Development of a Komagataella phaffii cell factory for sustainable production of ( +)-valencene by Jintao Cheng, Jiali Chen, Dingfeng Chen, Baoxian Li, Chaozhi Wei, Tao Liu, Xiao Wang, Zhengshun Wen, Yuanxiang Jin, Chenfan Sun, Guiling Yang

“…Besides, in-situ deletion of the promoter of ERG9 increased the yield of ( +)-valencene to 48.1 mg/L. Finally, we optimized the copy number of farnesyl pyrophosphate synthase and ( +)-valencene synthase fusion protein, and when the copy number reached three, the yield of ( +)-valencene achieved 173.6 mg/L in shake flask level, which was 82-fold higher than that of the starting strain CaVAL1. …”
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Retracted: Computer Medical Image Segmentation Based on Neural Network by Xiaopeng Wang, Lei Gu, Zhongyi Wang

“…We then applied the method to a computer-aided system to classify tumor lesions in mammograms. Finally, we propose an FPGA-based multilevel optimization architecture for energy-efficient cellular neural networks. …”
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Proteomic Analysis Reveals the Vital Role of Synaptic Plasticity in the Pathogenesis of Temporal Lobe Epilepsy by Xu Qian, Ji-Qiang Ding, Xin Zhao, Xin-Wen Sheng, Zhao-Rui Wang, Qi-xing Yang, Jing-Jun Zheng, Jia-Gui Zhong, Teng-Yue Zhang, Shu-Qiao He, Wei-Dong Ji, Wei Li, Mei Zhang

“…Bioinformatics analysis indicated 27 DEPs were mainly enriched in “regulation of synaptic plasticity and structure” and “calmodulin-dependent protein kinase activity,” which implicate synaptic remodeling may play a vital role in the pathogenesis of TLE. …”
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An Actor-Oriented and Architecture-Driven Approach for Spatially Explicit Agent-Based Modeling by Eric Fotsing, Severin Vianey Tuekam Kakeu, Eric Desire Kameni, Marcellin Julius Antonio Nkenlifack

“…Domain knowledge including spatial specifications is summarized in a class diagram which is later transformed into the agent-based model. Finally, the XML file representing the model produced is used as input in the transformation process leading to code. …”
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Effect of meloxicam on serum vitamin and cytokine levels during endotoxemia by Akile Ozlem Yurt

“…Lipopolysaccharide caused increase in damage indicator levels of heart, liver, kidney besides cholesterol and triglyceride (p<0.05) while meloxicam administration was inhibited increase in creatine kinase-MB and cholesterol levels but caused more increase in urea and triglyceride levels.…”
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Research on the rapid diagnosis method for hunting of high-speed trains by Wanru Xie, Yixin Zhao, Gang Zhao, Fei Yang, Zilong Wei, Jinzhao Liu

“…Then, the Short-Time Fourier Transform (STFT) is performed to calculate the marginal spectra. Finally, the presence of a continuous hunting problem is determined based on the results of the comparison calculations and diagnostic thresholds. …”
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Advanced Microgrid Protection Utilizing Zero Sequence Components With Hard-Ware-in-the-Loop Testing by Zahra Ghanem, Feras Alasali, Naser El-Naily, Hassen Loukil, Haytham Y. Mustafa, Saad M. Saad, Abdelaziz Salah Saidi, William Holderbaum

“…HIL testing confirms the practical applicability and robustness of the proposed protection scheme, enhancing its reliability. Finally, the study provides a comprehensive framework for the implementation of the proposed protection strategy in real-case protective relays. …”
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Effect of Double Masking with Silk or Cotton Over-masks on the Source Control Capabilities of a Surgical Mask by Adam F. Parlin, Mikhail Yermakov, Samuel M. Stratton, Susan R. Reutman, Theresa M. Culley, Patrick A. Guerra, Sergey A. Grinshpun

“…Not only can double masking reduce viral or bacterial transmission, but it can also promote surgical mask longevity, thereby reducing global waste and pollution associated with the use of disposable surgical masks. Finally, an additional study with five human subjects revealed no significant differences in perceived comfort (measured by proxies such as relative humidity, temperature, and CO2 level inside the mask) between single masking and double masking, as well as between double masking with either a silk or cotton over-mask.…”
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AI-enhanced 3D-QSAR screening of fragment-based novel designed molecules targeting Phalaris minor ACCase by Bikash Kumar Rajak, Priyanka Rani, Durg Vijay Singh, Nitesh Singh

“…The selected herbicide-like molecules are further processed through fragment-based design to generate a library of new compounds, refined using binding affinity thresholds (-8.5 kcal/mol) and Quantitative Structure-Activity Relationship (QSAR) models. Finally, molecular dynamics (MD) simulations validated the interaction stability of these potential herbicides over 100 ns, yielding four promising candidates optimized for ACCase inhibition. …”
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Comparing the Trends of Vector-Borne Diseases (VBDs) before and after the COVID-19 Pandemic and Their Spatial Distribution in Southern Iran by Zahra Gheibi, Mitra Boroomand, Aboozar Soltani

“…During COVID-19 outbreaks, some reasons, such as quarantine, movement restrictions, and social distancing, reduced human-vector contact and finally led to the reduction of VBDs in this area.…”
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Ovine Eimeria infection, OPG and determinants in and around Gondar town, Ethiopia by Senait Belay, Desie Sheferaw

“…Generally, this study's results provided useful information to design and implement appropriate control strategies. Finally, it is recommended that further study identify the species of Eimeria circulating in the areas. …”
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Extrapolation-Based Scale Effect Model for Granular Heap Modulus by Zhigang Ma, Shuaifeng Wu, Ran Wei

“…By conducting the confined experiments on ball heaps, the modulus variation with particle breakage was investigated and the breakage effect model was established consequently. Finally, via combining the effects from the size, boundary constrain, and particle breakage, a scale effect model was established for extrapolating prototype modulus from the laboratory modulus. …”
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The reaction of the social security systems of the European Union and the united states of America to financial crises: proposals for using the experience in Russia by V. A. Kalabin

“…Secondly, increasing the targeting of social support measures will lead to the performance growth of social protection system, allowing for a more rational distribution of limited budget resources. Finally, this social system can effectively reach the target segment of beneficiaries only if means-testing information systems are of high quality.…”
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Comparison of different developmental stages of jujube (Ziziphus jujuba) fruit and identification of Hub genes by Li Yalan, Ren Tian, Qu Siyu, Hao Qing, Fan Dingyu, Alimire Alimu

“…The relationships among DEGs within each group were assessed and hub genes were identified using the degree algorithm of Cytohubba. Finally, the expression levels of these hub genes were compared across the four stages. …”
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Research on Simulation and Performance Optimization of Mach 4 Civil Aircraft Propulsion Concept by Min Chen, Zihao Jia, Hailong Tang, Yi Xiao, Yonghang Yang, Feijia Yin

“…Third, the Stone model and the DLR method were investigated to estimate the engine jet noise and the NOx emission of the Mach 4 supersonic civil aircraft. Finally, a multiobjective optimization tool made up of a response surface method and a genetic algorithm was developed to optimize the design parameters and the control law of the TBCC engine, in order to make the Mach 4 supersonic civil aircraft engine with better performance, lower noise, and lower emissions. …”
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Development of robust constitutive synthetic promoter using genetic resources of plant pararetroviruses by Tsheten Sherpa, Tsheten Sherpa, Nrisingha Dey

“…We further evaluated the activity of the MFH17 promoter in Oryza sativa seedlings and studied the effect of as-1 elements present in it. Finally, we tested the efficacy and tissue specificity of the MFH17 promoter in planta by developing transgenic Nicotiana tabacum and Arabidopsis thaliana plants and found it highly constitutive and efficient in driving the gene throughout the plant tissues. …”
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Modeling, Analysis, and Implementation of Series-Series Compensated Inductive Coupled Power Transfer (ICPT) System for an Electric Vehicle by Moustapha Elwalaty, Mohamed Jemli, Hechmi Ben Azza

“…A mathematical expression of optimal equivalent load resistance, corresponding to a maximal transmission efficiency of a wireless charging system, was demonstrated in detail. Finally, a prototype of a wireless charging system has been constructed for using two rectangular coils. …”
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Political and socioeconomic implications of Classic Maya lithic artifacts from the Main Plaza of Aguateca, Guatemala by Kazuo Aoyama

“…The theatrical performance and dedication ritual involved in the deposition of the eccentrics and other artifacts in the temple reinforced the ruler’s political and economic power. Finally, the obsidian data show that the Terminal Classic Maya of the Petexbatún region were not isolated from other regions but participated in long-distance exchange networks during this period.…”
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The Cross-Modal Effects of Sensory Deprivation on Spatial and Temporal Processes in Vision and Audition: A Systematic Review on Behavioral and Neuroimaging Research since 2000 by Laura Bell, Lisa Wagels, Christiane Neuschaefer-Rube, Janina Fels, Raquel E. Gur, Kerstin Konrad

“…This finding suggests a more input-unspecific and processing principle-based organization of the brain. Finally, we highlight the importance of controlling for and stating factors that might impact neural plasticity and the need for further research into visual temporal processing in deaf subjects.…”
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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…Third, L. reuteri-CMVs increased the population of double positive (DP) CD4+CD8+ T cells in the intestinal epithelial layer, suppressing gut inflammation and maintaining gut mucosal homeostasis. Finally, L. reuteri-CMVs exhibited satisfactory stability and safety in the gastrointestinal tract and specifically targeted the desired sites in colitis mice. …”
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