cancer, such as tumor-initiation and epithelial-to-mesenchymal transition (EMT). Finally, we will discuss the potential targeting of these proteins for improved therapeutic outcomes within these degenerative disorders. …”
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ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…We investigated a novel pathway, namely extracellular signal regulated kinase 5 (ERK5) mediated signaling, in modulating glucose-induced vascular endothelial growth factor (VEGF) expression. …”
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The spectrum-efficacy correlation of Kai-Xin-San for cognition of Aβ42 transgenic Drosophila and verification of its active ingredients by Jinfu Wu, Hang Sun, Yiyang Zhao, Lian Lian, Hongsheng Bian, Yong Guo, Dan Li, Lili Huang

“…Subsequently, the effects of the 15 batches of KXS were assessed in an olfactory escape memory experiment, utilizing Aβ42 transgenic drosophila as a model. Finally, the spectrum-effect relationship between the KXS fingerprint and memory improvement was analyzed, with the active ingredients subjected to validation testing.ResultsThe results identified seventeen common peaks in the fingerprint, and eight active components were determined: polygalaxanthone III, 3-6-disinapoylsucrose, ginsenoside Rg1, ginsenoside Rb1, β-asarone, α-asarone, dehydrotumulosic acid, and dehydropachymic acid. …”
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Impact of Synthetic Porous Medium Geometric Properties on Solute Transport Using Direct 3D Pore-Scale Simulations by Paolo Roberto Di Palma, Nicolas Guyennon, Andrea Parmigiani, Christian Huber, Falk Heβe, Emanuele Romano

“…Our findings suggest that the advective transport is primarily affected by the specific surface area and the mean curvature of the porous medium, while the effective diffusion coefficient scales as the inverse of the tortuosity squared. Finally, the possibility of estimating the hydrodynamic dispersion coefficient knowing only the geometric properties of porous media and the applied pressure gradient has been tested, within the range of tested porous media, against advection-diffusion simulations at low Reynolds (<10-1) and Peclet numbers ranging from 101 to 10-2.…”
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The Effects of Six Weeks of Endurance Training and CGRP Inhibition on Nrf2 and AKT Expression in the Hippocampal Tissue of Male Wistar Rats by Maryam Zare, Shila Nayebifar, Soheil Aminizadeh, Majid Vahidian-Rezazadeh

“…To study the effects of a six-week endurance training protocol and calcitonin gene-related peptide (CGRP) inhibition on the nuclear factor erythroid 2-related factor 2 (Nrf2) and protein kinase B (PKB) or AKT expression in the hippocampal tissue of male Wistar rats. …”
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Downscaling of ERA5 reanalysis land surface temperature based on attention mechanism and Google Earth Engine by Shiyu Li, Hong Wan, Qun Yu, Xinyuan Wang

“…In addition, the Bayesian global optimization algorithm is used to select the optimal hyperparameters of the network in order to enhance the predictive performance of the model. Finally, the downscaling accuracy of the network was evaluated through simulated data experiments and real data experiments and compared with the Random Forest (RF) method. …”
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Design and Verification of a Deep Rock Corer with Retaining the In Situ Temperature by Zhiqiang He, Heping Xie, Mingzhong Gao, Ling Chen, Bo Yu, Yunqi Hu, Jianping Yang

“…Moreover, a heat transfer model that considered multiple heat dissipation surfaces was established, which can provide theoretical guidance for engineering applications. Finally, a verification test of the integrated active and passive thermal insulation system (graphene heating material and C1) was carried out. …”
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Clinical Characteristics of Neuropathic Pain and Its Relationship with Cancer in Different Corporal Areas—A Systematic Review by Fernanda Danés-López, Cristóbal Diaz-Palominos, Anggie Ortiz Domínguez, Alanna Silva Rodriguez, Constanza Astorga, Daniela Martínez-Hernández, Juan Jose Valenzuela-Fuenzalida, Juan Sanchis-Gimeno, Pablo Nova-Baeza, Alejandra Suazo-Santibáñez, Gustavo Oyanedel-Amaro, Mathias Orellana-Donoso, Héctor Gutiérrez Espinoza

“…Additionally, there is a direct relationship whereby the more advanced the cancer, the greater the likelihood of experiencing neuropathic pain. Finally, although chemotherapy is employed as a cancer treatment, this therapy is quite invasive, and one of its adverse effects is that treated patients have a higher probability of developing neuropathic pain. …”
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Self-adaptive fuzzing optimization method based on distribution divergence by XU Hang, JI Jiangan, MA Zheyu, ZHANG Chao

“…Then, a deep graph convolutional neural network was constructed to extract the feature embeddings of the interprocedural comparison flow graph, and this neural network was used as the deep Q-network for deep reinforcement learning. Finally, an online deep reinforcement learning model was established based on the dual deep Q-network model, and an intelligent agent was trained to optimize the fuzzing mutation strategy. …”
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Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review by Vanessa Bertolucci, André Felipe Ninomiya, Giovanna Barbarini Longato, Luisa Oliveira Kaneko, Nilson Nonose, Pedro Paulo Menezes Scariot, Leonardo Henrique Dalcheco Messias

“…In summary, these compounds modulate signaling pathways, including nuclear factor kappa beta, wingless-related integration site, mitogen-activated protein kinase, vascular endothelial growth factor, and reactive oxygen species. …”
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Optimizing the Extraction of Keratin from Cattle Hoof Using Central Composite Design by Kelem Tiessasie Yilma, Tamrat Tesfaye, Haymanot Enawgaw, Million Ayele, Derseh Yilie Limeneh, Magdi Gibril, Fangong Kong

“…Thus, it can be concluded that the cattle hoof by-product could offer an alternative keratin source. Finally, the extraction process had an optimum value of 0.5 M NaOH, 60 minutes reaction time, and 55°C temperature with 85% dissolution and 89.6% purity.…”
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Characteristic Parameter Optimization of Wireless Flaw Sensing System Based on Active Interference Suppression Algorithm by Wenping Wu

“…After that, the spectral characteristics of the harmonic components of the deception interference signal are analyzed, and the center frequency and the tuning frequency of the real target echo are obtained. Finally, by establishing a frequency modulation parameter library for possible interference harmonic signal components, the acquisition phase of the radar gate by the jammer matched analysis with the preestablished frequency modulation parameter library is implemented to achieve active deception interference detection. …”
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Systems Evaluation for Operational Risks of International Transport Corridors: A Case Study of China-Pakistan-Iran-Turkey International Transport Corridor by Zhou Xiaoxiang, Huang Chengfeng

“…On this basis, the quantitative method and rigorous statistical analysis were used to evaluate the China-Pakistan-Iran-Turkey International Transport Corridor in the south line of the Silk Road Economic Belt, whose operational risks from 2010 to 2019 were analyzed. Finally, the operational risk index was discussed in detail. …”
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Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing by Xinyi Feng, Yu Zhang, Jun Feng, Zhongjun Li, Zhi Zhang, Lin Zhu, Ruoyu Zhou, Haibo Wang, Xiaojun Dai, Yanqing Liu

“…Then, 16S rDNA sequencing was performed on fecal samples to study the differential intestinal microbiota in gastric cancer patients. Finally, conduct a correlation analysis between them. …”
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The study of the stylistic components of the \"Hajme Sabz\" of Sohrab Sepehri by شیرزاد طایفی, لیلا کمالخانی

“…It’s also seen the favor of the type of a special theosophy in his poem. Finally, Sohrab is a poet, with a simple and nice and sometimes ambiguous language, who could attract a group of readers that have different preferences.…”
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…In this study, we identified Receptor interacting protein kinase 1 (RIPK1) in hepatocytes as a critical regulator in preserving hepatic homeostasis during metabolic challenges, such as short-term fasting or high-fat dieting. …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…Quantitative PCR analysis further validated 9 important genes, and the results were well consistent with our transcriptomic data. Finally, 5 important transcription factors including WRI1, ABI3, FUS3, PKL and VAL1 were identified, and their main regulatory genes might contain ACCase, KASⅡ, LACS, FAD3 and LPAAT which were determined through correlation analysis of expression levels for 27 walnut samples. …”
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Los niños de la guerra: la Escuela Industrial España-México en Morelia (1936-1950) by Francisco Alía Miranda

“…Las dificultades no terminaron hasta finales de 1950, fecha en la que se culminó el regreso de los niños que habían sido reclamados por sus familias. …”
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Forecasting Carbon Emissions with Dynamic Model Averaging Approach: Time-Varying Evidence from China by Siqi Xu, Yifeng Zhang, Xiaodan Chen

“…In addition, we find that IP are losing its predictive power in recent years, while the proportion of value-added of the service sector in GDP presents not only a leading forecasting weight, but a continuous increasing prediction power in recent years. Finally, the dynamic model averaging (DMA) method can produce the most accurate forecasts of carbon emission in China compared to other commonly used forecasting methods.…”
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A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients by Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Alicia Martínez-López, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, María L. Cayuela, María L. Cayuela, María L. Cayuela, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…Using the unique advantages of the zebrafish model for gene editing, we have generated Tg(ifih1_mut) knocked down for mavs and ikbke, which completely abrogated the Poly I:C induction and activation of the GFP of the reporters. Finally, we used an FDA-approved drug, Baricitinib (Jak1/Jak2 inhibitor), which was able to reduce the inflammation and the ISG expression. …”
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