Simulating a travel-related origin of Candida auris in New York–New Jersey by Rita R. Verma, Edward Kiegle, Alexander C. Keyel, Sudha Chaturvedi, Vishnu Chaturvedi

“…We tested the hypothesis by simulating introductions to NY-NJ with a Monte Carlo simulation based on travel from South Asia, proportion of US population in NY-NJ, proportion of hospitals in NY-NJ, and finally, proportion of all travelers entering the United States through NY-NJ. …”
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Infection with Toxoplasma gondii triggers coagulation at the blood-brain barrier and a reduction in cerebral blood flow by Evelyn M. Hoover, Christine A. Schneider, Christian Crouzet, Tatiane S. Lima, Dario X. Figueroa Velez, Cuong J. Tran, Dritan Agalliu, Sunil P. Gandhi, Bernard Choi, Melissa B. Lodoen

“…Analysis of CBF using longitudinal laser-speckle imaging during T. gondii infection demonstrated that CBF decreased during acute infection, recovered during stable chronic infection, and decreased again during reactivation of the infection induced by IFN-γ depletion. Finally, we demonstrate that treatment of mice with a low-molecular-weight heparin, an anticoagulant, during infection partially rescued CBF in T. gondii-infected mice without affecting parasite burden. …”
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Towards Reliable Participation in UAV-Enabled Federated Edge Learning on Non-IID Data by Youssra Cheriguene, Wael Jaafar, Halim Yanikomeroglu, Chaker Abdelaziz Kerrache

“…Through experiments, we assess the effectiveness of our scheme in resisting different attack scenarios, in terms of convergence and achieved model accuracy. Finally, we demonstrate the performance superiority of the proposed approach compared to baseline methods.…”
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Based on network pharmacology and molecular docking to study the mechanisms of active ingredients of ginseng in the treatment of atopic dermatitis by BU Jialiang, SHEN Lin, MENG Yuan, PIAO Yingshi

“…GO functional enrichment and KEGG pathway analysis were performed on the overlapping targets of active ingredients in ginseng and AD. Finally, the binding ability of active ingredients to TOP4 core targets was verified through molecular docking, and the docking results were visualised. …”
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Consistent with this, N82L and N82W mutations abolish ORF3a-mediated water permeation. Finally, ORF3a expression in HEK293 cells leads to lysosomal volume increase, mitochondrial damage, and accumulation of intracellular membranes, all alterations reverted by the N82W mutation. …”
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Evaporative Cracking Characteristics of the Embankment Soil Affected by the Saline Concentration by Jiawei Liu, Yingzhi Xia, Hui Li, Guoping Hu, Mingming Hu

“…The results showed that the moisture content decreased linearly with the drying time in the early evaporation process, subsequently decreased slow down in the mid-term evaporation, and finally become got and remain a residual moisture content, which are 46.39%, 44.05%, 42.70%, and 40.27% with the increase of the saline concentration. …”
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Why Rights are Wrong in ASEAN and Beyond: A Critique of the Foundations of Universal Human Rights by D. Brian Scarnecchia

“…., the natural use principle and the precautionary principle, are analogous to natural law principles and, because ‘the book of nature is one”, these environmental law principles may help jurists to recognise a theory of natural law liability in order to promote and defend authentic human rights. Finally, the author recommends that NGOs of Catholic Inspiration should, when appropriate, appeal to immaterial realities, God and the human soul, as a firm foundation of human rights and, also, when appropriate, advance in domestic, regional and international venues a theory of natural law liability based on environmental law principles in order to promote and defend authentic human rights. …”
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Mapping in the Oiapoque Indigenous Territories by Rosélis Remor de Souza Mazurek

“…The comparison of the two mapping exercises suggests that focus on particular segments of society might achieve limited success if not associated with other strategies to strengthen their interaction with the villages in the long term. Finally, the study questions current practices: what remains of mapping exercises in the community? …”
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Study on Pressure Relief Technology of High-Pressure Water Jet of Residual Coal Pillar in Overlying Goaf in Close Seam Mining by Shang Yang, Xuehui Li, Jun Wang, Shuhao Yang, Zhen Shen, Guangzheng Xu

“…Then, a high-pressure water jet combined with mine pressure is proposed to weaken the residual coal pillar. Finally, through the residual coal pillar hydraulic cutting mechanical model and “double-drilling double-slot” model, the high-pressure water jet drilling layout parameters are determined, and an industrial field test is carried out. …”
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Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons by Lili Xie, Mao Mao, Liang Zhou, Lusi Zhang, Bing Jiang

“…Moreover, compared to 2D-MSCs, levels of 11 cytokines and IL-2Rα were significantly increased in conditioned medium from spheroid MSCs. Finally, to test if enhanced expression of these factors reflects altered immunomodulating activities, we assessed the effect of 2D-MSC-MVs and 3D-MSC-MVs on CD14+ cell chemoattraction. …”
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Hypoxia Inducible Factor-1α Regulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrin α4 by Jong Ho Choi, Yun Bin Lee, Jieun Jung, Seong Gyu Hwang, IL-Hoan Oh, Gi Jin Kim

“…The expression of integrin α4 was decreased in BM-MSCs by increased HIF-1α under hypoxia, whereas the expression of Rho-associated kinase 1 (ROCK1) and Rac1/2/3 was increased. After downregulation of HIF-1α by YC-1, which is an inhibitor of HIF-1α, BM-MSC migration was decreased via upregulation of integrin α4 and downregulation of ROCK1 and Rac1/2/3. …”
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Recent advances on federated learning systems and the design for computing power Internet of things by LU Jianfeng, QI Pan, PAN Linyu, LI Bing, CAO Shuqin, JIN Yan'an

“…Seeondly, various experiments for selecting federated learning systems and building complete systems were presented in multiple CPIoT scenarios, to assist developers in better realizing federated learning applications by utilizing the aforementioned technologies. Finally, the current state of standardization and development challenges in the field of federated learning system design were summarized, and future development prospects were discussed. …”
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L’action pédagogique de l’Emile : par-delà pragmatisme et idéalisme by Michel Soëtard

“…Il faut pour cela réfléchir aux conditions d’une telle action : qu’elle prenne en compte un aléatoire essentiel qui sauve la position de la particularité ; qu’elle ne s’abandonne ni à la nécessité du fait ni à la nécessité du sens, pour laisser jouer la liberté ; qu’elle garde finalement à l’action sa marge d’autonomie, et par rapport à une réalité qui ne se laisse pas épuiser, et par rapport à une idéalité qui ne se laisse pas chosifier.…”
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In-Depth Learning Layout and Path Optimization of Energy Service Urban Distribution Sites under e-Commerce Environment by Kun Wang, Ki-Hyung Bae

“…Algorithms mainly include two-stage hybrid heuristic algorithm of cluster analysis, maximum coverage and genetic algorithm; simulation analysis is conducted to verify the effectiveness of the model and algorithm by data simulation, finally get the integrated optimization plan of distribution center location and routing, and put forward the operation strategy through the result expansion analysis. …”
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Prediction of cardiovascular disease from factors associated with waist hip ratio by machine learning by Zeynep Kucukakcali, Ipek Balikci Cicek

“…Modeling with RF yielded accuracy, balanced accuracy, sensitivity, specificity, PPV, NPV, and F1 score from performance metrics. Finally, variable significance values determined the dependent variable's most relevant variables. …”
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Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets by Fatemeh Kazeminasab, Maryam Baharlooie, Kamran Ghaedi

“…We performed pathway enrichment analysis of total mRNAs based on KEGG repository data to screen the most potential pathways in the liver of MAFLD human subjects and mice model, and analyzed pathway interconnections via ClueGO. Finally, we screened disease causality of the MAFLD ncRNAs, which were associated with PPARs, and then discussed the role of revealed ncRNAs in PPAR signaling and MAFLD. …”
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Nature–Inspired Metaheuristic Optimization for Control Tuning of Complex Systems by Jesús Garicano-Mena, Matilde Santos

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Multichannel Enhanced Millimeter-Wave SAR Imaging via Low-Rank Tensor-Train Decomposition by Bangjie Zhang, Gang Xu, Xiang-Gen Xia, Jianlai Chen, Rui Zhou, Shuai Shao, Wei Hong

“…In addition, ket augmentation is introduced to exhibit the local data structure more clearly than the original tensor under TT decomposition. Finally, tensor-train nuclear norm is used to relax the NP-hard problem with low-rank constraint and the minimization problem is solved in the framework of alternating direction method of multipliers for enhanced imaging. …”
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Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell by Peng-Tai Tien, Chia-Hung Lin, Chih-Sheng Chen, Ching-Yao Chang, Hsiangyu Ku, Dekang Gan, Yi-Yu Tsai, Jamie Jiin-Yi Chen, Hui-Ju Lin, Lei Wan

“…Furthermore, diacerein inhibited inflammation by attenuating the phosphorylation of protein kinase B (AKT) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) pathway. …”
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Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy by Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci

“…Consistently, the levels of acetylated-tubulin, which is related with stable MTs, are significantly increased in cortical neurons derived from the patient’s iPSCs compared to control cells, supporting the idea that the altered dynamics of the MTs depends on their increased stability. Finally, performing live-imaging experiments using fluorescence recovery after photobleaching and by monitoring GFP-tagged end binding protein 3 (EB3) “comets,” we observe an impairment of the plus-end polymerization speed in PCDH19-mutated cortical neurons, therefore confirming the impaired MT dynamics. …”
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