O uso das tecnologias digitais na formação dos professores para a integração do ensino by José Soares Filho, Danielle Juliana Silva Martins

“…A importância da formação de professores no uso da tecnologia digital como recurso pedagógico foi enfatizada pelos resultados da pesquisa, ressaltando sua aplicação no ambiente escolar, especialmente durante as aulas. As considerações finais ao integrar as tecnologias digitais de maneira consciente e coerente na prática docente, Pode-se impulsionar o progresso dos alunos na construção de conhecimentos através de uma atuação ativa, crítica e criativa. …”
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Improvement of the knock-in effciency in the genome of human induced pluripotent stem cells using the CRISPR/Cas9 system by М. М. Gridina

“…A low survival rate of hiPS cells following genome editing experiments is another difculty on the way towards successful knock-in, and here several highly effective approaches addressing it are proposed. Finally, I describe the most promising strategies, one-step reprogramming and genome editing, which allows gene-modifed integration-free hiPS cells to be efciently generated directly from somatic cells.…”
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Some Complex Picture Fuzzy Aggregation Operators Based on Frank t-norm and t-conorm: An Application to Multi-Attribute Decision-Making (MADM) Process by Faisal Mehmood, Heng Liu

“…Furthermore, an algorithm for solving multi-attribute decision-making MADM problems has been presented under the framework of CPFSs by using CPFFWA and CPFFWG operators. Finally, in order to depict the potential applicability of our proposed technique, a numerical problem aiming at finding the best alternative has been solved and outcomes have been well compared with some existing techniques.…”
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The Value of Preemptive Pick-Up Services in Dynamic Vehicle Routing for Last-Mile Delivery: Space-Time Network-Based Formulation and Solution Algorithms by Weiran Meng, Lingyun Meng, Guoshuai Han, Xiaotian Zhuang, Lu Carol Tong, Shengnan Wu

“…This framework jointly integrates the processes of updating request information and obtaining optimal routes. Finally, the validity and effectiveness of the proposed methods are evaluated on an illustrative network and a real-world last-mile delivery network operated by a logistics company.…”
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Association between NT-proBNP Level and the Severity of COVID-19 Pneumonia by Lan Wang, Fei Chen, Lin Bai, Lang Bai, Zhixin Huang, Yong Peng

“…A total of 91 (92.9%) patients were finally included in this study. The median age of the patients was 61 years (IQR, 47–69), and 39 (43.0%) of them were male. …”
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Comprehensive Environmental Monitoring System for Industrial and Mining Enterprises Using Multimodal Deep Learning and CLIP Model by Shuqin Wang, Na Cheng, Yan Hu

“…Principal Component Analysis (PCA) is then applied to diminish the dimensionality of the amalgamated features derived from environmental monitoring images, descriptive texts, and sensor data collected by industrial and mining enterprises. Finally, a multimodal LSTM model is leveraged to detect anomalies in the monitoring data by capturing long-term dependencies within time series information. …”
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Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer by Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter

“…To explore the possibility of combining targeted drugs with Th1-polarizing vaccines, we undertook a study to examine the impact of combining Th1 cytokines with the relatively broad-spectrum receptor tyrosine kinase antagonist, sunitinib. We found that when a panel of five phenotypically diverse human breast cancer cell lines was subjected to treatment with sunitinib plus recombinant Th1 cytokines IFN-γ and TNF-α, synergistic effects were observed across a number of parameters including different aspects of apoptotic cell death. …”
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Designing a Qualitative Model of the Micro Foundations of Dynamic Capabilities in Cloud Computing Service Providers in Iran by Afshin Ghasemi, MohammadTaghi Isaai, Reza Bandarian, Ahmad EkhtiarZadeh

“…The three construct technology knowledge transfer, best practice, and legal requirements of ISO and quality are among the categories less mentioned in earlier research. Finally, contingent strategic management, organizational strategic empathy, customer experience management, and strategic perseverance have been less studied in reconfiguring. …”
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Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy by Zhang Z, Wang R, Chen L

“…Next, we discussed common nanomaterials in modern medicine and their respective impacts on the TME, CAFs, and interactions with tumors. Finally, we focus on the application of nano drug delivery system targeting CAFs in cancer therapy.Keywords: cancer-associated fibroblasts, drug delivery, nanomedicine, tumor microenvironment, cancer immunotherapy…”
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Numerical Study and Theoretical Model of Shaped Charge Jet Penetrating Into Thick-Walled Target With Following Velocity by Jun-run Li, Yong-gang Lu, Bin Liang, Hengwei Xu, Xing Chen, Jian Zhang

“…A greater jet penetration depth was achieved for the climbing-oblique penetration (COP) than the diving-oblique penetration (DOP) due to an increase in dynamic stand-off distance. Finally, the ratio of oblique to normal penetration depth for a jet with varying following velocities was derived based on the theory of steady-jet and hole expansion, and its accuracy was verified.…”
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lncRNA HHIP-AS1 Promotes the Osteogenic Differentiation Potential and Inhibits the Migration Ability of Periodontal Ligament Stem Cells by Qianyi Qin, Haoqing Yang, Chen Zhang, Xiao Han, Jing Guo, Zhipeng Fan, Jie Guo

“…In addition, the RNA sequencing data showed that 356 mRNAs and 14 lncRNAs were upregulated, including receptor tyrosine kinase-like orphan receptor 2 and nuclear-enriched abundant transcript 1, while 185 mRNAs and 6 lncRNAs were downregulated, including fibroblast growth factor 5 and LINC00973, in HHIP-AS1-depleted PDLSCs. …”
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Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride by Amr M. Mahmoud, Nariman A. El-Ragehy, Maha A. Hegazy, Samia A. Tawfik, Ghada A. Sedik

“…Additionally, three different approaches namely; Analytical EcoScale, Analytical GREEnness metric approach and finally, the most recent one; Red-Green-Blue model were applied to evaluate the greenness and whiteness profile of the developed method.…”
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Posttranscriptional Suppression of Lipopolysaccharide-Stimulated Inflammatory Responses by Macrophages in Middle-Aged Mice: A Possible Role for Eukaryotic Initiation Factor 2α by Ken Shirato, Kazuhiko Imaizumi

“…Moreover, LPS evoked similar levels of phosphorylation of c-Jun N-terminal kinase (JNK) and nuclear factor-κB (NF-κB) in young and middle-aged mice. …”
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Analisis strategi pengembangan industri sirup pokak di Probolinggo by Nita Kuswardhani, Nadia Putri Irkhana

“…This research uses IFAS and EFAS analysis techniques at the input stage, then mapped to the SWOT matrix and IE matrix at the matching stage, and finally QSPM analysis is carried out at the decision stage. …”
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Reduction in Carbon Dioxide Emission and Energy Saving Obtained by Renovation of Building Envelope of Existing Residential Buildings by Rui Chen, Xiaoping Feng, Chengjing Li, Huapeng Chen

“…Then, setting the static payback period as the evaluation index, we applied the orthogonal test method to determine the economic efficiency of different combinations of schemes. Finally, we identified the optimal combination for conserving energy and decreasing CO2 emissions as 120-mm-thick expanded polystyrene insulating board for both the exterior wall and the roof, and 5-mm-thick triple-silver low-emissivity glass and 5-mm-thick normal glass separated by 12 mm of air for the exterior windows, which resulted in a cooling capacity, heating consumption, total building energy consumption, static payback period, and dynamic payback period of 28.37 kWh m−2 a−1, 4.22 kWh m−2 a−1, 32.59 kWh m−2 a−1, 13.76 years, and 22.84 years, respectively, as well as an annual reduction in CO2, sulfur dioxide (SO2), and nitrogen oxides (NOx) emissions of 86.01 tons, 2.59 tons, and 1.29 tons, respectively.…”
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Antimicrobial Activity and Metabolomic Analysis of Linalool Against Pathogenic Bacteria Methicillin-Resistant Staphylococcus aureus by Long N, Qiu M, Zuo Y, Deng H

“…Nana Long,1,2 Min Qiu,2 Youwei Zuo,1 Hongping Deng1 1Center for Biodiversity Conservation and Utilization, School of Life Sciences, Southwest University, Beibei, Chongqing, People’s Republic of China; 2School of Laboratory Medicine, Chengdu Medical College, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Hongping Deng, Email denghp@swu.edu.cnPurpose: The purpose of this study was to evaluate the antibacterial activity and mechanism of linalool against Methicillin-resistant Staphylococcus aureus (MRSA).Methods: The determination of the antibacterial activity of linalool against clinically isolated MRSA strains was based on the minimum inhibitory concentration (MIC) and growth curve analysis. Finally, the inhibition mechanism of linalool was elucidated through metabolomic analysis and molecular docking.Results: Among the isolated strains, penicillin resistance was found to be the highest, while resistance to daptomycin/quinupristin-dalfopristin, linezolid, vancomycin, tetracycline, telithromycin, and levofloxacin was not observed. …”
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La música en el Conjunto Nacional de Folklore: apuntes y reflexiones sobre sus inicios y su posterior proyección, al cumplirse el 50° aniversario de fundación by Ricardo López Alcas

“…Como complemento a todo lo expuesto, y previo a unas reflexiones finales, se mostrará también cómo una institución pública en la actualidad intenta dar continuidad de manera simbólica al conjunto fundado por Victoria Santa Cruz hace 50 años.…”
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Coping Strategies in Migraine without Aura: A Cross-Sectional Study by Antonio Russo, Gabriella Santangelo, Alessandro Tessitore, Marcello Silvestro, Francesca Trojsi, Antonio De Mase, Federica Garramone, Luigi Trojano, Gioacchino Tedeschi

“…Although migraine patients appeared to be less oriented to transcendent (that means a reduced utilization of an adaptive coping strategy), they did not perceive daily living as more stressful than HCs. Finally, the reduced utilization of the “turning to religion” coping strategy is associated with a great impact of migraine on ability to function on the job or at school, at home, and in social situations in migraine patients.…”
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Current preeclampsia prediction model and biomarker by Anak Agung Ngurah Jaya Kusuma

“…Additionally, biomarkers like mean arterial pressure (MAP), UtA-PI, and the ratio of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) are employed to improve predictive accuracy. …”
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Improvement of Propeller Hydrodynamic Prediction Model Based on Multitask ANN and Its Application in Optimization Design by Liang Li, Yihong Chen, Lu Huang, Qing Hai, Denghai Tang, Chao Wang

“…Strong generalization was demonstrated when the model was tested on unseen propellers, with deviations of 2.2% for <i>K_T</i>, 4.6% for 10 <i>K_Q</i>, and 3.8% for <i>η</i>. Finally, the model was applied to optimize the propeller design for a 325,000 ton very large ore carrier ship, where a Pareto front with 58 non-dominant solutions for the maximum speed and fluctuating pressure was successfully generated and effectively verified by the model’s test results. …”
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