Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. …”
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Log-Driven Behavior Discrimination of Process Robots Using Entropy Similarity by Lu Li, Huan Fang

“…Then, JS and KL divergence is used to measure the statistical distance between the two probability distributions of processes, and these statistical distances are the foundations of log similarity measurements. Finally, a series of experiments are conducted on a set of publicly available datasets, validating the feasibility, generality, and effectiveness of the proposed method.…”
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Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers by John Metzcar, Rachael Guenter, Yafei Wang, Kimberly M Baker, Kate E Lines

“…We also provide a scope of the limited work that has been done in NETs and map how these techniques can be utilized in NET research to address specific outstanding challenges in the field. Finally, we include practical details such as hardware and data requirements, present advantages and disadvantages of various mathematical modeling approaches and discuss challenges of using mathematical modeling. …”
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Analysis of Rural Talent Scale in Hebei Province Based on Fractional GM (1,1) and the Grey Relational Analysis Model by Yibo Li, Wenbin Bi, Kuo Xiao, Huan Li, Shi Yin, Chaoyong Tang

“…Through the grey relational analysis, it was found that the infrastructure had the greatest impact on production-oriented talents, the agricultural industrialization operating rate had the strongest impact on service-oriented talents, and the urban-rural income level had the greatest impact on business-oriented talents, management-oriented talents, and skilled talents. Finally, according to the results of the GM (1,1) model and grey relational analysis, aiming at different types of rural talents, this paper puts forward countermeasures and suggestions from the aspects of strengthening rural infrastructure construction, improving rural medical and health conditions and improving income distribution pattern.…”
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A Comparative Study of the Most Commonly Used Metaphors in Covid-19 News Texts during the Outbreak and Peak of the Disease by Mansour Nikpanah, Mansoureh Delaramifar

“…Then, the metaphors placed in the “disease” semantic frame, and their frame elements were identified. Finally, the frequency of the most used metaphors including "Corona is war", "Corona is a natural phenomenon", "Corona is a travel" and "Corona is another living thing" in the two periods between the initial outbreak  and the third peak in October 2020 were determined. …”
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Investigating the impact of diversion projects on river health using the spherical fuzzy cloud TOPSIS model and the SHapley Additive exPlanation technique by Ting Cheng, Maosen Ju, Wenhui Zhang, Chenhui Wu, Qi Liu, Qingqing Ban

“…Second, the spherical fuzzy cloud technique for the order of preference by similarity to ideal solution (SFC-TOPSIS) assessment framework was developed and used to analyze the impact of water diversion projects on river health. Finally, the key factors affecting river health were identified using the SHapley Additive exPlanation (SHAP) sensitivity analysis. …”
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Observation System Optimization of Offshore Acoustic Exploration for Estimating Submarine Geological Structures via Directivity Analysis by Chao Fu, Lei Hao, Pengfei Zhou, Lei Chen, Xiaobin Xu, Kai Wang, Miaojun Sun

“…On this basis, combined with directivity analysis, the optimal observation system parameters are proposed. Finally, the proposed observation system is used to image the fault model. …”
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A Citrus bergamia Extract Decreases Adipogenesis and Increases Lipolysis by Modulating PPAR Levels in Mesenchymal Stem Cells from Human Adipose Tissue by Debora Lo Furno, Adriana Carol Eleonora Graziano, Rosanna Avola, Rosario Giuffrida, Vincenzo Perciavalle, Francesco Bonina, Giuliana Mannino, Venera Cardile

“…Moreover, the expression of peroxisome proliferator-activated receptor gamma (PPAR-γ), adipocytes fatty acid-binding protein (A-FABP), adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), monoglyceride lipase (MGL), 5′-adenosine monophosphate-activated protein kinase (AMPK)α1/2, and pAMPKα1/2 was evaluated by Western blot analysis and the release of glycerol by colorimetric assay. …”
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Kebaruan Fungsional Vertex Marker Terhadap Marker Based Augmented Reality Tracking Factors (Jarak, Sudut, dan Luas Permukaan) by Wahyu Teja Kusuma, Ahmad Afif Supianto, Herman Tolle, Mochammad Anshori

“…This study also compared the results of the functional testing of the vertex marker with the single marker. Finally, this research contributes to proving the novelty of functional vertex markers in the field of Marker-Based Augmented Reality tracking factors. …”
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FAILURE ANALYSIS AND EXPERIMENTAL STUDY OF COMPOSITE MULTI-PIN CONNECTIONS BASED ON CONTINUUM DAMAGE MECHANICS by LI Xi, LI YaZhi, MO ChengJie, QIN Qun, CHEN Hong

“…Secondly, the tensile properties of composite laminate plate and perforated plate are analyzed by using the above mechanical model, and the feasibility of the model is verified by comparing the test results. Finally, the failure and damage evolution process of the composite multi pin connection structure is analyzed by using the above mechanical model, and the results are compared with the experimental results. …”
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Teratogenic Effects of Coadministration of Fluoxetine and Olanzapine on Rat Fetuses by Azam Bakhtiarian, Nasrin Takzare, Mehdi Sheykhi, Narges Sistany, Farahnaz Jazaeri, Mario Giorgi, Vahid Nikoui

“…The sixth group received 9 mg/kg fluoxetine and 3 mg/kg olanzapine. Finally, the seventh group was administrated with fluoxetine and olanzapine at 18 mg/kg and 6 mg/kg, respectively. …”
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Design of Personalized Cervical Fixation Orthosis Based on 3D Printing Technology by Yangyang Xu, Xiangyu Li, Yafei Chang, Yi Wang, Lifang Che, Guopeng Shi, Xiaofen Niu, Haiyan Wang, Xiaohe Li, Yujie He, Baoqing Pei, Guoqiang Wei

“…The CT data of the patient’s cervical spine were collected, then mimics were used for reconstructing the skin of the cervical spine, the Geomagic Studio was used for surface fitting, the Inspire Studio was used for structural topology optimization, redundant structures were removed, the resulting orthotics were postprocessed, and finally, it was printed with a 3D printer. No signs of pain or discomfort were observed during the wearing. …”
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Duale Autonomie. Zur Rechtsgeschichte des Arbeitsmarktregimes by Gerd Bender

“…The discourse at the time was heavily influenced by vehement demands that the need of companies for more flexibility be met by favouring company agreements over collective ones, but the decline of the republic put an end to these debates. Finally, the article looks at parallels that emerged later in the West German debate on the functional deficits of collective bargaining autonomy. …”
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RNASeq analysis of drought-stressed guayule reveals the role of gene transcription for modulating rubber, resin, and carbohydrate synthesis by Chen Dong, Grisel Ponciano, Naxin Huo, Yong Gu, Daniel Ilut, Colleen McMahan

“…On the other hand, terpene resin biosynthesis genes were unevenly affected by water stress, implying unique environmental influences over transcriptional control of different terpene compounds or classes. Finally, drought induced expression of fructan catabolism genes in guayule and significantly suppressed these fructan biosynthesis genes. …”
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“Relief-Retaining” Control Technology of Floor Heave in Mining Roadway with Soft Rock: A Case Study by Ai Chen, Xuebin Li, Xuesheng Liu, Yunliang Tan, Ke Xu, Honglei Wang

“…Then, the specific parameters suitable for floor heave control of no. 130203 return airway are determined using numerical simulation method. Finally, the yield monitoring results show that both the deformation of surrounding rocks and the cable force are significantly reduced. …”
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El Imperio mongol y la formación de Occidente. Una actualización historiográfica by Antonio Garcia Espada

“…Nuevos trabajos, algunos realmente rompedores, sobre la Horda Dorada y el Ilkhanato, sobre la praxis comercial y la sensibilidad religiosa de los khanes, su imaginación geográfica y sus concepciones antropológicas, aportan valiosas claves hermenéuticas con importantes implicaciones también para el estudio del éxito de las ligas y las repúblicas comerciales latinas, de la transformación de la cruzada a finales del siglo XIII o del origen de una auténtica ideología misionera con un futuro prometedor en la historia de Occidente. …”
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Detection of The TNFSF Members BAFF, APRIL, TWEAK and Their Receptors in Normal Kidney and Renal Cell Carcinomas by Vassiliki Pelekanou, George Notas, Katerina Theodoropoulou, Marilena Kampa, Dimitrios Takos, Vassilia-Ismini Alexaki, Jelena Radojicic, Frank Sofras, Andreas Tsapis, Efstathios N. Stathopoulos, Elias Castanas

“…Therapeutic modalities targeting VEGF, PDGF, and c-kit using tyrosine kinase inhibitors and m-TOR using specific biologic factors are in development. …”
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ACCIDENTS AND OCCUPATIONAL ILLNESS ASSESSMENTS FOR 400/220/110/20 kV URECHESTI POWER SUBSTATION by Nicolae Daniel FÎȚĂ, Mila Ilieva OBRETENOVA, Florin MURESAN – GRECU, Gheorghe Eugen SAFTA, Adrian Mihai SCHIOPU, Dan Cristian LAZAR

“…Prevention of occupational risks is the only way to improve the safety and health conditions of the participants in the work process, as well as a reliable source for reducing costs, increasing labor productivity, quality of production and, finally, quality of social life. Risk management facilitates a structured and systematic approach to decision-making. …”
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A generalized interval-valued p,q Rung orthopair fuzzy Maclaurin symmetric mean and modified regret theory based sustainable supplier selection method by Shuang Chen, Jian Ren, KeTing Ye, FeiYan Li

“…Both of them consider the best alternative and worst alternative, so as to reflect the psychological state and risk attitude of DMs. Finally, a SSS problem is presented to manifest the effectiveness of the designed method. …”
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Test setup for analyzing the electrical resistance during fatigue loading for metastable austenite AISI 304L and its diffusion-brazed joints by Lukas M. Sauer, Johannes L. Otto, Jonas A. Ziman, Peter Starke, Frank Walther

“…The method was applied and evaluated on high-temperature diffusion-brazed joints with a metastable austenite as base material and Ni-based filler metal. Finally, the change in microstructure was evaluated through electron channeling contrast imaging (ECCI) analyses at different load cycles.…”
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